Search Results - "Chen, Chien Hsiun"

Population structure of Han Chinese in the modern Taiwanese population based on 10,000 participants in the Taiwan Biobank project by Chen, Chien-Hsiun, Yang, Jenn-Hwai, Chiang, Charleston W K, Hsiung, Chia-Ni, Wu, Pei-Ei, Chang, Li-Ching, Chu, Hou-Wei, Chang, Josh, Song, I-Wen, Yang, Show-Ling, Chen, Yuan-Tsong, Liu, Fu-Tong, Shen, Chen-Yang

“…The Taiwan Biobank (TWB) aims to build a nationwide research database that integrates genomic/epigenomic profiles, lifestyle patterns, dietary habits,…”
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Measurement of Pre-Existing IgG and IgM Antibodies against Polyethylene Glycol in Healthy Individuals by Chen, Bing-Mae, Su, Yu-Cheng, Chang, Chia-Jung, Burnouf, Pierre-Alain, Chuang, Kuo-Hsiang, Chen, Chien-Hsiun, Cheng, Tian-Lu, Chen, Yuan-Tsong, Wu, Jer-Yuarn, Roffler, Steve R

“…Polyethylene glycol (PEG) is a biocompatible polymer that is often attached to therapeutic molecules to improve bioavailability and therapeutic efficacy…”
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Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels by Spracklen, Cassandra N, Chen, Peng, Kim, Young Jin, Wang, Xu, Cai, Hui, Li, Shengxu, Long, Jirong, Wu, Ying, Wang, Ya Xing, Takeuchi, Fumihiko, Wu, Jer-Yuarn, Jung, Keum-Ji, Hu, Cheng, Akiyama, Koichi, Zhang, Yonghong, Moon, Sanghoon, Johnson, Todd A, Li, Huaixing, Dorajoo, Rajkumar, He, Meian, Cannon, Maren E, Roman, Tamara S, Salfati, Elias, Lin, Keng-Hung, Guo, Xiuqing, Sheu, Wayne H H, Absher, Devin, Adair, Linda S, Assimes, Themistocles L, Aung, Tin, Cai, Qiuyin, Chang, Li-Ching, Chen, Chien-Hsiun, Chien, Li-Hsin, Chuang, Lee-Ming, Chuang, Shu-Chun, Du, Shufa, Fan, Qiao, Fann, Cathy S J, Feranil, Alan B, Friedlander, Yechiel, Gordon-Larsen, Penny, Gu, Dongfeng, Gui, Lixuan, Guo, Zhirong, Heng, Chew-Kiat, Hixson, James, Hou, Xuhong, Hsiung, Chao Agnes, Hu, Yao, Hwang, Mi Yeong, Hwu, Chii-Min, Isono, Masato, Juang, Jyh-Ming Jimmy, Khor, Chiea-Chuen, Kim, Yun Kyoung, Koh, Woon-Puay, Kubo, Michiaki, Lee, I-Te, Lee, Sun-Ju, Lee, Wen-Jane, Liang, Kae-Woei, Lim, Blanche, Lim, Sing-Hui, Liu, Jianjun, Nabika, Toru, Pan, Wen-Harn, Peng, Hao, Quertermous, Thomas, Sabanayagam, Charumathi, Sandow, Kevin, Shi, Jinxiu, Sun, Liang, Tan, Pok Chien, Tan, Shu-Pei, Taylor, Kent D, Teo, Yik-Ying, Toh, Sue-Anne, Tsunoda, Tatsuhiko, van Dam, Rob M, Wang, Aili, Wang, Feijie, Wang, Jie, Wei, Wen Bin, Xiang, Yong-Bing, Yao, Jie, Yuan, Jian-Min, Zhang, Rong, Zhao, Wanting, Chen, Yii-Der Ida, Rich, Stephen S, Rotter, Jerome I, Wang, Tzung-Dau, Wu, Tangchun, Lin, Xu, Han, Bok-Ghee, Tanaka, Toshihiro, Cho, Yoon Shin, Katsuya, Tomohiro, Jia, Weiping

