Search Results - "Cheadle, Eleanor J"

Reprogramming the tumour microenvironment by radiotherapy: implications for radiotherapy and immunotherapy combinations by Colton, Madyson, Cheadle, Eleanor J, Honeychurch, Jamie, Illidge, Tim M

“…Radiotherapy (RT) is a highly effective anti-cancer therapy delivered to around 50-60% of patients. It is part of therapy for around 40% of cancer patients who…”
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Novel type II anti-CD20 monoclonal antibody (GA101) evokes homotypic adhesion and actin-dependent, lysosome-mediated cell death in B-cell malignancies by Alduaij, Waleed, Ivanov, Andrei, Honeychurch, Jamie, Cheadle, Eleanor J., Potluri, Sandeep, Lim, Sean H., Shimada, Kazuyuki, Chan, Claude H.T., Tutt, Alison, Beers, Stephen A., Glennie, Martin J., Cragg, Mark S., Illidge, Tim M.

“…The anti-CD20 mAb rituximab has substantially improved the clinical outcome of patients with a wide range of B-cell malignancies. However, many patients…”
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Antibody-induced nonapoptotic cell death in human lymphoma and leukemia cells is mediated through a novel reactive oxygen species-dependent pathway by Honeychurch, Jamie, Alduaij, Waleed, Azizyan, Mahsa, Cheadle, Eleanor J., Pelicano, Helene, Ivanov, Andrei, Huang, Peng, Cragg, Mark S., Illidge, Tim M.

“…Monoclonal antibodies (mAbs) have revolutionized the treatment of B-cell malignancies. Although Fc-dependent mechanisms of mAb-mediated tumor clearance have…”
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Understanding the Effects of Radiotherapy on the Tumour Immune Microenvironment to Identify Potential Prognostic and Predictive Biomarkers of Radiotherapy Response by Cheng, Shuhui, Cheadle, Eleanor J, Illidge, Timothy M

“…Radiotherapy (RT) is a highly effective anti-cancer treatment. Immunotherapy using immune checkpoint blockade (ICI) has emerged as a new and robust pillar in…”
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Reprogramming the immunosuppressive tumor microenvironment results in successful clearance of tumors resistant to radiation therapy and anti-PD-1/PD-L1 by Mukherjee, Debayan, Romano, Erminia, Walshaw, Richard, Zeef, Leo A. H., Banyard, Antonia, Kitcatt, Stephen J., Cheadle, Eleanor J., Tuomela, Karoliina, Pendharkar, Swati, Al-Deka, Aws, Salerno, Beatrice, Raby, Sophie, Mills, Ian G., Honeychurch, Jamie, Illidge, Tim M.

“…Despite breakthroughs in immune checkpoint inhibitors (ICI), the majority of tumors, including those poorly infiltrated by CD8+ T cells or heavily infiltrated…”
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Stromal cell inhibition of anti-CD20 antibody mediated killing of B-cell malignancies by Fagnano, Ester, Pendharkar, Swati, Colton, Madyson, Jones, Philip N, Sallan, Marta Crespi, Klymenko, Tetyana, Braun, Andrejs, Klein, Christian, Honeychurch, Jamie, Cheadle, Eleanor J, Illidge, Timothy M

“…The glycoengineered type II anti-CD20 monoclonal antibody obinutuzumab has been licensed for treatment in follicular non-Hodgkin lymphoma and B-CLL following…”
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Acquired resistance to fractionated radiotherapy can be overcome by concurrent PD-L1 blockade by Dovedi, Simon J, Adlard, Amy L, Lipowska-Bhalla, Grazyna, McKenna, Conor, Jones, Sherrie, Cheadle, Eleanor J, Stratford, Ian J, Poon, Edmund, Morrow, Michelle, Stewart, Ross, Jones, Hazel, Wilkinson, Robert W, Honeychurch, Jamie, Illidge, Tim M

“…Radiotherapy is a major part in the treatment of most common cancers, but many patients experience local recurrence with metastatic disease. In evaluating…”
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Fractionated Radiation Therapy Stimulates Antitumor Immunity Mediated by Both Resident and Infiltrating Polyclonal T-cell Populations when Combined with PD-1 Blockade by Dovedi, Simon J, Cheadle, Eleanor J, Popple, Amy L, Poon, Edmund, Morrow, Michelle, Stewart, Ross, Yusko, Erik C, Sanders, Catherine M, Vignali, Marissa, Emerson, Ryan O, Robins, Harlan S, Wilkinson, Robert W, Honeychurch, Jamie, Illidge, Timothy M

“…Radiotherapy is a highly effective anticancer treatment forming part of the standard of care for the majority of patients, but local and distal disease…”
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Eotaxin-2 and Colorectal Cancer: A Potential Target for Immune Therapy by CHEADLE, Eleanor J, RIYAD, Kallingal, SUBAR, Daren, ROTHWELL, Dominic G, ASHTON, Garry, BATHA, Hayley, SHERLOCK, David J, HAWKINS, Robert E, GILHAM, David E

“…Purpose: To study the production of chemokines by colorectal hepatic metastases. Experimental Design: Biopsies of resected colorectal hepatic metastases and…”
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Single-cell imaging of CAR T cell activity in vivo reveals extensive functional and anatomical heterogeneity by Cazaux, Marine, Grandjean, Capucine L, Lemaître, Fabrice, Garcia, Zacarias, Beck, Richard J, Milo, Idan, Postat, Jérémy, Beltman, Joost B, Cheadle, Eleanor J, Bousso, Philippe

“…CAR T cells represent a potentially curative strategy for B cell malignancies. However, the outcome and dynamics of CAR T cell interactions in distinct…”
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CAR T cells: driving the road from the laboratory to the clinic by Cheadle, Eleanor J., Gornall, Hannah, Baldan, Vania, Hanson, Vivien, Hawkins, Robert E., Gilham, David E.

