Search Results - "Chen, Hai‐Ning"

Helicobacter pylori eradication cannot reduce the risk of gastric cancer in patients with intestinal metaplasia and dysplasia: evidence from a meta-analysis by Chen, Hai-Ning, Wang, Zhu, Li, Xiao, Zhou, Zong-Guang

“…Background The effect of Helicobacter pylori ( H. pylori ) eradication on gastric cancer (GC) prevention is controversial. Intestinal metaplasia (IM) seems to…”
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Inhibition of NPC1L1 disrupts adaptive responses of drug‐tolerant persister cells to chemotherapy by Zhang, Zhe, Qin, Siyuan, Chen, Yan, Zhou, Li, Yang, Mei, Tang, Yongquan, Zuo, Jing, Zhang, Jian, Mizokami, Atsushi, Nice, Edouard C, Chen, Hai‐Ning, Huang, Canhua, Wei, Xiawei

“…Entering a drug‐tolerant persister (DTP) state of cancer cells is a transient self‐adaptive mechanism by which a residual cell subpopulation accelerates tumor…”
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Pan-cancer single-cell analysis reveals the heterogeneity and plasticity of cancer-associated fibroblasts in the tumor microenvironment by Luo, Han, Xia, Xuyang, Huang, Li-Bin, An, Hyunsu, Cao, Minyuan, Kim, Gyeong Dae, Chen, Hai-Ning, Zhang, Wei-Han, Shu, Yang, Kong, Xiangyu, Ren, Zhixiang, Li, Pei-Heng, Liu, Yang, Tang, Huairong, Sun, Ronghao, Li, Chao, Bai, Bing, Jia, Weiguo, Liu, Yi, Zhang, Wei, Yang, Li, Peng, Yong, Dai, Lunzhi, Hu, Hongbo, Jiang, Yong, Hu, Yiguo, Zhu, Jingqiang, Jiang, Hong, Li, Zhihui, Caulin, Carlos, Park, Jihwan, Xu, Heng

“…Cancer-associated fibroblasts (CAFs) are the predominant components of the tumor microenvironment (TME) and influence cancer hallmarks, but without systematic…”
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Ketoconazole exacerbates mitophagy to induce apoptosis by downregulating cyclooxygenase-2 in hepatocellular carcinoma by Chen, Yan, Chen, Hai-Ning, Wang, Kui, Zhang, Lu, Huang, Zhao, Liu, Jiayang, Zhang, Zhe, Luo, Maochao, Lei, Yunlong, Peng, Yong, Zhou, Zong-Guang, Wei, Yuquan, Huang, Canhua

“…[Display omitted] •Ketoconazole induces apoptosis in HCC cells by triggering excessive mitophagy.•Downregulation of cyclooxygenase 2 (COX-2) is key in the…”
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Genomic evolution and diverse models of systemic metastases in colorectal cancer by Chen, Hai-Ning, Shu, Yang, Liao, Fei, Liao, Xue, Zhang, Hongying, Qin, Yun, Wang, Zhu, Luo, Maochao, Liu, Qiuluo, Xue, Zhinan, Cao, Minyuan, Zhang, Shouyue, Zhang, Wei-Han, Hou, Qianqian, Xia, Xuyang, Luo, Han, Zhang, Yan, Yang, Lie, Hu, Jian-Kun, Fu, Xianghui, Liu, Bo, Hu, Hongbo, Huang, Canhua, Peng, Yong, Cheng, Wei, Dai, Lunzhi, Yang, Li, Zhang, Wei, Dong, Biao, Li, Yuan, Wei, Yuquan, Xu, Heng, Zhou, Zong-Guang

“…The systemic spread of colorectal cancer (CRC) is dominated by the portal system and exhibits diverse patterns of metastasis without systematical genomic…”
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Ivermectin Induces Cytostatic Autophagy by Blocking the PAK1/Akt Axis in Breast Cancer by Dou, Qianhui, Chen, Hai-Ning, Wang, Kui, Yuan, Kefei, Lei, Yunlong, Li, Kai, Lan, Jiang, Chen, Yan, Huang, Zhao, Xie, Na, Zhang, Lu, Xiang, Rong, Nice, Edouard C, Wei, Yuquan, Huang, Canhua

“…Breast cancer is the most common cancer among women worldwide, yet successful treatment remains a clinical challenge. Ivermectin, a broad-spectrum…”
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Hypoxia-induced lncRNA STEAP3-AS1 activates Wnt/β-catenin signaling to promote colorectal cancer progression by preventing m6A-mediated degradation of STEAP3 mRNA by Zhou, Li, Jiang, Jingwen, Huang, Zhao, Jin, Ping, Peng, Liyuan, Luo, Maochao, Zhang, Zhe, Chen, Yan, Xie, Na, Gao, Wei, Nice, Edouard C., Li, Jing-Quan, Chen, Hai-Ning, Huang, Canhua

“…Abstract Background Hypoxia, a typical hallmark of solid tumors, exhibits an essential role in the progression of colorectal cancer (CRC), in which the…”
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Disrupting metformin adaptation of liver cancer cells by targeting the TOMM34/ATP5B axis by Jin, Ping, Jiang, Jingwen, Zhou, Li, Huang, Zhao, Qin, Siyuan, Chen, Hai‐Ning, Peng, Liyuan, Zhang, Zhe, Li, Bowen, Luo, Maochao, Zhang, Tingting, Ming, Hui, Ding, Ning, Li, Lei, Xie, Na, Gao, Wei, Zhang, Wei, Nice, Edouard C, Wei, Yuquan, Huang, Canhua

