Search Results - "Chemistry of heterocyclic compounds (New York, N.Y. 1965)"

Heterocycles in drugs and drug discovery by Gomtsyan, A.

“…Heterocycles are common fragments of the vast majority of marketed drugs. This is a reflection of the central role that heterocycles play in modern drug…”
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Prediction of the Biological Activity Spectra of Organic Compounds Using the Pass Online Web Resource by Filimonov, D. A., Lagunin, A. A., Gloriozova, T. A., Rudik, A. V., Druzhilovskii, D. S., Pogodin, P. V., Poroikov, V. V.

“…The freely accessible web resource PASS Online is presented. This resource is designed for the prediction of the biological activity spectra of organic…”
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Biologically active compounds and drugs in the tetrazole series by Myznikov, Leonid V., Vorona, Svetlana V., Zevatskii, Yuri E.

“…The review summarizes the advances in medicinal chemistry of tetrazole biologically active compounds and drugs over the past 15 years. Most of the considered…”
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3-Nitro-1,2,4-triazol-5-one (NTO): High Explosive Insensitive Energetic Material by Sirach, Ruksana R., Dave, Pragnesh N.

“…5-Nitro-3 H -1,2,4-triazol-3-one (NTO) also known as nitrotriazolone is a low sensitive and thermally stable high energetic material containing a heterocyclic…”
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Synthesis and anticancer activity of arylazothiazoles and 1,3,4-thiadiazoles using chitosan-grafted-poly(4-vinylpyridine) as a novel copolymer basic catalyst by Gomha, Sobhi M., Riyadh, Sayed M., Mahmmoud, Elmahdi A., Elaasser, Mahmoud M.

“…A novel series of 4-substituted 5-arylazo-2-[1-(pyrrol-3-yl)ethylidenehydrazinyl]thiazoles and…”
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New achievements in the synthesis of pyrrolo[1,2-a]quinoxalines by Kalinin, Alexey A., Islamova, Liliya N., Fazleeva, Guzyal M.

“…This review article describes methods for the preparation of pyrrolo[1,2- a ]quinoxalines, covering literature sources from the last 10 years. The attention…”
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An overview of the synthetic routes toward [1, 2, 4]triazolo[3,4-b][1,3,4]thiadiazoles (microreview) by Lelyukh, Maryan I., Komarenska, Zoryana M., Chaban, Taras I., Chaban, Ihor H.

“…Fused systems combining 1,2,4-triazole and 1,3,4-thiadiazole rings occupy a prominent place in modern bioorganic and medicinal chemistry due to the diverse…”
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Advances in the synthesis of (3R,3aS,6aR)-hexahydrofuro-[2,3-b]furan-3-ol, a key ligand of the HIV protease inhibitors by Dong, Mengqi, Teng, Dawei, Cao, Guorui

“…(3 R ,3a S ,6a R )-Hexahydrofuro[2,3- b ]furan-3-ol (bis-THF alcohol) is a key intermediate for the synthesis of HIV protease inhibitors with lower toxicity…”
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Synthesis of ursane-derived regioisomeric 2-amino-1,3,4-oxadiazoles and 3-thioxo-1,2,4-triazoles by Popov, Sergey A., Shults, Elvira E., Shpatov, Alexander V., Semenova, Marya D.

“…In the present work, novel ursane-derived 2-amino-1,3,4-oxadiazoles and 3-thioxo-1,2,4-triazoles were prepared. Coupling aliphatic or aromatic hydrazides with…”
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Fluorination of heterocyclic compounds accompanied by molecular rearrangements by Borodkin, Gennady I.

“…Fluorination of heterocyclic compounds accompanied by molecular rearrangements is an area of synthesis experiencing rapid advances. One of the characteristics…”
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Reactions of thiiranes with NH-heterocycles: III. The synthesis of N2/N4-mono- and N2/N4-dithietane-containing 5-bromo-2,4-dihydro-1,2,4-triazol-3-ones and their antidepressant activity by Klen, Elena E., Nikitina, Irina L., Khaliullin, Ferkat A., Rozit, Galina A., Nikitina, Ekaterina A., Gaisina, Gul’nara G., Samorodov, Aleksandr V., Pavlov, Valentin N.

