Search Results - "Chen, Carol C L"

H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis by Harutyunyan, Ashot S., Krug, Brian, Chen, Haifen, Papillon-Cavanagh, Simon, Zeinieh, Michele, De Jay, Nicolas, Deshmukh, Shriya, Chen, Carol C. L., Belle, Jad, Mikael, Leonie G., Marchione, Dylan M., Li, Rui, Nikbakht, Hamid, Hu, Bo, Cagnone, Gael, Cheung, Warren A., Mohammadnia, Abdulshakour, Bechet, Denise, Faury, Damien, McConechy, Melissa K, Pathania, Manav, Jain, Siddhant U., Ellezam, Benjamin, Weil, Alexander G., Montpetit, Alexandre, Salomoni, Paolo, Pastinen, Tomi, Lu, Chao, Lewis, Peter W., Garcia, Benjamin A., Kleinman, Claudia L., Jabado, Nada, Majewski, Jacek

“…Lys-27-Met mutations in histone 3 genes (H3K27M) characterize a subgroup of deadly gliomas and decrease genome-wide H3K27 trimethylation. Here we use primary…”
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Mutant H3 histones drive human pre-leukemic hematopoietic stem cell expansion and promote leukemic aggressiveness by Boileau, Meaghan, Shirinian, Margret, Gayden, Tenzin, Harutyunyan, Ashot S., Chen, Carol C. L., Mikael, Leonie G., Duncan, Heather M., Neumann, Andrea L., Arreba-Tutusaus, Patricia, De Jay, Nicolas, Zeinieh, Michele, Rossokhata, Katya, Zhang, Yelu, Nikbakht, Hamid, Mouawad, Carine, Massoud, Radwan, Frey, Felice, Nasr, Rihab, El Cheikh, Jean, El Sabban, Marwan, Kleinman, Claudia L., Mahfouz, Rami, Minden, Mark D., Jabado, Nada, Bazarbachi, Ali, Eppert, Kolja

“…Our ability to manage acute myeloid leukemia (AML) is limited by our incomplete understanding of the epigenetic disruption central to leukemogenesis, including…”
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H3S10ph broadly marks early-replicating domains in interphase ESCs and shows reciprocal antagonism with H3K9me2 by Chen, Carol C L, Goyal, Preeti, Karimi, Mohammad M, Abildgaard, Marie H, Kimura, Hiroshi, Lorincz, Matthew C

“…Phosphorylation of histone H3 at serine 10 (H3S10ph) by Aurora kinases plays an important role in mitosis; however, H3S10ph also marks regulatory regions of…”
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SMARCA4 vulnerability in H3K27M midline glioma: A silver bullet for a lethal disease by Chen, Carol C.L., Andrade, Augusto Faria, Jabado, Nada

“…To investigate epigenetic dependencies and identify therapeutic vulnerabilities, Mo et al.1 and Panditharatna et al.2 performed CRISPR screens and show that…”
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Oncohistones in brain tumors: the soil and seed by Andrade, Augusto Faria, Chen, Carol C L, Jabado, Nada

“…Recurrent somatic mutations in histone 3 (H3) variants (termed 'oncohistones') have been identified in high-grade gliomas (HGGs) in children and young adults…”
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Single substitution in H3.3G34 alters DNMT3A recruitment to cause progressive neurodegeneration by Khazaei, Sima, Chen, Carol C.L., Andrade, Augusto Faria, Kabir, Nisha, Azarafshar, Pariya, Morcos, Shahir M., França, Josiane Alves, Lopes, Mariana, Lund, Peder J., Danieau, Geoffroy, Worme, Samantha, Adnani, Lata, Nzirorera, Nadine, Chen, Xiao, Yogarajah, Gayathri, Russo, Caterina, Zeinieh, Michele, Wong, Cassandra J., Bryant, Laura, Hébert, Steven, Tong, Bethany, Sihota, Tianna S., Faury, Damien, Puligandla, Evan, Jawhar, Wajih, Sandy, Veronica, Cowan, Mitra, Nakada, Emily M., Jerome-Majewska, Loydie A., Ellezam, Benjamin, Gomes, Carolina Cavalieri, Denecke, Jonas, Lessel, Davor, McDonald, Marie T., Pizoli, Carolyn E., Taylor, Kathryn, Cocanougher, Benjamin T., Bhoj, Elizabeth J., Gingras, Anne-Claude, Garcia, Benjamin A., Lu, Chao, Campos, Eric I., Kleinman, Claudia L., Garzia, Livia, Jabado, Nada

