Search Results - "Chen, Barbara B"

Structure−Activity Relationship Studies on 1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine (SC-22716), a Potent Inhibitor of Leukotriene A4 (LTA4) Hydrolase by Penning, Thomas D, Chandrakumar, Nizal S, Chen, Barbara B, Chen, Helen Y, Desai, Bipin N, Djuric, Stevan W, Docter, Stephen H, Gasiecki, Alan F, Haack, Richard A, Miyashiro, Julie M, Russell, Mark A, Yu, Stella S, Corley, David G, Durley, Richard C, Kilpatrick, Brian F, Parnas, Barry L, Askonas, Leslie J, Gierse, James K, Harding, Elizabeth I, Highkin, Maureen K, Kachur, James F, Kim, Suzanne H, Krivi, Gwen G, Villani-Price, Doreen, Pyla, E. Yvonne, Smith, Walter G, Ghoreishi-Haack, Nayereh S

“…Leukotriene B4 (LTB4) is a pro-inflammatory mediator that has been implicated in the pathogenesis of a number of diseases including inflammatory bowel disease…”
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Synthesis of pyrazoles and isoxazoles as potent αvβ3 receptor antagonists by PENNING, Thomas D, KHILEVICH, Albert, HANNEKE, Melanie L, KEENE, Jeffery L, KLOVER, Jon A, NICKOLS, G. Allen, NICKOLS, Maureen A, RADER, Randall K, SETTLE, Steven L, SHANNON, Kristen E, STEININGER, Christina N, WESTLIN, Marisa M, CHEN, Barbara B, WESTLIN, William F, RUSSELL, Mark A, BOYS, Mark L, YAPING WANG, DUFFIN, Tiffany, ENGLEMAN, V. Wayne, FINN, Mary Beth, FREEMAN, Sandra K

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Convergent, parallel synthesis of a series of β-substituted 1,2,4-oxadiazole butanoic acids as potent and selective αvβ3 receptor antagonists by BOYS, Mark L, SCHRETZMAN, Lori A, STENMARK, Heather G, HONGWEI WU, SPANGLER, Dale P, CLARE, Michael, DESAI, Bipin N, KHANNA, Ish K, NGUYEN, Maria N, DUFFIN, Tiffany, WAYNE ENGLEMAN, V, FINN, Mary Beth, CHANDRAKUMAR, Nizal S, FREEMAN, Sandra K, HANNEKE, Melanie L, KEENE, Jeffery L, KLOVER, Jon A, NICKOLS, G. Allen, NICKOLS, Maureen A, STEININGER, Christina N, WESTLIN, Marisa, WESTLIN, William, YU, Yi X, TOLLEFSON, Michael B, YAPING WANG, DALTON, Christopher R, NORRING, Sarah A, MOHLER, Scott B, DOWNS, Victoria L, PENNING, Thomas D, RUSSELL, Mark A, WENDT, John A, CHEN, Barbara B

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Discovery of + (2 -{4 -[2 -(5,6,7,8 -tetrahydro -1,8 -naphthyridin -2-yl )ethoxy ]phenyl} -cyclopropyl )acetic acid as potent and selective αvβ3 inhibitor : Design, synthesis, and optimization by NAGARAJAN, Srinivasan R, LU, Hwang-Fun, KEENE, Jeffery L, DUFFIN, Tiffany, ENGLEMAN, V. Wayne, FINN, Mary B, FREEMAN, Sandra K, KLOVER, Jon A, NICKOLS, G. Alan, NICKOLS, Maureen A, SHANNON, Kristen E, STEININGER, Christina A, GASIECKI, Alan F, WESTLIN, William F, WESTLIN, Marisa M, WILLIAMS, Melanie L, KHANNA, Ish K, PARIKH, Mihir D, DESAI, Bipinchandra N, ROGERS, Thomas E, CLARE, Michael, CHEN, Barbara B, RUSSELL, Mark A

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Synthesis of 2,5-thiazole butanoic acids as potent and selective αvβ3 integrin receptor antagonists with improved oral pharmacokinetic properties by WENDT, John A, HONGWEI WU, KEENE, Jeffery L, WAYNE ENGLEMAN, V, FREEMAN, Sandra K, HANNEKE, Melanie L, SHANNON, Kristen E, NICKOLS, Maureen A, STEININGER, Christina N, WESTLIN, Marissa, KLOVER, Jon A, WESTLIN, William, STENMARK, Heather G, NICKOLS, G. Allen, RUSSELL, Mark A, BOYS, Mark L, DOWNS, Victoria L, PENNING, Thomas D, CHEN, Barbara B, YAPING WANG, DUFFIN, Tiffany, FINN, Mary Beth

