Search Results - "Chen, Georgia"

Tyrosine Phosphorylation of Mitochondrial Pyruvate Dehydrogenase Kinase 1 Is Important for Cancer Metabolism by Hitosugi, Taro, Fan, Jun, Chung, Tae-Wook, Lythgoe, Katherine, Wang, Xu, Xie, Jianxin, Ge, Qingyuan, Gu, Ting-Lei, Polakiewicz, Roberto D., Roesel, Johannes L., Chen, Georgia Z., Boggon, Titus J., Lonial, Sagar, Fu, Haian, Khuri, Fadlo R., Kang, Sumin, Chen, Jing

“…Many tumor cells rely on aerobic glycolysis instead of oxidative phosphorylation for their continued proliferation and survival. Myc and HIF-1 are believed to…”
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Therapeutic Nanoparticles for Drug Delivery in Cancer by CHO, Kwangjae, XU WANG, SHUMING NIE, ZHUO CHEN, SHIN, Dong M

“…Cancer nanotherapeutics are rapidly progressing and are being implemented to solve several limitations of conventional drug delivery systems such as…”
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Nanoparticle therapeutics: an emerging treatment modality for cancer by Davis, Mark E, Chen, Zhuo (Georgia), Shin, Dong M

“…Key Points Nanoparticles are emerging as a new class of therapeutics for cancer because they can perform in ways that other therapeutic modalities cannot…”
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Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth by Hitosugi, Taro, Zhou, Lu, Elf, Shannon, Fan, Jun, Kang, Hee-Bum, Seo, Jae Ho, Shan, Changliang, Dai, Qing, Zhang, Liang, Xie, Jianxin, Gu, Ting-Lei, Jin, Peng, Alečković, Masa, LeRoy, Gary, Kang, Yibin, Sudderth, Jessica A., DeBerardinis, Ralph J., Luan, Chi-Hao, Chen, Georgia Z., Muller, Susan, Shin, Dong M., Owonikoko, Taofeek K., Lonial, Sagar, Arellano, Martha L., Khoury, Hanna J., Khuri, Fadlo R., Lee, Benjamin H., Ye, Keqiang, Boggon, Titus J., Kang, Sumin, He, Chuan, Chen, Jing

“…It is unclear how cancer cells coordinate glycolysis and biosynthesis to support rapidly growing tumors. We found that the glycolytic enzyme phosphoglycerate…”
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Hyperspectral imaging and quantitative analysis for prostate cancer detection by Akbari, Hamed, Halig, Luma V, Schuster, David M, Osunkoya, Adeboye, Master, Viraj, Nieh, Peter T, Chen, Georgia Z, Fei, Baowei

“…Hyperspectral imaging (HSI) is an emerging modality for various medical applications. Its spectroscopic data might be able to be used to noninvasively detect…”
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MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation by Jin, Lingtao, Chun, Jaemoo, Pan, Chaoyun, Li, Dan, Lin, Ruiting, Alesi, Gina N., Wang, Xu, Kang, Hee-Bum, Song, Lina, Wang, Dongsheng, Zhang, Guojing, Fan, Jun, Boggon, Titus J., Zhou, Lu, Kowalski, Jeanne, Qu, Cheng-Kui, Steuer, Conor E., Chen, Georgia Z., Saba, Nabil F., Boise, Lawrence H., Owonikoko, Taofeek K., Khuri, Fadlo R., Magliocca, Kelly R., Shin, Dong M., Lonial, Sagar, Kang, Sumin

“…Platinum-based chemotherapeutics represent a mainstay of cancer therapy, but resistance limits their curative potential. Through a kinome RNAi screen, we…”
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New Perspectives of Curcumin in Cancer Prevention by PARK, Wungki, RUHUL AMIN, A. R. M, GEORGIA CHEN, Zhuo, SHIN, Dong M

“…Numerous natural compounds have been extensively investigated for their potential for cancer prevention over the decades. Curcumin, from Curcuma longa, is a…”
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Cisplatin-mediated activation of glucocorticoid receptor induces platinum resistance via MAST1 by Pan, Chaoyun, Kang, JiHoon, Hwang, Jung Seok, Li, Jie, Boese, Austin C., Wang, Xu, Yang, Likun, Boggon, Titus J., Chen, Georgia Z., Saba, Nabil F., Shin, Dong M., Magliocca, Kelly R., Jin, Lingtao, Kang, Sumin

“…Agonists of glucocorticoid receptor (GR) are frequently given to cancer patients with platinum-containing chemotherapy to reduce inflammation, but how GR…”
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HPV16 E6 and E7 proteins induce a chronic oxidative stress response via NOX2 that causes genomic instability and increased susceptibility to DNA damage in head and neck cancer cells by Marullo, Rossella, Werner, Erica, Zhang, Hongzheng, Chen, Georgia Z, Shin, Dong M, Doetsch, Paul W

“…Human papillomavirus (HPV) is the causative agent of a subgroup of head and neck cancer characterized by an intrinsic radiosensitivity. HPV initiates cellular…”
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Detection of Circulating Tumor Cells in Human Peripheral Blood Using Surface-Enhanced Raman Scattering Nanoparticles by XU WANG, XIMEI QIAN, BEITLER, Jonathan J, ZHUO GEORGIA CHEN, KHURI, Fadlo R, LEWIS, Melinda M, SHIN, Hyung Ju C, SHUMING NIE, SHIN, Dong M

“…The detection and characterization of circulating tumor cells (CTC) holds great promise for personalizing medicine and optimizing systemic therapy. However,…”
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In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags by Nie, Shuming, Qian, Ximei, Peng, Xiang-Hong, Ansari, Dominic O, Yin-Goen, Qiqin, Chen, Georgia Z, Shin, Dong M, Yang, Lily, Young, Andrew N, Wang, May D

