Search Results - "Cheah, P. Y."

Randomized comparison of the efficacies and tolerabilities of three artemisinin-based combination treatments for children with acute Plasmodium falciparum malaria in the Democratic Republic of the Congo by Onyamboko, M A, Fanello, C I, Wongsaen, K, Tarning, J, Cheah, P Y, Tshefu, K A, Dondorp, A M, Nosten, F, White, N J, Day, N P J

“…An open-label, randomized controlled trial was carried out in 2011-2012 in the Democratic Republic of the Congo to test the efficacy, safety, and tolerability…”
Get full text

Mapping of hereditary mixed polyposis syndrome (HMPS) to chromosome 10q23 by genomewide high-density single nucleotide polymorphism (SNP) scan and identification of BMPR1A loss of function by Cao, X, Eu, K W, Kumarasinghe, M P, Li, H H, Loi, C, Cheah, P Y

“…Background: Hereditary mixed polyposis syndrome (HMPS) is characterised by colonic polyps of mixed histological types that are autosomal dominantly inherited…”
Get full text

In search of germline variants associated with metastasis risk in sporadic colorectal carcinomas: towards personalized therapeutic decision by Thean, L.F., Lo, M., Chew, M.H., Tang, C.L., Cheah, P.Y.

Get full text

NM23-H1 immunostaining is inversely associated with tumour staging but not overall survival or disease recurrence in colorectal carcinomas by CHEAH, P. Y, CAO, X, EU, K. W, SEOW-CHOEN, F

“…The NM23-H1 gene product has been recently identified as a potential metastasis suppressor. Studies on breast carcinomas have shown an inverse correlation…”
Get full text

Jumeaux, a novel Drosophila winged-helix family protein, is required for generating asymmetric sibling neuronal cell fates by Cheah, P Y, Chia, W, Yang, X

“…The great majority of neurons in the Drosophila embryonic CNS are generated through two successive asymmetric cell divisions; neuroblasts (NBs) divide to…”
Get full text

Genome-wide scan identifies a copy number variable region at 3q26 that regulates PPM1L in APC mutation-negative familial colorectal cancer patients by Thean, L. F., Loi, C., Ho, K. S., Koh, P. K., Eu, K. W., Cheah, P. Y.

“…Familial adenomatous polyposis (FAP) is an autosomal dominantly inherited form of colorectal cancer (CRC) caused by mutation in the adenomatous polyposis coli…”
Get full text

Topoisomerase-I- and Alu-mediated genomic deletions of the APC gene in familial adenomatous polyposis by Cao, X, Eu, K W, Seow-Choen, F, Zhao, Y, Cheah, P Y

“…Germline mutation in the adenomatous polyposis coli (APC) gene results in familial adenomatous polyposis (FAP), a heritable form of colorectal cancer. We have…”
Get full text

The Drosophila l(2)35Ba/nocA gene encodes a putative Zn finger protein involved in the development of the embryonic brain and the adult ocellar structures by CHEAH, P. Y, MENG, Y. B, YANG, X, KIMBRELL, D, ASHBURNER, M, CHIA, W

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Microsatellite instability and aneuploidy rate in young colorectal‐cancer patients do not differ significantly from those in older patients by Yao, Jocelyn, Eu, Kong Weng, Seow‐Choen, Francis, Vijayan, Viji, Cheah, Peh Yean

“…DNA and chromosomal instabilities are thought to promote colorectal carcinogenesis. Mismatch repair (MMR) deficiency affects DNA‐sequence integrity, resulting…”
Get full text

Colorectal cancer screening: yield of faecal occult blood testing by Teoh, Mei Lin, Puvan, R, Cheah, P Y, Yuen, Y

“…The incidence of colorectal cancer is rising and increasing public awareness of this condition has stimulated interest in screening tests. Colorectal cancer is…”
Get more information

Metabolic profiling in colorectal cancer reveals signature metabolic shifts during tumorigenesis by Ong, Eng Shi, Zou, Li, Li, Shaoxia, Cheah, Peh Yean, Eu, Kong Weng, Ong, Choon Nam

“…Colorectal cancer (CRC) arises as the consequence of progressive changes from normal epithelial cells through polyp to tumor, and thus is an useful model for…”
Get full text

Modification of DNA by bile acids: a possible factor in the etiology of colon cancer by Cheah, P Y, Bernstein, H

“…Bile acids have been implicated as promoters and cocarcinogens in the etiology of colon cancer and as comutagens and mutagens in bacteria. These observations…”
Get more information

GG genotype of cyclin D1 G870A polymorphism is associated with increased risk and advanced colorectal cancer in patients in Singapore by Hong, Yi, Eu, Kong Weng, Seow-Choen, Francis, Fook-Chong, Stephanie, Cheah, Peh Yean

“…Recent studies have implicated cyclin D1 G870A single-nucleotide polymorphism (SNP) in susceptibility to and early onset of colorectal cancers (CRC). We…”
Get full text

Down‐regulation of p27 is a significant predictor of poor overall survival and may facilitate metastasis in colorectal carcinomas by Yao, Jocelyn, Eu, Kong Weng, Seow‐Choen, Francis, Cheah, Peh Yean

“…The p27 gene product has been shown to have prognostic significance in a range of tumors. Down‐regulation of p27 has also been implicated in loss of cell…”
Get full text

Improved high-performance liquid chromatographic analysis of terazosin in human plasma by Cheah, Phaik Yeong, Yuen, Kah Hay, Liong, Men Long

“…A simple, sensitive and reproducible high-performance liquid chromatography (HPLC) method was developed for the determination of terazosin in human plasma. The…”
Get full text

Functional complementation of the malvolio mutation in the taste pathway of Drosophila melanogaster by the human natural resistance-associated macrophage protein 1 (Nramp-1) by D'Souza, J, Cheah, P Y, Gros, P, Chia, W, Rodrigues, V

“…The malvolio (mvl) gene of Drosophila melanogaster encodes a protein with a high degree of homology to natural resistance-associated macrophage proteins…”
Get full text

Update of genetics in colorectal carcinomas: genomic instability and somatic evolution by Cheah, P Y, Eu, K W, Seow, F C

“…Currently, there are two contrasting viewpoints on what drives the process of carcinogenesis. The genomic (DNA or chromosomal) instability model contends that…”
Get more information

APC mutation and phenotypic spectrum of Singapore familial adenomatous polyposis patients by Cao, X, Eu, K W, Seow-Choen, F, Zao, Y, Cheah, P Y

“…Familial adenomatous polyposis (FAP) is a familial form of colon cancer caused by mutation of the adenomatous polyposis coli (APC) gene. Although the APC gene…”
Get full text

Hypotheses for the etiology of colorectal cancer--an overview by Cheah, P Y

“…Colorectal cancer is the second most common cancer in the United States. Various dietary, colonic, and fecal components have been implicated as causative…”
Get more information

Germline mutations are frequent in the APC gene but absent in the β-Catenin gene in familial adenomatous polyposis patients by Cao, Xia, Eu, Kong Weng, Seow-Choen, Francis, Cheah, Peh Yean

“…Inactivation of the adenomatous polyposis coli (APC) gene has been shown to initiate the majority of colorectal cancer (CRC), including a familial form called…”
Get full text