Search Results - "Cheallaigh, Aisling Ní"

Synthesis of a B‐Antigen Hexasaccharide, a B‐Lewis b Heptasaccharide and Glycoconjugates Thereof to Investigate Binding Properties of Helicobacter pylori by Reihill, Mark, Fournière, Viviane, Cheallaigh, Aisling Ní, Edlund, Johan Olofsson, Miller, Gavin John, Borén, Thomas, Lahmann, Martina, Oscarson, Stefan

“…Infecting the stomach of almost 50 % of people, Helicobacter pylori is a causative agent of gastritis, peptic ulcers and stomach cancers. Interactions between…”
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The UbiX flavin prenyltransferase reaction mechanism resembles class I terpene cyclase chemistry by Marshall, Stephen A., Payne, Karl A. P., Fisher, Karl, White, Mark D., Ní Cheallaigh, Aisling, Balaikaite, Arune, Rigby, Stephen E. J., Leys, David

“…The UbiX-UbiD enzymes are widespread in microbes, acting in concert to decarboxylate alpha-beta unsaturated carboxylic acids using a highly modified flavin…”
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Structural Basis of Catalysis in the Bacterial Monoterpene Synthases Linalool Synthase and 1,8-Cineole Synthase by Karuppiah, Vijaykumar, Ranaghan, Kara E, Leferink, Nicole G. H, Johannissen, Linus O, Shanmugam, Muralidharan, Ní Cheallaigh, Aisling, Bennett, Nathan J, Kearsey, Lewis J, Takano, Eriko, Gardiner, John M, van der Kamp, Marc W, Hay, Sam, Mulholland, Adrian J, Leys, David, Scrutton, Nigel S

“…Terpenoids form the largest and stereochemically most diverse class of natural products, and there is considerable interest in producing these by biocatalysis…”
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Oxidative Maturation and Structural Characterization of Prenylated FMN Binding by UbiD, a Decarboxylase Involved in Bacterial Ubiquinone Biosynthesis by Marshall, Stephen A., Fisher, Karl, Ní Cheallaigh, Aisling, White, Mark D., Payne, Karl A.P., Parker, D.A., Rigby, Stephen E.J., Leys, David

“…The activity of the reversible decarboxylase enzyme Fdc1 is dependent on prenylated FMN (prFMN), a recently discovered cofactor. The oxidized prFMN supports a…”
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Harnessing a Biocatalyst to Bioremediate the Purification of Alkylglycosides by Wahart, Alice J. C., Dolan, Jonathan P., Anderson, Simon D., Cheallaigh, Aisling Ní, Staniland, Jessica, Lima, Marcelo A., Skidmore, Mark A., Miller, Gavin J., Cosgrove, Sebastian C.

“…As the world moves towards net‐zero carbon emissions, the development of sustainable chemical manufacturing processes is essential. Within manufacturing,…”
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Chemoenzymatic Synthesis of the Intermediates in the Peppermint Monoterpenoid Biosynthetic Pathway by Cheallaigh, Aisling Ní, Mansell, David J, Toogood, Helen S, Tait, Shirley, Lygidakis, Antonios, Scrutton, Nigel S, Gardiner, John M

“…A chemoenzymatic approach providing access to all four intermediates in the peppermint biosynthetic pathway between limonene and menthone/isomenthone,…”
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Enzymatic Menthol Production: One-Pot Approach Using Engineered Escherichia coli by Toogood, Helen S, Cheallaigh, Aisling Ní, Tait, Shirley, Mansell, David J, Jervis, Adrian, Lygidakis, Antonios, Humphreys, Luke, Takano, Eriko, Gardiner, John M, Scrutton, Nigel S

“…Menthol isomers are high-value monoterpenoid commodity chemicals, produced naturally by mint plants, Mentha spp. Alternative clean biosynthetic routes to these…”
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Pinpointing a Mechanistic Switch Between Ketoreduction and "Ene" Reduction in Short-Chain Dehydrogenases/Reductases by Lygidakis, Antonios, Karuppiah, Vijaykumar, Hoeven, Robin, Ní Cheallaigh, Aisling, Leys, David, Gardiner, John M., Toogood, Helen S., Scrutton, Nigel S.

“…Three enzymes of the Mentha essential oil biosynthetic pathway are highly homologous, namely the ketoreductases (−)‐menthone:(−)‐menthol reductase and…”
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Excited-State Properties of Protochlorophyllide Analogues and Implications for Light-Driven Synthesis of Chlorophyll by Heyes, Derren J, Hardman, Samantha J. O, Mansell, David, Ní Cheallaigh, Aisling, Gardiner, John M, Johannissen, Linus O, Greetham, Gregory M, Towrie, Michael, Scrutton, Nigel S

“…Protochlorophyllide (Pchlide), an intermediate in the biosynthesis of chlorophyll, is the substrate for the light-driven enzyme protochlorophyllide…”
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Chemical synthesis of amphiphilic glycoconjugates: Access to amino, fluorinated and sulfhydryl oleyl glucosides by Porter, Jack, Parisi, Daniele, Miller, Timothy, Cheallaigh, Aisling Ní, Miller, Gavin J.

