Search Results - "Chen, Alan"

High-resolution reversible folding of hyperstable RNA tetraloops using molecular dynamics simulations by Chen, Alan A., García, Angel E.

“…We report the de novo folding of three hyperstable RNA tetraloops to 1–3 Å rmsd from their experimentally determined structures using molecular dynamics…”
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Bootstrapping the String Kawai-Lewellen-Tye Kernel by Chen, Alan Shih-Kuan, Elvang, Henriette, Herderschee, Aidan

“…We show that double-copy maps for amplitudes in effective field theory are severely constrained at four points by self-consistency and locality at six points…”
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Toehold clipping: A mechanism for remote control of DNA strand displacement by Faheem, Hiba, Mathivanan, Johnsi, Talbot, Hannah, Zeghal, Hana, Vangaveti, Sweta, Sheng, Jia, Chen, Alan A, Chandrasekaran, Arun Richard

“…Abstract The ability to create stimuli-responsive DNA nanostructures has played a prominent role in dynamic DNA nanotechnology. Primary among these is the…”
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Influenza Virus: A Master Tactician in Innate Immune Evasion and Novel Therapeutic Interventions by Hsu, Alan Chen-Yu

“…Influenza is a contagion that has plagued mankind for many decades, and continues to pose concerns every year, with millions of infections globally. The…”
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Noncanonical role of transferrin receptor 1 is essential for intestinal homeostasis by Chen, Alan C., Donovan, Adriana, Ned-Sykes, Renee, Andrews, Nancy C.

“…Transferrin receptor 1 (Tfr1) facilitates cellular iron uptake through receptor-mediated endocytosis of iron-loaded transferrin. It is expressed in the…”
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Are Gastrointestinal Symptoms Specific for Coronavirus 2019 Infection? A Prospective Case-Control Study From the United States by Chen, Alan, Agarwal, Amol, Ravindran, Nishal, To, Chau, Zhang, Talan, Thuluvath, Paul J.

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Exosomes from human umbilical cord mesenchymal stem cells attenuate the inflammation of severe steroid-resistant asthma by reshaping macrophage polarization by Dong, Bing, Wang, Chao, Zhang, Jing, Zhang, Jinrong, Gu, Yinuo, Guo, Xiaoping, Zuo, Xu, Pan, He, Hsu, Alan Chen-Yu, Wang, Guoqiang, Wang, Fang

“…Severe, steroid-resistant asthma (SSRA) is a serious clinical problem in asthma management. Affected patients have severe clinical symptoms, worsened quality…”
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IL‐17A is a common and critical driver of impaired lung function and immunopathology induced by influenza virus, rhinovirus and respiratory syncytial virus by Liu, Xiaoming, Nguyen, Thi Hiep, Sokulsky, Leon, Li, Xiang, Garcia Netto, Keilah, Hsu, Alan Chen‐Yu, Liu, Chi, Laurie, Karen, Barr, Ian, Tay, Hock, Eyers, Fiona, Foster, Paul S., Yang, Ming

“…Background and objective Influenza virus (FLU), rhinovirus (RV) and respiratory syncytial virus (RSV) are the most common acute respiratory infections…”
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Computationally reconstructing cotranscriptional RNA folding from experimental data reveals rearrangement of non-native folding intermediates by Yu, Angela M, Gasper, Paul M., Cheng, Luyi, Lai, Lien B., Kaur, Simi, Gopalan, Venkat, Chen, Alan A., Lucks, Julius B.

“…The series of RNA folding events that occur during transcription can critically influence cellular RNA function. Here, we present reconstructing RNA dynamics…”
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Base-pair conformational switch modulates miR-34a targeting of Sirt1 mRNA by Baronti, Lorenzo, Guzzetti, Ileana, Ebrahimi, Parisa, Friebe Sandoz, Sarah, Steiner, Emilie, Schlagnitweit, Judith, Fromm, Bastian, Silva, Luis, Fontana, Carolina, Chen, Alan A., Petzold, Katja

“…MicroRNAs (miRNAs) regulate the levels of translation of messenger RNAs (mRNAs). At present, the major parameter that can explain the selection of the target…”
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Design, synthesis and biological evaluation of novel pyxinol derivatives with anti-heart failure activity by Liu, Junli, Liu, Yunhe, Yu, Hui, Zhang, Ying, Hsu, Alan Chen-Yu, Zhang, Mingming, Gou, Yawei, Sun, Wei, Wang, Fang, Li, Pingya, Liu, Jinping

