Search Results - "Chen, Charles H."

Development and Challenges of Antimicrobial Peptides for Therapeutic Applications by Chen, Charles H, Lu, Timothy K

“…More than 3000 antimicrobial peptides (AMPs) have been discovered, seven of which have been approved by the U.S. Food and Drug Administration (FDA). Now…”
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Spontaneous formation of structurally diverse membrane channel architectures from a single antimicrobial peptide by Wang, Yukun, Chen, Charles H., Hu, Dan, Ulmschneider, Martin B., Ulmschneider, Jakob P.

“…Many antimicrobial peptides (AMPs) selectively target and form pores in microbial membranes. However, the mechanisms of membrane targeting, pore formation and…”
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Integrated Design of a Membrane‐Lytic Peptide‐Based Intravenous Nanotherapeutic Suppresses Triple‐Negative Breast Cancer by Chen, Charles H., Liu, Yu‐Han, Eskandari, Arvin, Ghimire, Jenisha, Lin, Leon Chien‐Wei, Fang, Zih‐Syun, Wimley, William C., Ulmschneider, Jakob P., Suntharalingam, Kogularamanan, Hu, Che‐Ming Jack, Ulmschneider, Martin B.

“…Membrane‐lytic peptides offer broad synthetic flexibilities and design potential to the arsenal of anticancer therapeutics, which can be limited by…”
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Synthetic molecular evolution of antimicrobial peptides by Chen, Charles H, Bepler, Tristan, Pepper, Karen, Fu, Debbie, Lu, Timothy K

“…As we learn more about how peptide structure and activity are related, we anticipate that antimicrobial peptides will be engineered to have strong potency and…”
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Simulation-Guided Rational de Novo Design of a Small Pore-Forming Antimicrobial Peptide by Chen, Charles H, Starr, Charles G, Troendle, Evan, Wiedman, Gregory, Wimley, William C, Ulmschneider, Jakob P, Ulmschneider, Martin B

“…In the age of failing small-molecule antibiotics, tapping the near-infinite structural and chemical repertoire of antimicrobial peptides (AMPs) offers one of…”
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Absorption and folding of melittin onto lipid bilayer membranes via unbiased atomic detail microsecond molecular dynamics simulation by Chen, Charles H., Wiedman, Gregory, Khan, Ayesha, Ulmschneider, Martin B.

“…Unbiased molecular simulation is a powerful tool to study the atomic details driving functional structural changes or folding pathways of highly fluid systems,…”
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Understanding and modelling the interactions of peptides with membranes: from partitioning to self-assembly by Chen, Charles H, Melo, Marcelo CR, Berglund, Nils, Khan, Ayesha, de la Fuente-Nunez, Cesar, Ulmschneider, Jakob P, Ulmschneider, Martin B

“…Atomic detail simulations are starting to reveal how flexible polypeptides interact with fluid lipid bilayers. These insights are transforming our…”
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Predicting Membrane-Active Peptide Dynamics in Fluidic Lipid Membranes by Chen, Charles H, Pepper, Karen, Ulmschneider, Jakob P, Ulmschneider, Martin B, Lu, Timothy K

“…Understanding the interactions between peptides and lipid membranes could not only accelerate the development of antimicrobial peptides as treatments for…”
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Mechanisms of a Small Membrane-Active Antimicrobial Peptide from Hyla punctata by Chen, Charles H, Ulmschneider, Jakob P, Ulmschneider, Martin B

“…Thousands of antimicrobial peptides have been observed and studied in the past decades; however, their membrane-active mechanisms are ambiguous due to their…”
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Tuning of a Membrane-Perforating Antimicrobial Peptide to Selectively Target Membranes of Different Lipid Composition by Chen, Charles H., Starr, Charles G., Guha, Shantanu, Wimley, William C., Ulmschneider, Martin B., Ulmschneider, Jakob P.

