Search Results - "Chegou, Novel N."

Tuberculous Meningitis: Pathogenesis, Immune Responses, Diagnostic Challenges, and the Potential of Biomarker-Based Approaches by Manyelo, Charles M, Solomons, Regan S, Walzl, Gerhard, Chegou, Novel N

“…Tuberculous meningitis (TBM) is the most devastating form of tuberculosis (TB), causing high mortality or disability. Clinical management of the disease is…”
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The gut microbiome in tuberculosis susceptibility and treatment response: guilty or not guilty? by Eribo, Osagie A., du Plessis, Nelita, Ozturk, Mumin, Guler, Reto, Walzl, Gerhard, Chegou, Novel N.

“…Although tuberculosis (TB) is a curable disease, it remains the foremost cause of death from a single pathogen. Globally, approximately 1.6 million people died…”
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Higher SARS-CoV-2 seroprevalence in workers with lower socioeconomic status in Cape Town, South Africa by Shaw, Jane Alexandra, Meiring, Maynard, Cummins, Tracy, Chegou, Novel N, Claassen, Conita, Du Plessis, Nelita, Flinn, Marika, Hiemstra, Andriette, Kleynhans, Léanie, Leukes, Vinzeigh, Loxton, Andre G, MacDonald, Candice, Mtala, Nosipho, Reuter, Helmuth, Simon, Donald, Stanley, Kim, Tromp, Gerard, Preiser, Wolfgang, Malherbe, Stephanus T, Walzl, Gerhard

“…Inequality is rife throughout South Africa. The first wave of COVID-19 may have affected people in lower socioeconomic groups worse than the affluent. The…”
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Editorial: Immuno-diagnosis of active tuberculosis; are we making progress? by Mayanja-Kizza, Harriet, Cardona, Pere-Joan, Chegou, Novel N

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Exploring the associations of tobacco smoking and serum cotinine levels with selected inflammatory markers in adults with HIV in South Africa by Peer, Nasheeta, Nguyen, Kim Anh, Peprah, Emmanuel, Xu, Huichun, Matsha, Tandi E., Chegou, Novel N., Kengne, Andre-Pascal

“…This study examined the associations between tobacco smoking and serum cotinine levels, an objective biochemical measure of tobacco smoke exposure, with…”
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Identification of novel host biomarkers in plasma as candidates for the immunodiagnosis of tuberculosis disease and monitoring of tuberculosis treatment response by Jacobs, Ruschca, Malherbe, Stephanus, Loxton, Andre G, Stanley, Kim, van der Spuy, Gian, Walzl, Gerhard, Chegou, Novel N

“…There is an urgent need for new tools for the rapid diagnosis of tuberculosis disease. We evaluated the potentials of 74 host markers as biomarkers for the…”
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Utility of host markers detected in Quantiferon supernatants for the diagnosis of tuberculosis in children in a high-burden setting by Chegou, Novel N, Detjen, Anne K, Thiart, Lani, Walters, Elisabetta, Mandalakas, Anna M, Hesseling, Anneke C, Walzl, Gerhard

“…The diagnosis of childhood tuberculosis (TB) disease remains a challenge especially in young and HIV-infected children. Recent studies have identified…”
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Diagnostic Potential of Novel Salivary Host Biomarkers as Candidates for the Immunological Diagnosis of Tuberculosis Disease and Monitoring of Tuberculosis Treatment Response by Jacobs, Ruschca, Maasdorp, Elizna, Malherbe, Stephanus, Loxton, Andre G, Stanley, Kim, van der Spuy, Gian, Walzl, Gerhard, Chegou, Novel N

“…There is an urgent need for new tools for the early diagnosis of TB disease and monitoring of the response to treatment, especially in resource-constrained…”
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Increased Interferon-Induced Protein With Tetracopeptides (IFITs) Reduces Mycobacterial Growth by Madhvi, Abhilasha, Mishra, Hridesh, Chegou, Novel N., Baker, Bienyameen

“…Objectives The host immune response towards Mycobacterium tuberculosis ( M. tb ) is known to vary with the virulence of mycobacterial species. While the…”
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Serum and cerebrospinal fluid host proteins indicate stroke in children with tuberculous meningitis by Manyelo, Charles M, Chegou, Novel N, Seddon, James A, Snyders, Candice I, Mutavhatsindi, Hygon, Manngo, Portia M, Walzl, Gerhard, Stanley, Kim, Solomons, Regan S

“…Stroke is a common complication in children with tuberculous meningitis (TBM). Host proteins may give us insight into the mechanisms of stroke in TBM and serve…”
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Long-Term Impact of Neonatal Intake of Oleanolic Acid on the Expression of AMP-Activated Protein Kinase, Adiponectin and Inflammatory Cytokines in Rats Fed with a High Fructose Diet by Matumba, Mashudu Given, Ayeleso, Ademola Olabode, Nyakudya, Trevor, Erlwanger, Kennedy, Chegou, Novel N, Mukwevho, Emmanuel

“…AMP-activated protein kinase (AMPK) is known to regulate both glucose and lipid metabolism, which play vital roles in the development of metabolic syndrome…”
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Host biomarkers detected in saliva show promise as markers for the diagnosis of pulmonary tuberculosis disease and monitoring of the response to tuberculosis treatment by Jacobs, Ruschca, Tshehla, Enock, Malherbe, Stephanus, Kriel, Magdalena, Loxton, Andre G., Stanley, Kim, van der Spuy, Gian, Walzl, Gerhard, Chegou, Novel N.