“…Metformin, a well‐known antidiabetic drug, has been repurposed for cancer treatment; however, recently observed drug resistance and tumor metastasis have…”
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Prediction of symptomatic anastomotic leak after rectal cancer surgery: A machine learning approach by Shen, Yu, Huang, Li‐Bin, Lu, Anqing, Yang, Tinghan, Chen, Hai‐Ning, Wang, Ziqiang

“…Introduction Anastomotic leakage (AL) remains the most dreaded and unpredictable major complication after low anterior resection for mid‐low rectal cancer. The…”
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PHGDH arginine methylation by PRMT1 promotes serine synthesis and represents a therapeutic vulnerability in hepatocellular carcinoma by Wang, Kui, Luo, Li, Fu, Shuyue, Wang, Mao, Wang, Zihao, Dong, Lixia, Wu, Xingyun, Dai, Lunzhi, Peng, Yong, Shen, Guobo, Chen, Hai-Ning, Nice, Edouard Collins, Wei, Xiawei, Huang, Canhua

“…Serine synthesis is crucial for tumor growth and survival, but its regulatory mechanism in cancer remains elusive. Here, using integrative metabolomics and…”
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Metastasis organotropism in colorectal cancer: advancing toward innovative therapies by He, Kai, Wang, Zhihan, Luo, Maochao, Li, Bowen, Ding, Ning, Li, Lei, He, Bo, Wang, Han, Cao, Jiangjun, Huang, Canhua, Yang, Jun, Chen, Hai-Ning

“…Abstract Distant metastasis remains a leading cause of mortality among patients with colorectal cancer (CRC). Organotropism, referring to the propensity of…”
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Predictive Role of Tumor Budding in T1 Colorectal Cancer Lymph Node Metastasis by Huang, Li-Bin, Yang, Ting-Han, Chen, Hai-Ning

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ZNF37A promotes tumor metastasis through transcriptional control of THSD4/TGF-β axis in colorectal cancer by Liu, Jiayang, Huang, Zhao, Chen, Hai-Ning, Qin, Siyuan, Chen, Yan, Jiang, Jingwen, Zhang, Zhe, Luo, Maochao, Ye, Qin, Xie, Na, Zhou, Zong-Guang, Wei, Yuquan, Xie, Ke, Huang, Canhua

“…Poorly differentiated colorectal cancer (CRC) is characterized by aggressive invasion and stromal fibroblast activation, which results in rapid progression and…”
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Amino acid metabolic reprogramming in tumor metastatic colonization by Wang, Zihao, Wu, Xingyun, Chen, Hai-Ning, Wang, Kui

“…Metastasis is considered as the major cause of cancer death. Cancer cells can be released from primary tumors into the circulation and then colonize in distant…”
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Epigenetic Regulation of Epithelial to Mesenchymal Transition in the Cancer Metastatic Cascade: Implications for Cancer Therapy by Liu, Qiu-Luo, Luo, Maochao, Huang, Canhua, Chen, Hai-Ning, Zhou, Zong-Guang

“…Metastasis is the end stage of cancer progression and the direct cause of most cancer-related deaths. The spreading of cancer cells from the primary site to…”
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Repurposing Brigatinib for the Treatment of Colorectal Cancer Based on Inhibition of ER-phagy by Zhang, Zhe, Gao, Wei, Zhou, Li, Chen, Yan, Qin, Siyuan, Zhang, Lu, Liu, Jiayang, He, Yujia, Lei, Yunlong, Chen, Hai-Ning, Han, Junhong, Zhou, Zong-Guang, Nice, Edouard C, Li, Changlong, Huang, Canhua, Wei, Xiawei

“…: The sustained and severe endoplasmic reticulum (ER) stress in cancer cells may contribute to apoptotic cell death, thus representing a potential target for…”
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PRKAA/AMPK restricts HBV replication through promotion of autophagic degradation by Xie, Na, Yuan, Kefei, Zhou, Li, Wang, Kui, Chen, Hai-Ning, Lei, Yunlong, Lan, Jiang, Pu, Qinqin, Gao, Wei, Zhang, Lu, Shen, Guobo, Li, Qifu, Xiao, Hengyi, Tang, Hong, Xiang, Rong, He, Mingliang, Feng, Pinghui, Nice, Edouard C., Wei, Yuquan, Zhang, Haiyuan, Yang, Jiayin, Huang, Canhua

“…Adenosine monophosphate-activated protein kinase (AMPK) is a crucial energy sensor that maintains cellular energy homeostasis. AMPK plays a critical role in…”
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Thiol-based redox proteomics in cancer research by Yuan, Kefei, Liu, Yuan, Chen, Hai-Ning, Zhang, Lu, Lan, Jiang, Gao, Wei, Dou, Qianhui, Nice, Edouard C., Huang, Canhua

“…Cancer cells maintain their intracellular ROS concentrations at required levels for their survival. Changes in ROS concentrations can regulate biochemical…”
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Enhanced wettability of zinc passivation layer by coating organic–inorganic multilayers by Shao, Xiao-Dan, Zhu, Li-Qun, Li, Wei-Ping, Chen, Hai-Ning, Liu, Hui-Cong

“…Zinc Cr(III) passivation layer (Zn-PL) could effectively protect NdFeB materials from corrosion. However, long-term exposure of Zn-PL to ambient atmosphere…”
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Targeting PSAT1 to mitigate metastasis in tumors with p53-72Pro variant by Jiang, Jingwen, Chen, Hai-Ning, Jin, Ping, Zhou, Li, Peng, Liyuan, Huang, Zhao, Qin, Siyuan, Li, Bowen, Ming, Hui, Luo, Maochao, Xie, Na, Gao, Wei, Nice, Edouard C., Yu, Qiang, Huang, Canhua

“…The single-nucleotide polymorphism (SNP) of p53, in particular the codon 72 variants, has recently been implicated as a critical regulator in tumor…”
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