Search Results - "Chen, Carol L"

Myocarditis with tremelimumab plus durvalumab combination therapy for endometrial cancer: A case report by Mahmood, Syed S., Chen, Carol L., Shapnik, Natalie, Krishnan, Udhay, Singh, Harsimran S., Makker, Vicky

“…Fulminant myocarditis has been reported in patients treated with immune checkpoint inhibitors. We present the first described case of acute immune-mediated…”
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Incremental Value of Global Longitudinal Strain for Predicting Survival in Patients With Advanced AL Amyloidosis by Lee Chuy, Katherine, Drill, Esther, Yang, Ji Can, Landau, Heather, Hassoun, Hani, Nahhas, Omar, Chen, Carol L., Yu, Anthony F., Steingart, Richard M., Liu, Jennifer E.

“…Advanced light-chain (AL) amyloidosis is associated with poor prognosis, with a 5-year survival rate of <25%. Prognostication is based on the revised Mayo…”
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H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis by Harutyunyan, Ashot S., Krug, Brian, Chen, Haifen, Papillon-Cavanagh, Simon, Zeinieh, Michele, De Jay, Nicolas, Deshmukh, Shriya, Chen, Carol C. L., Belle, Jad, Mikael, Leonie G., Marchione, Dylan M., Li, Rui, Nikbakht, Hamid, Hu, Bo, Cagnone, Gael, Cheung, Warren A., Mohammadnia, Abdulshakour, Bechet, Denise, Faury, Damien, McConechy, Melissa K, Pathania, Manav, Jain, Siddhant U., Ellezam, Benjamin, Weil, Alexander G., Montpetit, Alexandre, Salomoni, Paolo, Pastinen, Tomi, Lu, Chao, Lewis, Peter W., Garcia, Benjamin A., Kleinman, Claudia L., Jabado, Nada, Majewski, Jacek

“…Lys-27-Met mutations in histone 3 genes (H3K27M) characterize a subgroup of deadly gliomas and decrease genome-wide H3K27 trimethylation. Here we use primary…”
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Myocarditis in Patients Treated With Immune Checkpoint Inhibitors by Mahmood, Syed S., Fradley, Michael G., Cohen, Justine V., Nohria, Anju, Reynolds, Kerry L., Heinzerling, Lucie M., Sullivan, Ryan J., Damrongwatanasuk, Rongras, Chen, Carol L., Gupta, Dipti, Kirchberger, Michael C., Awadalla, Magid, Hassan, Malek Z.O., Moslehi, Javid J., Shah, Sachin P., Ganatra, Sarju, Thavendiranathan, Paaladinesh, Lawrence, Donald P., Groarke, John D., Neilan, Tomas G.

“…Myocarditis is an uncommon, but potentially fatal, toxicity of immune checkpoint inhibitors (ICI). Myocarditis after ICI has not been well characterized. The…”
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Histopathologic Characterization of Myocarditis Associated With Immune Checkpoint Inhibitor Therapy by Sobol, Irina, Chen, Carol L, Mahmood, Syed S, Borczuk, Alain C

“…Cardiac complications of immune checkpoint inhibitor therapy are rare, but reports of myocarditis are increasing. The findings have been described in case…”
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Cardiovascular magnetic resonance in immune checkpoint inhibitor-associated myocarditis by Zhang, Lili, Awadalla, Magid, Mahmood, Syed S, Nohria, Anju, Hassan, Malek Z O, Thuny, Franck, Zlotoff, Daniel A, Murphy, Sean P, Stone, James R, Golden, Doll Lauren Alexandra, Alvi, Raza M, Rokicki, Adam, Jones-O'Connor, Maeve, Cohen, Justine V, Heinzerling, Lucie M, Mulligan, Connor, Armanious, Merna, Barac, Ana, Forrestal, Brian J, Sullivan, Ryan J, Kwong, Raymond Y, Yang, Eric H, Damrongwatanasuk, Rongras, Chen, Carol L, Gupta, Dipti, Kirchberger, Michael C, Moslehi, Javid J, Coelho-Filho, Otavio R, Ganatra, Sarju, Rizvi, Muhammad A, Sahni, Gagan, Tocchetti, Carlo G, Mercurio, Valentina, Mahmoudi, Michael, Lawrence, Donald P, Reynolds, Kerry L, Weinsaft, Jonathan W, Baksi, A John, Ederhy, Stephane, Groarke, John D, Lyon, Alexander R, Fradley, Michael G, Thavendiranathan, Paaladinesh, Neilan, Tomas G