“…[Display omitted] •A total of 32 novel fatty acid ester derivatives of pyxinol were synthesized.•Compounds 2e and 3b displayed excellent ACE inhibitory…”
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Effects of Real-time Prescription Benefit Recommendations on Patient Out-of-Pocket Costs: A Cluster Randomized Clinical Trial by Desai, Sunita M, Chen, Alan Z, Wang, Jiejie, Chung, Wei-Yi, Stadelman, Jay, Mahoney, Chris, Szerencsy, Adam, Anzisi, Lisa, Mehrotra, Ateev, Horwitz, Leora I

“…Rising drug costs contribute to medication nonadherence and adverse health outcomes. Real-time prescription benefit (RTPB) systems present prescribers with…”
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Targeting PI3K-p110α Suppresses Influenza Virus Infection in Chronic Obstructive Pulmonary Disease by Hsu, Alan Chen-Yu, Starkey, Malcolm R, Hanish, Irwan, Parsons, Kristy, Haw, Tatt Jhong, Howland, Linda J, Barr, Ian, Mahony, James B, Foster, Paul S, Knight, Darryl A, Wark, Peter A, Hansbro, Philip M

“…Chronic obstructive pulmonary disease (COPD) and influenza virus infections are major global health issues. Patients with COPD are more susceptible to…”
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Endoplasmic reticulum-unfolded protein response signalling is altered in severe eosinophilic and neutrophilic asthma by Pathinayake, Prabuddha S, Waters, David W, Nichol, Kristy S, Brown, Alexandra C, Reid, Andrew T, Hsu, Alan Chen-Yu, Horvat, Jay C, Wood, Lisa G, Baines, Katherine J, Simpson, Jodie L, Gibson, Peter G, Hansbro, Philip M, Wark, Peter A B

“…The significance of endoplasmic reticulum (ER) stress in asthma is unclear. Here, we demonstrate that ER stress and the unfolded protein response (UPR) are…”
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Characterizing the Folding Transition-State Ensembles in the Energy Landscape of an RNA Tetraloop by Viegas, Rafael G., Sanches, Murilo N., Chen, Alan A., Paulovich, Fernando V., Garcia, Angel E., Leite, Vitor B. P.

“…Molecular dynamics (MD) simulations have become increasingly powerful and can now describe the folding/unfolding of small biomolecules in atomic detail…”
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Cotranscriptional RNA strand exchange underlies the gene regulation mechanism in a purine-sensing transcriptional riboswitch by Cheng, Luyi, White, Elise N, Brandt, Naomi L, Yu, Angela M, Chen, Alan A, Lucks, Julius B

“…RNA folds cotranscriptionally to traverse out-of-equilibrium intermediate structures that are important for RNA function in the context of gene regulation. To…”
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THE INTRACTABILITY OF QUALIFIED IMMUNITY by Chen, Alan K

“…The federal common law doctrine of qualified immunity, a key feature of American civil rights law, protects public officials from damages lawsuits unless their…”
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Activated non-neuronal cholinergic system correlates with non-type 2 inflammation and exacerbations in severe asthma by Huang, Dan, Zhang, Li, Liu, Ying, Wang, Ji, Zhang, Jie, Baines, Katherine J., Liu, Gang, Hsu, Alan Chen-Yu, Wang, Fang, Chen, Zhihong, Oliver, Brian G., Xie, Min, Qin, Ling, Liu, Dan, Wan, Huajing, Luo, Fengming, Li, Weimin, Wang, Gang, Gibson, Peter G.

“…Non-neuronal cholinergic system (NNCS) contributes to various inflammatory airway diseases. However, the role of NNCS in severe asthma (SA) remains largely…”
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FREE SPEECH AND DEMOCRACY IN THE VIDEO AGE by Marceau, Justin, Chen, Alan K.

“…This Article examines constitutional theory and doctrine as applied to emerging government regulation of video image capture across a spectrum of regulatory…”
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Chitinase-like protein YKL-40 correlates with inflammatory phenotypes, anti-asthma responsiveness and future exacerbations by Liu, Lei, Zhang, Xin, Liu, Ying, Zhang, Li, Zheng, Jing, Wang, Ji, Hansbro, Philip M, Wang, Lei, Wang, Gang, Hsu, Alan Chen-Yu

“…Asthma is a heterogeneous chronic airway disease, which may be classified into different phenotypes. YKL-40 is a chitin-binding glycoprotein with unclear…”
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