Search Results - "Chemical research in toxicology"

Clustering a Chemical Inventory for Safety Assessment of Fragrance Ingredients: Identifying Read-Across Analogs to Address Data Gaps by Date, Mihir S, O’Brien, Devin, Botelho, Danielle J, Schultz, Terry W, Liebler, Daniel C, Penning, Trevor M, Salvito, Daniel T

“…A valuable approach to chemical safety assessment is the use of read-across chemicals to provide safety data to support the assessment of structurally similar…”
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Use of Zebrafish in Drug Discovery Toxicology by Cassar, Steven, Adatto, Isaac, Freeman, Jennifer L, Gamse, Joshua T, Iturria, Iñaki, Lawrence, Christian, Muriana, Arantza, Peterson, Randall T, Van Cruchten, Steven, Zon, Leonard I

“…Unpredicted human safety events in clinical trials for new drugs are costly in terms of human health and money. The drug discovery industry attempts to…”
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Advances in Toxicological Research of the Anticancer Drug Cisplatin by Qi, Luyu, Luo, Qun, Zhang, Yanyan, Jia, Feifei, Zhao, Yao, Wang, Fuyi

“…Cisplatin is one of the most widely used chemotherapeutic agents for various solid tumors in the clinic due to its high efficacy and broad spectrum. The…”
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The Tox21 10K Compound Library: Collaborative Chemistry Advancing Toxicology by Richard, Ann M, Huang, Ruili, Waidyanatha, Suramya, Shinn, Paul, Collins, Bradley J, Thillainadarajah, Inthirany, Grulke, Christopher M, Williams, Antony J, Lougee, Ryan R, Judson, Richard S, Houck, Keith A, Shobair, Mahmoud, Yang, Chihae, Rathman, James F, Yasgar, Adam, Fitzpatrick, Suzanne C, Simeonov, Anton, Thomas, Russell S, Crofton, Kevin M, Paules, Richard S, Bucher, John R, Austin, Christopher P, Kavlock, Robert J, Tice, Raymond R

“…Since 2009, the Tox21 project has screened ∼8500 chemicals in more than 70 high-throughput assays, generating upward of 100 million data points, with all data…”
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ToxCast Chemical Landscape: Paving the Road to 21st Century Toxicology by Richard, Ann M, Judson, Richard S, Houck, Keith A, Grulke, Christopher M, Volarath, Patra, Thillainadarajah, Inthirany, Yang, Chihae, Rathman, James, Martin, Matthew T, Wambaugh, John F, Knudsen, Thomas B, Kancherla, Jayaram, Mansouri, Kamel, Patlewicz, Grace, Williams, Antony J, Little, Stephen B, Crofton, Kevin M, Thomas, Russell S

“…The U.S. Environmental Protection Agency’s (EPA) ToxCast program is testing a large library of Agency-relevant chemicals using in vitro high-throughput…”
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RBOH-Dependent ROS Synthesis and ROS Scavenging by Plant Specialized Metabolites To Modulate Plant Development and Stress Responses by Chapman, Jordan M, Muhlemann, Joëlle K, Gayomba, Sheena R, Muday, Gloria K

“…Reactive oxygen species (ROS) regulate plant growth and development. ROS are kept at low levels in cells to prevent oxidative damage, allowing them to be…”
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Exposure of Human Lung Cells to Polystyrene Microplastics Significantly Retards Cell Proliferation and Triggers Morphological Changes by Goodman, Kerestin E, Hare, Joan T, Khamis, Zahraa I, Hua, Timothy, Sang, Qing-Xiang Amy

“…Microplastics in the environment produced by decomposition of globally increasing waste plastics have become a dominant component of both water and air…”
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Formation and Biological Targets of Quinones: Cytotoxic versus Cytoprotective Effects by Bolton, Judy L, Dunlap, Tareisha

“…Quinones represent a class of toxicological intermediates, which can create a variety of hazardous effects in vivo including, acute cytotoxicity,…”
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Chemical Composition of Aerosol from an E‑Cigarette: A Quantitative Comparison with Cigarette Smoke by Margham, Jennifer, McAdam, Kevin, Forster, Mark, Liu, Chuan, Wright, Christopher, Mariner, Derek, Proctor, Christopher

“…There is interest in the relative toxicities of emissions from electronic cigarettes and tobacco cigarettes. Lists of cigarette smoke priority toxicants have…”
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Nanotoxicity of Graphene and Graphene Oxide by Seabra, Amedea B, Paula, Amauri J, de Lima, Renata, Alves, Oswaldo L, Durán, Nelson

