Search Results - "Chen, Bonan"

Generation of hereditary spastic paraplegia patient-derived induced pluripotent stem cell line UJSi003-A by Sun, Tingkai, Chen, Bonan, Zhang, Dingqi, Xu, Xuan, Gao, Jing, Sun, Jing, Wei, Muyun

“…Hereditary spastic paraplegia (HSP) is a rare neurodegenerative disorder with the predominant clinical manifestation of spasticity in the lower extremities…”
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Gentiopicroside improves NASH and liver fibrosis by suppressing TLR4 and NLRP3 signaling pathways by Yong, Qiuhong, Huang, Chaoyuan, Chen, Bonan, An, Jinqi, Zheng, Yiyuan, Zhao, Lina, Peng, Chong, Liu, Fengbin

“…Non-alcoholic steatohepatitis (NASH) and liver fibrosis are progressive conditions associated with non-alcoholic fatty liver disease (NAFLD), characterized by…”
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Hederagenin potentiated cisplatin- and paclitaxel-mediated cytotoxicity by impairing autophagy in lung cancer cells by Wang, Kun, Liu, Xiaodong, Liu, Quanmeng, Ho, Idy ht, Wei, Xianli, Yin, Ting, Zhan, Yujuan, Zhang, Wenjing, Zhang, Wenbo, Chen, Bonan, Gu, Jiangyong, Tan, Yuhui, Zhang, Lin, Chan, Matthew Tv, Wu, William Kk, Du, Biaoyan, Xiao, Jianyong

“…Autophagy inhibition has been demonstrated to increase the efficacy of conventional chemotherapy. In this study, we identified hederagenin, a triterpenoid…”
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Dioscin Inhibits the Invasion and Migration of Hepatocellular Carcinoma HepG2 Cells by Reversing TGF-β1-Induced Epithelial-Mesenchymal Transition by Chen, Bonan, Zhou, Shikun, Zhan, Yujuan, Ke, Junzi, Wang, Kun, Liang, Qiqi, Hou, Yu, Zhu, Pingping, Ao, Weizhen, Wei, Xianli, Xiao, Jianyong

“…Dioscin is a natural steroidal saponin that can be isolated from Chinese medicine, such as Dioscoreae rhizoma. It has wild range of pharmacological activities…”
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Epimedium for Osteoporosis Based on Western and Eastern Medicine: An Updated Systematic Review and Meta-Analysis by Shi, Shihua, Wang, Fei, Huang, Yong, Chen, Bonan, Pei, Caixia, Huang, Demei, Wang, Xiaomin, Wang, Yilan, Kou, Shuo, Li, Weihao, Ma, Tianhong, Wu, Yongcan, Wang, Zhenxing

“…The efficacy of conventional pharmacotherapy on osteoporosis was limited and accompanied with serious side effects. Epimedium might have the potential to be…”
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Cellular zinc metabolism and zinc signaling: from biological functions to diseases and therapeutic targets by Chen, Bonan, Yu, Peiyao, Chan, Wai Nok, Xie, Fuda, Zhang, Yigan, Liang, Li, Leung, Kam Tong, Lo, Kwok Wai, Yu, Jun, Tse, Gary M. K., Kang, Wei, To, Ka Fai

“…Zinc metabolism at the cellular level is critical for many biological processes in the body. A key observation is the disruption of cellular homeostasis, often…”
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Exploring the gut microbiome's role in colorectal cancer: diagnostic and prognostic implications by Chen, Guoming, Ren, Qing, Zhong, Zilan, Li, Qianfan, Huang, Zhiqiang, Zhang, Cheng, Yuan, Hongchao, Feng, Zixin, Chen, Bonan, Wang, Ning, Feng, Yibin

“…The intricate interplay between the gut microbiome and colorectal cancer (CRC) presents novel avenues for early diagnosis and prognosis, crucial for improving…”
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The Novel Autophagy Inhibitor Alpha-Hederin Promoted Paclitaxel Cytotoxicity by Increasing Reactive Oxygen Species Accumulation in Non-Small Cell Lung Cancer Cells by Zhan, Yujuan, Wang, Kun, Li, Qiao, Zou, Yidan, Chen, Bonan, Gong, Qing, Ho, Hiuting Idy, Yin, Ting, Zhang, Fangyuan, Lu, Yuhua, Wu, Weijie, Zhang, Yilin, Tan, Yuhui, Du, Biaoyan, Liu, Xiaodong, Xiao, Jianyong

“…Chemoresistance is a major limiting factor that impairs the outcome of non-small cell lung cancer (NSCLC) chemotherapy. Paclitaxel (Tax) induces protective…”
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N -Methylparoxetine Blocked Autophagic Flux and Induced Apoptosis by Activating ROS-MAPK Pathway in Non-Small Cell Lung Cancer Cells by Wang, Kun, Chen, Bonan, Yin, Ting, Zhan, Yujuan, Lu, Yuhua, Zhang, Yilin, Chen, Jiawei, Wu, Weijie, Zhou, Shikun, Mao, Wenli, Tan, Yuhui, Du, Biaoyan, Liu, Xiaodong, Ho, Hiuting Idy, Xiao, Jianyong

“…The main mechanistic function of most chemotherapeutic drugs is mediated by inducing mitochondria-dependent apoptosis. Tumor cells usually respond to…”
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An updated meta-analysis of Chinese herbal medicine for the prevention of COVID-19 based on Western-Eastern medicine by Hu, Siying, Luo, Dan, Zhu, Qikui, Pan, Jie, Chen, Bonan, Furian, Michael, Harkare, Harsh Vivek, Sun, Shoukai, Fansa, Adel, Wu, Xiaoping, Yu, Baili, Ma, Tianhong, Wang, Fei, Shi, Shihua