“…Summary Blockbuster antibody therapies have catapulted immune‐based approaches to treat cancer into the consciousness of mainstay clinical research. On the…”
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Pretreatment Lymphocyte Count Predicts Benefit From Concurrent Chemotherapy With Radiotherapy in Oropharyngeal Cancer by Price, James M, Mistry, Hitesh B, Betts, Guy, Cheadle, Eleanor J, Dixon, Lynne, Garcez, Kate, Illidge, Tim, Iyizoba-Ebozue, Zsuzsanna, Lee, Lip Wai, McPartlin, Andrew, Prestwich, Robin J D, Papageorgiou, Savvas, Pritchard, Dylan J, Sykes, Andrew, West, Catharine M, Thomson, David J

“…There is a need to refine the selection of patients with oropharyngeal squamous cell carcinoma (OPSCC) for treatment de-escalation. We investigated whether…”
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Preclinical Assessment of CAR T-Cell Therapy Targeting the Tumor Antigen 5T4 in Ovarian Cancer by Owens, Gemma L, Sheard, Victoria E, Kalaitsidou, Milena, Blount, Daniel, Lad, Yatish, Cheadle, Eleanor J, Edmondson, Richard J, Kooner, Gurdeep, Gilham, David E, Harrop, Richard

“…Chimeric antigen receptor (CAR) T cells represent a novel targeted approach to overcome both quantitative and qualitative shortfalls of the host immune system…”
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Immuno-regulatory antibodies for the treatment of cancer by Honeychurch, Jamie, Cheadle, Eleanor J, Dovedi, Simon J, Illidge, Timothy M

“…After years of limited success, progress of anti-cancer immuno-therapeutics has been considerable over the past decade. Key to this progress has been the…”
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Ex vivo expanded tumour-infiltrating lymphocytes from ovarian cancer patients release anti-tumour cytokines in response to autologous primary ovarian cancer cells by Owens, Gemma L., Price, Marcus J., Cheadle, Eleanor J., Hawkins, Robert E., Gilham, David E., Edmondson, Richard J.

“…Epithelial ovarian cancer (EOC) is the leading cause of gynaecological cancer-related death in Europe. Although most patients achieve an initial complete…”
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Closely Related Mycobacterial Strains Demonstrate Contrasting Levels of Efficacy as Antitumor Vaccines and Are Processed for Major Histocompatibility Complex Class I Presentation by Multiple Routes in Dendritic Cells by Cheadle, Eleanor J, O'Donnell, Dearbhaile, Selby, Peter J, Jackson, Andrew M

“…Mycobacteria expressing recombinant antigens are already being developed as vaccines against both infections and tumors. Little is known about how dendritic…”
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Antitumor Efficacy of Radiation plus Immunotherapy Depends upon Dendritic Cell Activation of Effector CD8+ T Cells by Dovedi, Simon J, Lipowska-Bhalla, Grazyna, Beers, Stephen A, Cheadle, Eleanor J, Mu, Lijun, Glennie, Martin J, Illidge, Timothy M, Honeychurch, Jamie

“…Tumor cells dying after cytotoxic therapy are a potential source of antigen for T-cell priming. Antigen-presenting cells (APC) can cross-present MHC…”
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Differential role of Th1 and Th2 cytokines in autotoxicity driven by CD19-specific second-generation chimeric antigen receptor T cells in a mouse model by Cheadle, Eleanor J, Sheard, Victoria, Rothwell, Dominic G, Bridgeman, John S, Ashton, Garry, Hanson, Vivien, Mansoor, A Wasat, Hawkins, Robert E, Gilham, David E

“…T cells engrafted with chimeric AgRs (CAR) are showing exciting potential for targeting B cell malignancies in early-phase clinical trials. To determine…”
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Update on obinutuzumab in the treatment of B-cell malignancies by Illidge, Tim, Cheadle, Eleanor J, Donaghy, Claire, Honeychurch, Jamie

“…The anti-CD20 mAb rituximab has revolutionized the treatment of B-cell malignancies, improving outcome for patients. Despite these improvements, the majority…”
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Improving therapeutic activity of anti-CD20 antibody therapy through immunomodulation in lymphoid malignancies by Lipowska-Bhalla, Grazyna, Fagnano, Ester, Illidge, Timothy M., Cheadle, Eleanor J.

“…Nearly two decades ago rituximab heralded a new era in management of B cell malignancies significantly increasing response rates and survival. However, despite…”
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