Search Results - "Chello, Paul L."

Differential synthesis of methotrexate polyglutamates in normal proliferative and neoplastic mouse tissues in vivo by Poser, R G, Sirotnak, F M, Chello, P L

“…Synthesis of poly-gamma-glutamyl metabolites of methotrexate was demonstrated in mouse small intestine, liver, and bone marrow and in L1210 leukemia, Sarcoma…”
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Different effects of vincristine on methotrexate uptake by L1210 cells and mouse intestinal epithelia in vitro and in vivo by Chello, P L, Sirotnak, F M, Dorick, D M

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Therapeutic relevance of differences in the structural specificity of the transport systems for folate analogs in L1210 tumor cells and in isolated murine intestinal epithelial cells by Chello, P L, Sirotnak, F M, Dorick, D M, Donsbach, R C

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5-Methyl-5,6,7,8-tetrahydropteroyl oligo-γ-L-glutamates. Synthesis and kinetic studies with methionine synthetase from bovine brain by Coward, James K, Chello, Paul L, Cashmore, Arlene R, Parameswaran, K. N, DeAngelis, Lisa M, Bertino, Joseph R

“…The synthesis of 5-methyl-5,6,7,8-tetrahydropteroly tri-, pena-, and heptaglutamate has been accomplished by reductive methylation of the tetrahydropteroyl…”
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Synthesis of an N-aminopyrazinonium analog of cytidine by Lee, Tzoong Chyh, Chello, Paul L, Chou, Ting Chao, Templeton, Mary Agnes, Parham, James C

“…An N-aminated pyrazine analogue of cytidine, in which the pyrimidine N(3) ring nitrogen and C(4) amino group were replaced by a C-amino and an N-amino…”
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Elevation of dihydrofolate reductase, thymidylate synthetase, and thymidine kinase in cultured mammalian cells after exposure to folate antagonists by Chello, P L, McQueen, C A, DeAngelis, L M, Bertino, J R

“…Roswell Park Memorial Institute 4265 human lymphoblasts were grown with three dihydrofolate reductase inhibitors: a 2,4-diaminopteridine, methotrexate; a…”
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Synthesis and properties of the sulfonyl analogs of 4(5)-aminoimidazole-5(4)-carboxamide, 4(5)-(formylamino)imidazole-5(4)-carboxamide, guanine, and xanthine by Huang, Bao-Shan, Chello, Paul L, Yip, Lily, Parham, James C

“…Reduction of 4(5)-nitroimidazole-5(4)-sulfonamide afforded the sulfonamide analogue of 4(5)-aminoimidazole-5(4)-carboxamide (AICA). This was formylated to…”
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Dependence of 5-methyltetrahydrofolate utilization by L5178Y murine leukemia cells in vitro on the presence of hydroxycobalamin and transcobalamin II by Chello, P L, Bertino, J R

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Extracellular recovery of methotrexate-polyglutamates following efflux from L1210 leukemia cells by Poser, R G, Sirotnak, F, Chello, P L

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Alterations in the kinetics of methotrexate transport during growth of L1210 murine leukemia cells in culture by Chello, P L, Sirotnak, F M, Dorick, D M

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Effect of methionine deprivation on L5178Y murine leukemia cells in culture interference with the antineoplastic effect of methotrexate by Chello, P L, Bertino, J R

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Further studies stereospecificity at carbon 6 for membrane transport of tetrahydrofolates. Diastereoisomers of 5-methyltetrahydrofolates as competitive inhibitors of transport of methotrexate in L1210 cells by Chello, P L, Sirotnak, F M, Wong, E, Kisliuk, R L, Gaumont, Y, Combepine, G

“…The unnatural d diastereoisomer at carbon 6 of 5-methyltetrahydrofolate was only slightly less effective than the natural 1 diastereoisomer as a competitive…”
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Analog specific aberrancies in antifolate inhibition of L1210 cell dihydrofolate reductase by Sirotnak, F M, Chello, P L, Moccio, D M, Piper, J R, Montgomery, J A, Parham, J C

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Synthesis and Properties of 10-Benzylaminopterin by Parham, James C., Templeton, Mary Agnes, Chello, Paul L., Sirotnak, Francis M.

“…Substitution of a benzyl group for the methyl at N‐10 of Methotrexate caused only a slight decrease in the inhibitory properties of the folate analog against…”
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Isolation, Partial Purification, and Properties of Thymidine Kinase from Trypanosoma (Trypanozoon) brucei rhodesiense by Chello, Paul L., Jaffe, Julian J.

“…Thymidine kinase was isolated from the Wellcome CT strain of T. (T.) brucei rhodesiense and purified 6- to 7-fold by a stepwise fractionation with saturated…”
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Comparative properties of trypanosomal and mammalian thymidine kinases by Chello, P L, Jaffe, J J

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Improved purification of tetrahydrofolate dehydrogenase from L1210 leukemia by affinity chromatography by Chello, P L, Cashmore, A R, Jacobs, S A, Bertino, J R

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