Search Results - "Chen, Anlu"

Multiplex base editing to convert TAG into TAA codons in the human genome by Chen, Yuting, Hysolli, Eriona, Chen, Anlu, Casper, Stephen, Liu, Songlei, Yang, Kevin, Liu, Chenli, Church, George

“…Whole-genome recoding has been shown to enable nonstandard amino acids, biocontainment and viral resistance in bacteria. Here we take the first steps to extend…”
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Widespread epistasis regulates glucose homeostasis and gene expression by Chen, Anlu, Liu, Yang, Williams, Scott M, Morris, Nathan, Buchner, David A

“…The relative contributions of additive versus non-additive interactions in the regulation of complex traits remains controversial. This may be in part because…”
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A Novel Mapping Strategy Utilizing Mouse Chromosome Substitution Strains Identifies Multiple Epistatic Interactions That Regulate Complex Traits by Miller, Anna K, Chen, Anlu, Bartlett, Jacquelaine, Wang, Li, Williams, Scott M, Buchner, David A

“…The genetic contribution of additive non-additive (epistatic) effects in the regulation of complex traits is unclear. While genome-wide association studies…”
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Abstract P455: Epistatic Regulation of Hematological-related Traits and Gene Expression in Mice Reveals Additional Heritability Missed by Standard GWAS-type Analyses by Miller, Anna, Chen, Anlu, Buchner, David, Williams, Scott

“…Abstract only The genetic contribution of additive versus non-additive (epistasis) effects in the regulation of hematologic and other complex traits is…”
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Multiplex base editing to convert $\mathrm{TAG}$ into $\mathrm{TAA}$ codons in the human genome by Chen, Yuting, Hysolli, Eriona, Chen, Anlu, Casper, Stephen, Liu, Songlei, Yang, Kevin, Liu, Chenli, Church, George

“…Whole-genome recoding has been shown to enable nonstandard amino acids, biocontainment and viral resistance in bacteria. Here we take the first steps to extend…”
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Germline USP8 Mutation Associated With Pediatric Cushing Disease and Other Clinical Features: A New Syndrome by Cohen, Michal, Persky, Rebecca, Stegemann, Rachel, Hernández-Ramírez, Laura C, Zeltser, Deena, Lodish, Maya B, Chen, Anlu, Keil, Margaret F, Tatsi, Christina, Faucz, Fabio R, Buchner, David A, Stratakis, Constantine A, Tiosano, Dov

“…Abstract Background Somatic mutations in the ubiquitin-specific peptidase 8 (USP8) gene are common in corticotropinomas of children with Cushing disease (CD)…”
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PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation by Gulluni, Federico, Prever, Lorenzo, Li, Huayi, Krafcikova, Petra, Corrado, Ilaria, Lo, Wen-Ting, Margaria, Jean Piero, Chen, Anlu, De Santis, Maria Chiara, Cnudde, Sophie J, Fogerty, Joseph, Yuan, Alex, Massarotti, Alberto, Sarijalo, Nasrin Torabi, Vadas, Oscar, Williams, Roger L, Thelen, Marcus, Powell, David R, Schueler, Markus, Wiesener, Michael S, Balla, Tamas, Baris, Hagit N, Tiosano, Dov, McDermott, Jr, Brian M, Perkins, Brian D, Ghigo, Alessandra, Martini, Miriam, Haucke, Volker, Boura, Evzen, Merlo, Giorgio Roberto, Buchner, David A, Hirsch, Emilio

“…Cytokinetic membrane abscission is a spatially and temporally regulated process that requires ESCRT (endosomal sorting complexes required for…”
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Mutations in the mitochondrial ribosomal protein MRPS22 lead to primary ovarian insufficiency by Chen, Anlu, Tiosano, Dov, Guran, Tulay, Baris, Hagit N, Bayram, Yavuz, Mory, Adi, Shapiro-Kulnane, Laura, Hodges, Craig A, Akdemir, Zeynep C, Turan, Serap, Jhangiani, Shalini N, van den Akker, Focco, Hoppel, Charles L, Salz, Helen K, Lupski, James R, Buchner, David A

“…Abstract Primary ovarian insufficiency (POI) is characterized by amenorrhea and loss or dysfunction of ovarian follicles prior to the age of 40. POI has been…”
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Mutations in PIK3C2A cause syndromic short stature, skeletal abnormalities, and cataracts associated with ciliary dysfunction by Tiosano, Dov, Baris, Hagit N, Chen, Anlu, Hitzert, Marrit M, Schueler, Markus, Gulluni, Federico, Wiesener, Antje, Bergua, Antonio, Mory, Adi, Copeland, Brett, Gleeson, Joseph G, Rump, Patrick, van Meer, Hester, Sival, Deborah A, Haucke, Volker, Kriwinsky, Josh, Knaup, Karl X, Reis, André, Hauer, Nadine N, Hirsch, Emilio, Roepman, Ronald, Pfundt, Rolph, Thiel, Christian T, Wiesener, Michael S, Aslanyan, Mariam G, Buchner, David A

“…PIK3C2A is a class II member of the phosphoinositide 3-kinase (PI3K) family that catalyzes the phosphorylation of phosphatidylinositol (PI) into PI(3)P and the…”
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Applying Forward Genetic Approaches to Rare Mendelian Disorders and Complex Traits by Chen, Anlu

“…Forward genetics utilizes unbiased genetic approaches to locate causal genetic variants of heritable traits. Classic forward genetics approaches were…”
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