“…Large-scale meta-analyses of genome-wide association studies (GWAS) have identified >175 loci associated with fasting cholesterol levels, including total…”
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Carbamazepine-Induced Toxic Effects and HLA-B1502 Screening in Taiwan by Chen, Pei, Chen, Chien-Hsiun, Chen, Ying-Ju, Chen, Yuan-Tsong, Chen, Luke, Lin, Shu-Yi, Lin, Juei-Jueng, Lin, Yu-Hsuan, Lu, Chung-Ta, Lu, Chin-Song, Lu, Cheng-Hsien, Ong, Cheung-Ter, Hsieh, Peiyuan F, Yang, Chih-Chao, Tai, Chih-Ta, Wu, Jer-Yuarn, Wu, Shey-Lin, Hsu, Yung-Chu, Yu, Hsiang-Yu, Ro, Long-Sun, Chu, Chun-Che, Tsai, Pei-Joung, Tsai, Jing-Jane, Su, Yu-Hsiang, Lan, Sheng-Hsing, Sung, Sheng-Feng, Chuang, Hui-Ping, Huang, Li-Chen, Liao, Hung-Ting, Chung, Wen-Hung, Hung, Shuen-Iu, Chang, Chi-Feng, Shen, Chen-Yang

“…In this prospective study, Han Chinese subjects who were candidates for carbamazepine therapy were screened for the HLA-B*1502 allele because of its…”
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Mapping Human Genetic Diversity in Asia by Abdulla, Mahmood Ameen, Ahmed, Ikhlak, Assawamakin, Anunchai, Bhak, Jong, Brahmachari, Samir K, Calacal, Gayvelline C, Chaurasia, Amit, Chen, Chien-Hsiun, Chen, Jieming, Chen, Yuan-Tsong, Chu, Jiayou, Cutiongco-de la Paz, Eva Maria C, De Ungria, Maria Corazon A, Delfin, Frederick C, Edo, Juli, Fuchareon, Suthat, Ghang, Ho, Gojobori, Takashi, Han, Junsong, Ho, Sheng-Feng, Hoh, Boon Peng, Huang, Wei, Inoko, Hidetoshi, Jha, Pankaj, Jinam, Timothy A, Jin, Li, Jung, Jongsun, Kangwanpong, Daoroong, Kampuansai, Jatupol, Kennedy, Giulia C, Khurana, Preeti, Kim, Hyung-Lae, Kim, Kwangjoong, Kim, Sangsoo, Kim, Woo-Yeon, Kimm, Kuchan, Kimura, Ryosuke, Koike, Tomohiro, Kulawonganunchai, Supasak, Kumar, Vikrant, Lai, Poh San, Lee, Jong-Young, Lee, Sunghoon, Liu, Edison T, Majumder, Partha P, Mandapati, Kiran Kumar, Marzuki, Sangkot, Mitchell, Wayne, Mukerji, Mitali, Naritomi, Kenji, Ngamphiw, Chumpol, Niikawa, Norio, Nishida, Nao, Oh, Bermseok, Oh, Sangho, Ohashi, Jun, Oka, Akira, Ong, Rick, Padilla, Carmencita D, Palittapongarnpim, Prasit, Perdigon, Henry B, Phipps, Maude Elvira, Png, Eileen, Sakaki, Yoshiyuki, Salvador, Jazelyn M, Sandraling, Yuliana, Scaria, Vinod, Seielstad, Mark, Sidek, Mohd Ros, Sinha, Amit, Srikummool, Metawee, Sudoyo, Herawati, Sugano, Sumio, Suryadi, Helena, Suzuki, Yoshiyuki, Tabbada, Kristina A, Tan, Adrian, Tokunaga, Katsushi, Tongsima, Sissades, Villamor, Lilian P, Wang, Eric, Wang, Ying, Wang, Haifeng, Wu, Jer-Yuarn, Xiao, Huasheng, Xu, Shuhua, Yang, Jin Ok, Shugart, Yin Yao, Yoo, Hyang-Sook, Yuan, Wentao, Zhao, Guoping, Zilfalil, Bin Alwi

“…Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we…”
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Genome-wide transcriptome analysis to further understand neutrophil activation and lncRNA transcript profiles in Kawasaki disease by Ko, Tai-Ming, Chang, Jeng-Sheng, Chen, Shih-Ping, Liu, Yi-Min, Chang, Chia-Jung, Tsai, Fuu-Jen, Lee, Yi-Ching, Chen, Chien-Hsiun, Chen, Yuan-Tsong, Wu, Jer-Yuarn

