Search Results - "Checco, James W."

Differential Post-Translational Amino Acid Isomerization Found among Neuropeptides in Aplysia californica by Mast, David H, Checco, James W, Sweedler, Jonathan V

“…d-Amino acid-containing peptides (DAACPs) make up a class of post-translationally modified peptides in animals that play important roles as cell-to-cell…”
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Targeting diverse protein–protein interaction interfaces with α/β-peptides derived from the Z-domain scaffold by Checco, James W., Kreitler, Dale F., Thomas, Nicole C., Belair, David G., Rettko, Nicholas J., Murphy, William L., Forest, Katrina T., Gellman, Samuel H.

“…Significance Medium-sized peptides that bind tightly to a specific partner protein can be biomedically useful. However, conventional peptides, comprised…”
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Aplysia allatotropin-related peptide and its newly identified d-amino acid–containing epimer both activate a receptor and a neuronal target by Checco, James W., Zhang, Guo, Yuan, Wang-ding, Le, Zi-wei, Jing, Jian, Sweedler, Jonathan V.

“…l- to d-residue isomerization is a post-translational modification (PTM) present in neuropeptides, peptide hormones, and peptide toxins from several animals…”
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Peptidomics analysis reveals changes in small urinary peptides in patients with interstitial cystitis/bladder pain syndrome by Abid, Md Shadman Ridwan, Qiu, Haowen, Tripp, Bridget A., de Lima Leite, Aline, Roth, Heidi E., Adamec, Jiri, Powers, Robert, Checco, James W.

“…Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic and debilitating pain disorder of the bladder and urinary tract with poorly understood…”
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Identifying and Measuring Endogenous Peptides through Peptidomics by Checco, James W.

“…Endogenous peptides, such as neuropeptides and peptide hormones, play important roles in intercellular communication, can provide information on physiology,…”
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Targeting recognition surfaces on natural proteins with peptidic foldamers by Checco, James W, Gellman, Samuel H

“…•Peptidic foldamers can display improved properties over natural peptides in vivo.•Designed d-peptides and α/β-peptides can target irregularly-shaped protein…”
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Label-Free Quantitation of Endogenous Peptides by Abid, Md Shadman Ridwan, Qiu, Haowen, Checco, James W

“…Liquid chromatography-mass spectrometry (LC-MS)-based peptidomics methods allow for the detection and identification of many peptides in a complex biological…”
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Affinity-Driven Aryl Diazonium Labeling of Peptide Receptors on Living Cells by Sharma, Sheryl, Naldrett, Michael J., Gill, Makayla J., Checco, James W.

“…Peptide–receptor interactions play critical roles in a wide variety of physiological processes. Methods to link bioactive peptides covalently to unmodified…”
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Endogenous l- to d-amino acid residue isomerization modulates selectivity between distinct neuropeptide receptor family members by Yussif, Baba M, Blasing, Cole V, Checco, James W

“…The l- to d-amino acid residue isomerization of neuropeptides is an understudied post-translational modification found in animals across several phyla. Despite…”
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Evaluation of endogenous peptide stereochemistry using liquid chromatography-mass spectrometry-based spiking experiments by Yussif, Baba M, Checco, James W

“…Functional d-amino acid-containing peptides are endogenously found throughout nature, generated through non-ribosomal peptide synthesis or through…”
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Advancing d-amino acid-containing peptide discovery in the metazoan by Mast, David H., Checco, James W., Sweedler, Jonathan V.

“…The discovery of enzyme-derived d-amino acid-containing peptides (DAACPs) that have physiological importance in the metazoan challenges previous assumptions…”
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Peptidomic Analysis Reveals Seasonal Neuropeptide and Peptide Hormone Changes in the Hypothalamus and Pituitary of a Hibernating Mammal by Mousavi, Somayeh, Qiu, Haowen, Andrews, Matthew T., Checco, James W.