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Synthesis of cinnamic acids and related isosteres as potent and selective αvβ3 receptor antagonists by Penning, Thomas D., Russell, Mark A., Chen, Barbara B., Chen, Helen Y., Desai, Bipin N., Docter, Stephen H., Edwards, David J., Gesicki, Glen J., Liang, Chi-Dean, Malecha, James W., Yu, Stella S., Engleman, V.Wayne, Freeman, Sandra K., Hanneke, Melanie L., Shannon, Kristen E., Westlin, Marisa M., Nickols, G.Allen

“…We describe a series of conformationally-restricted cinnamic acid peptidomimetics as well as several cinnamic acid isosteres, including 3-phenylpropionic…”
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Synthesis of Potent Leukotriene A4 Hydrolase Inhibitors. Identification of 3-[Methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic Acid by Penning, Thomas D, Russell, Mark A, Chen, Barbara B, Chen, Helen Y, Liang, Chi-Dean, Mahoney, Matthew W, Malecha, James W, Miyashiro, Julie M, Yu, Stella S, Askonas, Leslie J, Gierse, James K, Harding, Elizabeth I, Highkin, Maureen K, Kachur, James F, Kim, Suzanne H, Villani-Price, Doreen, Pyla, E. Yvonne, Ghoreishi-Haack, Nayereh S, Smith, Walter G

“…Leukotriene B4 (LTB4) is a potent, proinflammatory mediator involved in the pathogenesis of a number of diseases including inflammatory bowel disease,…”
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Discovery of +(2-{4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl}-cyclopropyl)acetic acid as potent and selective alphavbeta3 inhibitor: design, synthesis, and optimization by Nagarajan, Srinivasan R, Lu, Hwang-Fun, Gasiecki, Alan F, Khanna, Ish K, Parikh, Mihir D, Desai, Bipinchandra N, Rogers, Thomas E, Clare, Michael, Chen, Barbara B, Russell, Mark A, Keene, Jeffery L, Duffin, Tiffany, Engleman, V Wayne, Finn, Mary B, Freeman, Sandra K, Klover, Jon A, Nickols, G Alan, Nickols, Maureen A, Shannon, Kristen E, Steininger, Christina A, Westlin, William F, Westlin, Marisa M, Williams, Melanie L

“…The integrin alpha(v)beta(3) is expressed in a number of cell types and is thought to play a major role in several pathological conditions. Various small…”
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Discovery of +(2-{4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl}-cyclopropyl)acetic acid as potent and selective α vβ 3 inhibitor: Design, synthesis, and optimization by Nagarajan, Srinivasan R., Lu, Hwang-Fun, Gasiecki, Alan F., Khanna, Ish K., Parikh, Mihir D., Desai, Bipinchandra N., Rogers, Thomas E., Clare, Michael, Chen, Barbara B., Russell, Mark A., Keene, Jeffery L., Duffin, Tiffany, Engleman, V. Wayne, Finn, Mary B., Freeman, Sandra K., Klover, Jon A., Nickols, G. Alan, Nickols, Maureen A., Shannon, Kristen E., Steininger, Christina A., Westlin, William F., Westlin, Marisa M., Williams, Melanie L.

“…The tripeptide RGD a common binding motif in several ligands that bind to α vβ 3, has been depeptidized and optimized in our efforts toward discovering a small…”
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Synthesis of potent leukotriene A(4) hydrolase inhibitors. Identification of 3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid by Penning, Thomas D, Russell, Mark A, Chen, Barbara B, Chen, Helen Y, Liang, Chi-Dean, Mahoney, Matthew W, Malecha, James W, Miyashiro, Julie M, Yu, Stella S, Askonas, Leslie J, Gierse, James K, Harding, Elizabeth I, Highkin, Maureen K, Kachur, James F, Kim, Suzanne H, Villani-Price, Doreen, Pyla, E Yvonne, Ghoreishi-Haack, Nayereh S, Smith, Walter G

“…Leukotriene B(4) (LTB(4)) is a potent, proinflammatory mediator involved in the pathogenesis of a number of diseases including inflammatory bowel disease,…”
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Synthesis of pyrazoles and isoxazoles as potent alpha(v)beta3 receptor antagonists by Penning, Thomas D, Khilevich, Albert, Chen, Barbara B, Russell, Mark A, Boys, Mark L, Wang, Yaping, Duffin, Tiffany, Engleman, V Wayne, Finn, Mary Beth, Freeman, Sandra K, Hanneke, Melanie L, Keene, Jeffery L, Klover, Jon A, Nickols, G Allen, Nickols, Maureen A, Rader, Randall K, Settle, Steven L, Shannon, Kristen E, Steininger, Christina N, Westlin, Marisa M, Westlin, William F