“…Kawasaki disease (KD) is the most common cause of acquired cardiac disease in children in developed countries. However, little is known regarding the role of…”
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Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index by Wen, Wanqing, Zheng, Wei, Okada, Yukinori, Takeuchi, Fumihiko, Tabara, Yasuharu, Hwang, Joo-Yeon, Dorajoo, Rajkumar, Li, Huaixing, Tsai, Fuu-Jen, Yang, Xiaobo, He, Jiang, Wu, Ying, He, Meian, Zhang, Yi, Liang, Jun, Guo, Xiuqing, Sheu, Wayne Huey-Herng, Delahanty, Ryan, Guo, Xingyi, Kubo, Michiaki, Yamamoto, Ken, Ohkubo, Takayoshi, Go, Min Jin, Liu, Jian Jun, Gan, Wei, Chen, Ching-Chu, Gao, Yong, Li, Shengxu, Lee, Nanette R, Wu, Chen, Zhou, Xueya, Song, Huaidong, Yao, Jie, Lee, I-Te, Long, Jirong, Tsunoda, Tatsuhiko, Akiyama, Koichi, Takashima, Naoyuki, Cho, Yoon Shin, Ong, Rick Th, Lu, Ling, Chen, Chien-Hsiun, Tan, Aihua, Rice, Treva K, Adair, Linda S, Gui, Lixuan, Allison, Matthew, Lee, Wen-Jane, Cai, Qiuyin, Isomura, Minoru, Umemura, Satoshi, Kim, Young Jin, Seielstad, Mark, Hixson, James, Xiang, Yong-Bing, Isono, Masato, Kim, Bong-Jo, Sim, Xueling, Lu, Wei, Nabika, Toru, Lee, Juyoung, Lim, Wei-Yen, Gao, Yu-Tang, Takayanagi, Ryoichi, Kang, Dae-Hee, Wong, Tien Yin, Hsiung, Chao Agnes, Wu, I-Chien, Juang, Jyh-Ming Jimmy, Shi, Jiajun, Choi, Bo Youl, Aung, Tin, Hu, Frank, Kim, Mi Kyung, Lim, Wei Yen, Wang, Tzung-Dao, Shin, Min-Ho, Lee, Jeannette, Ji, Bu-Tian, Lee, Young-Hoon, Young, Terri L, Shin, Dong Hoon, Chun, Byung-Yeol, Cho, Myeong-Chan, Han, Bok-Ghee, Hwu, Chii-Min, Assimes, Themistocles L, Absher, Devin, Yan, Xiaofei, Kim, Eric, Kuo, Jane Z, Kwon, Soonil, Taylor, Kent D, Chen, Yii-Der I, Rotter, Jerome I, Qi, Lu, Zhu, Dingliang, Wu, Tangchun, Mohlke, Karen L, Gu, Dongfeng

“…Recent genetic association studies have identified 55 genetic loci associated with obesity or body mass index (BMI). The vast majority, 51 loci, however, were…”
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A genome-wide association study identifies a novel susceptibility locus for the immunogenicity of polyethylene glycol by Chang, Chia-Jung, Chen, Chien-Hsiun, Chen, Bing-Mae, Su, Yu-Cheng, Chen, Ying-Ting, Hershfield, Michael S., Lee, Ming-Ta Michael, Cheng, Tian-Lu, Chen, Yuan-Tsong, Roffler, Steve R., Wu, Jer-Yuarn

“…Conjugation of polyethylene glycol (PEG) to therapeutic molecules can improve bioavailability and therapeutic efficacy. However, some healthy individuals have…”
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Warfarin pharmacogenetics: a single VKORC1 polymorphism is predictive of dose across 3 racial groups by Limdi, Nita A., Wadelius, Mia, Cavallari, Larisa, Eriksson, Niclas, Crawford, Dana C., Lee, Ming-Ta M., Chen, Chien-Hsiun, Motsinger-Reif, Alison, Sagreiya, Hersh, Liu, Nianjun, Wu, Alan H.B., Gage, Brian F., Jorgensen, Andrea, Pirmohamed, Munir, Shin, Jae-Gook, Suarez-Kurtz, Guilherme, Kimmel, Stephen E., Johnson, Julie A., Klein, Teri E., Wagner, Michael J.