“…The use of designed antimicrobial peptides as drugs has been impeded by the absence of simple sequence-structure–function relationships and design rules. The…”
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Development of membrane‐active peptide therapeutics in oncology by Chen, Charles H., Zan, Bing, Ulmschneider, Jakob P., Wimley, William C., Lu, Timothy K., Ulmschneider, Martin B., Zhou, Liping

“…Membrane‐active peptides play an essential role in many living organisms and their immune systems and counter many infectious diseases. Many have dual or…”
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Catalysis with Cu(II) (bpy) improves alkaline hydrogen peroxide pretreatment by Li, Zhenglun, Chen, Charles H, Liu, Tongjun, Mathrubootham, Vaidyanathan, Hegg, Eric L, Hodge, David B

“…Copper(II) 2,2'-bipyridine (Cu(II) (bpy))-catalyzed alkaline hydrogen peroxide (AHP) pretreatment was performed on three biomass feedstocks including alkali…”
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Catalysis with CuII(bpy) improves alkaline hydrogen peroxide pretreatment by Li, Zhenglun, Chen, Charles H., Liu, Tongjun, Mathrubootham, Vaidyanathan, Hegg, Eric L., Hodge, David B.

“…Copper(II) 2,2′‐bipyridine (CuII(bpy))‐catalyzed alkaline hydrogen peroxide (AHP) pretreatment was performed on three biomass feedstocks including alkali…”
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Mechanisms of Membrane Pore Formation by Amyloidogenic Peptides in Amyotrophic Lateral Sclerosis by Chen, Charles H., Khan, Ayesha, Huang, Joseph Jen-Tse, Ulmschneider, Martin B.

“…Using unbiased atomic‐detailed molecular dynamics simulations, the C‐terminal fragments of TDP‐43 are observed to aggregate and form disordered‐toroidal pores…”
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Passive Internalization of Bioactive β-Casein Peptides into Phospholipid (POPC) Bilayers. Free Energy Landscapes from Unbiased Equilibrium MD Simulations at μs-Time Scale by Jardón-Valadez, Eduardo, Chen, Charles H., García-Garibay, Mariano, Jiménez-Guzmán, Judith, Ulmschneider, Martin B.

“…Absorption of bioactive peptides in the intestinal epithelium take place in the apical or the basolateral tight junctions of the cells. Depending on the…”
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Optimization of Host Cell-Compatible, Antimicrobial Peptides Effective against Biofilms and Clinical Isolates of Drug-Resistant Bacteria by Ghimire, Jenisha, Hart, Robert J., Soldano, Anabel, Chen, Charles H., Guha, Shantanu, Hoffmann, Joseph P., Hall, Kalen M., Sun, Leisheng, Nelson, Benjamin J., Lu, Timothy K., Kolls, Jay K., Rivera, Mario, Morici, Lisa A., Wimley, William C.

“…Here, we describe the continued synthetic molecular evolution of a lineage of host-compatible antimicrobial peptides (AMP) intended for the treatment of wounds…”
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Proline‐Rich Chaperones Are Compared Computationally and Experimentally for Their Abilities to Facilitate Recombinant Butyrylcholinesterase Tetramerization in CHO Cells by Wang, Qiong, Chen, Charles H., Chung, Cheng‐yu, Priola, Joseph, Chu, Jeffrey H., Tang, Juechun, Ulmschneider, Martin B., Betenbaugh, Michael J.

“…Human butyrylcholinesterase (BChE), predominantly tetramers with a residence time of days, offers the potential to scavenge organophosphorus pesticides and…”
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Rapid and effective oxidative pretreatment of woody biomass at mild reaction conditions and low oxidant loadings by Li, Zhenglun, Chen, Charles H, Hegg, Eric L, Hodge, David B

“…BACKGROUND: One route for producing cellulosic biofuels is by the fermentation of lignocellulose-derived sugars generated from a pretreatment that can be…”
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Regioselective Hydroxylation of C12-C15 Fatty Acids with Fluorinated Substituents by Cytochrome P450 BM3 by Chiang, Chih-Hsiang, Ramu, Ravirala, Tu, Yi-Jung, Yang, Chung-Ling, Ng, Kok Yaoh, Luo, Wen-I, Chen, Charles H., Lu, Yu-Ying, Liu, Chen-Lun, Yu, Steve S.-F.

“…We demonstrate herein that wild‐type cytochrome P450 BM3 can recognize non‐natural substrates, such as fluorinated C12–C15 chain‐length fatty acids, and show…”
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Chemical and structural changes associated with Cu-catalyzed alkaline-oxidative delignification of hybrid poplar by Li, Zhenglun, Bansal, Namita, Azarpira, Ali, Bhalla, Aditya, Chen, Charles H, Ralph, John, Hegg, Eric L, Hodge, David B

“…Alkaline hydrogen peroxide pretreatment catalyzed by Cu(II) 2,2'-bipyridine complexes has previously been determined to substantially improve the enzymatic…”
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