Argon-plasma-assisted graft polymerization of thick hydrogels with controllable water swelling on Chronoflex

Chronoflex, a polyurethane, is a suitable material for use in polymeric tracheobronchial stents. A controlled release layer on the stent is required for effective localized delivery of cancer drugs to the tumor cells. This paper reports on the investigation of coating Chronoflex with acrylated oligo...

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Bibliographic Details
Published in:	Journal of adhesion science and technology Vol. 18; no. 14; pp. 1663 - 1673
Main Authors:	Chan-Park, Mary B., Zhu, Aiping, Sing Lim, Chu, Chean Lim, Hwee
Format:	Journal Article
Language:	English
Published:	Leiden Taylor & Francis Group 01-01-2004 Brill
Subjects:	Application fields Applied sciences ARGON PLASMA Biological and medical sciences CONTROLLED RELEASE Exact sciences and technology GRAFT COPOLYMERIZATION HYDROGEL Medical sciences PEG Polymer industry, paints, wood POLYURETHANE STENTS Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology of polymers Technology. Biomaterials. Equipments UV IRRADIATION Plasma Surface reaction Graft copolymer Drug carrier Stent Property formulation relationship Cyclic ether copolymer Acrylate copolymer Biomaterial Propylene oxide copolymer Pretreatment Stents Swelling graft copolymerization Control release polymer Use Photochemical grafting UV irradiation argon plasma Ethylene oxide copolymer Experimental study Urethane copolymer controlled release PEG Polyurethane Hydrogel
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Summary:	Chronoflex, a polyurethane, is a suitable material for use in polymeric tracheobronchial stents. A controlled release layer on the stent is required for effective localized delivery of cancer drugs to the tumor cells. This paper reports on the investigation of coating Chronoflex with acrylated oligomers by argon plasma assisted UV graft polymerization. Coatings of poly(ethylene glycol) diacrylate (PEGDA) with molecular weight 700 or a 50 : 50 mixture of PEGDA with poly(propylene glycol) diacrylate (PPGDA) with molecular weight 900 which were tens of micrometers thick were shown to have good adhesion to Chronoflex. No photoinitiator was added. Formulations containing photoinitiator or a trifunctional crosslinker which increases strength and decreases water swelling showed poor adhesion to Chronoflex. The degree of water swelling of grafted PEGDA coating reached about 709%, making it suitable for use as a hydrogel coating for controlled drug release on Chronoflex. Adding PPGDA to PEGDA was shown to decrease the degree of water swelling. Hence, removal of the photoinitiator, use of oligomeric diacrylate with high molecular weight per acrylate group and a clean Chronoflex surface are found to be important factors for ensuring adhesion between the thick hydrogel coating and Chronoflex.
ISSN:	0169-4243 1568-5616
DOI:	10.1163/1568561042411303