“…Warfarin-dosing algorithms incorporating CYP2C9 and VKORC1 −1639G>A improve dose prediction compared with algorithms based solely on clinical and demographic…”
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CXCL10/IP-10 Is a Biomarker and Mediator for Kawasaki Disease by Ko, Tai-Ming, Kuo, Ho-Chang, Chang, Jeng-Sheng, Chen, Shih-Ping, Liu, Yi-Min, Chen, Hui-Wen, Tsai, Fuu-Jen, Lee, Yi-Ching, Chen, Chien-Hsiun, Wu, Jer-Yuarn, Chen, Yuan-Tsong

“…RATIONALE:Kawasaki disease (KD), an acute febrile vasculitis, is the most common cause of acquired heart disease in childhood; however, diagnosing KD can be…”
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Genetic profiles of 103,106 individuals in the Taiwan Biobank provide insights into the health and history of Han Chinese by Wei, Chun-Yu, Yang, Jenn-Hwai, Yeh, Erh-Chan, Tsai, Ming-Fang, Kao, Hsiao-Jung, Lo, Chen-Zen, Chang, Lung-Pao, Lin, Wan-Jia, Hsieh, Feng-Jen, Belsare, Saurabh, Bhaskar, Anand, Su, Ming-Wei, Lee, Te-Chang, Lin, Yi-Ling, Liu, Fu-Tong, Shen, Chen-Yang, Li, Ling-Hui, Chen, Chien-Hsiun, Wall, Jeffrey D., Wu, Jer-Yuarn, Kwok, Pui-Yan

“…Personalized medical care focuses on prediction of disease risk and response to medications. To build the risk models, access to both large-scale genomic…”
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Enrichment of Prevotella intermedia in human colorectal cancer and its additive effects with Fusobacterium nucleatum on the malignant transformation of colorectal adenomas by Lo, Chia-Hui, Wu, Deng-Chyang, Jao, Shu-Wen, Wu, Chang-Chieh, Lin, Chung-Yen, Chuang, Chia-Hsien, Lin, Ya-Bo, Chen, Chien-Hsiun, Chen, Ying-Ting, Chen, Jiann-Hwa, Hsiao, Koung-Hung, Chen, Ying-Ju, Chen, Yuan-Tsong, Wang, Jaw-Yuan, Li, Ling-Hui

“…Abstract Background Owing to the heterogeneity of microbiota among individuals and populations, only Fusobacterium nucleatum and Bacteroides fragilis have been…”
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A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese by Tsai, Fuu-Jen, Yang, Chi-Fan, Chen, Ching-Chu, Chuang, Lee-Ming, Lu, Chieh-Hsiang, Chang, Chwen-Tzuei, Wang, Tzu-Yuan, Chen, Rong-Hsing, Shiu, Chiung-Fang, Liu, Yi-Min, Chang, Chih-Chun, Chen, Pei, Chen, Chien-Hsiun, Fann, Cathy S J, Chen, Yuan-Tsong, Wu, Jer-Yuarn

“…To investigate the underlying mechanisms of T2D pathogenesis, we looked for diabetes susceptibility genes that increase the risk of type 2 diabetes (T2D) in a…”
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Association of an IGHV3-66 gene variant with Kawasaki disease by Johnson, Todd A, Mashimo, Yoichi, Wu, Jer-Yuarn, Yoon, Dankyu, Hata, Akira, Kubo, Michiaki, Takahashi, Atsushi, Tsunoda, Tatsuhiko, Ozaki, Kouichi, Tanaka, Toshihiro, Ito, Kaoru, Suzuki, Hiroyuki, Hamada, Hiromichi, Kobayashi, Tohru, Hara, Toshiro, Chen, Chien-Hsiun, Lee, Yi-Ching, Liu, Yi-Min, Chang, Li-Ching, Chang, Chun-Ping, Hong, Young-Mi, Jang, Gi-Young, Yun, Sin-Weon, Yu, Jeong-Jin, Lee, Kyung-Yil, Kim, Jae-Jung, Park, Taesung, Lee, Jong-Keuk, Chen, Yuan-Tsong, Onouchi, Yoshihiro

“…In a meta-analysis of three GWAS for susceptibility to Kawasaki disease (KD) conducted in Japan, Korea, and Taiwan and follow-up studies with a total of 11,265…”
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Common risk allele in aromatic antiepileptic-drug induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Han Chinese by Hung, Shuen-Iu, Chung, Wen-Hung, Liu, Zhi-Sheng, Chen, Chien-Hsiun, Hsih, Mo-Song, Hui, Rosaline Chung-yee, Chu, Chia-Yu, Chen, Yuan-Tsong

