Search Results - "Chen, Brian"

mLiftOver: harmonizing data across Infinium DNA methylation platforms by Chen, Brian H, Zhou, Wanding

“…Infinium DNA methylation BeadChips are widely used for genome-wide DNA methylation profiling at the population scale. Recent updates to probe content and…”
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Prolonged operative duration is associated with complications: a systematic review and meta-analysis by Cheng, Hang, Clymer, Jeffrey W., Po-Han Chen, Brian, Sadeghirad, Behnam, Ferko, Nicole C., Cameron, Chris G., Hinoul, Piet

“…The aim of this study was to systematically synthesize the large volume of literature reporting on the association between operative duration and complications…”
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Prolonged Operative Duration Increases Risk of Surgical Site Infections: A Systematic Review by Cheng, Hang, Chen, Brian Po-Han, Soleas, Ireena M, Ferko, Nicole C, Cameron, Chris G, Hinoul, Piet

“…The incidence of surgical site infection (SSI) across surgical procedures, specialties, and conditions is reported to vary from 0.1% to 50%. Operative duration…”
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Deep Eutectic Solvents: A Review of Fundamentals and Applications by Hansen, Benworth B, Spittle, Stephanie, Chen, Brian, Poe, Derrick, Zhang, Yong, Klein, Jeffrey M, Horton, Alexandre, Adhikari, Laxmi, Zelovich, Tamar, Doherty, Brian W, Gurkan, Burcu, Maginn, Edward J, Ragauskas, Arthur, Dadmun, Mark, Zawodzinski, Thomas A, Baker, Gary A, Tuckerman, Mark E, Savinell, Robert F, Sangoro, Joshua R

“…Deep eutectic solvents (DESs) are an emerging class of mixtures characterized by significant depressions in melting points compared to those of the neat…”
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Contextual modifiers of healthspan, lifespan, and epigenome in mice under chronic social stress by Razzoli, Maria, Nyuyki-Dufe, Kewir, Chen, Brian H, Bartolomucci, Alessandro

“…Sustained life stress and low socioeconomic status are among the major causes of aging-related diseases and decreased life expectancy. Experimental rodent…”
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Multi-Modal Diagnosis of Alzheimer's Disease using Interpretable Graph Convolutional Networks by Zhou, Houliang, He, Lifang, Chen, Brian Y., Shen, Li, Zhang, Yu

“…The interconnection between brain regions in neurological disease encodes vital information for the advancement of biomarkers and diagnostics. Although graph…”
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An epigenetic biomarker of aging for lifespan and healthspan by Levine, Morgan E, Lu, Ake T, Quach, Austin, Chen, Brian H, Assimes, Themistocles L, Bandinelli, Stefania, Hou, Lifang, Baccarelli, Andrea A, Stewart, James D, Li, Yun, Whitsel, Eric A, Wilson, James G, Reiner, Alex P, Aviv, Abraham, Lohman, Kurt, Liu, Yongmei, Ferrucci, Luigi, Horvath, Steve

“…Identifying reliable biomarkers of aging is a major goal in geroscience. While the first generation of epigenetic biomarkers of aging were developed using…”
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Homology Directed Knockin of Point Mutations in the Zebrafish tardbp and fus Genes in ALS Using the CRISPR/Cas9 System by Armstrong, Gary Alan Barclay, Liao, Meijiang, You, Zhipeng, Lissouba, Alexandra, Chen, Brian Edwin, Drapeau, Pierre

“…The methodology for site-directed editing of single nucleotides in the vertebrate genome is of considerable interest for research in biology and medicine. The…”
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Menopause accelerates biological aging by Levine, Morgan E., Lu, Ake T., Chen, Brian H., Hernandez, Dena G., Singleton, Andrew B., Ferrucci, Luigi, Bandinelli, Stefania, Salfati, Elias, Manson, JoAnn E., Quach, Austin, Kusters, Cynthia D. J., Kuh, Diana, Wong, Andrew, Teschendorff, Andrew E., Widschwendter, Martin, Ritz, Beate R., Absher, Devin, Assimes, Themistocles L., Horvath, Steve

“…Although epigenetic processes have been linked to aging and disease in other systems, it is not yet known whether they relate to reproductive aging. Recently,…”
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Dscam and DSCAM: complex genes in simple animals, complex animals yet simple genes by Schmucker, Dietmar, Chen, Brian