“…We describe a series of pyrazole and isoxazole analogs as antagonists of the alpha(v)beta3 receptor. Compounds showed low to sub-nanomolar potency against…”
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Synthesis of pyrazoles and isoxazoles as potent alpha sub(v) beta sub(3) receptor antagonists by Penning, Thomas D, Khilevich, Albert, Chen, Barbara B, Russell, Mark A, Boys, Mark L, Wang, Yaping, Duffin, Tiffany, Engleman, VWayne, Finn, Mary Beth, Freeman, Sandra K, Hanneke, Melanie L, Keene, Jeffery L, Klover, Jon A, Nickols, GAllen, Nickols, Maureen A, Rader, Randall K, Settle, Steven L, Shannon, Kristen E, Steininger, Christina N, Westlin, Marisa M, Westlin, William F

“…We describe a series of pyrazole and isoxazole analogs as antagonists of the alpha sub(v) beta sub(3) receptor. Compounds showed low to sub-nanomolar potency…”
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Synthesis of 2,5-thiazole butanoic acids as potent and selective alpha(v)beta3 integrin receptor antagonists with improved oral pharmacokinetic properties by Wendt, John A, Wu, Hongwei, Stenmark, Heather G, Boys, Mark L, Downs, Victoria L, Penning, Thomas D, Chen, Barbara B, Wang, Yaping, Duffin, Tiffany, Finn, Mary Beth, Keene, Jeffery L, Engleman, V Wayne, Freeman, Sandra K, Hanneke, Melanie L, Shannon, Kristen E, Nickols, Maureen A, Steininger, Christina N, Westlin, Marissa, Klover, Jon A, Westlin, William, Nickols, G Allen, Russell, Mark A

“…We describe a series of 2,5 thiazole containing compounds, which are potent antagonists of the integrin alpha(v)beta3 and show selectivity relative to the…”
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Synthesis of 2,5-thiazole butanoic acids as potent and selective alpha sub(v) beta sub(3) integrin receptor antagonists with improved oral pharmacokinetic properties by Wendt, John A, Wu, Hongwei, Stenmark, Heather G, Boys, Mark L, Downs, Victoria L, Penning, Thomas D, Chen, Barbara B, Wang, Yaping, Duffin, Tiffany, Finn, Mary Beth, Keene, Jeffery L, Engleman, VWayne, Freeman, Sandra K, Hanneke, Melanie L, Shannon, Kristen E, Nickols, Maureen A, Steininger, Christina N, Westlin, Marissa, Klover, Jon A, Westlin, William, Nickols, GAllen, Russell, Mark A

“…We describe a series of 2,5 thiazole containing compounds, which are potent antagonists of the integrin alpha sub(v) beta sub(3) and show selectivity relative…”
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Synthesis of 2,5-thiazole butanoic acids as potent and selective α vβ 3 integrin receptor antagonists with improved oral pharmacokinetic properties by Wendt, John A., Wu, Hongwei, Stenmark, Heather G., Boys, Mark L., Downs, Victoria L., Penning, Thomas D., Chen, Barbara B., Wang, Yaping, Duffin, Tiffany, Finn, Mary Beth, Keene, Jeffery L., Engleman, V. Wayne, Freeman, Sandra K., Hanneke, Melanie L., Shannon, Kristen E., Nickols, Maureen A., Steininger, Christina N., Westlin, Marissa, Klover, Jon A., Westlin, William, Nickols, G. Allen, Russell, Mark A.

“…A series of 2,5 thiazole containing compounds are described, which are potent antagonists of the integrin α vβ 3 and show selectivity relative to the other…”
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Synthesis of pyrazoles and isoxazoles as potent α vβ 3 receptor antagonists by Penning, Thomas D., Khilevich, Albert, Chen, Barbara B., Russell, Mark A., Boys, Mark L., Wang, Yaping, Duffin, Tiffany, Engleman, V. Wayne, Finn, Mary Beth, Freeman, Sandra K., Hanneke, Melanie L., Keene, Jeffery L., Klover, Jon A., Nickols, G. Allen, Nickols, Maureen A., Rader, Randall K., Settle, Steven L., Shannon, Kristen E., Steininger, Christina N., Westlin, Marisa M., Westlin, William F.