“…Germline histone H3.3 amino acid substitutions, including H3.3G34R/V, cause severe neurodevelopmental syndromes. To understand how these mutations impact brain…”
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TULIPs decorate the three-dimensional genome of PFA ependymoma by Johnston, Michael J, Lee, John J Y, Hu, Bo, Nikolic, Ana, Hasheminasabgorji, Elham, Baguette, Audrey, Paik, Seungil, Chen, Haifen, Kumar, Sachin, Chen, Carol C L, Jessa, Selin, Balin, Polina, Fong, Vernon, Zwaig, Melissa, Michealraj, Kulandaimanuvel Antony, Chen, Xun, Zhang, Yanlin, Varadharajan, Srinidhi, Billon, Pierre, Juretic, Nikoleta, Daniels, Craig, Rao, Amulya Nageswara, Giannini, Caterina, Thompson, Eric M, Garami, Miklos, Hauser, Peter, Pocza, Timea, Ra, Young Shin, Cho, Byung-Kyu, Kim, Seung-Ki, Wang, Kyu-Chang, Lee, Ji Yeoun, Grajkowska, Wieslawa, Perek-Polnik, Marta, Agnihotri, Sameer, Mack, Stephen, Ellezam, Benjamin, Weil, Alex, Rich, Jeremy, Bourque, Guillaume, Chan, Jennifer A, Yong, V Wee, Lupien, Mathieu, Ragoussis, Jiannis, Kleinman, Claudia, Majewski, Jacek, Blanchette, Mathieu, Jabado, Nada, Taylor, Michael D, Gallo, Marco

“…Posterior fossa group A (PFA) ependymoma is a lethal brain cancer diagnosed in infants and young children. The lack of driver events in the PFA linear genome…”
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Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas by Krug, Brian, De Jay, Nicolas, Harutyunyan, Ashot S., Deshmukh, Shriya, Marchione, Dylan M., Guilhamon, Paul, Bertrand, Kelsey C., Mikael, Leonie G., McConechy, Melissa K., Chen, Carol C.L., Khazaei, Sima, Koncar, Robert F., Agnihotri, Sameer, Faury, Damien, Ellezam, Benjamin, Weil, Alexander G., Ursini-Siegel, Josie, De Carvalho, Daniel D., Dirks, Peter B., Lewis, Peter W., Salomoni, Paolo, Lupien, Mathieu, Arrowsmith, Cheryl, Lasko, Paul F., Garcia, Benjamin A., Kleinman, Claudia L., Jabado, Nada, Mack, Stephen C.

“…High-grade gliomas defined by histone 3 K27M driver mutations exhibit global loss of H3K27 trimethylation and reciprocal gain of H3K27 acetylation,…”
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Histone H3.3 K27M and K36M mutations de-repress transposable elements through perturbation of antagonistic chromatin marks by Chaouch, Amel, Berlandi, Johannes, Chen, Carol C.L., Frey, Felice, Badini, Shireen, Harutyunyan, Ashot S., Chen, Xiao, Krug, Brian, Hébert, Steven, Jeibmann, Astrid, Lu, Chao, Kleinman, Claudia L., Hasselblatt, Martin, Lasko, Paul, Shirinian, Margret, Jabado, Nada

