Search Results - "Cheepala, Satish"

The ABCC4 membrane transporter modulates platelet aggregation by Cheepala, Satish B., Pitre, Aaron, Fukuda, Yu, Takenaka, Kazumasa, Zhang, Yuanyuan, Wang, Yao, Frase, Sharon, Pestina, Tamara, Gartner, T. Kent, Jackson, Carl, Schuetz, John D.

“…Controlling the activation of platelets is a key strategy to mitigate cardiovascular disease. Previous studies have suggested that the ATP-binding cassette…”
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ABCC4 impacts megakaryopoiesis and protects megakaryocytes against 6-mercaptopurine induced cytotoxicity by Ranjit, Sabina, Wang, Yao, Zhu, Jingwen, Cheepala, Satish B, Schuetz, Erin G, Cho, Woo Jung, Xu, Beisi, Robinson, Camenzind G, Wu, Gang, Naren, Anjaparavanda P, Schuetz, John D

“…The role of ABCC4, an ATP-binding cassette transporter, in the process of platelet formation, megakaryopoiesis, is unknown. Here, we show that ABCC4 is highly…”
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Cyclic Nucleotide Compartmentalization: Contributions of Phosphodiesterases and ATP-Binding Cassette Transporters by CHEEPALA, Satish, HULOT, Jean-Sebastien, MORGAN, Jessica A, SASSI, Yassine, WEIQIANG ZHANG, NAREN, Anjaparavanda P, SCHUETZ, John D

“…Cyclic nucleotides [e.g., cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP)] are ubiquitous second messengers that affect…”
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Human immunodeficiency virus protease inhibitors interact with ATP binding cassette transporter 4/multidrug resistance protein 4: a basis for unanticipated enhanced cytotoxicity by Fukuda, Yu, Takenaka, Kazumasa, Sparreboom, Alex, Cheepala, Satish B, Wu, Chung-Pu, Ekins, Sean, Ambudkar, Suresh V, Schuetz, John D

“…Human immunodeficiency virus (HIV) pharmacotherapy, by combining different drug classes such as nucleoside analogs and HIV protease inhibitors (PIs), has…”
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Identification of the B-Raf/Mek/Erk MAP kinase pathway as a target for all-trans retinoic acid during skin cancer promotion by Cheepala, Satish B, Yin, Weihong, Syed, Zanobia, Gill, Jennifer N, McMillian, Alaina, Kleiner, Heather E, Lynch, Mark, Loganantharaj, Rasiah, Trutschl, Marjan, Cvek, Urska, Clifford, John L

“…Retinoids have been studied extensively for their potential as therapeutic and chemopreventive agents for a variety of cancers, including nonmelanoma skin…”
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ABCG2 Transporter Expression Impacts Group 3 Medulloblastoma Response to Chemotherapy by Morfouace, Marie, Cheepala, Satish, Jackson, Sadhana, Fukuda, Yu, Patel, Yogesh T, Fatima, Soghra, Kawauchi, Daisuke, Shelat, Anang A, Stewart, Clinton F, Sorrentino, Brian P, Schuetz, John D, Roussel, Martine F

“…While a small number of plasma membrane ABC transporters can export chemotherapeutic drugs and confer drug resistance, it is unknown whether these transporters…”
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Multi-drug Resistance Protein 4 (MRP4)-mediated Regulation of Fibroblast Cell Migration Reflects a Dichotomous Role of Intracellular Cyclic Nucleotides by Sinha, Chandrima, Ren, Aixia, Arora, Kavisha, Moon, Chang-Suk, Yarlagadda, Sunitha, Zhang, Weiqiang, Cheepala, Satish B., Schuetz, John D., Naren, Anjaparavanda P.

“…It has long been known that cyclic nucleotides and cyclic nucleotide-dependent signaling molecules control cell migration. However, the concept that it is not…”
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Deregulated Hepatic Metabolism Exacerbates Impaired Testosterone Production in Mrp4-deficient Mice by Morgan, Jessica A., Cheepala, Satish B., Wang, Yao, Neale, Geoff, Adachi, Masashi, Nachagari, Deepa, Leggas, Mark, Zhao, Wenchen, Boyd, Kelli, Venkataramanan, Raman, Schuetz, John D.

“…The physiological role of multidrug resistance protein 4 (Mrp4, Abcc4) in the testes is unknown. We found that Mrp4 is expressed primarily in mouse and human…”
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Curcumin inhibition of integrin (alpha6beta4)-dependent breast cancer cell motility and invasion by Kim, Hong Im, Huang, Huang, Cheepala, Satish, Huang, Shile, Chung, Jun

“…Curcumin, a polyphenol natural product isolated from the rhizome of the plant Curcuma longa, has emerged as a promising anticancer therapeutic agent. However,…”
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Crucial Role for Phylogenetically Conserved Cytoplasmic Loop 3 in ABCC4 Protein Expression by Cheepala, Satish B., Bao, Ju, Nachagari, Deepa, Sun, Daxi, Wang, Yao, Zhong, Tao, Naren, Anjaparavanda P., Zheng, Jie, Schuetz, John D.

