Search Results - "Chemical & pharmaceutical bulletin"

The Latest Research and Development into the Antibody–Drug Conjugate, [fam-] Trastuzumab Deruxtecan (DS-8201a), for HER2 Cancer Therapy by Nakada, Takashi, Sugihara, Kiyoshi, Jikoh, Takahiro, Abe, Yuki, Agatsuma, Toshinori

“…A major limitation of traditional chemotherapy for cancer is dose-limiting toxicity, caused by the exposure of non-tumor cells to cytotoxic agents. Use of…”
Get full text

1,4-Naphthoquinones: Some Biological Properties and Application by Aminin, Dmitry, Polonik, Sergey

“…Over the past decade, a number of new 1,4-naphthoquinones have been isolated from natural sources and new 1,4-naphthoquinones with diverse structural features…”
Get full text

Smart Strategies for Therapeutic Agent Delivery into Brain across the Blood–Brain Barrier Using Receptor-Mediated Transcytosis by Tashima, Toshihiko

“…Discriminatory drug delivery into target cells is essential to effectively elicit the drug activity and to avoid off-target side effects; however, transporting…”
Get full text

Potential Anticancer Activity of Auranofin by Onodera, Takefumi, Momose, Isao, Kawada, Manabu

“…Gold compounds have a long history of use in medicine. Auranofin was developed more than 30 years ago as an oral therapy for rheumatoid arthritis. Now,…”
Get full text

The New Delivery Strategy of Albumin Carrier Utilizing the Interaction with Albumin Receptors by Ishima, Yu, Maruyama, Toru, Otagiri, Masaki, Chuang, Victor T. G., Ishida, Tatsuhiro

“…Albumin, the most abundant protein in human serum, is applied to various diseases as a drug delivery carrier because of its superior blood retention, high…”
Get full text

Co-delivery Systems of Multiple Drugs Using Nanotechnology for Future Cancer Therapy by Fumoto, Shintaro, Nishida, Koyo

“…Cancer treatments have improved significantly during the last decade but are not yet satisfactory. Combination therapy is often administered to improve…”
Get full text

Recent Advances in Drug–Antibody Ratio Determination of Antibody–Drug Conjugates by Matsuda, Yutaka, Mendelsohn, Brian A.

“…Antibody–drug conjugates (ADCs) are biopharmaceuticals produced by chemically linking small molecules (payloads) to antibodies that possess specific affinity…”
Get full text

Chitosan Nanoparticles: A Promising System in Novel Drug Delivery by Nagpal, Kalpana, Singh, Shailendra Kumar, Mishra, Dina Nath

“…The ability of nanoparticles to manipulate the molecules and their structures has revolutionized the conventional drug delivery system. The chitosan…”
Get full text

Design and Synthesis of New CDK2 Inhibitors Containing Thiazolone and Thiazolthione Scafold with Apoptotic Activity by Nour E. A. Abd El-Sattar, Badawy, Eman H. K., AbdEl-Hady, Wafaa H., Abo-Alkasem, Mohamed I., Mandour, Asmaa A., Ismail, Nasser S. M.

“…Cyclin dependent kinase 2 (CDK2) inhibition is a well-established strategy for treating cancer. Different series of novel thiazolone (1, 7–9) together with…”
Get full text

Facile Discrimination of Aldose Enantiomers by Reversed-Phase HPLC by Tanaka, Takashi, Nakashima, Tatsuya, Ueda, Toshihisa, Tomii, Kenji, Kouno, Isao

“…One-pot reactions of aldoses with L-cysteine methyl ester and o-tolyl isothiocyanate yielded methyl…”
Get full text

Synthesis and Anticancer Activity of New ((Furan-2-yl)-1,3,4-thiadiazolyl)-1,3,4-oxadiazole Acyclic Sugar Derivatives by Kassem, Asmaa F., Nassar, Ibrahim F., Abdel-Aal, Mohammed T., Awad, Hanem M., El-Sayed, Wael A.

“…New sugar hydrazones incorporating furan and/or 1,3,4-thiadiazole ring systems were synthesized by reaction of the corresponding hydrazide with different…”
Get full text

Antibody–Drug Conjugate Payloads; Study of Auristatin Derivatives by Akaiwa, Michinori, Dugal-Tessier, Julien, Mendelsohn, Brian A.

“…Auristatins are important payloads used in antibody drug conjugates (ADCs), and the most well-known compound family member, monomethyl auristatin (MMAE), is…”
Get full text

Natural Compounds with BMI1 Promoter Inhibitory Activity from Mammea siamensis and Andrographis paniculata by Fujii, Kazuki, Hara, Yasumasa, Arai, Midori A., Sadhu, Samir K., Ahmed, Firoj, Ishibashi, Masami

“…A new coumarin derivative (1) and 30 known compounds were isolated from Mammea siamensis and Andrographis paniculata, guided by B cell-specific Moloney murine…”
Get full text

Development of Chiral Thiourea Catalysts and Its Application to Asymmetric Catalytic Reactions by Takemoto, Yoshiji

“…We have developed several multifunctional thiourea catalysts bearing a tertiary amine or an 1,2-amino alcohol in expectation of their synchronous activation of…”
Get full text

i-Motif-Binding Ligands and Their Effects on the Structure and Biological Functions of i-Motif by Masoud, Shadi Sedghi, Nagasawa, Kazuo

“…The i-motif is a high-order DNA structure formed by hemiprotonated cytosine–cytosine base pairs under acidic conditions. It is less well studied than other…”
Get full text

Structure and Function of Δ9-Fatty Acid Desaturase by Nagao, Kohjiro, Murakami, Akira, Umeda, Masato

“…Δ9-Fatty acid desaturase (Δ9-desaturase) is a rate-limiting enzyme of unsaturated fatty acid biosynthesis in animal cells and specifically introduces a…”
Get full text

Bone-Targeted Drug Delivery Systems and Strategies for Treatment of Bone Metastasis by Katsumi, Hidemasa, Yamashita, Shugo, Morishita, Masaki, Yamamoto, Akira

“…Bone metastases can cause high morbidity and mortality, often developing as they advance, especially in patients with prostate and breast cancers. Most drugs…”
Get full text

Viscosity-Induced Emission of 5-(Diarylmethylene)imidazolone with Extended Conjugation via Attachment of N-Methylpyrrole at the 2-Position by Ikejiri, Masahiro, Yoshimizu, Aki, Shiota, Fumika, Nagayama, Ai, Fujisaka, Aki, Kuboki, Yuichi, Miyashita, Kazuyuki

“…We have developed a series of 2-monoaryl-5-diarylmethylene analogs of the green fluorescent protein chromophore to study their viscosity-induced emission (VIE)…”
Get full text

Current Understanding of Direct Translocation of Arginine-Rich Cell-Penetrating Peptides and Its Internalization Mechanisms by Takeuchi, Toshihide, Futaki, Shiroh

“…Arginine-rich cell-penetrating peptides (CPPs) including Tat, Penetratin and oligoarginine peptides are a series of short peptides that can be efficiently…”
Get full text

Sulfonate Derivatives Containing a Kakuol Moiety as Potential Fungicidal Candidates: Design, Synthesis and Antifungal Activity Evaluation by Sui, Guoqing, Shu, Lili, Zhang, Ailing, Li, Dan, Cao, Shuhua

“…As a part of our continuing exploration to discover new potential promising fungicide candidates, eighteen sulfonate derivatives (3a–3r) containing a kakuol…”
Get full text