Search Results - "Chen, Benny J"

The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function by Macintyre, Andrew N., Gerriets, Valerie A., Nichols, Amanda G., Michalek, Ryan D., Rudolph, Michael C., Deoliveira, Divino, Anderson, Steven M., Abel, E. Dale, Chen, Benny J., Hale, Laura P., Rathmell, Jeffrey C.

“…CD4 T cell activation leads to proliferation and differentiation into effector (Teff) or regulatory (Treg) cells that mediate or control immunity. While each…”
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BAFF promotes heightened BCR responsiveness and manifestations of chronic GVHD after allogeneic stem cell transplantation by Jia, Wei, Poe, Jonathan C., Su, Hsuan, Anand, Sarah, Matsushima, Glenn K., Rathmell, Jeffrey C., Maillard, Ivan, Radojcic, Vedran, Imai, Kazuhiro, Reyes, Nancy J., Cardona, Diana M., Li, Zhiguo, Suthers, Amy N., Curry-Chisolm, Itaevia M., DiCioccio, Rachel A., Saban, Daniel R., Chen, Benny J., Chao, Nelson J., Sarantopoulos, Stefanie

“…Patients with chronic graft-versus-host disease (cGVHD) have increased B cell–activating factor (BAFF) levels, but whether BAFF promotes disease after…”
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Tracing Tumor Evolution in Sarcoma Reveals Clonal Origin of Advanced Metastasis by Tang, Yuning J., Huang, Jianguo, Tsushima, Hidetoshi, Ban, Ga I., Zhang, Hongyuan, Oristian, Kristianne M., Puviindran, Vijitha, Williams, Nerissa, Ding, Xiruo, Ou, Jianhong, Jung, Sin-Ho, Lee, Chang-Lung, Jiao, Yiqun, Chen, Benny J., Kirsch, David G., Alman, Benjamin A.

“…Cellular heterogeneity is frequently observed in cancer, but the biological significance of heterogeneous tumor clones is not well defined. Using multicolor…”
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Alphavirus Replicon Particle Vaccine Breaks B Cell Tolerance and Rapidly Induces IgG to Murine Hematolymphoid Tumor Associated Antigens by Su, Hsuan, Imai, Kazuhiro, Jia, Wei, Li, Zhiguo, DiCioccio, Rachel A, Serody, Jonathan S, Poe, Jonathan C, Chen, Benny J, Doan, Phuong L, Sarantopoulos, Stefanie

“…immune responses to myeloid and other blood-borne tumors are notably limited and ineffective, making our ability to promote immune responses with vaccines a…”
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High-resolution in vivo imaging of blood vessels without labeling by Fu, Dan, Ye, Tong, Matthews, Thomas E, Chen, Benny J, Yurtserver, Gunay, Warren, Warren S

“…We demonstrate that both oxyhemoglobin and deoxyhemoglobin have sequential two-color, two-photon absorption properties that can serve as endogenous contrasts…”
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T cell metabolism in graft-versus-host disease by Zou, Yujing, Chen, Benny J.

“…Graft-versus-host disease (GVHD) is a major source of morbidity and mortality following allogeneic hematopoietic stem cell transplant (allo-HSCT), one of the…”
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Targeting Glycolysis in Alloreactive T Cells to Prevent Acute Graft- Versus -Host Disease While Preserving Graft-Versus-Leukemia Effect by Huang, Ying, Zou, Yujing, Jiao, Yiqun, Shi, Peijie, Nie, Xiaoli, Huang, Wei, Xiong, Chuanfeng, Choi, Michael, Huang, Charles, Macintyre, Andrew N, Nichols, Amanda, Li, Fang, Li, Chuan-Yuan, MacIver, Nancie J, Cardona, Diana M, Brennan, Todd V, Li, Zhiguo, Chao, Nelson J, Rathmell, Jeffrey C, Chen, Benny J

“…Alloreactive donor T cells undergo extensive metabolic reprogramming to become activated and induce graft-versus-host disease (GVHD) upon alloantigen…”
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Chronic GVHD of the CNS by Chen, Benny J.

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Donor Allospecific CD44high Central Memory T Cells Have Decreased Ability to Mediate Graft-vs.-Host Disease by Huang, Wei, Mo, Wenjian, Jiang, Jieling, Chao, Nelson J., Chen, Benny J.