“…Compared with other categories of drugs, such as antibiotics and NSAIDs, antiepileptic therapies are associated with a high incidence of Stevens-Johnson…”
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Variant GADL1 and Response to Lithium Therapy in Bipolar I Disorder by Chen, Chien-Hsiun, Lee, Chau-Shoun, Lee, Ming-Ta Michael, Ouyang, Wen-Chen, Chen, Chiao-Chicy, Chong, Mian-Yoon, Wu, Jer-Yuarn, Tan, Happy Kuy-Lok, Lee, Yi-Ching, Chuo, Liang-Jen, Chiu, Nan-Ying, Tsang, Hin-Yeung, Chang, Ta-Jen, Lung, For-Wey, Chiu, Chen-Huan, Chang, Cheng-Ho, Chen, Ying-Sheue, Hou, Yuh-Ming, Chen, Cheng-Chung, Lai, Te-Jen, Tung, Chun-Liang, Chen, Chung-Ying, Lane, Hsien-Yuan, Su, Tung-Ping, Feng, Jung, Lin, Jin-Jia, Chang, Ching-Jui, Teng, Po-Ren, Liu, Chia-Yih, Chen, Chih-Ken, Liu, I-Chao, Chen, Jiahn-Jyh, Lu, Ti, Fan, Chun-Chieh, Wu, Ching-Kuan, Li, Chang-Fang, Wang, Kathy Hsiao-Tsz, Wu, Lawrence Shih-Hsin, Peng, Hsin-Ling, Chang, Chun-Ping, Lu, Liang-Suei, Chen, Yuan-Tsong, Cheng, Andrew Tai-Ann

“…The response to lithium for the treatment of bipolar disease is variable. This genetic study showed a strong association between variants in GADL1 and response…”
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Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis by Lee, Yi-Ching, Kuo, Ho-Chang, Chang, Jeng-Sheng, Chang, Luan-Yin, Huang, Li-Min, Chen, Ming-Ren, Liang, Chi-Di, Chi, Hsin, Huang, Fu-Yuan, Lee, Meng-Luen, Huang, Yhu-Chering, Hwang, Betau, Chiu, Nan-Chang, Hwang, Kao-Pin, Lee, Pi-Chang, Chang, Li-Ching, Liu, Yi-Min, Chen, Ying-Ju, Chen, Chien-Hsiun, Alliance, Taiwan Pediatric ID, Chen, Yuan-Tsong, Tsai, Fuu-Jen, Wu, Jer-Yuarn

“…Jer-Yuarn Wu, Fuu-Jen Tsai, Yuan-Tsong Chen and colleagues report a genome-wide association study of Kawasaki disease. They show that common variants near BLK…”
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Glucose transporter 10 modulates adipogenesis via an ascorbic acid-mediated pathway to protect mice against diet-induced metabolic dysregulation by Jiang, Chung-Lin, Jen, Wei-Ping, Tsao, Chang-Yu, Chang, Li-Ching, Chen, Chien-Hsiun, Lee, Yi-Ching

“…The development of type 2 diabetes mellitus (T2DM) depends on interactions between genetic and environmental factors, and a better understanding of gene-diet…”
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Genetic risk score constructed from common genetic variants is associated with cardiovascular disease risk in type 2 diabetes mellitus by Cheng, Chi‐Fung, Lin, Ying‐Ju, Lin, Mei‐Chen, Liang, Wen‐Miin, Chen, Ching‐Chu, Chen, Chien‐Hsiun, Wu, Jer‐Yuarn, Lin, Ting‐Hsu, Liao, Chiu‐Chu, Huang, Shao‐Mei, Hsieh, Ai‐Ru, Tsai, Fuu‐Jen

“…Background Patients with type 2 diabetes mellitus (T2DM) experience a two‐fold increased risk of cardiovascular diseases. Genome‐wide association studies…”
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HLA-B5801 Allele as a Genetic Marker for Severe Cutaneous Adverse Reactions Caused by Allopurinol by Hung, Shuen-lu, Chung, Wen-Hung, Liou, Lieh-Bang, Chu, Chen-Chung, Lin, Marie, Huang, Hsien-Ping, Lin, Yen-Ling, Lan, Joung-Liang, Yang, Li-Cheng, Hong-Shang Hong, Chen, Ming-Jing, Lai, Ping-Chin, Wu, Mai-Szu, Chu, Chia-Yu, Wang, Kuo-Hsien, Chen, Chien-Hsiun, Cathy S. J. Fann, Wu, Jer-Yuarn, Chen, Yuan-Tsong, Sly, William S.

“…Allopurinol, a commonly prescribed medication for gout and hyperuricemia, is a frequent cause of severe cutaneous adverse reactions (SCAR), which include the…”
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