Search Results - "Chen, Ching‐Hsien"

Dual and Specific Inhibition of NAMPT and PAK4 By KPT-9274 Decreases Kidney Cancer Growth by Abu Aboud, Omran, Chen, Ching-Hsien, Senapedis, William, Baloglu, Erkan, Argueta, Christian, Weiss, Robert H

“…Kidney cancer (or renal cell carcinoma, RCC) is the sixth most common malignancy in the United States and one of the relatively few whose incidence is…”
Get full text

Myristoylated alanine-rich C kinase substrate (MARCKS): a multirole signaling protein in cancers by Fong, Lon Wolf R., Yang, David C., Chen, Ching-Hsien

“…Emerging evidence implicates myristoylated alanine-rich C-kinase substrate (MARCKS), a major substrate of protein kinase C (PKC), in a critical role for cancer…”
Get full text

MTAP deficiency contributes to immune landscape remodelling and tumour evasion by Chang, Wen‐Hsin, Hsu, Ssu‐Wei, Zhang, Jun, Li, Ji‐Min, Yang, David D., Chu, Chih‐Wei, Yoo, Estelle E., Zhang, Weici, Yu, Sung‐Liang, Chen, Ching‐Hsien

“…Methylthioadenosine phosphorylase (MTAP) deficiency occurs in various malignancies and is associated with poor survival in cancer patients. However, the…”
Get full text

Targeting the phosphorylation site of myristoylated alanine‐rich C kinase substrate alleviates symptoms in a murine model of steroid‐resistant asthma by Wang, Chien‐Neng, Lin, Yu‐Chao, Chang, Bo‐Chun, Chen, Ching‐Hsien, Wu, Reen, Lee, Chen‐Chen

“…Background and Purpose Myristoylated alanine‐rich C kinase substrate (MARCKS), a PKC substrate, facilitates mucus production and neutrophil migration. However,…”
Get full text

Glutathione metabolism rewiring protects renal tubule cells against cisplatin-induced apoptosis and ferroptosis by Dong, Xing-Qiang, Chu, Li-Kai, Cao, Xu, Xiong, Qian-Wei, Mao, Yi-Ming, Chen, Ching-Hsien, Bi, Yun-Li, Liu, Jun, Yan, Xiang-Ming

“…Renal proximal tubular cells are highly vulnerable to different types of assaults during filtration and reabsorption, leading to acute renal dysfunction and…”
Get full text

Autophagy of OTUD5 destabilizes GPX4 to confer ferroptosis-dependent kidney injury by Chu, Li-Kai, Cao, Xu, Wan, Lin, Diao, Qiang, Zhu, Yu, Kan, Yu, Ye, Li-Li, Mao, Yi-Ming, Dong, Xing-Qiang, Xiong, Qian-Wei, Fu, Ming-Cui, Zhang, Ting, Zhou, Hui-Ting, Cai, Shi-Zhong, Ma, Zhou-Rui, Hsu, Ssu-Wei, Wu, Reen, Chen, Ching-Hsien, Yan, Xiang-Ming, Liu, Jun

“…Ferroptosis is an iron-dependent programmed cell death associated with severe kidney diseases, linked to decreased glutathione peroxidase 4 (GPX4). However,…”
Get full text

Reduced symmetric dimethylation stabilizes vimentin and promotes metastasis in MTAP‐deficient lung cancer by Chang, Wen‐Hsin, Chen, Yi‐Ju, Hsiao, Yi‐Jing, Chiang, Ching‐Cheng, Wang, Chia‐Yu, Chang, Ya‐Ling, Hong, Qi‐Sheng, Lin, Chien‐Yu, Lin, Shr‐Uen, Chang, Gee‐Chen, Chen, Hsuan‐Yu, Chen, Yu‐Ju, Chen, Ching‐Hsien, Yang, Pan‐Chyr, Yu, Sung‐Liang

“…The aggressive nature and poor prognosis of lung cancer led us to explore the mechanisms driving disease progression. Utilizing our invasive cell‐based model,…”
Get full text

Tackling MARCKS‐PIP3 circuit attenuates fibroblast activation and fibrosis progression by Yang, David C., Li, Ji‐Min, Xu, Jihao, Oldham, Justin, Phan, Sem H., Last, Jerold A., Wu, Reen, Chen, Ching‐Hsien

“…Targeting activated fibroblasts, including myofibroblast differentiation, has emerged as a key therapeutic strategy in patients with idiopathic pulmonary…”
Get full text

Inositol possesses antifibrotic activity and mitigates pulmonary fibrosis by Li, Ji-Min, Chang, Wen-Hsin, Li, Linhui, Yang, David C, Hsu, Ssu-Wei, Kenyon, Nicholas J, Chen, Ching-Hsien

“…Myo-inositol (or inositol) and its derivatives not only function as important metabolites for multiple cellular processes but also act as co-factors and second…”
Get full text

Targeting myristoylated alanine-rich C kinase substrate phosphorylation site domain in lung cancer. Mechanisms and therapeutic implications by Chen, Ching-Hsien, Statt, Sarah, Chiu, Chun-Lung, Thai, Philip, Arif, Muhammad, Adler, Kenneth B, Wu, Reen

