Search Results - "Chen, Helen"

Improving radiotherapy in cancer treatment: Promises and challenges by Chen, Helen H W, Kuo, Macus Tien

“…Effective radiotherapy for cancer has relied on the promise of maximally eradicating tumor cells while minimally killing normal cells. Technological…”
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Prognostic Value of Whole-Body Total Lesion Glycolysis at Pretreatment FDG PET/CT in Non―Small Cell Lung Cancer by CHEN, Helen H. W, CHIU, Nan-Tsing, SU, Wu-Chou, GUO, How-Ran, LEE, Bi-Fang

“…To determine whether whole-body total lesion glycolysis (TLG), which combines volumetric and metabolic information from fluorine 18 fluorodeoxyglucose (FDG)…”
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Intrauterine Microbiota: Missing, or the Missing Link? by Chen, Helen J., Gur, Tamar L.

“…The intrauterine environment provides a key interface between the mother and the developing fetus during pregnancy, and is a target for investigating…”
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Overcoming Radiation Resistance by Iron-Platinum Metal Alloy Nanoparticles in Human Copper Transport 1-Overexpressing Cancer Cells via Mitochondrial Disturbance by Tsai, Tsung-Lin, Lai, Yu-Hsuan, Hw Chen, Helen, Su, Wu-Chou

“…Radiation therapy remains an important treatment modality in cancer therapy, however, resistance is a major problem for treatment failure. Elevated expression…”
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Modulating Chemosensitivity of Tumors to Platinum-Based Antitumor Drugs by Transcriptional Regulation of Copper Homeostasis by Lai, Yu-Hsuan, Kuo, Chin, Kuo, Macus Tien, Chen, Helen H W

“…Platinum (Pt)-based antitumor agents have been effective in treating many human malignancies. Drug importing, intracellular shuffling, and exporting-carried…”
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Role of the Human High-Affinity Copper Transporter in Copper Homeostasis Regulation and Cisplatin Sensitivity in Cancer Chemotherapy by TIEN KUO, Macus, SIQING FU, SAVARAJ, Niramol, CHEN, Helen H. W

“…The high-affinity copper transporter (Ctr1; SCLC31A1) plays an important role in regulating copper homeostasis because copper is an essential micronutrient and…”
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Targeting the Proline-Glutamine-Asparagine-Arginine Metabolic Axis in Amino Acid Starvation Cancer Therapy by Kuo, Macus Tien, Chen, Helen H W, Feun, Lynn G, Savaraj, Niramol

“…Proline, glutamine, asparagine, and arginine are conditionally non-essential amino acids that can be produced in our body. However, they are essential for the…”
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What social media told us in the time of COVID-19: a scoping review by Tsao, Shu-Feng, Chen, Helen, Tisseverasinghe, Therese, Yang, Yang, Li, Lianghua, Butt, Zahid A

“…With the onset of the COVID-19 pandemic, social media has rapidly become a crucial communication tool for information generation, dissemination, and…”
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Adverse effects of anticancer agents that target the VEGF pathway by Chen, Helen X, Cleck, Jessica N

“…Antiangiogenic agents that target the VEGF pathway have become an important part of standard therapy in multiple cancer indications. Although most adverse…”
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Accelerated coronary calcium burden in breast cancer patients after radiotherapy: a comparison with age and race matched healthy women by Lai, Yu-Hsuan, Chen, Helen H W, Tsai, Yi-Shan

“…Radiotherapy (RT) might lead to atherosclerotic plaque buildup and coronary artery stenosis of breast cancer (BC) survivors, and coronary artery calcium (CAC)…”
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Temporal Regulation of the Metabolome and Proteome in Photosynthetic and Photorespiratory Pathways Contributes to Maize Heterosis by Li, Zhi, Zhu, Andan, Song, Qingxin, Chen, Helen Y, Harmon, Frank G, Chen, Z Jeffrey

“…Heterosis or hybrid vigor is widespread in plants and animals. Although the molecular basis for heterosis has been extensively studied, metabolic and proteomic…”
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Presenteeism: A Public Health Hazard by Widera, Eric, Chang, Anna, Chen, Helen L.

“…"Presenteeism" occurs when an employee goes to work despite a medical illness that will prevent him or her from fully functioning at work. This problem has…”
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Argininosuccinate synthetase 1 (ASS1) is a common metabolic marker of chemosensitivity for targeted arginine- and glutamine-starvation therapy by Long, Yan, Tsai, Wen-Bin, Wang, Dajuan, Hawke, David H, Savaraj, Niramol, Feun, Lynn G, Hung, Mien-Chie, Chen, Helen H.W, Kuo, Macus Tien

“…Abstract Argininosuccinate synthetase 1 (ASS1) is the rate-limiting enzyme that catalyzes the biosynthesis of arginine (Arg). Many malignant human tumors are…”
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A new concordant partial AUC and partial c statistic for imbalanced data in the evaluation of machine learning algorithms by Carrington, André M, Fieguth, Paul W, Qazi, Hammad, Holzinger, Andreas, Chen, Helen H, Mayr, Franz, Manuel, Douglas G

