Search Results - "Chen, David Y"

CH Activation: A Complementary Tool in the Total Synthesis of Complex Natural Products by Chen, David Y.-K., Youn, So Won

“…The recent advent of transition‐metal mediated CH activation is revolutionizing the synthetic field and gradually infusing a “CH activation mind‐set” in both…”
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Recent advances in the total synthesis of cyclopropane-containing natural products by Chen, David Y-K, Pouwer, Rebecca H, Richard, Jean-Alexandre

“…In this tutorial review, recent advances in the synthesis of cyclopropane-containing natural products are discussed, highlighting the application of novel…”
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The Chemistry of the Polycyclic Polyprenylated Acylphloroglucinols by Richard, Jean-Alexandre, Pouwer, Rebecca H., Chen, David Y.-K.

“…With their fascinating biological profiles and stunningly complex molecular architectures, the polycyclic polyprenylated acylphloroglucinols (PPAPs) have long…”
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A general approach for detecting expressed mutations in AML cells using single cell RNA-sequencing by Petti, Allegra A., Williams, Stephen R., Miller, Christopher A., Fiddes, Ian T., Srivatsan, Sridhar N., Chen, David Y., Fronick, Catrina C., Fulton, Robert S., Church, Deanna M., Ley, Timothy J.

“…Virtually all tumors are genetically heterogeneous, containing mutationally-defined subclonal cell populations that often have distinct phenotypes. Single-cell…”
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A Local‐Desymmetrization‐Based Divergent Synthesis of Quinine and Quinidine by Lee, Jaehoo, Chen, David Y.‐K.

“…Herein we report a novel synthetic entry to the legendary quinuclidine natural products quinine and quinidine. The developed strategy is based on the use of a…”
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A Desymmetrization‐Based Total Synthesis of Reserpine by Park, Jisook, Chen, David Y.‐K.

“…Reported herein is a desymmetrization‐based synthetic approach to the fused polycyclic indole alkaloid reserpine. The centerpiece of the developed strategy…”
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Small Renal Masses Progressing to Metastases Under Active Surveillance: A Systematic Review and Pooled Analysis by SMALDONE, Marc C, KUTIKOV, Alexander, EGLESTON, Brian L, CANTER, Daniel J, VITERBO, Rosalia, CHEN, David Y. T, JEWETT, Michael A, GREENBERG, Richard E, UZZO, Robert G

“…The authors systematically reviewed the literature and conducted a pooled analysis of studies on small renal masses who underwent active surveillance to…”
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Total Synthesis and Biological Evaluation of the Resveratrol-Derived Polyphenol Natural Products Hopeanol and Hopeahainol A by Nicolaou, K. C, Kang, Qiang, Wu, T. Robert, Lim, Chek Shik, Chen, David Y.-K

“…The total synthesis and biological evaluation of the resveratrol-derived natural products hopeanol (2) and hopeahainol A (3) in their racemic and antipodal…”
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Asymmetric Total Syntheses of Communesin F and a Putative Member of the Communesin Family by Park, Jisook, Jean, Alexandre, Chen, David Y.‐K.

“…Here we report asymmetric total syntheses of communesin F and a putative member of the communesin family of bis‐aminal alkaloid natural products. The…”
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Total Synthesis of Englerin A by Nicolaou, K. C, Kang, Qiang, Ng, Sin Yee, Chen, David Y.-K

“…Total synthesis of englerin A, a recently reported sesquiterpenoid exhibiting potent and selective growth inhibition against renal cancer cell lines, has been…”
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Accelerated Methotrexate, Vinblastine, Doxorubicin, and Cisplatin Is Safe, Effective, and Efficient Neoadjuvant Treatment for Muscle-Invasive Bladder Cancer: Results of a Multicenter Phase II Study With Molecular Correlates of Response and Toxicity by PLIMACK, Elizabeth R, HOFFMAN-CENSITS, Jean H, KUTIKOV, Alexander, DOTAN, Efrat, BRENNAN, Timothy A, PALMA, Norma, DULAIMI, Essel, MEHRAZIN, Reza, BOORJIAN, Stephen A, KELLY, William Kevin, UZZO, Robert G, HUDES, Gary R, VITERBO, Rosalia, TRABULSI, Edouard J, ROSS, Eric A, GREENBERG, Richard E, CHEN, David Y. T, LALLAS, Costas D, WONG, Yu-Ning, JIANQING LIN

