Search Results - "Chen, Aishe"

A maternal high‐fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates by Suter, Melissa A., Chen, Aishe, Burdine, Marie S., Choudhury, Mahua, Harris, R. Alan, Lane, Robert H., Friedman, Jacob E., Grove, Kevin L., Tackett, Alan J., Aagaard, Kjersti M.

“…In nonhuman primates, we previously demonstrated that a maternal high‐fat diet (MHFD) induces fetal nonalcoholic fatty liver disease (NAFLD) and alters the…”
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Activation of GPR4 by acidosis increases endothelial cell adhesion through the cAMP/Epac pathway by Chen, Aishe, Dong, Lixue, Leffler, Nancy R, Asch, Adam S, Witte, Owen N, Yang, Li V

“…Endothelium-leukocyte interaction is critical for inflammatory responses. Whereas the tissue microenvironments are often acidic at inflammatory sites, the…”
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Identification by Site-directed Mutagenesis of Residues Involved in Ligand Recognition and Activation of the Human A3 Adenosine Receptor by Gao, Zhan-Guo, Chen, Aishe, Barak, Dov, Kim, Soo-Kyung, Müller, Christa E., Jacobson, Kenneth A.

“…Ligand recognition has been extensively explored in G protein-coupled A1, A2A, and A2B adenosine receptors but not in the A3receptor, which is…”
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Acyclic Analogues of Adenosine Bisphosphates as P2Y Receptor Antagonists:  Phosphate Substitution Leads to Multiple Pathways of Inhibition of Platelet Aggregation by Xu, Bin, Stephens, Andrew, Kirschenheuter, Gary, Greslin, Arthur F, Cheng, Xiaoquin, Sennelo, Joe, Cattaneo, Marco, Zighetti, Maddalena L, Chen, Aishe, Kim, Soon-Ai, Kim, Hak Sung, Bischofberger, Norbert, Cook, Gary, Jacobson, Kenneth A

“…Activation by ADP of both P2Y1 and P2Y12 receptors in platelets contributes to platelet aggregation, and antagonists at these receptor subtypes have…”
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Neoceptor Concept Based on Molecular Complementarity in GPCRs:  A Mutant Adenosine A3 Receptor with Selectively Enhanced Affinity for Amine-Modified Nucleosides by Jacobson, Kenneth A, Gao, Zhan-Guo, Chen, Aishe, Barak, Dov, Kim, Soon-Ai, Lee, Kyeong, Link, Andreas, Rompaey, Philippe Van, van Calenbergh, Serge, Liang, Bruce T

“…Adenosine A3 receptors are of interest in the treatment of cardiac ischemia, inflammation, and neurodegenerative diseases. In an effort to create a unique…”
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p53-Independent induction of Fas and apoptosis in leukemic cells by an adenosine derivative, Cl-IB-MECA by Kim, Seong Gon, Ravi, Gnana, Hoffmann, Carsten, Jung, Yun-Jin, Kim, Min, Chen, Aishe, Jacobson, Kenneth A.

“…A 3 adenosine receptor (A 3AR) agonists have been reported to influence cell death and survival. The effects of an A 3AR agonist,…”
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Constitutive Activation of A3 Adenosine Receptors by Site-Directed Mutagenesis by Chen, Aishe, Gao, Zhan-Guo, Barak, Dov, Liang, Bruce T., Jacobson, Kenneth A.