“…Myocarditis is a potentially fatal complication of immune checkpoint inhibitors (ICI). Sparse data exist on the use of cardiovascular magnetic resonance (CMR)…”
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Mutant H3 histones drive human pre-leukemic hematopoietic stem cell expansion and promote leukemic aggressiveness by Boileau, Meaghan, Shirinian, Margret, Gayden, Tenzin, Harutyunyan, Ashot S., Chen, Carol C. L., Mikael, Leonie G., Duncan, Heather M., Neumann, Andrea L., Arreba-Tutusaus, Patricia, De Jay, Nicolas, Zeinieh, Michele, Rossokhata, Katya, Zhang, Yelu, Nikbakht, Hamid, Mouawad, Carine, Massoud, Radwan, Frey, Felice, Nasr, Rihab, El Cheikh, Jean, El Sabban, Marwan, Kleinman, Claudia L., Mahfouz, Rami, Minden, Mark D., Jabado, Nada, Bazarbachi, Ali, Eppert, Kolja

“…Our ability to manage acute myeloid leukemia (AML) is limited by our incomplete understanding of the epigenetic disruption central to leukemogenesis, including…”
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Cardiac Disease and Heart Failure in Cancer Patients: Is Our Training Adequate to Provide Optimal Care? by Chen, Carol L., MD, Steingart, Richard, MD

“…The care of patients with cancer who have cardiac disease is dispersed both sequentially and concurrently across multiple providers, and an important goal of…”
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H3S10ph broadly marks early-replicating domains in interphase ESCs and shows reciprocal antagonism with H3K9me2 by Chen, Carol C L, Goyal, Preeti, Karimi, Mohammad M, Abildgaard, Marie H, Kimura, Hiroshi, Lorincz, Matthew C

“…Phosphorylation of histone H3 at serine 10 (H3S10ph) by Aurora kinases plays an important role in mitosis; however, H3S10ph also marks regulatory regions of…”
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Cardiovascular Prevention in the Cancer Survivor by Chen, Carol L.

“…Cancer survivorship should be defined starting not from completion of treatment, but from the time of diagnosis. Assessing and controlling the cancer patient’s…”
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Prognostic and Added Value of Two-Dimensional Global Longitudinal Strain for Prediction of Survival in Patients with Light Chain Amyloidosis Undergoing Autologous Hematopoietic Cell Transplantation by Pun, Shawn C., Landau, Heather J., Riedel, Elyn R., Jordan, Jonathan, Yu, Anthony F., Hassoun, Hani, Chen, Carol L., Steingart, Richard M., Liu, Jennifer E.

“…Autologous hematopoietic cell transplantation (HCT) is a first-line therapy for prolonging survival in patients with light-chain (AL) amyloidosis. Cardiac…”
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Managing the Risks of Cardiac Therapy in Cancer Patients by Chen, Carol L, Parameswaran, Rekha

“…The purpose of this review was to highlight the more commonly used cardiac medications that should be closely monitored or possibly discontinued during cancer…”
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Asystole during pacemaker magnet application by Ip, James E., Liu, Todd J., Chen, Carol L., Lerman, Bruce B.

“…Pacemaker magnet application during surgery for patients who are pacemaker‐dependent is often utilized to avoid perioperative inhibition from electromagnetic…”
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Influenza vaccination and myocarditis among patients receiving immune checkpoint inhibitors by Awadalla, Magid, Golden, Doll Lauren Alexandra, Mahmood, Syed S, Alvi, Raza M, Mercaldo, Nathaniel D, Hassan, Malek Z O, Banerji, Dahlia, Rokicki, Adam, Mulligan, Connor, Murphy, Sean P T, Jones-O'Connor, Maeve, Cohen, Justine V, Heinzerling, Lucie M, Armanious, Merna, Sullivan, Ryan J, Damrongwatanasuk, Rongras, Chen, Carol L, Gupta, Dipti, Kirchberger, Michael C, Moslehi, Javid J, Shah, Sachin P, Ganatra, Sarju, Thavendiranathan, Paaladinesh, Rizvi, Muhammad A, Sahni, Gagan, Lyon, Alexander R, Tocchetti, Carlo G, Mercurio, Valentina, Thuny, Franck, Ederhy, Stephane, Mahmoudi, Michael, Lawrence, Donald P, Groarke, John D, Nohria, Anju, Fradley, Michael G, Reynolds, Kerry L, Neilan, Tomas G