“…Histone H3.3 lysine-to-methionine substitutions K27M and K36M impair the deposition of opposing chromatin marks, H3K27me3/me2 and H3K36me3/me2. We show that…”
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Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas by Krug, Brian, De Jay, Nicolas, Harutyunyan, Ashot S., Deshmukh, Shriya, Marchione, Dylan M., Guilhamon, Paul, Bertrand, Kelsey C., Mikael, Leonie G., McConechy, Melissa K., Chen, Carol C.L., Khazaei, Sima, Koncar, Robert F., Agnihotri, Sameer, Faury, Damien, Ellezam, Benjamin, Weil, Alexander G., Ursini-Siegel, Josie, De Carvalho, Daniel D., Dirks, Peter B., Lewis, Peter W., Salomoni, Paolo, Lupien, Mathieu, Arrowsmith, Cheryl, Lasko, Paul F., Garcia, Benjamin A., Kleinman, Claudia L., Jabado, Nada, Mack, Stephen C.

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Meet the authors: Amel Chaouch, Carol C.L. Chen, and Margret Shirinian

“…We talk to two of the first authors, Amel Chaouch and Carol C.L. Chen, as well as one of the corresponding authors, Margret Shirinian, about their paper,…”
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Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis by Chen, Carol C.L., Deshmukh, Shriya, Jessa, Selin, Hadjadj, Djihad, Lisi, Véronique, Andrade, Augusto Faria, Faury, Damien, Jawhar, Wajih, Dali, Rola, Suzuki, Hiromichi, Pathania, Manav, A, Deli, Dubois, Frank, Woodward, Eleanor, Hébert, Steven, Coutelier, Marie, Karamchandani, Jason, Albrecht, Steffen, Brandner, Sebastian, De Jay, Nicolas, Gayden, Tenzin, Bajic, Andrea, Harutyunyan, Ashot S., Marchione, Dylan M., Mikael, Leonie G., Juretic, Nikoleta, Zeinieh, Michele, Russo, Caterina, Maestro, Nicola, Bassenden, Angelia V., Hauser, Peter, Virga, József, Bognar, Laszlo, Klekner, Almos, Zapotocky, Michal, Vicha, Ales, Krskova, Lenka, Vanova, Katerina, Zamecnik, Josef, Sumerauer, David, Ekert, Paul G., Ziegler, David S., Ellezam, Benjamin, Filbin, Mariella G., Blanchette, Mathieu, Hansford, Jordan R., Khuong-Quang, Dong-Anh, Berghuis, Albert M., Weil, Alexander G., Garcia, Benjamin A., Garzia, Livia, Mack, Stephen C., Beroukhim, Rameen, Ligon, Keith L., Taylor, Michael D., Bandopadhayay, Pratiti, Kramm, Christoph, Pfister, Stefan M., Korshunov, Andrey, Sturm, Dominik, Jones, David T.W., Salomoni, Paolo, Kleinman, Claudia L., Jabado, Nada

“…Histone H3.3 glycine 34 to arginine/valine (G34R/V) mutations drive deadly gliomas and show exquisite regional and temporal specificity, suggesting a…”
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H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone by Khazaei, Sima, De Jay, Nicolas, Deshmukh, Shriya, Hendrikse, Liam D, Jawhar, Wajih, Chen, Carol C L, Mikael, Leonie G, Faury, Damien, Marchione, Dylan M, Lanoix, Joel, Bonneil, Éric, Ishii, Takeaki, Jain, Siddhant U, Rossokhata, Kateryna, Sihota, Tianna S, Eveleigh, Robert, Lisi, Véronique, Harutyunyan, Ashot S, Jung, Sungmi, Karamchandani, Jason, Dickson, Brendan C, Turcotte, Robert, Wunder, Jay S, Thibault, Pierre, Lewis, Peter W, Garcia, Benjamin A, Mack, Stephen C, Taylor, Michael D, Garzia, Livia, Kleinman, Claudia L, Jabado, Nada

“…Glycine 34-to-tryptophan (G34W) substitutions in H3.3 arise in approximately 90% of giant cell tumor of bone (GCT). Here, we show H3.3 G34W is necessary for…”
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