Search Results - "Chen, Fei Xavier"

PAF1, a Molecular Regulator of Promoter-Proximal Pausing by RNA Polymerase II by Chen, Fei Xavier, Woodfin, Ashley R., Gardini, Alessandro, Rickels, Ryan A., Marshall, Stacy A., Smith, Edwin R., Shiekhattar, Ramin, Shilatifard, Ali

“…The control of promoter-proximal pausing and the release of RNA polymerase II (Pol II) is a widely used mechanism for regulating gene expression in metazoans,…”
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Born to run: control of transcription elongation by RNA polymerase II by Chen, Fei Xavier, Smith, Edwin R., Shilatifard, Ali

“…The dynamic regulation of transcription elongation by RNA polymerase II (Pol II) is an integral part of the implementation of gene expression programmes during…”
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SPT5 stabilizes RNA polymerase II, orchestrates transcription cycles, and maintains the enhancer landscape by Hu, Shibin, Peng, Linna, Xu, Congling, Wang, Zhenning, Song, Aixia, Chen, Fei Xavier

“…Transcription progression is governed by multitasking regulators including SPT5, an evolutionarily conserved factor implicated in virtually all transcriptional…”
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Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase by Zheng, Hai, Qi, Yilun, Hu, Shibin, Cao, Xuan, Xu, Congling, Yin, Zhinang, Chen, Xizi, Li, Yan, Liu, Weida, Li, Jie, Wang, Jiawei, Wei, Gang, Liang, Kaiwei, Chen, Fei Xavier, Xu, Yanhui

“…The 14-subunit metazoan-specific Integrator contains an endonuclease that cleaves nascent RNA transcripts. Here, we identified a complex containing Integrator…”
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Demethylase-independent roles of LSD1 in regulating enhancers and cell fate transition by Zeng, Cheng, Chen, Jiwei, Cooke, Emmalee W., Subuddhi, Arijita, Roodman, Eliana T., Chen, Fei Xavier, Cao, Kaixiang

“…The major enhancer regulator lysine-specific histone demethylase 1A (LSD1) is required for mammalian embryogenesis and is implicated in human congenital…”
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Structural basis of INTAC-regulated transcription by Zheng, Hai, Jin, Qianwei, Wang, Xinxin, Qi, Yilun, Liu, Weida, Ren, Yulei, Zhao, Dan, Chen, Fei Xavier, Cheng, Jingdong, Chen, Xizi, Xu, Yanhui

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PAF1 regulation of promoter-proximal pause release via enhancer activation by Chen, Fei Xavier, Xie, Peng, Collings, Clayton K., Cao, Kaixiang, Aoi, Yuki, Marshall, Stacy A., Rendleman, Emily J., Ugarenko, Michal, Ozark, Patrick A., Zhang, Anda, Shiekhattar, Ramin, Smith, Edwin R., Zhang, Michael Q., Shilatifard, Ali

“…Gene expression in metazoans is regulated by RNA polymerase II (Pol II) promoter-proximal pausing and its release. Previously,we showed that Pol II–associated…”
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Histone H3K4 methylation-dependent and -independent functions of Set1A/COMPASS in embryonic stem cell self-renewal and differentiation by Sze, Christie C, Cao, Kaixiang, Collings, Clayton K, Marshall, Stacy A, Rendleman, Emily J, Ozark, Patrick A, Chen, Fei Xavier, Morgan, Marc A, Wang, Lu, Shilatifard, Ali

“…Of the six members of the COMPASS (complex of proteins associated with Set1) family of histone H3 Lys4 (H3K4) methyltransferases identified in mammals, Set1A…”
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Mechanisms of SOSS‐Integrator–PP2A complex in attenuating R‐loops and promoting genome stability by Wang, Jingwen, Xu, Conglin, Zhang, Zhen, Chen, Fei Xavier

“…[...]this study suggests that activation of the innate immune pathway could indicate a distinct pathological role of R-loops differed from the typical DNA…”
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Protocol for rapidly inducing genome-wide RNA Pol II hyperphosphorylation by selectively disrupting INTAC phosphatase activity by Ji, Yu-Xin, Hu, Shibin, Chen, Fei Xavier

