Search Results - "Chekulaeva, Marina"

Mechanisms of miRNA-mediated post-transcriptional regulation in animal cells by Chekulaeva, Marina, Filipowicz, Witold

“…MicroRNAs (miRNAs) are 20-nt-long to 24-nt-long noncoding RNAs acting as post-transcriptional regulators of gene expression in animals and plants. In mammals,…”
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Roles of Long Noncoding RNAs and Circular RNAs in Translation by Chekulaeva, Marina, Rajewsky, Nikolaus

“…Most of the eukaryotic genome is pervasively transcribed, yielding hundreds to thousands of long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs), some of…”
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Human Pat1b Connects Deadenylation with mRNA Decapping and Controls the Assembly of Processing Bodies by Ozgur, Sevim, Chekulaeva, Marina, Stoecklin, Georg

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Alternative 3′ UTRs direct localization of functionally diverse protein isoforms in neuronal compartments by Ciolli Mattioli, Camilla, Rom, Aviv, Franke, Vedran, Imami, Koshi, Arrey, Gerard, Terne, Mandy, Woehler, Andrew, Akalin, Altuna, Ulitsky, Igor, Chekulaeva, Marina

“…Abstract The proper subcellular localization of RNAs and local translational regulation is crucial in highly compartmentalized cells, such as neurons. RNA…”
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RNA localization is a key determinant of neurite-enriched proteome by Zappulo, Alessandra, van den Bruck, David, Ciolli Mattioli, Camilla, Franke, Vedran, Imami, Koshi, McShane, Erik, Moreno-Estelles, Mireia, Calviello, Lorenzo, Filipchyk, Andrei, Peguero-Sanchez, Esteban, Müller, Thomas, Woehler, Andrew, Birchmeier, Carmen, Merino, Enrique, Rajewsky, Nikolaus, Ohler, Uwe, Mazzoni, Esteban O., Selbach, Matthias, Akalin, Altuna, Chekulaeva, Marina

“…Protein subcellular localization is fundamental to the establishment of the body axis, cell migration, synaptic plasticity, and a vast range of other…”
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Bruno Acts as a Dual Repressor of oskar Translation, Promoting mRNA Oligomerization and Formation of Silencing Particles by Chekulaeva, Marina, Hentze, Matthias W., Ephrussi, Anne

“…Prior to reaching the posterior pole of the Drosophila oocyte, oskar mRNA is translationally silenced by Bruno binding to BREs in the 3′ untranslated region…”
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Multiple independent domains of dGW182 function in miRNA-mediated repression in Drosophila by Chekulaeva, Marina, Filipowicz, Witold, Parker, Roy

“…miRNA-mediated repression affects a wide range of biological processes including development and human pathologies. The GW182 protein is a key component of…”
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A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion by Witte, Franziska, Ruiz-Orera, Jorge, Mattioli, Camilla Ciolli, Blachut, Susanne, Adami, Eleonora, Schulz, Jana Felicitas, Schneider-Lunitz, Valentin, Hummel, Oliver, Patone, Giannino, Mücke, Michael Benedikt, Šilhavý, Jan, Heinig, Matthias, Bottolo, Leonardo, Sanchis, Daniel, Vingron, Martin, Chekulaeva, Marina, Pravenec, Michal, Hubner, Norbert, van Heesch, Sebastiaan

“…Little is known about the impact of trans-acting genetic variation on the rates with which proteins are synthesized by ribosomes. Here, we investigate the…”
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Conservation of miRNA-mediated silencing mechanisms across 600 million years of animal evolution by Mauri, Marta, Kirchner, Marieluise, Aharoni, Reuven, Ciolli Mattioli, Camilla, van den Bruck, David, Gutkovitch, Nadya, Modepalli, Vengamanaidu, Selbach, Matthias, Moran, Yehu, Chekulaeva, Marina

“…Our current knowledge about the mechanisms of miRNA silencing is restricted to few lineages such as vertebrates, arthropods, nematodes and land plants…”
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GW/WG repeats of Drosophila GW182 function as effector motifs for miRNA-mediated repression by Chekulaeva, Marina, Parker, Roy, Filipowicz, Witold

