Search Results - "Che, Karlhans"

Systemic IL-26 correlates with improved asthma control in children sensitized to dog allergen by Kovach, Melissa A, Käck, Ulrika, Che, Karlhans F, Brundin, Bettina, Konradsen, Jon R, Lindén, Anders

“…Interleukin (IL)-26 is produced by T helper type 17 (Type 17) cells and exerts immunomodulatory plus antimicrobial effects. Previous studies show that local…”
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HIV-1 induction of tolerogenic dendritic cells is mediated by cellular interaction with suppressive T cells by Svanberg, Cecilia, Nyström, Sofia, Govender, Melissa, Bhattacharya, Pradyot, Che, Karlhans F., Ellegård, Rada, Shankar, Esaki M., Larsson, Marie

“…HIV-1 infection gives rise to a multi-layered immune impairment in most infected individuals. The chronic presence of HIV-1 during the priming and activation…”
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Molecular signatures of T-cell inhibition in HIV-1 infection by Larsson, Marie, Shankar, Esaki M, Che, Karlhans F, Saeidi, Alireza, Ellegård, Rada, Barathan, Muttiah, Velu, Vijayakumar, Kamarulzaman, Adeeba

“…Cellular immune responses play a crucial role in the control of viral replication in HIV-infected individuals. However, the virus succeeds in exploiting the…”
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Interleukin-26 in antibacterial host defense of human lungs. Effects on neutrophil mobilization by Che, Karlhans F, Tengvall, Sara, Levänen, Bettina, Silverpil, Elin, Smith, Margaretha E, Awad, Muhammed, Vikström, Max, Palmberg, Lena, Qvarfordt, Ingemar, Sköld, Magnus, Lindén, Anders

“…The role of the presumed Th17 cytokine IL-26 in antibacterial host defense of the lungs is not known. To characterize the role of IL-26 in antibacterial host…”
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TLR4-mediated release of heparin-binding protein in human airways: a co-stimulatory role for IL-26 by Paulsson, Magnus, Cardenas, Eduardo I, Che, Karlhans F, Brundin, Bettina, Smith, Margaretha, Qvarfordt, Ingemar, Lindén, Anders

“…Bacterial infection causes accumulation of neutrophils that release antimicrobial proteins including heparin-binding protein (HBP). In human airways, this…”
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Complex Involvement of Interleukin-26 in Bacterial Lung Infection by Che, Karlhans F, Paulsson, Magnus, Piersiala, Krzysztof, Sax, Jakob, Mboob, Ibrahim, Rahman, Mizanur, Rekha, Rokeya S, Säfholm, Jesper, Adner, Mikael, Bergman, Peter, Cardell, Lars-Olaf, Riesbeck, Kristian, Lindén, Anders

“…Pneumonia is a global cause of mortality, and this provides a strong incentive to improve the mechanistic understanding of innate immune responses in the…”
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Complement opsonization of HIV-1 enhances the uptake by dendritic cells and involves the endocytic lectin and integrin receptor families by Tjomsland, Veronica, Ellegård, Rada, Che, Karlhans, Hinkula, Jorma, Lifson, Jeffrey D, Larsson, Marie

“…Interaction with the complement system is an underappreciated aspect of HIV-1 infection; even in primary infection, complement fragments are found on virions…”
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Asymptomatic SARS-CoV-2 infection: is it all about being refractile to innate immune sensing of viral spare-parts?—Clues from exotic animal reservoirs by Shankar, Esaki M, Che, Karlhans F, Yong, Yean K, Girija, A S Smiline, Velu, Vijayakumar, Ansari, Abdul W, Larsson, Marie

“…ABSTRACT A vast proportion of coronavirus disease 2019 (COVID-19) individuals remain asymptomatic and can shed severe acute respiratory syndrome (SARS-CoV)…”
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The neutrophil-mobilizing cytokine interleukin-26 in the airways of long-term tobacco smokers by Che, Karlhans Fru, Tufvesson, Ellen, Tengvall, Sara, Lappi-Blanco, Elisa, Kaarteenaho, Riitta, Levänen, Bettina, Ekberg, Marie, Brauner, Annelie, Wheelock, Åsa M, Bjermer, Leif, Sköld, C Magnus, Lindén, Anders

“…Long-term tobacco smokers with chronic obstructive pulmonary disease (COPD) or chronic bronchitis display an excessive accumulation of neutrophils in the…”
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Bacterial Outer Membrane Vesicles Induce Vitronectin Release Into the Bronchoalveolar Space Conferring Protection From Complement-Mediated Killing by Paulsson, Magnus, Che, Karlhans F, Ahl, Jonas, Tham, Johan, Sandblad, Linda, Smith, Margaretha E, Qvarfordt, Ingemar, Su, Yu-Ching, Lindén, Anders, Riesbeck, Kristian

“…Pathogens causing pneumonia utilize the complement regulator vitronectin to evade complement-mediated killing. Although vitronectin is associated with several…”
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Expression of a broad array of negative costimulatory molecules and Blimp-1 in T cells following priming by HIV-1 pulsed dendritic cells by Shankar, Esaki Muthu, Che, Karlhans Fru, Messmer, Davorka, Lifson, Jeffrey D, Larsson, Marie