“…•33 biomarkers were evaluated in saliva samples from patients with presumed TB disease.•A seven-marker saliva biosignature has potential in the diagnosis TB…”
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A Plasma 5-Marker Host Biosignature Identifies Tuberculosis in High and Low Endemic Countries by Chendi, Bih H, Snyders, Candice I, Tonby, Kristian, Jenum, Synne, Kidd, Martin, Walzl, Gerhard, Chegou, Novel N, Dyrhol-Riise, Anne M

“…Several host inflammatory markers have been proposed as biomarkers for diagnosis and treatment response in Tuberculosis (TB), but few studies compare their…”
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Candidate Biomarkers to Distinguish Spinal Tuberculosis From Mechanical Back Pain in a Tuberculosis Endemic Setting by Mann, Theresa N, Davis, Johan H, Walzl, Gerhard, Beltran, Caroline G, du Toit, Jacques, Lamberts, Robert P, Chegou, Novel N

“…Spinal tuberculosis (TB) may have a variable, non-specific presentation including back pain with- or without- constitutional symptoms. Further tools are needed…”
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Centella asiatica enhances hepatic antioxidant status and regulates hepatic inflammatory cytokines in type 2 diabetic rats by Oyenihi, Ayodeji B., Chegou, Novel N., Oguntibeju, Oluwafemi O., Masola, Bubuya

“…Context: Neutralizing the over-activation of oxidative stress and inflammation remains an important goal in the management of type 2 diabetes mellitus (T2DM)…”
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Host urine immunological biomarkers as potential candidates for the diagnosis of tuberculosis by Eribo, Osagie A., Leqheka, Monkoe S., Malherbe, Stephanus T., McAnda, Shirley, Stanley, Kim, van der Spuy, Gian D., Walzl, Gerhard, Chegou, Novel N.

“…•Twenty-nine host biomarkers were evaluated in urine samples obtained from TB suspects.•Seven individual biomarkers showed potential as promising diagnostic…”
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Transmission Of Tuberculosis Among illicit drug use Linkages (TOTAL): A cross-sectional observational study protocol using respondent driven sampling by Carney, Tara, Rooney, Jennifer A, Niemand, Nandi, Myers, Bronwyn, Theron, Danie, Wood, Robin, White, Laura F, Meade, Christina S, Chegou, Novel N, Ragan, Elizabeth, Walzl, Gerhard, Horsburgh, Robert, Warren, Robin M, Jacobson, Karen R

“…People who use illicit drugs (PWUDs) have been identified as a key at-risk group for tuberculosis (TB). Examination of illicit drug use networks has potential…”
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Suitability of saliva for Tuberculosis diagnosis: comparing with serum by Namuganga, Anna Ritah, Chegou, Novel N, Mubiri, Paul, Walzl, Gerhard, Mayanja-Kizza, Harriet

“…In the search for fast, simple and better ways for diagnosis of tuberculosis (TB), there is need to discover and evaluate new biomarkers that are found in…”
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Evaluation of Host Serum Protein Biomarkers of Tuberculosis in sub-Saharan Africa by Morris, Thomas C, Hoggart, Clive J, Chegou, Novel N, Kidd, Martin, Oni, Tolu, Goliath, Rene, Wilkinson, Katalin A, Dockrell, Hazel M, Sichali, Lifted, Banda, Louis, Crampin, Amelia C, French, Neil, Walzl, Gerhard, Levin, Michael, Wilkinson, Robert J, Hamilton, Melissa S

“…Accurate and affordable point-of-care diagnostics for tuberculosis (TB) are needed. Host serum protein signatures have been derived for use in primary care…”
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Application of Cerebrospinal Fluid Host Protein Biosignatures in the Diagnosis of Tuberculous Meningitis in Children from a High Burden Setting by Chegou, Novel N., Walzl, Gerhard, Kriel, Belinda, Mutavhatsindi, Hygon, Manngo, Portia M., Snyders, Candice I., Solomons, Regan S., Manyelo, Charles M., Stanley, Kim

“…Background. The diagnosis of tuberculous meningitis (TBM) especially in children is challenging. New tests are urgently needed for the diagnosis of the…”
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