“…The control of messenger RNA (mRNA) function by micro RNAs (miRNAs) in animal cells requires the GW182 protein. GW182 is recruited to the miRNA repression…”
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Mechanistic insights into the basis of widespread RNA localization by Chekulaeva, Marina

“…The importance of subcellular mRNA localization is well established, but the underlying mechanisms mostly remain an enigma. Early studies suggested that…”
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First demonstration of miRNA-dependent mRNA decay by Chekulaeva, Marina

“…Marina Chekulaeva describes the experiments that showed that microRNAs cause degradation of their target mRNAs…”
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Eyes on Translation by Chekulaeva, Marina, Landthaler, Markus

“…Translation is a fundamental biological process by which ribosomes decode genetic information into proteins. The regulation of this process plays a key role in…”
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Translation of CircRNAs by Pamudurti, Nagarjuna Reddy, Bartok, Osnat, Jens, Marvin, Ashwal-Fluss, Reut, Stottmeister, Christin, Ruhe, Larissa, Hanan, Mor, Wyler, Emanuel, Perez-Hernandez, Daniel, Ramberger, Evelyn, Shenzis, Shlomo, Samson, Moshe, Dittmar, Gunnar, Landthaler, Markus, Chekulaeva, Marina, Rajewsky, Nikolaus, Kadener, Sebastian

“…Circular RNAs (circRNAs) are abundant and evolutionarily conserved RNAs of largely unknown function. Here, we show that a subset of circRNAs is translated…”
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miRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved W-containing motifs by Filipowicz, Witold, Chekulaeva, Marina, Mathys, Hansruedi, Zipprich, Jakob T, Attig, Jan, Colic, Marija, Parker, Roy

“…The function of GW182 proteins in miRNA-mediated gene silencing has been unclear. Studies in human and fly cells now identify tryptophan-containing motifs as…”
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Charcot–Marie–Tooth mutation in glycyl-tRNA synthetase stalls ribosomes in a pre-accommodation state and activates integrated stress response by Mendonsa, Samantha, von Kuegelgen, Nicolai, Bujanic, Lucija, Chekulaeva, Marina

“…Abstract Toxic gain-of-function mutations in aminoacyl-tRNA synthetases cause a degeneration of peripheral motor and sensory axons, known as…”
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The key features of SARS-CoV-2 leader and NSP1 required for viral escape of NSP1-mediated repression by Bujanic, Lucija, Shevchuk, Olga, von Kügelgen, Nicolai, Kalinina, Anna, Ludwik, Katarzyna, Koppstein, David, Zerna, Nadja, Sickmann, Albert, Chekulaeva, Marina

“…SARS-CoV-2, responsible for the ongoing global pandemic, must overcome a conundrum faced by all viruses. To achieve its own replication and spread, it…”
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Massively parallel identification of mRNA localization elements in primary cortical neurons by Mendonsa, Samantha, von Kügelgen, Nicolai, Dantsuji, Sayaka, Ron, Maya, Breimann, Laura, Baranovskii, Artem, Lödige, Inga, Kirchner, Marieluise, Fischer, Meret, Zerna, Nadja, Bujanic, Lucija, Mertins, Philipp, Ulitsky, Igor, Chekulaeva, Marina

“…Cells adopt highly polarized shapes and form distinct subcellular compartments in many cases due to the localization of many mRNAs to specific areas, where…”
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Conservation of a core neurite transcriptome across neuronal types and species by Kügelgen, Nicolai, Chekulaeva, Marina

“…A core transcriptome form neurites was consistently detected across multiple neuronal types and includes mRNAs enriched for components of the translation…”
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Genome-wide analysis of RNA and protein localization and local translation in mESC-derived neurons by Ludwik, Katarzyna A., von Kuegelgen, Nicolai, Chekulaeva, Marina

“…•Here we describe neurite/soma separation scheme applied to mESC-derived neurons.•Neurite/soma separation is combined with mass spectrometry, RNAseq and…”
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