“…We describe biocompatible and nontoxic nanoparticles for in vivo tumor targeting and detection based on pegylated gold nanoparticles and surface-enhanced Raman…”
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Targeted Iron-Oxide Nanoparticle for Photodynamic Therapy and Imaging of Head and Neck Cancer by Wang, Dongsheng, Fei, Baowei, Halig, Luma V, Qin, Xulei, Hu, Zhongliang, Xu, Hong, Wang, Yongqiang Andrew, Chen, Zhengjia, Kim, Sungjin, Shin, Dong M, Chen, Zhuo (Georgia)

“…Photodynamic therapy (PDT) is a highly specific anticancer treatment modality for various cancers, particularly for recurrent cancers that no longer respond to…”
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Tyrosine Phosphorylation of Lactate Dehydrogenase A Is Important for NADH/NAD+ Redox Homeostasis in Cancer Cells by Fan, Jun, Hitosugi, Taro, Chung, Tae-Wook, Xie, Jianxin, Ge, Qingyuan, Gu, Ting-Lei, Polakiewicz, Roberto D., Chen, Georgia Z., Boggon, Titus J., Lonial, Sagar, Khuri, Fadlo R., Kang, Sumin, Chen, Jing

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth by Hitosugi, Taro, Kang, Sumin, Vander Heiden, Matthew G, Chung, Tae-Wook, Elf, Shannon, Lythgoe, Katherine, Dong, Shaozhong, Lonial, Sagar, Wang, Xu, Chen, Georgia Z, Xie, Jianxin, Gu, Ting-Lei, Polakiewicz, Roberto D, Roesel, Johannes L, Boggon, Titus J, Khuri, Fadlo R, Gilliland, D Gary, Cantley, Lewis C, Kaufman, Jonathan, Chen, Jing

“…The Warburg effect describes a pro-oncogenic metabolism switch such that cancer cells take up more glucose than normal tissue and favor incomplete oxidation of…”
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Exploring the impact of GSTM1 as a novel molecular determinant of survival in head and neck cancer patients of African descent by Yang, Fan, Chen, Fanghui, Shay, Chloe, Chen, Georgia Z, Saba, Nabil F, Teng, Yong

“…Blacks/African American (BAA) patients diagnosed with head and neck squamous cell carcinoma (HNSCC) have worse survival outcomes than White patients. However,…”
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Application of Nanotechnology in Cancer Therapy and Imaging by Wang, Xu, Yang, Lily, Chen, Zhuo (Georgia), Shin, Dong M

“…Recent developments in nanotechnology have provided researchers with new tools for cancer imaging and treatment. This technology has enabled the development of…”
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Pembrolizumab and cabozantinib in recurrent metastatic head and neck squamous cell carcinoma: a phase 2 trial by Saba, Nabil F., Steuer, Conor E., Ekpenyong, Asari, McCook-Veal, Ashley, Magliocca, Kelly, Patel, Mihir, Schmitt, Nicole C., Stokes, William, Bates, James E., Rudra, Soumon, Remick, Jill, McDonald, Mark, Abousaud, Marin, Tan, Aik Choon, Fadlullah, Muhammad Zaki Hidayatullah, Chaudhary, Ritu, Muzaffar, Jameel, Kirtane, Kedar, Liu, Yuan, Chen, Georgia Z., Shin, Dong M., Teng, Yong, Chung, Christine H.

“…Anti-programmed cell death protein 1 (PD-1) therapy is a standard of care in recurrent metastatic head and neck squamous cell carcinoma (RMHNSCC). Vascular…”
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Targeting HER (ERBB) signaling in head and neck cancer: An essential update by Zhang, Jun, Saba, Nabil F., Chen, Georgia (Zhuo), Shin, Dong M.

“…HNC (head and neck cancer) remains the 6th most common carcinoma worldwide. The suboptimal survival and toxicities observed with conventional approaches…”
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Lysine Acetylation Activates 6-Phosphogluconate Dehydrogenase to Promote Tumor Growth by Shan, Changliang, Elf, Shannon, Ji, Quanjiang, Kang, Hee-Bum, Zhou, Lu, Hitosugi, Taro, Jin, Lingtao, Lin, Ruiting, Zhang, Liang, Seo, Jae Ho, Xie, Jianxin, Tucker, Meghan, Gu, Ting-Lei, Sudderth, Jessica, Jiang, Lei, DeBerardinis, Ralph J., Wu, Shaoxiong, Li, Yuancheng, Mao, Hui, Chen, Peng R., Wang, Dongsheng, Chen, Georgia Zhuo, Lonial, Sagar, Arellano, Martha L., Khoury, Hanna J., Khuri, Fadlo R., Lee, Benjamin H., Brat, Daniel J., Ye, Keqiang, Boggon, Titus J., He, Chuan, Kang, Sumin, Fan, Jun, Chen, Jing

“…Although the oxidative pentose phosphate pathway is important for tumor growth, how 6-phosphogluconate dehydrogenase (6PGD) in this pathway is upregulated in…”
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RRM2 Regulates Bcl-2 in Head and Neck and Lung Cancers: A Potential Target for Cancer Therapy by MOHAMMAD AMINUR RAHMAN, RUHUL AMIN, A. R. M, SHIN, Dong M, DONGSHENG WANG, KOENIG, Lydia, NANNAPANENI, Sreenivas, ZHENGJIA CHEN, ZHIBO WANG, SICA, Gabriel, XINGMING DENG, CHEN, Zhuo

“…Ribonucleotide reductase subunit M2 (RRM2) plays an active role in tumor progression. Recently, we reported that depletion of RRM2 by systemic delivery of a…”
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