“…The objective of this study was to create constitutively active mutant human A3 adenosine receptors (ARs) using single amino acid replacements, based on…”
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Acupuncture induces adenosine in fibroblasts through energy metabolism and promotes proliferation by activating MAPK signaling pathway via adenosine3 receptor by Qu, Fei, Cui, Yanru, Zeng, Jie, Zhang, Mingyue, Qiu, Shaying, Huang, Xiaoting, Chen, Aishe

“…Acupuncture has many advantages in the treatment of certain diseases as opposed to drug therapy. Besides, adenosine has been revealed to affect cellular…”
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Acupuncture induces adenosine in fibroblasts through energy metabolism and promotes proliferation by activating MAPK signaling pathway via adenosine 3 receptor by Qu, Fei, Cui, Yanru, Zeng, Jie, Zhang, Mingyue, Qiu, Shaying, Huang, Xiaoting, Chen, Aishe

“…Acupuncture has many advantages in the treatment of certain diseases as opposed to drug therapy. Besides, adenosine has been revealed to affect cellular…”
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Engineering of A3 adenosine and P2Y nucleotide receptors and their ligands by Jacobson, Kenneth A., Kim, Hak Sung, Ravi, Gnana, Kim, Soo-Kyung, Lee, Kyeong, Chen, Aishe, Chen, Wangzhong, Kim, Seong Gon, Barak, Dov, Liang, Bruce T., Gao, Zhan-Guo

“…Modification of the ribose moiety of nucleotides and nucleosides has provided new insights into structural and conformational requirements for ligands at P2Y…”
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Modeling the Adenosine Receptors:  Comparison of the Binding Domains of A2A Agonists and Antagonists by Kim, Soo-Kyung, Gao, Zhan-Guo, Van Rompaey, Philippe, Gross, Ariel S, Chen, Aishe, Van Calenbergh, Serge, Jacobson, Kenneth A

“…A three-dimensional model of the human A2A adenosine receptor (AR) and its docked ligands was built by homology to rhodopsin and validated with site-directed…”
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Fetal Hepatic Sirt1, a Histone H3 Deacetylase, Is Decreased in a Nonhuman Primate Model of Maternal Obesity by Chen, Aishe, Suter, Melissa, Hu, Min, Shope, Cynthia, Tackett, Alan, Aagaard-Tillery, Kjersti

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216: A maternal high fat diet reprograms the histone code to modulate fetal thyroid gene expression and thyroid associated proteins in a primate model of obesity by Suter, Melissa, Chen, Aishe, Hu, Min, Showalter, Lori, Shope, Cynthia, Brown, Kathleen, Grove, Kevin, Lane, Robert, Aagaard, Kjersti

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Identification of essential residues involved in the allosteric modulation of the human A(3) adenosine receptor by Gao, Zhan-Guo, Kim, Soo-Kyung, Gross, Ariel S, Chen, Aishe, Blaustein, Joshua B, Jacobson, Kenneth A

“…We examined the effects on allosteric modulation and ligand binding of the mutation of amino acid residues of the human A(3) adenosine receptor (A(3)AR) that…”
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Modeling the Adenosine Receptors:  Comparison of the Binding Domains of A 2A Agonists and Antagonists by Kim, Soo-Kyung, Gao, Zhan-Guo, Van Rompaey, Philippe, Gross, Ariel S., Chen, Aishe, Van Calenbergh, Serge, Jacobson, Kenneth A.

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Neoceptor Concept Based on Molecular Complementarity in GPCRs:  A Mutant Adenosine A 3 Receptor with Selectively Enhanced Affinity for Amine-Modified Nucleosides by Jacobson, Kenneth A., Gao, Zhan-Guo, Chen, Aishe, Barak, Dov, Kim, Soon-Ai, Lee, Kyeong, Link, Andreas, Rompaey, Philippe Van, van Calenbergh, Serge, Liang, Bruce T.

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Engineering of A 3 adenosine and P2Y nucleotide receptors and their ligands by Jacobson, Kenneth A., Kim, Hak Sung, Ravi, Gnana, Kim, Soo‐Kyung, Lee, Kyeong, Chen, Aishe, Chen, Wangzhong, Kim, Seong Gon, Barak, Dov, Liang, Bruce T., Gao, Zhan‐Guo

“…Abstract Modification of the ribose moiety of nucleotides and nucleosides has provided new insights into structural and conformational requirements for ligands…”
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