Search Results - "Chen, David K"

CH Activation: A Complementary Tool in the Total Synthesis of Complex Natural Products by Chen, David Y.-K., Youn, So Won

“…The recent advent of transition‐metal mediated CH activation is revolutionizing the synthetic field and gradually infusing a “CH activation mind‐set” in both…”
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Recent advances in the total synthesis of cyclopropane-containing natural products by Chen, David Y-K, Pouwer, Rebecca H, Richard, Jean-Alexandre

“…In this tutorial review, recent advances in the synthesis of cyclopropane-containing natural products are discussed, highlighting the application of novel…”
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The Chemistry of the Polycyclic Polyprenylated Acylphloroglucinols by Richard, Jean-Alexandre, Pouwer, Rebecca H., Chen, David Y.-K.

“…With their fascinating biological profiles and stunningly complex molecular architectures, the polycyclic polyprenylated acylphloroglucinols (PPAPs) have long…”
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A Local‐Desymmetrization‐Based Divergent Synthesis of Quinine and Quinidine by Lee, Jaehoo, Chen, David Y.‐K.

“…Herein we report a novel synthetic entry to the legendary quinuclidine natural products quinine and quinidine. The developed strategy is based on the use of a…”
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A Desymmetrization‐Based Total Synthesis of Reserpine by Park, Jisook, Chen, David Y.‐K.

“…Reported herein is a desymmetrization‐based synthetic approach to the fused polycyclic indole alkaloid reserpine. The centerpiece of the developed strategy…”
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Asymmetric Total Syntheses of Communesin F and a Putative Member of the Communesin Family by Park, Jisook, Jean, Alexandre, Chen, David Y.‐K.

“…Here we report asymmetric total syntheses of communesin F and a putative member of the communesin family of bis‐aminal alkaloid natural products. The…”
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Total Synthesis and Biological Evaluation of the Resveratrol-Derived Polyphenol Natural Products Hopeanol and Hopeahainol A by Nicolaou, K. C, Kang, Qiang, Wu, T. Robert, Lim, Chek Shik, Chen, David Y.-K

“…The total synthesis and biological evaluation of the resveratrol-derived natural products hopeanol (2) and hopeahainol A (3) in their racemic and antipodal…”
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Stereo‐Controlled Synthesis of Vicinal Tertiary Carbinols: Application in the Synthesis of a Diol Substructure of Zaragozic Acid, Pactamycin and Ryanodol by Kim, Byungjoo, Puthukanoori, Ravi Kumar, Martha, Bhikshapathi, Reddy Muthyala, Nagarjuna, Thota, Srinivas, Thummala, Venkatesham, Rao Paraselli, Bheema, Chen, David Y.‐K.

“…Abstract A novel and flexible approach for the stereo‐controlled synthesis of vicinal tertiary carbinols is reported. The developed strategy featured a highly…”
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Total Synthesis of Englerin A by Nicolaou, K. C, Kang, Qiang, Ng, Sin Yee, Chen, David Y.-K

“…Total synthesis of englerin A, a recently reported sesquiterpenoid exhibiting potent and selective growth inhibition against renal cancer cell lines, has been…”
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Total Synthesis of Strychnine by Lee, Geun Seok, Namkoong, Gil, Park, Jisook, Chen, David Y.‐K.

“…The total synthesis of the flagship Strychnos indole alkaloid, strychnine, has been accomplished. The developed synthetic sequence features a novel vinylogous…”
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Total Synthesis of Actinophyllic Acid by Yoshii, Yu, Tokuyama, Hidetoshi, Chen, David Y.‐K.

“…Herein we report a total synthesis of the indolohydroazocine natural product actinophyllic acid. The target molecule was retrosynthetically deconvoluted to…”
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Total Synthesis of (+)-Haplophytine by Nicolaou, K.C, Dalby, Stephen M, Li, Shuoliang, Suzuki, Takahiro, Chen, David Y.-K

“…A problem solved: Haplophytine (1) yields to total synthesis through a convergent strategy employing modern synthetic methods. Key steps include hypervalent…”
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Cortistatin A is a High-Affinity Ligand of Protein Kinases ROCK, CDK8, and CDK11 by Cee, Victor J., Chen, David Y.-K., Lee, Matthew R., Nicolaou, K. C.

“…Antiproliferative alkaloid: Cortistatin A is a high‐affinity ligand for a small set of protein kinases including Rho‐associated, coiled‐coil‐containing protein…”
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Total Synthesis of the Originally Proposed and Revised Structures of Palmerolide A and Isomers Thereof by Nicolaou, K. C, Sun, Ya-Ping, Guduru, Ramakrishna, Banerji, Biswadip, Chen, David Y.-K

“…Palmerolide A is a recently disclosed marine natural product possessing striking biological properties, including potent and selective activity against the…”
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Total Synthesis of (+)-Cortistatin A by Nicolaou, K.C, Sun, Ya-Ping, Peng, Xiao-Shui, Polet, Damien, Chen, David Y.-K

“…Marine engineering: A modular strategy featuring an intramolecular 1,4‐addition/aldol/dehydration cascade sequence (see scheme; TBS=tert‐butyldimethylsilyl)…”
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Total Synthesis of the Originally Proposed and Revised Structures of Palmerolide A by Nicolaou, K.C, Guduru, Ramakrishna, Sun, Ya-Ping, Banerji, Biswadip, Chen, David Y.-K

“…In the palm of your hand: Total syntheses of the originally proposed and revised structures of the marine antitumor agent palmerolide A (see picture,…”
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Total Synthesis of Hopeahainol A and Hopeanol by Nicolaou, K.C, Wu, T. Robert, Kang, Qiang, Chen, David Y.-K

“…Similar, but different: Possessing almost the same but not identical structures, the recently discovered natural products hopeahainol A (1) and hopeanol (2)…”
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Proteomic Signature of Fatty Acid Biosynthesis Inhibition Available for In Vivo Mechanism-of-Action Studies by WENZEL, Michaela, PATRA, Malay, ALBRECHT, Dirk, CHEN, David Y.-K, NICOLAOU, K. C, METZLER-NOLTE, Nils, BANDOW, Julia E

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Total Synthesis and Biological Evaluation of Cortistatins A and J and Analogues Thereof by Nicolaou, K. C, Peng, Xiao-Shui, Sun, Ya-Ping, Polet, Damien, Zou, Bin, Lim, Chek Shik, Chen, David Y.-K

“…Total syntheses of the highly selective antiproliferative natural products cortistatins A (1) and J (5) in their naturally occurring enantiomeric forms are…”
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Chiral Pool Based Synthesis of Platensimycin by Nicolaou, K.C, Pappo, Doron, Tsang, Kit Y, Gibe, Romelo, Chen, David Y.-K

“…Extensive pharming: An expedient entry into the tetracycle 2, a late‐stage synthetic intermediate en route to the broad‐spectrum antibiotic (−)‐platensimycin…”
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