“…The ABC transporter ABCC4 is recognized as an ATP-dependent exporter of endogenous substances as well as an increasing variety of anionic chemotherapeutics. A…”
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Active Stat3 is required for survival of human squamous cell carcinoma cells in serum-free conditions by Yin, Weihong, Cheepala, Satish, Roberts, Jennifer N, Syson-Chan, Keith, DiGiovanni, John, Clifford, John L

“…Squamous cell carcinoma (SCC) of the skin is the most aggressive form of non-melanoma skin cancer (NMSC), and is the single most commonly diagnosed cancer in…”
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All-trans retinoic acid suppresses Stat3 signaling during skin carcinogenesis by Syed, Zanobia, Cheepala, Satish B, Gill, Jennifer N, Stein, Jennica, Nathan, Cherie Ann, Digiovanni, John, Batra, Vinita, Adegboyega, Patrick, Kleiner, Heather E, Clifford, John L

“…Squamous cell carcinoma (SCC) of the skin is the most clinically aggressive form of nonmelanoma skin cancer. We have determined the effects of all-trans…”
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Retinoids and skin: Microarrays shed new light on chemopreventive action of all-trans retinoic acid by Cheepala, Satish B., Syed, Zanobia, Trutschl, Marjan, Cvek, Urska, Clifford, John L.

“…Despite the use of retinoids in the clinic for many years, their mode of action in the prevention of skin cancer is still unclear. Recent microarray analyses…”
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Identification of a novel splice variant of X-linked inhibitor of apoptosis-associated factor 1 by Yin, Weihong, Cheepala, Satish, Clifford, John L.

“…XAF1 (XIAP-associated factor 1) binds to XIAP and blocks its anti-apoptotic activity. It has been reported that XAF1 is mainly expressed in normal tissues but…”
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Chemoprevention of Skin Carcinogenesis by Phenylretinamides: Retinoid Receptor–Independent Tumor Suppression by HUI XU, CHEEPALA, Satish, MCCAULEY, Elisabeth, COOMBES, Kevin, LIANCHUN XIAO, FISCHER, Susan M, CLIFFORD, John L

“…Fenretinide [ N -(4-hydroxyphenyl)retinamide or 4-HPR] is a synthetic retinoid analogue with antitumor and chemopreventive activities. N…”
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Genetic Ablation of the ABC Transporter Abcc4 Impairs Lymphoid Leukemogenesis by Crawford, Rebecca R., Cheepala, Satish, Lian, Shangli, Fukuda, Yu, Wang, Yao, Schuetz, John D.

“…ABCC4 is an ABC transporter of the C sub‐family that is ubiquitously expressed and exports key endogenous compounds including cAMP and prostaglandins, and…”
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Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport by Jin, Daqing, Ni, Terri T., Sun, Jianjian, Wan, Haiyan, Amack, Jeffrey D., Yu, Guangju, Fleming, Jonathan, Chiang, Chin, Li, Wenyan, Papierniak, Anna, Cheepala, Satish, Conseil, Gwenaëlle, Cole, Susan P. C., Zhou, Bin, Drummond, Iain A., Schuetz, John D., Malicki, Jarema, Zhong, Tao P.

“…Cilia are microtubule-based organelles that mediate signal transduction in a variety of tissues. Despite their importance, the signalling cascades that…”
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Heme Interaction with the Pyruvate Dehydrogenase Complex: A Novel Strategy to Promote Hypoxic Survival by Lynch, John Allan, Fukuda, Yu, Krishnamurthy, Partha, Wijaya, Juwina, Wang, Yao, Herras, Andras, Cheepala, Satish, Bao, Ju, Nourse, Amanda, Milasta, Sandra, Neale, Geoffrey, Zheng, Jie, Green, Douglas, Chi, Hongbo, Schuetz, John

“…Heme is an important regulator of biological processes, but an unresolved question remains, can heme regulate the switch between glycolysis and mitochondrial…”
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Metric for measuring the effectiveness of clustering of DNA microarray expression by Loganantharaj, Raja, Cheepala, Satish, Clifford, John

“…The recent advancement of microarray technology with lower noise and better affordability makes it possible to determine expression of several thousand genes…”
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The Role of ABC Transporter Abcc4 in Platelets Physiologic Function and Its Impact On Collagen Meditated Platelet Aggregation by Cheepala, Satish B., Takenaka, Kazumasa, Pestina, Tamara I., Jackson, Carl W., Schuetz, John D.

“…Abstract 1063 Platelet activation is a highly regulated process, and cyclic nucleotide mediated signaling pathways are crucial to effective platelet…”
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