“…While several inhibitors targeting RNA polymerase II (Pol II) kinases have been applied for inhibiting RNA Pol II phosphorylation, there are few approaches for…”
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Measuring Nascent Transcripts by Nascent-seq by Chen, Fei Xavier, Marshall, Stacy A, Deng, Yu, Tianjiao, Sun

“…A complete understanding of transcription and co-transcriptional RNA processing events by polymerase requires precise and robust approaches to visualize…”
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Coordinated regulation of cellular identity-associated H3K4me3 breadth by the COMPASS family by Sze, Christie C, Ozark, Patrick A, Cao, Kaixiang, Ugarenko, Michal, Das, Siddhartha, Wang, Lu, Marshall, Stacy A, Rendleman, Emily J, Ryan, Caila A, Zha, Didi, Douillet, Delphine, Chen, Fei Xavier, Shilatifard, Ali

“…Set1A and Set1B, two members of the COMPASS family of methyltransferases that methylate the histone H3 lysine 4 (H3K4) residue, have been accredited as primary…”
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Cell scientist to watch – Fei Xavier Chen

“…ABSTRACT Fei Xavier Chen received his Bachelor's degree from Shandong University, China, and his Master's degree from Fudan University, where he worked on the…”
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The pleiotropic roles of SPT5 in transcription by Song, Aixia, Chen, Fei Xavier

“…Initially discovered by genetic screens in budding yeast, SPT5 and its partner SPT4 form a stable complex known as DSIF in metazoa, which plays pleiotropic…”
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Combined Aurora Kinase A and CHK1 Inhibition enhances radiosensitivity of triple-negative breast cancer through induction of apoptosis and mitotic catastrophe associated with excessive DNA damage by Li, Chunyan, Wang, Xuanyi, Liao, Jiatao, Chen, Fei, Guo, Xiaomao, Chen, Xingxing

“…There is an urgent need for biomarkers and new actionable targets to improve radiosensitivity of triple negative breast cancer (TNBC) tumors. In this paper, we…”
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INTAC endonuclease and phosphatase modules differentially regulate transcription by RNA polymerase II by Hu, Shibin, Peng, Linna, Song, Aixia, Ji, Yu-Xin, Cheng, Jingdong, Wang, Mengyun, Chen, Fei Xavier

“…Gene expression in metazoans is controlled by promoter-proximal pausing of RNA polymerase II, which can undergo productive elongation or promoter-proximal…”
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H3K4me2/3 modulate the stability of RNA polymerase II pausing by Hu, Shibin, Song, Aixia, Peng, Linna, Tang, Nan, Qiao, Zhibin, Wang, Zhenning, Lan, Fei, Chen, Fei Xavier

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From snapshots to a movie: Capturing eukaryotic transcription initiation at single-nucleotide resolution by Shang, Xue-Ying, Xu, Congling, Chen, Fei Xavier

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R-loop-dependent promoter-proximal termination ensures genome stability by Xu, Congling, Li, Chengyu, Chen, Jiwei, Xiong, Yan, Qiao, Zhibin, Fan, Pengyu, Li, Conghui, Ma, Shuangyu, Liu, Jin, Song, Aixia, Tao, Bolin, Xu, Tao, Xu, Wei, Chi, Yayun, Xue, Jingyan, Wang, Pu, Ye, Dan, Gu, Hongzhou, Zhang, Peng, Wang, Qiong, Xiao, Ruijing, Cheng, Jingdong, Zheng, Hai, Yu, Xiaoli, Zhang, Zhen, Wu, Jiong, Liang, Kaiwei, Liu, Yan-Jun, Lu, Huasong, Chen, Fei Xavier

“…The proper regulation of transcription is essential for maintaining genome integrity and executing other downstream cellular functions 1 , 2 . Here we identify…”
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Synergy between arsenic trioxide and JQ1 on autophagy in pancreatic cancer by Xu, Congling, Wang, Xinrui, Zhou, Yu, Chen, Fei Xavier, Wang, Haiwei, Li, Kening, Fan, Huiyong, Tang, Xiaomei, Jiang, Guojuan, Zhang, Ji

“…Pancreatic cancer is a deadliest type of malignancy and lacks effective intervention. We here report a potential strategy for treatment of this malignancy by…”
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