“…Graphene and its derivatives are promising candidates for important biomedical applications because of their versatility. The prospective use of graphene-based…”
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High-Nicotine Electronic Cigarette Products: Toxicity of JUUL Fluids and Aerosols Correlates Strongly with Nicotine and Some Flavor Chemical Concentrations by Omaiye, Esther E, McWhirter, Kevin J, Luo, Wentai, Pankow, James F, Talbot, Prue

“…Whereas JUUL electronic cigarettes (ECs) have captured the majority of the EC market, with a large fraction of their sales going to adolescents, little is…”
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Hematite and Magnetite Nanostructures for Green and Sustainable Energy Harnessing and Environmental Pollution Control: A Review by Ashraf, Muhammad, Khan, Ibrahim, Usman, Muhammad, Khan, Abuzar, Shah, Syed Shaheen, Khan, Abdul Zeeshan, Saeed, Khalid, Yaseen, Muhammad, Ehsan, Muhammad Fahad, Tahir, Muhammad Nawaz, Ullah, Nisar

“…The optoelectrical and magnetic characteristics of naturally existing iron-based nanostructures, especially hematite and magnetite nanoparticles (H-NPs and…”
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Survey of Human Oxidoreductases and Cytochrome P450 Enzymes Involved in the Metabolism of Xenobiotic and Natural Chemicals by Rendic, Slobodan, Guengerich, F. Peter

“…Analyzing the literature resources used in our previous reports, we calculated the fractions of the oxidoreductase enzymes FMO (microsomal flavin-containing…”
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Biological Interactions of Graphene-Family Nanomaterials: An Interdisciplinary Review by Sanchez, Vanesa C, Jachak, Ashish, Hurt, Robert H, Kane, Agnes B

“…Graphene is a single-atom thick, two-dimensional sheet of hexagonally arranged carbon atoms isolated from its three-dimensional parent material, graphite…”
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An Overview of Machine Learning and Big Data for Drug Toxicity Evaluation by Vo, Andy H, Van Vleet, Terry R, Gupta, Rishi R, Liguori, Michael J, Rao, Mohan S

“…Drug toxicity evaluation is an essential process of drug development as it is reportedly responsible for the attrition of approximately 30% of drug candidates…”
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N‑Acetylcysteine: Antioxidant, Aldehyde Scavenger, and More by Zhitkovich, Anatoly

“…N-Acetylcysteine is a commonly used antioxidant that is broadly effective despite its limited reactive oxygen species (ROS) reactivity. Chemoprotection by…”
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Molecular Mechanisms of Aldehyde Toxicity: A Chemical Perspective by LoPachin, Richard M, Gavin, Terrence

“…Aldehydes are electrophilic compounds to which humans are pervasively exposed. Despite a significant health risk due to exposure, the mechanisms of aldehyde…”
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Concentration Ranges of Antibacterial Cations for Showing the Highest Antibacterial Efficacy but the Least Cytotoxicity against Mammalian Cells: Implications for a New Antibacterial Mechanism by Ning, Chengyun, Wang, Xiaolan, Li, Lihua, Zhu, Ye, Li, Mei, Yu, Peng, Zhou, Lei, Zhou, Zhengnan, Chen, Junqi, Tan, Guoxin, Zhang, Yu, Wang, Yingjun, Mao, Chuanbin

“…Antibacterial metal ions, such as Ag+, Zn2+ and Cu2+, have been extensively used in medical implants and devices due to their strong broad spectrum of…”
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Thirdhand Smoke: New Evidence, Challenges, and Future Directions by Jacob, Peyton, Benowitz, Neal L, Destaillats, Hugo, Gundel, Lara, Hang, Bo, Martins-Green, Manuela, Matt, Georg E, Quintana, Penelope J. E, Samet, Jonathan M, Schick, Suzaynn F, Talbot, Prue, Aquilina, Noel J, Hovell, Melbourne F, Mao, Jian-Hua, Whitehead, Todd P

“…Thirdhand smoke (THS) is the contamination that persists after secondhand tobacco smoke has been emitted into air. It refers to the tobacco-related gases and…”
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Novel 3D Culture Systems for Studies of Human Liver Function and Assessments of the Hepatotoxicity of Drugs and Drug Candidates by Lauschke, Volker M, Hendriks, Delilah F. G, Bell, Catherine C, Andersson, Tommy B, Ingelman-Sundberg, Magnus

“…The liver is an organ with critical importance for drug treatment as the disposition and response to a given drug is often determined by its hepatic…”
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