“…During the winter, hibernating mammals undergo extreme changes in physiology, which allow them to survive several months without access to food. These animals…”
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Nontargeted Identification of D-Amino Acid-Containing Peptides Through Enzymatic Screening, Chiral Amino Acid Analysis, and LC-MS by Okyem, Samuel, Romanova, Elena V, Tai, Hua-Chia, Checco, James W, Sweedler, Jonathan V

“…D-amino acid-containing peptides (DAACPs) in animals are a class of bioactive molecules formed via the posttranslational modification of peptides consisting of…”
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Mass Spectrometry Approaches Empowering Neuropeptide Discovery and Therapeutics by Anapindi, Krishna D B, Romanova, Elena V, Checco, James W, Sweedler, Jonathan V

“…The discovery of insulin in the early 1900s ushered in the era of research related to peptides acting as hormones and neuromodulators, among other regulatory…”
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Proteomic Identification of Seasonally Expressed Proteins Contributing to Heart Function and the Avoidance of Skeletal Muscle Disuse Atrophy in a Hibernating Mammal by Abid, Md Shadman Ridwan, Bredahl, Eric C., Clifton, Ashley D., Qiu, Haowen, Andrews, Matthew T., Checco, James W.

“…Hibernation in the thirteen-lined ground squirrel (Ictidomys tridecemlineatus) takes place over 4–6 months and is characterized by multiday bouts of…”
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Trimer-to-Monomer Disruption Mechanism for a Potent, Protease-Resistant Antagonist of Tumor Necrosis Factor‑α Signaling by Niu, Jiani, Cederstrand, Annika J., Eddinger, Geoffrey A., Yin, Boyu, Checco, James W., Bingman, Craig A., Outlaw, Victor K., Gellman, Samuel H.

“…Aberrant tumor necrosis factor-α (TNFα) signaling is associated with many inflammatory diseases. The homotrimeric quaternary structure of TNFα is essential for…”
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Iterative Nonproteinogenic Residue Incorporation Yields α/β‐Peptides with a Helix–Loop–Helix Tertiary Structure and High Affinity for VEGF by Checco, James W., Gellman, Samuel H.

“…Inhibition of specific protein–protein interactions is attractive for a range of therapeutic applications, but the large and irregularly shaped contact…”
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α/β-Peptide Foldamers Targeting Intracellular Protein–Protein Interactions with Activity in Living Cells by Checco, James W, Lee, Erinna F, Evangelista, Marco, Sleebs, Nerida J, Rogers, Kelly, Pettikiriarachchi, Anne, Kershaw, Nadia J, Eddinger, Geoffrey A, Belair, David G, Wilson, Julia L, Eller, Chelcie H, Raines, Ronald T, Murphy, William L, Smith, Brian J, Gellman, Samuel H, Fairlie, W. Douglas

“…Peptides can be developed as effective antagonists of protein–protein interactions, but conventional peptides (i.e., oligomers of l-α-amino acids) suffer from…”
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Two C-terminal isoforms of Aplysia tachykinin–related peptide receptors exhibit phosphorylation-dependent and phosphorylation-independent desensitization mechanisms by Mao, Rui-ting, Guo, Shi-qi, Zhang, Guo, Li, Ya-dong, Xu, Ju-ping, Wang, Hui-ying, Fu, Ping, Liu, Cui-ping, Wu, Shao-qian, Chen, Ping, Mei, Yu-shuo, Jin, Qing-chun, Liu, Cheng-yi, Zhang, Yan-chu-fei, Ding, Xue-ying, Liu, Wei-jia, Romanova, Elena V., Zhou, Hai-bo, Cropper, Elizabeth C., Checco, James W., Sweedler, Jonathan V., Jing, Jian

“…Diversity, a hallmark of G protein-coupled receptor (GPCR) signaling, partly stems from alternative splicing of a single gene generating more than one isoform…”
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AI protein structure prediction-based modeling and mutagenesis of a protostome receptor and peptide ligands reveal key residues for their interaction by Guo, Shi-Qi, Li, Ya-Dong, Chen, Ping, Zhang, Guo, Wang, Hui-Ying, Jiang, Hui-Min, Liu, Wei-Jia, Xu, Ju-Ping, Ding, Xue-Ying, Fu, Ping, Yu, Ke, Zhou, Hai-Bo, Checco, James W., Jing, Jian

“…The protostome leucokinin (LK) signaling system, including LK peptides and their G protein-coupled receptors, has been characterized in several species…”
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