“…Background and aims: Chinese herbal medicine (CHM) was used to prevent and treat coronavirus disease 2019 (COVID-19) in clinical practices. Many studies have…”
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Efficacy and Safety of Shenfu Injection for Severe Pneumonia in the Elderly: A Systematic Review and Meta-Analysis Based on Western and Eastern Medicine by Shi, Shihua, Wang, Fei, Chen, Bonan, Pan, Jie, Luo, Dan, Pei, Caixia, Huang, Demei, Wang, Xiaomin, Wang, Yilan, Shen, Zherui, Li, Weihao, Wu, Yongcan, He, Yacong, Wang, Zhenxing

“…Background: Although increasing clinical trials studying Shenfu injection (SFI) comprising panaxoside 0.8 mg/ml extracted from Panax ginseng C.A. Mey. and…”
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STK3 promotes gastric carcinogenesis by activating Ras-MAPK mediated cell cycle progression and serves as an independent prognostic biomarker by Chen, Bonan, Chan, Wai Nok, Mui, Chun Wai, Liu, Xiaoli, Zhang, Jinglin, Wang, Yifei, Cheung, Alvin H K, Chan, Aden K Y, Chan, Ronald C K, Leung, Kam Tong, Dong, Yujuan, Pan, Yi, Ke, Huixing, Liang, Li, Zhou, Zhaocai, Wong, Chi Chun, Wu, William K K, Cheng, Alfred S L, Yu, Jun, Lo, Kwok Wai, To, Ka Fai, Kang, Wei

“…Keywords: STK3, Gastric cancer, Oncogene, Ras-MAPK signaling…”
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Targeting the oncogenic LARP1/DKK4/β‐catenin axis in hepatoblastoma by Xie, Fuda, Chen, Bonan, Shin, Wing Sum, Yu, Jun, To, Ka Fai, Kang, Wei

“…[...]it is still urgent to identify the underlying pathogenesis to achieve a better prognosis for HB patients. In Cui's work, they proved that the Ser672…”
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The CRM1‐mediated nuclear export effectuates the role conversion of tumour suppressor gene BATF2 in colorectal cancer by Yu, Peiyao, Chen, Bonan, Xie, Fuda, Yu, Jun, To, Ka Fai, Kang, Wei

“…Correspondingly, exportin-1 (XPO1, also known as chromosomal region maintenance 1, or CRM1) is involved in the nuclear transport of not only tumour suppressor…”
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Blockage of Autophagic Flux and Induction of Mitochondria Fragmentation by Paroxetine Hydrochloride in Lung Cancer Cells Promotes Apoptosis via the ROS-MAPK Pathway by Wang, Kun, Gong, Qing, Zhan, Yujuan, Chen, Bonan, Yin, Ting, Lu, Yuhua, Zhang, Yilin, Wang, Huiqi, Ke, Junzi, Du, Biaoyan, Liu, Xiaodong, Xiao, Jianyong

“…Cancer cells are characterized by malignant proliferation and aberrant metabolism and are thereby liable to the depletion of nutrients and accumulation of…”
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Cyclin‐dependent kinase 12‐mediated super‐enhancers as promising targets in cancer therapy by Xie, Fuda, Chen, Bonan, Liu, Xiaoli, Yu, Jun, To, Ka Fai, Kang, Wei

“…In Dai's work, a set of essential SEs for gene transcription associated with RNA polymerase II (RNA pol II) were evaluated. CDK12 belongs to the…”
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Blocking Ubiquitin‐Specific Protease 7 Induces Ferroptosis in Gastric Cancer via Targeting Stearoyl‐CoA Desaturase by Guan, Xiaoqing, Wang, Yichao, Yu, Wenkai, Wei, Yong, Lu, Yang, Dai, Enyu, Dong, Xiaowu, Zhao, Bing, Hu, Can, Yuan, Li, Luan, Xin, Miao, Kai, Chen, Bonan, Cheng, Xiang‐Dong, Zhang, Weidong, Qin, Jiang‐Jiang

“…Gastric cancer (GC) presents a formidable global health challenge, and conventional therapies face efficacy limitations. Ubiquitin‐specific protease 7 (USP7)…”
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Oral Chinese Herbal Medicine on Immune Responses During Coronavirus Disease 2019: A Systematic Review and Meta-Analysis by Shi, Shihua, Wang, Fei, Yao, Huan, Kou, Shuo, Li, Weihao, Chen, Bonan, Wu, Yongcan, Wang, Xiaomin, Pei, Caixia, Huang, Demei, Wang, Yilan, Zhang, Pan, He, Yacong, Wang, Zhenxing

“…Cellular immune responses including lymphocyte functions and immune effector cells are critical for the control of coronavirus infection. Chinese herbal…”
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The crosstalk between the RNA demethylase, non‐coding RNAs, and transcription factors in gastric cancer: An ALKBH5 perspective by Xie, Fuda, Chen, Bonan, Cheung, Alvin H. K., Yu, Jun, To, Ka Fai, Kang, Wei

“…LINC00659 AND YTHDF2 Along with the blooming of transcriptome analysis, lncRNAs have emerged as nonnegligible participators in carcinogenesis due to their…”
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Mint3‐targeted therapy: A novel therapeutic strategy for urothelial carcinoma by Xie, Fuda, Chen, Bonan, Cheung, Alvin H.K., Yu, Jun, To, Ka Fai, Kang, Wei

“…In general, platinum-based chemotherapy is the recommended first-line standard therapy for suitable patients, while cisplatin is preferred to carboplatin…”
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