“…Influenza vaccination (FV) is recommended for patients with cancer. Recent data suggested that the administration of the FV was associated with an increase in…”
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Electrocardiographic features of immune checkpoint inhibitor associated myocarditis by Zlotoff, Daniel A, Hassan, Malek Z O, Zafar, Amna, Alvi, Raza M, Awadalla, Magid, Mahmood, Syed S, Zhang, Lili, Chen, Carol L, Ederhy, Stephane, Barac, Ana, Banerji, Dahlia, Jones-O'Connor, Maeve, Murphy, Sean P, Armanious, Merna, Forrestal, Brian J, Kirchberger, Michael C, Coelho-Filho, Otavio R, Rizvi, Muhammad A, Sahni, Gagan, Mandawat, Anant, Tocchetti, Carlo G, Hartmann, Sarah, Gilman, Hannah K, Zatarain-Nicolás, Eduardo, Mahmoudi, Michael, Gupta, Dipti, Sullivan, Ryan, Ganatra, Sarju, Yang, Eric H, Heinzerling, Lucie M, Thuny, Franck, Zubiri, Leyre, Reynolds, Kerry L, Cohen, Justine V, Lyon, Alexander R, Groarke, John, Thavendiranathan, Paaladinesh, Nohria, Anju, Fradley, Michael G, Neilan, Tomas G

“…BackgroundMyocarditis is a highly morbid complication of immune checkpoint inhibitor (ICI) use that remains inadequately characterized. The QRS duration and…”
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Unstable angina associated with cisplatin and carboplatin in a patient with advanced melanoma by Khan, Shaheer, Chen, Carol L, Brady, Mary S, Parameswaran, Rekha, Moore, Russell, Hassoun, Hani, Carvajal, Richard D

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SMARCA4 vulnerability in H3K27M midline glioma: A silver bullet for a lethal disease by Chen, Carol C.L., Andrade, Augusto Faria, Jabado, Nada

“…To investigate epigenetic dependencies and identify therapeutic vulnerabilities, Mo et al.1 and Panditharatna et al.2 performed CRISPR screens and show that…”
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Congenital cardiac liver cirrhosis with combined hepatocellular-cholangiocarcinoma-a case report by El Dika, Imane, Shia, Jinru, Chen, Carol L, Paroder, Viktoriya, Carver, Alan, Shamseddine, Ali, Mukherji, Deborah, Sirohi, Bhawna, Makondi, Precious Takondwa, Asseily, Clara, Matar, Charbel F, Elias, Rawad, Slater, Emily, Rosenbaum, Marlon Steven, Paramesawaran, Rekha, Breitbart, William, Abou-Alfa, Ghassan K

“…Cardiac liver cirrhosis secondary to Fontan procedure has been associated with hepatocellular carcinoma at a younger age. However, Fontan associated liver…”
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Oncohistones in brain tumors: the soil and seed by Andrade, Augusto Faria, Chen, Carol C L, Jabado, Nada

“…Recurrent somatic mutations in histone 3 (H3) variants (termed 'oncohistones') have been identified in high-grade gliomas (HGGs) in children and young adults…”
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Single substitution in H3.3G34 alters DNMT3A recruitment to cause progressive neurodegeneration by Khazaei, Sima, Chen, Carol C.L., Andrade, Augusto Faria, Kabir, Nisha, Azarafshar, Pariya, Morcos, Shahir M., França, Josiane Alves, Lopes, Mariana, Lund, Peder J., Danieau, Geoffroy, Worme, Samantha, Adnani, Lata, Nzirorera, Nadine, Chen, Xiao, Yogarajah, Gayathri, Russo, Caterina, Zeinieh, Michele, Wong, Cassandra J., Bryant, Laura, Hébert, Steven, Tong, Bethany, Sihota, Tianna S., Faury, Damien, Puligandla, Evan, Jawhar, Wajih, Sandy, Veronica, Cowan, Mitra, Nakada, Emily M., Jerome-Majewska, Loydie A., Ellezam, Benjamin, Gomes, Carolina Cavalieri, Denecke, Jonas, Lessel, Davor, McDonald, Marie T., Pizoli, Carolyn E., Taylor, Kathryn, Cocanougher, Benjamin T., Bhoj, Elizabeth J., Gingras, Anne-Claude, Garcia, Benjamin A., Lu, Chao, Campos, Eric I., Kleinman, Claudia L., Garzia, Livia, Jabado, Nada

“…Germline histone H3.3 amino acid substitutions, including H3.3G34R/V, cause severe neurodevelopmental syndromes. To understand how these mutations impact brain…”
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