“…Data from both animal models and humans have demonstrated that effector memory T cells (T EM ) and central memory T cells (T CM ) from unprimed donors have…”
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Selective enhancement of donor hematopoietic cell engraftment by the CXCR4 antagonist AMD3100 in a mouse transplantation model by Kang, Yubin, Chen, Benny J, Deoliveira, Divino, Mito, Jeffrey, Chao, Nelson J

“…The interaction between stromal cell-derived factor-1 (SDF-1) with CXCR4 chemokine receptors plays an important role in hematopoiesis following hematopoietic…”
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Thioredoxin mitigates radiation-induced hematopoietic stem cell injury in mice by Sundaramoorthy, Pasupathi, Wang, Qinhong, Zheng, Zhihong, Jiao, Yiqun, Chen, Benny J, Doan, Phuong L, Chao, Nelson J, Kang, Yubin

“…Radiation exposure poses a significant threat to public health. Hematopoietic injury is one of the major manifestations of acute radiation sickness. Protection…”
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SYK inhibitor entospletinib prevents ocular and skin GVHD in mice by Poe, Jonathan C, Jia, Wei, Di Paolo, Julie A, Reyes, Nancy J, Kim, Ji Yun, Su, Hsuan, Sundy, John S, Cardones, Adela R, Perez, Victor L, Chen, Benny J, Chao, Nelson J, Cardona, Diana M, Saban, Daniel R, Sarantopoulos, Stefanie

“…Graft-versus-host disease (GVHD) is a major complication of hematopoietic stem cell transplantation (HCT). The tyrosine kinase SYK contributes to both acute…”
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Growth hormone mitigates against lethal irradiation and enhances hematologic and immune recovery in mice and nonhuman primates by Chen, Benny J, Deoliveira, Divino, Spasojevic, Ivan, Sempowski, Gregory D, Jiang, Chen, Owzar, Kouros, Wang, Xiaojuan, Gesty-Palmer, Diane, Cline, J Mark, Bourland, J Daniel, Dugan, Greg, Meadows, Sarah K, Daher, Pamela, Muramoto, Garrett, Chute, John P, Chao, Nelson J

“…Medications that can mitigate against radiation injury are limited. In this study, we investigated the ability of recombinant human growth hormone (rhGH) to…”
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Insulin-Like Growth Factor 1 Mitigates Hematopoietic Toxicity After Lethal Total Body Irradiation by Zhou, Dunhua, MD, PhD, Deoliveira, Divino, PhD, Kang, Yubin, MD, Choi, Seung S, Li, Zhiguo, PhD, Chao, Nelson J., MD, Chen, Benny J., MD

“…Purpose To investigate whether and how insulin-like growth factor 1 (IGF-1) mitigates hematopoietic toxicity after total body irradiation. Methods and…”
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Progenitor cell dose determines the pace and completeness of engraftment in a xenograft model for cord blood transplantation by Liu, Congxiao, Chen, Benny J., DeOliveira, Divinomar, Sempowski, Gregory D., Chao, Nelson J., Storms, Robert W.

“…Two critical concerns in clinical cord blood transplantation are the initial time to engraftment and the subsequent restoration of immune function. These…”
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Endothelial Cell Derived Extracellular Vesicles and Hematopoiesis by Sukhnanan, Kareena, Ross, Joel R., Chao, Nelson J., Chen, Benny J.

“…Extracellular vesicles (EVs) have been recognized as a novel way of cell-to-cell communication in the last several decades. It is believed that EVs exert their…”
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The Critical Role of Hematopoietic Cells in Lipopolysaccharide-induced Airway Inflammation by Hollingsworth, John W, Chen, Benny J, Brass, David M, Berman, Katie, Gunn, M. Dee, Cook, Donald N, Schwartz, David A

“…Rapid and selective recruitment of neutrophils into the airspace in response to LPS facilitates the clearance of bacterial pathogens. However, neutrophil…”
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Long-term in vivo imaging of multiple organs at the single cell level by Chen, Benny J, Jiao, Yiqun, Zhang, Ping, Sun, Albert Y, Pitt, Geoffrey S, Deoliveira, Divino, Drago, Nicholas, Ye, Tong, Liu, Chen, Chao, Nelson J

“…Two-photon microscopy has enabled the study of individual cell behavior in live animals. Many organs and tissues cannot be studied, especially longitudinally,…”
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Prophylaxis and Treatment of Acute Graft-Versus-Host Disease by Chao, Nelson J., Chen, Benny J.

“…Acute graft-versus-host disease (GVHD) remains a major obstacle to successful allogeneic hematopoietic stem cell transplantation (HSCT). The ability to prevent…”
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Prebiotic galactooligosaccharides interact with mouse gut microbiota to attenuate acute graft-versus-host disease by Holmes, Zachary C., Tang, Helen, Liu, Congxiao, Bush, Amy, Neubert, Benjamin C., Jiao, Yiqun, Covington, Megan, Cardona, Diana M., Kirtley, Michelle C., Chen, Benny J., Chao, Nelson J., David, Lawrence A., Sung, Anthony D.

“…Previous studies suggest that gut microbiome disruption induced by chemotherapy, dietary deficiencies, and/or antibiotics are associated with increased…”
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