High Granulocyte-Macrophage Colony Stimulating Factor to Interleukin 10 Ratio and Marked Antioxidant Enzyme Activities Predominate in Symptomatic Cattle Naturally Infected with Candidatus Mycoplasma haemobos, Theileria orientalis, Theileria sinensis and Trypanosoma evansi

High Granulocyte-Macrophage Colony Stimulating Factor to Interleukin 10 Ratio and Marked Antioxidant Enzyme Activities Predominate in Symptomatic Cattle Naturally Infected with Candidatus Mycoplasma haemobos, Theileria orientalis, Theileria sinensis and Trypanosoma evansi

The aim of this study was to measure the serum proinflammatory (IL-12, GM-CSF & IFN-γ) to anti-inflammatory (IL-10, IL-4) cytokine ratio, oxidant (MDA) level and antioxidant enzyme (SOD; GPx) activities after blood parasite infections. The blood and serum samples were obtained from 130 cattle an...

Full description

Saved in:
Bibliographic Details
Published in:Animals (Basel) Vol. 11; no. 8; p. 2235
Main Authors: Agina, Onyinyechukwu Ada, Cheah, Kim Tho, Sayuti, Nurul Syahirah Ahmad, Shaari, Mohd Rosly, Isa, Nur Mahiza Md, Ajat, Mokrish, Zamri-Saad, Mohd, Mazlan, Mazlina, Hamzah, Hazilawati
Format: Journal Article
Language:English
Published: Basel MDPI AG 29-07-2021
MDPI
Subjects:
Anemia
Animals
Anorexia
Antioxidants
Asymptomatic
asymptomatic and symptomatic cattle
Blood
Blood parasites
Candidatus Mycoplasma haemobos
Cattle
Cell growth
Colony-stimulating factor
Cytokines
Dendritic cells
ELISA
Enzymatic activity
Enzymes
Farms
Fibroblasts
Free radicals
Glutathione peroxidase
Granulocyte-macrophage colony stimulating factor
Granulocytes
Immune response
Immune system
Infections
Inflammation
Interferon
Interleukin 1
Interleukin 10
Interleukin 12
Interleukin 4
Leukocytes (granulocytic)
Lipid peroxidation
Macrophages
Malondialdehyde
oxidant/antioxidant
Oxidants
Oxidizing agents
Parasite resistance
Parasites
Pathogens
Peroxidase
serum
Superoxide dismutase
Theileria orientalis
Theileria sinensis
Trypanosoma evansi
γ-Interferon
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of this study was to measure the serum proinflammatory (IL-12, GM-CSF & IFN-γ) to anti-inflammatory (IL-10, IL-4) cytokine ratio, oxidant (MDA) level and antioxidant enzyme (SOD; GPx) activities after blood parasite infections. The blood and serum samples were obtained from 130 cattle and screened for identity of the infecting blood parasites by conventional PCR. The following blood parasite species were detected: Candidatus Mycoplasma haemobos (70/130); Theileria orientalis (65/130); Theileria sinensis (32/130); Anaplasma marginale (49/130); Anaplasma platys (7/130); and Trypanosoma evansi (4/130). The GM-CSF/IL-10 ratio showed significantly higher values in all the symptomatic blood parasite infected cattle groups except for symptomatic A. platys infected cattle groups. Anti-inflammatory cytokine immune responses were notable findings in symptomatic and asymptomatic cattle infected with C. M. haemobos and T. orientalis characterized by low serum IL-12:IL-10, IFN-γ:IL-10, IL-12:IL-4 and IFN-γ:IL-4 (p < 0.05). Therefore, high serum GM-CSF:IL:10 in the symptomatic blood parasite infected cattle, low serum IL-12:IL-10, IFN-γ:IL-10, IL-12:IL-4 and IFN-γ:IL-4 ratios in asymptomatic cattle, high MDA level, and increased antioxidant enzyme activities could be useful predictive tools for outcome of natural blood parasite infections in cattle.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:2076-2615
2076-2615
DOI:10.3390/ani11082235