“…Neoadjuvant cisplatin-based chemotherapy is standard of care for muscle-invasive bladder cancer (MIBC); however, it is infrequently adopted in practice because…”
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Stereo‐Controlled Synthesis of Vicinal Tertiary Carbinols: Application in the Synthesis of a Diol Substructure of Zaragozic Acid, Pactamycin and Ryanodol by Kim, Byungjoo, Puthukanoori, Ravi Kumar, Martha, Bhikshapathi, Reddy Muthyala, Nagarjuna, Thota, Srinivas, Thummala, Venkatesham, Rao Paraselli, Bheema, Chen, David Y.‐K.

“…Abstract A novel and flexible approach for the stereo‐controlled synthesis of vicinal tertiary carbinols is reported. The developed strategy featured a highly…”
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Objective Measures of Renal Mass Anatomic Complexity Predict Rates of Major Complications Following Partial Nephrectomy by Simhan, Jay, Smaldone, Marc C, Tsai, Kevin J, Canter, Daniel J, Li, Tianyu, Kutikov, Alexander, Viterbo, Rosalia, Chen, David Y.T, Greenberg, Richard E, Uzzo, Robert G

“…Abstract Background The association between tumor complexity and postoperative complications after partial nephrectomy (PN) has not been well characterized…”
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Organocatalytic and Late-Stage CH-Functionalization Enabled Asymmetric Synthesis of Communesin F and Putative Communesins by Park, Jisook, Jean, Alexandre, Chen, David Y.-K

“…Herein we report the total syntheses of communesin F and putative members of the communesin family of polycyclic bis-aminal alkaloids. The successful strategy…”
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A desymmetrization-based approach to morphinans: application in the total synthesis of oxycodone by Park, Kun Ho Kenny, Chen, David Y-K

“…Here we report a total synthesis of the pharmacologically significant morphinan alkaloid, oxycodone. The centerpiece of the developed strategy features the…”
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Total Synthesis of (+)-Haplophytine by Nicolaou, K.C, Dalby, Stephen M, Li, Shuoliang, Suzuki, Takahiro, Chen, David Y.-K

“…A problem solved: Haplophytine (1) yields to total synthesis through a convergent strategy employing modern synthetic methods. Key steps include hypervalent…”
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Total Synthesis of Strychnine by Lee, Geun Seok, Namkoong, Gil, Park, Jisook, Chen, David Y.‐K.

“…The total synthesis of the flagship Strychnos indole alkaloid, strychnine, has been accomplished. The developed synthetic sequence features a novel vinylogous…”
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Total Synthesis of Actinophyllic Acid by Yoshii, Yu, Tokuyama, Hidetoshi, Chen, David Y.‐K.

“…Herein we report a total synthesis of the indolohydroazocine natural product actinophyllic acid. The target molecule was retrosynthetically deconvoluted to…”
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Natural history, growth kinetics, and outcomes of untreated clinically localized renal tumors under active surveillance by Crispen, Paul L., Viterbo, Rosalia, Boorjian, Stephen A., Greenberg, Richard E., Chen, David Y. T., Uzzo, Robert G.

“…BACKGROUND: The growth kinetics of untreated solid organ malignancies are not defined. Radiographic active surveillance (AS) of renal tumors in patients unfit…”
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Anatomic Features of Enhancing Renal Masses Predict Malignant and High-Grade Pathology: A Preoperative Nomogram Using the RENAL Nephrometry Score by Kutikov, Alexander, Smaldone, Marc C, Egleston, Brian L, Manley, Brandon J, Canter, Daniel J, Simhan, Jay, Boorjian, Stephen A, Viterbo, Rosalia, Chen, David Y.T, Greenberg, Richard E, Uzzo, Robert G

“…Abstract Background Counseling patients with enhancing renal mass currently occurs in the context of significant uncertainty regarding tumor pathology…”
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