“…2-Thietane-containing 5-bromo-2,4-dihydro-1,2,4-triazol-3-ones were synthesized from 3,5-dibromo-1-(thietan-3-yl)-1,2,4-triazole by the reaction with sodium…”
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The synthesis and study of antimicrobial activity of 5-oxo-1-(thiazol-2-yl)pyrrolidine-3-carboxylic acids by Serkov, Sergei A., Kostikova, Natalya N., Sigay, Natalya V., Tyurin, Anton P., Kolotyrkina, Natalya G., Gazieva, Galina A.

“…A series of novel 5-oxo-1-(thiazol-2-yl)pyrrolidine-3-carboxylic acids were synthesized via condensation of 2-aminothiazole derivatives and itaconic acid by…”
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Synthesis of imidazo[2,1-b]thiazol-5-amines using Groebke–Blackburn–Bienaymé multicomponent reaction (microreview) by Longo, Luiz S., Siqueira, Fernanda A.

“…This microreview discusses the recent studies (last 10 years) on the synthesis of imidazo[2,1- b ]thiazol-5-amines using the Groebke–Blackburn–Bienaymé…”
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A simple and efficient method for the synthesis of 2-spiroquinazolinones employing aluminum metal–organic frameworks as multifunctional carriers by Ivanov, Il’ya Yu, Sokolov, Andrey V.

“…In this study we demonstrated a successful synthesis of 2-spiro-2,3-dihydroquinazolin-4(1 H )-ones from 2-aminobenzamides and cyclic ketones using aluminum…”
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Cinnamaldehyde: a potential building block for the synthesis of polycyclic fused heterocycles by multicomponent reactions (microreview) by Mehar, Aatka, Parvin, Tasneem

“…Cinnamaldehyde, a versatile and naturally occurring organic compound, has garnered significant attention as a key building block in the synthesis of polycyclic…”
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Effective synthesis of 4,5-dibromobenzo[1,2-c:3,4-c']-bis([1,2,5]thiadiazole) by bromination of benzo[1,2-c:3,4-c']-bis([1,2,5]thiadiazole) by Chechulina, Alexandra S., Konstantinova, Lidia S., Obruchnikova, Natalia V., Knyazeva, Ekaterina A., Kan, Bin, Duan, Tainan, Chen, Yongsheng, Aysin, Rinat A., Rakitin, Oleg A.

“…The bromination of benzo[1,2- c :3,4- c ']bis([1,2,5]thiadiazole) was studied. An efficient method has been developed for the synthesis of…”
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The synthesis and antimicrobial activity of 6-aryl-2-spiro-substituted 5-trichloroacetyl-4H-1,3-dioxin-4-onesS by Lisovenko, Natalya Yu, Kharitonova, Svetlana S., Balandina, Svetlana Yu

“…Thermolysis of 5-aryl-4-trichloroacetylfuran-2,3-diones in the presence of cyclic ketones yielded 6-aryl-2-spiro-substituted 5-trichloroacetyl-4 H…”
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Synthesis of 1,2-oxazine N-oxides via noncatalyzed hetero-Diels–Alder reactions of nitroalkenes (microreview) by Jasiński, Radomir

“…In this microreview, the application of noncatalyzed hetero-Diels–Alder reaction (formally [4+2] cycloaddition) with participation of conjugated nitroalkenes…”
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Synthesis of 2-arylquinazolines by Chan–Evans–Lam coupling of 2-formylphenylboronic acids with amidines by Solomin, Vitalii V., Zaharova, Darija, Jirgensons, Aigars

“…A method for the synthesis of 2-arylquinazolines is described which involves Chan–Evans–Lam coupling of 2-formylphenylboronic acids with amidines. The reaction…”
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Synthesis and structure of new substituted furan-3-carboxylate hydrazones by Gomonov, Kirill A., Pelipko, Vasilii V., Litvinov, Igor A., Baichurin, Ruslan I., Makarenko, Sergey V.

“…The reaction of acetyl-containing furan-3-carboxylates with substituted hydrazines in an alcohol solution leads to the formation of substituted…”
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