“…In classification and diagnostic testing, the receiver-operator characteristic (ROC) plot and the area under the ROC curve (AUC) describe how an adjustable…”
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Increased apoptotic potential and dose‐enhancing effect of gold nanoparticles in combination with single‐dose clinical electron beams on tumor‐bearing mice by Chang, Meng‐Ya, Shiau, Ai‐Li, Chen, Yu‐Hung, Chang, Chih‐Jui, Chen, Helen H‐W, Wu, Chao‐Liang

“…High atomic number material, such as gold, may be used in conjunction with radiation to provide dose enhancement in tumors. In the current study, we…”
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A Phase II Basket Trial of Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors (DART SWOG 1609) in Patients with Nonpancreatic Neuroendocrine Tumors by Patel, Sandip P, Othus, Megan, Chae, Young Kwang, Giles, Francis J, Hansel, Donna E, Singh, Preet Paul, Fontaine, Annette, Shah, Manisha H, Kasi, Anup, Baghdadi, Tareq Al, Matrana, Marc, Gatalica, Zoran, Korn, W Michael, Hayward, Jourdain, McLeod, Christine, Chen, Helen X, Sharon, Elad, Mayerson, Edward, Ryan, Christopher W, Plets, Melissa, Blanke, Charles D, Kurzrock, Razelle

“…Immune checkpoint blockade has improved outcomes across tumor types; little is known about the efficacy of these agents in rare tumors. We report the results…”
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Strategies for optimizing combinations of molecularly targeted anticancer agents by Dancey, Janet E, Chen, Helen X

“…The rapid emergence of hundreds of new agents that modulate an ever-growing list of cancer-specific molecular targets offers tremendous hope for cancer…”
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Combination Dabrafenib and Trametinib Versus Combination Nivolumab and Ipilimumab for Patients With Advanced BRAF -Mutant Melanoma: The DREAMseq Trial-ECOG-ACRIN EA6134 by Atkins, Michael B, Lee, Sandra J, Chmielowski, Bartosz, Tarhini, Ahmad A, Cohen, Gary I, Truong, Thach-Giao, Moon, Helen H, Davar, Diwakar, O'Rourke, Mark, Stephenson, Joseph J, Curti, Brendan D, Urba, Walter J, Brell, Joanna M, Funchain, Pauline, Kendra, Kari L, Ikeguchi, Alexandra P, Jaslowski, Anthony, Bane, Charles L, Taylor, Mark A, Bajaj, Madhuri, Conry, Robert M, Ellis, Robert J, Logan, Theodore F, Laudi, Noel, Sosman, Jeffrey A, Crockett, David G, Pecora, Andrew L, Okazaki, Ian J, Reganti, Sowjanya, Chandra, Sunandana, Guild, Samantha, Chen, Helen X, Streicher, Howard Z, Wolchok, Jedd D, Ribas, Antoni, Kirkwood, John M

“…Combination programmed cell death protein 1/cytotoxic T-cell lymphocyte-4-blockade and dual BRAF/MEK inhibition have each shown significant clinical benefit in…”
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Risk Factors, Presentation, and Course of Coronavirus Disease 2019 in a Large, Academic Long-Term Care Facility by Shi, Sandra M., Bakaev, Innokentiy, Chen, Helen, Travison, Thomas G., Berry, Sarah D.

“…To describe clinical characteristics and risk factors associated with coronavirus disease 2019 (COVID-19) in long-stay nursing home residents. Retrospective…”
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Durvalumab plus tremelimumab alone or in combination with low-dose or hypofractionated radiotherapy in metastatic non-small-cell lung cancer refractory to previous PD(L)-1 therapy: an open-label, multicentre, randomised, phase 2 trial by Schoenfeld, Jonathan D, Giobbie-Hurder, Anita, Ranasinghe, Srinika, Kao, Katrina Z, Lako, Ana, Tsuji, Junko, Liu, Yang, Brennick, Ryan C, Gentzler, Ryan D, Lee, Carrie, Hubbard, Joleen, Arnold, Susanne M, Abbruzzese, James L, Jabbour, Salma K, Uboha, Nataliya V, Stephans, Kevin L, Johnson, Jennifer M, Park, Haeseong, Villaruz, Liza C, Sharon, Elad, Streicher, Howard, Ahmed, Mansoor M, Lyon, Hayley, Cibuskis, Carrie, Lennon, Niall, Jhaveri, Aashna, Yang, Lin, Altreuter, Jennifer, Gunasti, Lauren, Weirather, Jason L, Mak, Raymond H, Awad, Mark M, Rodig, Scott J, Chen, Helen X, Wu, Catherine J, Monjazeb, Arta M, Hodi, F Stephen

“…Patients with non-small-cell lung cancer (NSCLC) that is resistant to PD-1 and PD-L1 (PD[L]-1)-targeted therapy have poor outcomes. Studies suggest that…”
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