“…Amphiphilic glycoconjugates offer an important prospect for development as chemical biology tools and biosurfactants. The chemical synthesis of such materials…”
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Formation and immunological evaluation of Moraxella catarrhalis glycoconjugates based on synthetic oligosaccharides by Anderson, Taigh, Jiang, Hao, Cheallaigh, Aisling Ní, Bengtsson, Dennis, Oscarson, Stefan, Cairns, Chantelle, St. Michael, Frank, Cox, Andrew, Kuttel, Michelle M.

“…Published work has shown that glycoconjugate vaccines, based on truncated detoxified lipopolysaccharides from Moraxella catarrhalis attached through their…”
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Chemical synthesis of a sulfated d-glucosamine library and evaluation of cell proliferation capabilities by Ní Cheallaigh, Aisling, Guimond, Scott E., Oscarson, Stefan, Miller, Gavin J.

“…[Display omitted] •Chemical synthesis of a sulphated d-glucosamine library.•Access to α- and β-O-methyl glycosides of d-glucosamine with O6 sulfation and…”
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Cover Feature: Harnessing a Biocatalyst to Bioremediate the Purification of Alkylglycosides (ChemBioChem 1/2024) by Wahart, Alice J. C., Dolan, Jonathan P., Anderson, Simon D., Cheallaigh, Aisling Ní, Staniland, Jessica, Lima, Marcelo A., Skidmore, Mark A., Miller, Gavin J., Cosgrove, Sebastian C.

“…Wahart et al. demonstrate the use of an immobilised oxidase enzyme coupled to an extractive amino resin for the bioremediation of a common industrial…”
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Synthesis of building blocks for an iterative approach towards oligomers of the Streptococcus pneumoniae type 1 zwitterionic capsular polysaccharide repeating unit by Ní Cheallaigh, Aisling, Oscarson, Stefan

“…Zwitterionic capsular polysaccharide extracts, ∼8 kDa in mass, from Streptococcus pneumoniae type 1 (Spt1) have shown unique T-cell activating properties…”
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Pinpointing a Mechanistic Switch Between Ketoreduction and "Ene" Reduction in Short-Chain Dehydrogenases/Reductases by Lygidakis, Antonios, Karuppiah, Vijaykumar, Hoeven, Robin, Ní Cheallaigh, Aisling, Leys, David, Gardiner, John M., Toogood, Helen S., Scrutton, Nigel S.

“…Three enzymes of the Mentha essential oil biosynthetic pathway are highly homologous, namely the ketoreductases (−)‐menthone:(−)‐menthol reductase and…”
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Conjugation at the oligonucleotide level based on isoxazole phosphoramidites generated by click chemistry by Freeman, Colin, Ni Cheallaigh, Aisling, Heaney, Frances

“…The versatility of the isoxazole generating nitrile oxide–alkyne Huisgen cycloaddition for provision of chemically modified oligonucleotides has been extended;…”
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Virtual screening, identification and in vitro validation of small molecule GDP-mannose dehydrogenase inhibitors by Dolan, Jonathan P, Ahmadipour, Sanaz, Wahart, Alice J C, Cheallaigh, Aisling Ní, Sari, Suat, Eurtivong, Chatchakorn, Lima, Marcelo A, Skidmore, Mark A, Volcho, Konstantin P, Reynisson, Jóhannes, Field, Robert A, Miller, Gavin J

“…Upon undergoing mucoid conversion within the lungs of cystic fibrosis patients, the pathogenic bacterium synthesises copious quantities of the virulence factor…”
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Virtual screening, identification and validation of small molecule GDP-mannose dehydrogenase inhibitors by Dolan, Jonathan P, Ahmadipour, Sanaz, Wahart, Alice J. C, Cheallaigh, Aisling Ní, Sari, Suat, Eurtivong, Chatchakorn, Lima, Marcelo A, Skidmore, Mark A, Volcho, Konstantin P, Reynisson, Jóhannes, Field, Robert A, Miller, Gavin J

“…Upon undergoing mucoid conversion within the lungs of cystic fibrosis patients, the pathogenic bacterium Pseudomonas aeruginosa synthesises copious quantities…”
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Correction: Virtual screening, identification and in vitro validation of small molecule GDP-mannose dehydrogenase inhibitors by Dolan, Jonathan P, Ahmadipour, Sanaz, Wahart, Alice J C, Cheallaigh, Aisling Ní, Sari, Suat, Eurtivong, Chatchakorn, Lima, Marcelo A, Skidmore, Mark A, Volcho, Konstantin P, Reynisson, Jóhannes, Field, Robert A, Miller, Gavin J

“…[This corrects the article DOI: 10.1039/D3CB00126A.]…”
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