“…Phosphorylation of myristoylated alanine-rich C kinase substrate (phospho-MARCKS) at the phosphorylation site domain (PSD) is crucial for mucus granule…”
Get full text

The association between bone density of lumbar spines and different daily protein intake in different renal function by Lee, Chia-Lin, Chen, Kun-Hui, Liu, Wei-Ju, Chen, Ching-Hsien, Tsai, Shang-Feng

“…Low protein intake (LPI) has been suggested as a treatment for chronic kidney disease (CKD). However, protein intake is essential for bone health. We studied…”
Get full text

Associations of Long-Term Physical Activity Trajectories With All-Cause Mortality in a General Population by Lee, Chia-Lin, Liu, Wei-Ju, Chen, Ching-Hsien, Wang, Jun-Sing

“…We investigated the associations of mean levels of leisure-time physical activity (LTPA) and latent LTPA trajectories with all-cause mortality risk…”
Get full text

A Novel Renoprotective Strategy: Upregulation of PD-L1 Mitigates Cisplatin-Induced Acute Kidney Injury by Liu, Jun, Yang, David C, Zhang, Jun, Hsu, Ssu-Wei, Weiss, Robert H, Chen, Ching-Hsien

“…The innate and adaptive immunities have been documented to participate in the pathogenesis of nephrotoxic acute kidney injury (AKI); however, the mechanisms…”
Get full text

Utilizing a Mild and Effective Catalyst, Alum (KAl(SO4)2⋅12H2O), for Carbohydrate Protection by Chen, Jyun‐Siao, Zhang, Kai‐Min, Ke, Yi‐Fan, Hsu, Hsiao‐Lin, Liou, De‐Cian, Chen, Ching‐Hsien, Kou, Chia‐Yang, Yen, Wei‐Chung, Wu, Hsin‐Ru, Chen, Chien‐Sheng, Luo, Shun‐Yuan

“…This study aimed to optimize the per‐O‐acetylation, deacetylation, and benzylidene protection of carbohydrates and investigate the scope of saccharides via…”
Get full text

Amplitude-Aided 1-Bit Compressive Sensing Over Noisy Wireless Sensor Networks by Chen, Ching-Hsien, Wu, Jwo-Yuh

“…One-bit compressive sensing (CS) is known to be particularly suited for resource-constrained wireless sensor networks (WSNs). In this letter, we consider 1-bit…”
Get full text

Inhibiting tryptophan metabolism enhances interferon therapy in kidney cancer by Trott, Josephine F, Kim, Jeffrey, Abu Aboud, Omran, Wettersten, Hiromi, Stewart, Benjamin, Berryhill, Grace, Uzal, Francisco, Hovey, Russell C, Chen, Ching-Hsien, Anderson, Katie, Graef, Ashley, Sarver, Aaron L, Modiano, Jaime F, Weiss, Robert H

“…Renal cell carcinoma (RCC) is increasing in incidence, and a complete cure remains elusive. While immune-checkpoint antibodies are promising, interferon-based…”
Get full text

L‐arginine as a potential GLP‐1‐mediated immunomodulator of Th17‐related cytokines in people with obesity and asthma by Liao, Shu‐Yi, Linderholm, Angela, Showalter, Megan R., Chen, Ching‐Hsien, Fiehn, Oliver, Kenyon, Nicholas J.

“…Obesity is considered as a risk factor for COVID‐19 with insulin resistance and increased production of inflammatory cytokines as likely mechanisms…”
Get full text

Single‐Cell Spatial Transcriptomics Unveils Platelet‐Fueled Cycling Macrophages for Kidney Fibrosis by Liu, Jun, Zheng, Bo, Cui, Qingya, Zhu, Yu, Chu, Likai, Geng, Zhi, Mao, Yiming, Wan, Lin, Cao, Xu, Xiong, Qianwei, Guo, Fujia, Yang, David C, Hsu, Ssu‐Wei, Chen, Ching‐Hsien, Yan, Xiangming

“…With the increasing incidence of kidney diseases, there is an urgent need to develop therapeutic strategies to combat post‐injury fibrosis. Immune cells,…”
Get full text

Cigarette Smoke Regulates the Competitive Interactions between NRF2 and BACH1 for Heme Oxygenase-1 Induction by Chang, Wen-Hsin, Thai, Philip, Xu, Jihao, Yang, David C, Wu, Reen, Chen, Ching-Hsien

“…Cigarette smoke has been shown to trigger aberrant signaling pathways and pathophysiological processes; however, the regulatory mechanisms underlying…”
Get full text

Assessment of hypermucoviscosity as a virulence factor for experimental Klebsiella pneumoniae infections: comparative virulence analysis with hypermucoviscosity-negative strain by Lin, Yi-Chun, Lu, Min-Chi, Tang, Hui-Ling, Liu, Hsu-Chung, Chen, Ching-Hsien, Liu, Keh-Sen, Lin, Chingju, Chiou, Chien-Shun, Chiang, Ming-Ko, Chen, Chuan-Mu, Lai, Yi-Chyi

“…Klebsiella pneumoniae displaying the hypermucoviscosity (HV) phenotype are considered more virulent than HV-negative strains. Nevertheless, the emergence of…”
Get full text