“…The synthesis and biological evaluation of a series of pyrazole and isoxazole α vβ 3 antagonists is described. We describe a series of pyrazole and isoxazole…”
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Synthesis of cinnamic acids and related isosteres as potent and selective alpha v beta 3 receptor antagonists by Penning, Thomas D, Russell, Mark A, Chen, Barbara B, Chen, Helen Y, Desai, Bipin N, Docter, Stephen H, Edwards, David J, Gesicki, Glen J, Liang, Chi-Dean, Malecha, James W, Yu, Stella S, Engleman, V Wayne, Freeman, Sandra K, Hanneke, Melanie L, Shannon, Kristen E, Westlin, Marisa M, Nickols, G Allen

“…We describe a series of conformationally-restricted cinnamic acid peptidomimetics as well as several cinnamic acid isosteres, including 3-phenylpropionic…”
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Convergent, parallel synthesis of a series of beta-substituted 1,2,4-oxadiazole butanoic acids as potent and selective alpha(v)beta3 receptor antagonists by Boys, Mark L, Schretzman, Lori A, Chandrakumar, Nizal S, Tollefson, Michael B, Mohler, Scott B, Downs, Victoria L, Penning, Thomas D, Russell, Mark A, Wendt, John A, Chen, Barbara B, Stenmark, Heather G, Wu, Hongwei, Spangler, Dale P, Clare, Michael, Desai, Bipin N, Khanna, Ish K, Nguyen, Maria N, Duffin, Tiffany, Engleman, V Wayne, Finn, Mary Beth, Freeman, Sandra K, Hanneke, Melanie L, Keene, Jeffery L, Klover, Jon A, Nickols, G Allen, Nickols, Maureen A, Steininger, Christina N, Westlin, Marisa, Westlin, William, Yu, Yi X, Wang, Yaping, Dalton, Christopher R, Norring, Sarah A

“…We describe a series of 1,2,4-oxadiazoles, which are potent antagonists of the integrin alpha(v)beta3 and, in addition, show selectivity relative to the other…”
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Convergent, parallel synthesis of a series of beta -substituted 1,2,4- oxadiazole butanoic acids as potent and selective alpha sub(v) beta sub(3) receptor antagonists by Boys, Mark L, Schretzman, Lori A, Chandrakumar, Nizal S, Tollefson, Michael B, Mohler, Scott B, Downs, Victoria L, Penning, Thomas D, Russell, Mark A, Wendt, John A, Chen, Barbara B, Stenmark, Heather G, Wu, Hongwei, Spangler, Dale P, Clare, Michael, Desai, Bipin N, Khanna, Ish K, Nguyen, Maria N, Duffin, Tiffany, Engleman, VWayne, Finn, Mary Beth, Freeman, Sandra K, Hanneke, Melanie L, Keene, Jeffery L, Klover, Jon A, Nickols, GAllen, Nickols, Maureen A, Steininger, Christina N, Westlin, Marisa, Westlin, William, Yu, Yi X, Wang, Yaping, Dalton, Christopher R, Norring, Sarah A

“…We describe a series of 1,2,4-oxadiazoles, which are potent antagonists of the integrin alpha sub(v) beta sub(3) and, in addition, show selectivity relative to…”
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Convergent, parallel synthesis of a series of β-substituted 1,2,4-oxadiazole butanoic acids as potent and selective α vβ 3 receptor antagonists by Boys, Mark L., Schretzman, Lori A., Chandrakumar, Nizal S., Tollefson, Michael B., Mohler, Scott B., Downs, Victoria L., Penning, Thomas D., Russell, Mark A., Wendt, John A., Chen, Barbara B., Stenmark, Heather G., Wu, Hongwei, Spangler, Dale P., Clare, Michael, Desai, Bipin N., Khanna, Ish K., Nguyen, Maria N., Duffin, Tiffany, Engleman, V. Wayne, Finn, Mary Beth, Freeman, Sandra K., Hanneke, Melanie L., Keene, Jeffery L., Klover, Jon A., Nickols, G. Allen, Nickols, Maureen A., Steininger, Christina N., Westlin, Marisa, Westlin, William, Yu, Yi X., Wang, Yaping, Dalton, Christopher R., Norring, Sarah A.

“…Synthesis of a series of potent and selective α vβ 3 antagonists containing a 1,2,4-oxadiazole core is reported. We describe a series of 1,2,4-oxadiazoles,…”
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