Search Results - "Chen, Amy N. Y."

Identification of monellin as the first naturally derived proteinaceous allosteric agonist of metabotropic glutamate receptor 5 by Chen, Amy N. Y., Hellyer, Shane D., Trinh, Phuc N. H., Leach, Katie, Gregory, Karen J.

“…Allosteric modulators bind sites distinct from orthosteric ligands, allowing for improved spatiotemporal control of receptors and greater subtype selectivity…”
Get full text

Development of Clickable Photoaffinity Ligands for Metabotropic Glutamate Receptor 2 Based on Two Positive Allosteric Modulator Chemotypes by Hellyer, Shane D, Aggarwal, Shaili, Chen, Amy N Y, Leach, Katie, Lapinsky, David J, Gregory, Karen J

“…The metabotropic glutamate receptor 2 (mGlu ) is a transmembrane-spanning class C G protein-coupled receptor that is an attractive therapeutic target for…”
Get full text

Detection and quantification of allosteric modulation of endogenous m4 muscarinic acetylcholine receptor using impedance-based label-free technology in a neuronal cell line by Chen, Amy N Y, Malone, Daniel T, Pabreja, Kavita, Sexton, Patrick M, Christopoulos, Arthur, Canals, Meritxell

“…Allosteric modulators of G protein-coupled receptors have the potential to achieve greater receptor subtype selectivity compared with ligands targeting the…”
Get more information