“…Accumulating evidence indicates that immune impairment in persistent viral infections could lead to T-cell exhaustion. To evaluate the potential contribution…”
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Glucose Homeostasis in Relation to Neutrophil Mobilization in Smokers with COPD by Pournaras, Nikolaos, Andersson, Anders, Kovach, Melissa A, Padra, Médea, Che, Karlhans F, Brundin, Bettina, Yoshihara, Shigemi, Bozinovski, Steven, Lindén, Sara K, Jansson, Per-Anders, Sköld, Magnus C, Qvarfordt, Ingemar, Lindén, Anders

“…Type 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS) are common comorbidities in chronic obstructive pulmonary disease (COPD), but the underlying…”
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Complement opsonization of HIV‐1 results in a different intracellular processing pattern and enhanced MHC class I presentation by dendritic cells by Tjomsland, Veronica, Ellegård, Rada, Burgener, Adam, Mogk, Kenzie, Che, Karlhans F., Westmacott, Garrett, Hinkula, Jorma, Lifson, Jeffrey D., Larsson, Marie

“…Induction of optimal HIV‐1‐specific T‐cell responses, which can contribute to controlling viral infection in vivo, depends on antigen processing and…”
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Chronic hepatitis C virus infection triggers spontaneous differential expression of biosignatures associated with T cell exhaustion and apoptosis signaling in peripheral blood mononucleocytes by Barathan, Muttiah, Gopal, Kaliappan, Mohamed, Rosmawati, Ellegård, Rada, Saeidi, Alireza, Vadivelu, Jamuna, Ansari, Abdul W., Rothan, Hussin A., Ravishankar Ram, M., Zandi, Keivan, Chang, Li Y., Vignesh, Ramachandran, Che, Karlhans F., Kamarulzaman, Adeeba, Velu, Vijayakumar, Larsson, Marie, Kamarul, Tunku, Shankar, Esaki M.

“…Persistent hepatitis C virus (HCV) infection appears to trigger the onset of immune exhaustion to potentially assist viral persistence in the host, eventually…”
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Regulation of CD8+ T-cell cytotoxicity in HIV-1 infection by Saeidi, Alireza, Buggert, Marcus, Che, Karlhans F., Kong, Yong Y., Velu, Vijayakumar, Larsson, Marie, Shankar, Esaki M.

“…•Cytotoxic T cells are critical for effective viral clearance.•Transcription factors regulate the cytotoxic potentials of CD8+ T cells in HIV infection.•High…”
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Dendritic cell activation by sensing Mycobacterium tuberculosis –induced apoptotic neutrophils via DC-SIGN by Hedlund, Sebastian, Persson, Alexander, Vujic, Ana, Che, Karlhans Fru, Stendahl, Olle, Larsson, Marie

“…Abstract Mycobacterium tuberculosis (Mtb) manipulates cells of the innate immune system to provide the bacteria with a sustainable intracellular niche. Mtb…”
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HIV-1 impairs in vitro priming of naïve T cells and gives rise to contact-dependent suppressor T cells by Che, Karlhans F, Sabado, Rachel L, Shankar, Esaki M, Tjomsland, Veronica, Messmer, Davorka, Bhardwaj, Nina, Lifson, Jeffrey D, Larsson, Marie

“…Priming of T cells in lymphoid tissues of HIV-infected individuals occurs in the presence of HIV-1. DC in this milieu activate T cells and disseminate HIV-1 to…”
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Enhanced local production of IL-26 in uncontrolled compared with controlled adult asthma by Tufvesson, Ellen, Jogdand, Prajakta, Che, Karlhans Fru, Levänen, Bettina, Erjefält, Jonas S., Bjermer, Leif, Lindén, Anders

“…There were strong similar trends for total leukocytes in these groups (Fig E1, A). [...]there was a corresponding correlation for macrophages in the pooled…”
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Pharmacological Modulation of Endotoxin-Induced Release of IL-26 in Human Primary Lung Fibroblasts by Che, Karlhans Fru, Sun, Jitong, Linden, Anders

“…Background: Interleukin (IL)-26 is a neutrophil-mobilizing and bactericidal cytokine that is enhanced in human airways in vivo in response to endotoxin from…”
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Concurrent loss of co-stimulatory molecules and functional cytokine secretion attributes leads to proliferative senescence of CD8+ T cells in HIV/TB co-infection by Saeidi, Alireza, Chong, Yee K., Yong, Yean K., Tan, Hong Y., Barathan, Muttiah, Rajarajeswaran, Jayakumar, Sabet, Negar S., Sekaran, Shamala D., Ponnampalavanar, Sasheela, Che, Karlhans F., Velu, Vijayakumar, Kamarulzaman, Adeeba, Larsson, Marie, Shankar, Esaki M.

“…•HIV/TB co-infection increases plasma HIV viremia and decreases CD4/CD8 T-cell ratio.•Close association between the expression of CD38 and CD57 on…”
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