“…Cadherins and the immunoglobulin (Ig) proteins give rise to a multitude of surface receptors, which function as diverse cell adhesion molecules (CAMs) or…”
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Epigenetic clock analysis of diet, exercise, education, and lifestyle factors by Quach, Austin, Levine, Morgan E, Tanaka, Toshiko, Lu, Ake T, Chen, Brian H, Ferrucci, Luigi, Ritz, Beate, Bandinelli, Stefania, Neuhouser, Marian L, Beasley, Jeannette M, Snetselaar, Linda, Wallace, Robert B, Tsao, Philip S, Absher, Devin, Assimes, Themistocles L, Stewart, James D, Li, Yun, Hou, Lifang, Baccarelli, Andrea A, Whitsel, Eric A, Horvath, Steve

“…Behavioral and lifestyle factors have been shown to relate to a number of health-related outcomes, yet there is a need for studies that examine their…”
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Why Biologics and Biosimilars Remain So Expensive: Despite Two Wins for Biosimilars, the Supreme Court’s Recent Rulings do not Solve Fundamental Barriers to Competition by Chen, Brian K., Yang, Y. Tony, Bennett, Charles L.

“…Biologics and biosimilars are medicines made from living cells that treat common and serious diseases such as cancer, diabetes, rheumatoid arthritis, and other…”
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False alarm? Estimating the marginal value of health signals by Iizuka, Toshiaki, Nishiyama, Katsuhiko, Chen, Brian, Eggleston, Karen

“…•We study efficiency of response to health signals from mandatory checkups.•Regression discontinuity analysis of diabetes thresholds reveals heterogeneous…”
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DNA methylation age of blood predicts future onset of lung cancer in the women's health initiative by Levine, Morgan E, Hosgood, H Dean, Chen, Brian, Absher, Devin, Assimes, Themistocles, Horvath, Steve

“…Lung cancer is considered an age-associated disease, whose progression is in part due to accumulation of genomic instability as well as age-related decline in…”
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The role of epigenetic aging in education and racial/ethnic mortality disparities among older U.S. Women by Liu, Zuyun, Chen, Brian H., Assimes, Themistocles L., Ferrucci, Luigi, Horvath, Steve, Levine, Morgan E.

“…•Investigate the role of epigenetic aging in sociodemographic mortality disparities.•Blacks and less educated postmenopausal women exhibit higher epigenetic…”
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VASP-E: specificity annotation with a volumetric analysis of electrostatic isopotentials by Chen, Brian Y

“…Algorithms for comparing protein structure are frequently used for function annotation. By searching for subtle similarities among very different proteins,…”
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An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease by Horvath, Steve, Gurven, Michael, Levine, Morgan E, Trumble, Benjamin C, Kaplan, Hillard, Allayee, Hooman, Ritz, Beate R, Chen, Brian, Lu, Ake T, Rickabaugh, Tammy M, Jamieson, Beth D, Sun, Dianjianyi, Li, Shengxu, Chen, Wei, Quintana-Murci, Lluis, Fagny, Maud, Kobor, Michael S, Tsao, Philip S, Reiner, Alexander P, Edlefsen, Kerstin L, Absher, Devin, Assimes, Themistocles L

“…Epigenetic biomarkers of aging (the "epigenetic clock") have the potential to address puzzling findings surrounding mortality rates and incidence of…”
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Acoustically actuated ultra-compact NEMS magnetoelectric antennas by Nan, Tianxiang, Lin, Hwaider, Gao, Yuan, Matyushov, Alexei, Yu, Guoliang, Chen, Huaihao, Sun, Neville, Wei, Shengjun, Wang, Zhiguang, Li, Menghui, Wang, Xinjun, Belkessam, Amine, Guo, Rongdi, Chen, Brian, Zhou, James, Qian, Zhenyun, Hui, Yu, Rinaldi, Matteo, McConney, Michael E., Howe, Brandon M., Hu, Zhongqiang, Jones, John G., Brown, Gail J., Sun, Nian Xiang

“…State-of-the-art compact antennas rely on electromagnetic wave resonance, which leads to antenna sizes that are comparable to the electromagnetic wavelength…”
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Epigenome-Wide Association Study of Fasting Blood Lipids in the Genetics of Lipid-Lowering Drugs and Diet Network Study by Irvin, Marguerite R, Zhi, Degui, Joehanes, Roby, Mendelson, Michael, Aslibekyan, Stella, Claas, Steven A, Thibeault, Krista S, Patel, Nikita, Day, Kenneth, Jones, Lindsay Waite, Liang, Liming, Chen, Brian H, Yao, Chen, Tiwari, Hemant K, Ordovas, Jose M, Levy, Daniel, Absher, Devin, Arnett, Donna K

“…BACKGROUND—Genetic research regarding blood lipids has largely focused on DNA sequence variation; few studies have explored epigenetic effects. Genome-wide…”
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Minimum standards for evaluating machine-learned models of high-dimensional data by Chen, Brian H

“…The maturation of machine learning and technologies that generate high dimensional data have led to the growth in the number of predictive models, such as the…”
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