Search Results - "Checkel, JL"

IL-4 Plays a Pivotal Role in Regulating the Development of Th2 and Th17 Responses in the Airways by Kobayashi, T, Iijima, K, Checkel, J.L, Kita, H

“…IL-33 is produced by tissue cells, such as airway epithelial cells and endothelial cells, and has been implicated in the development of Th2-type inflammatory…”
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Airway Exposure to IL-33 Induces IL-5-dominant Th2-type Immune Responses to Inhaled Antigens and Asthma-like Pathology by Kobayashi, T, Iijima, K, Checkel, J.L, Kita, H

“…Airway challenge of these mice with OVA markedly increased bronchoalveolar lavage levels of Th2 cytokines and provoked airway eosinophilia, mucus…”
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Eosinophils Are Not Involved in the Sensitization Phase of Allergic Responses by Kobayashi, T, Iijima, K, Checkel, J.L, Kita, H

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Airway Exposure to Papain, a Cysteine Protease, Induces Allergic Inflammation by Karakelides, M, Iijima, K, Checkel, J.L, Kobayashi, T, Kita, H

“…The effects of papain were abolished by heat-inactivation or by pretreatment with a cysteine protease inhibitor, E64, suggesting that protease activity is…”
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Identification of basophils by a mAb directed against pro–major basic protein 1 by Plager, Douglas A., Weiss, Ellen A., Kephart, Gail M., Mocharla, Robert M., Matsumoto, Ryoji, Checkel, James L., Schwartz, Lawrence B., Gleich, Gerald J., Leiferman, Kristin M.

“…Basophils possess characteristics of both mast cells and eosinophils, and all 3 cell types often are found together, particularly during allergic reactions. A…”
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Allergen-specific IgE, IgG, and Th2-type Cytokine Responses are Effectively Downregulated by Immunotherapy with the Novel Dendritic Cell (DC)-Stimulating Antibody, B7-DCXAb by Kita, H, Checkel, J.L, Iijima, K, Radhakrishnan, S, Van Keulen, V.P, Mcclimon, B.J, Kobayashi, T, Plager, D.A, Pease, L.R

“…Mice were sensitized by intraperitoneal injection of OVA or house dust mite (HDM) antigens plus alum and then treated by intravenous B7-DCXAb injection plus…”
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Differential extraction of eosinophil granule proteins by Ohnuki, Lyo E., Wagner, Lori A., Georgelas, Ann, Loegering, David A., Checkel, James L., Plager, Douglas A., Gleich, Gerald J.

“…Eosinophil granules contain several toxic cationic proteins that contribute to the pathophysiology of allergic diseases. These include eosinophil peroxidase,…”
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Major Basic Protein Homolog (MBP2): A Specific Human Eosinophil Marker by Plager, D.A., Loegering, D.A., Checkel, J.L., Tang, J., Kephart, G.M., Caffes, P.L., Adolphson, C.R., Ohnuki, L.E., Gleich, G.J.

“…Specific monoclonal antibodies for MBP2 were selected using slot blot analyses and employed in a two-site immunoassay, Western blotting, and immunofluorescence…”
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A Novel and Highly Divergent Homolog of Human Eosinophil Granule Major Basic Protein by Plager, Douglas A., Loegering, David A., Weiler, Deborah A., Checkel, James L., Wagner, Jill M., Clarke, Nigel J., Naylor, Stephen, Page, Scott M., Thomas, Larry L., Akerblom, Ingrid, Cocks, Ben, Stuart, Susan, Gleich, Gerald J.

“…Eosinophils are important effector cells in defense against helminth infection and in allergic diseases. To identify novel eosinophil proteins, large scale…”
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Eosinophil-derived neurotoxin and human liver ribonuclease. Identity of structure and linkage of neurotoxicity to nuclease activity by Sorrentino, S, Glitz, D G, Hamann, K J, Loegering, D A, Checkel, J L, Gleich, G J

“…Eosinophil-derived neurotoxin (EDN) and human liver RNase were found to be indistinguishable from each other but distinct from the pancreatic ribonucleases in…”
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Eosinophil granule proteins in peripheral blood granulocytes by Abu-Ghazaleh, R I, Dunnette, S L, Loegering, D A, Checkel, J L, Kita, H, Thomas, L L, Gleich, G J

“…Eosinophils contain four principal cationic proteins, major basic protein (MBP), eosinophil-derived neurotoxin (EDN), eosinophil cationic protein (ECP), and…”
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In vitro killing of microfilariae of Brugia pahangi and Brugia malayi by eosinophil granule proteins by Hamann, KJ, Gleich, GJ, Checkel, JL, Loegering, DA, McCall, JW, Barker, RL

“…Eosinophil infiltration and degranulation around the tissue-invasive stages of several species of helminths have been observed. Release of eosinophil granule…”
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Biochemical and Functional Similarities between Human Eosinophil-Derived Neurotoxin and Eosinophil Cationic Protein: Homology with Ribonuclease by Gleich, Gerald J., Loegering, David A., Bell, Michael P., Checkel, James L., Ackerman, Steven J., McKean, David J.

“…Eosinophil-derived neurotoxin (EDN) and eosinophil cationic protein (ECP) were isolated from lysates of human eosinophil granules by gel filtration and ion…”
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Acidic polyamino acids inhibit human eosinophil granule major basic protein toxicity : evidence of a functional role for ProMBP by BARKER, R. L, GUNDEL, R. H, GLEICH, G. J, CHECKEL, J. L, LOEGERING, D. A, PEASE, L. R, HAMANN, K. J

“…Eosinophil granule major basic protein (MBP), a potent toxin for helminths and mammalian cells in vitro, is a single polypeptide chain rich in arginine. MBP…”
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Expression, purification, and characterization of the recombinant proform of eosinophil granule major basic protein by Popken-Harris, P, McGrogan, M, Loegering, DA, Checkel, JL, Kubo, H, Thomas, LL, Moy, JN, Sottrup-Jensen, L, Snable, JL, Kikuchi, MT

“…The cDNA for the highly toxic eosinophil granule major basic protein (MBP) encodes a 25-kDa acidic precursor (proMBP) that is processed to form the 14-kDa…”
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Analysis of pregnancy-associated major basic protein levels throughout gestation by Wagner, J M, Bartemes, K, Vernof, K K, Dunnette, S, Offord, K P, Checkel, J L, Gleich, G J

“…Previous studies have shown that MBP levels rise before labour and have suggested the use of pMBP levels as a predictor of labour. We hypothesize that pMBP…”
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