Search Results - "Chazot, P L"

Models of anxiety: Responses of rats to novelty in an open space and an enclosed space by Ennaceur, A., Michalikova, S., Chazot, P.L.

“…Exposure to novelty has been shown to induce anxiety responses in a variety of behavioural paradigms. The purpose of the present study was to investigate…”
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Do rats really express neophobia towards novel objects? Experimental evidence from exposure to novelty and to an object recognition task in an open space and an enclosed space by Ennaceur, A., Michalikova, S., Chazot, P.L.

“…Three set of experiments were performed in an enclosed space (open-field) and in an open space (elevated platform). The surface of the open-field and the…”
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Emotional responses and memory performance of middle-aged CD1 mice in a 3D maze: Effects of low infrared light by Michalikova, S., Ennaceur, A., van Rensburg, R., Chazot, P.L.

“…Non-thermal near infra-red (IR) has been shown to have many beneficial photobiological effects on a range of cell types, including neurons. In the present…”
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Antagonism of histamine H4 receptors exacerbates clinical and pathological signs of experimental autoimmune encephalomyelitis by Ballerini, C, Aldinucci, A, Luccarini, I, Galante, A, Manuelli, C, Blandina, P, Katebe, M, Chazot, P L, Masini, E, Passani, M B

“…Background and Purpose The histamine H4 receptor has a primary role in inflammatory functions, making it an attractive target for the treatment of asthma and…”
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Anxiety responses in Balb/c, c57 and CD-1 mice exposed to a novel open space test by Michalikova, S., van Rensburg, R., Chazot, P.L., Ennaceur, A.

“…In the present report we describe the behavior of two albinos (BALB/c and CD-1) and one pigmented (c57/BL6) strains of mice exposed to a novel open space…”
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Bio‐prospecting endemic Mascarene Aloes for potential neuroprotectants by Lobine, D., Howes, M‐J.R., Cummins, I., Govinden‐Soulange, J., Ranghoo‐Sanmukhiya, M., Lindsey, K., Chazot, P.L.

“…The Mascarene Aloes are used in the traditional pharmacopoeia against various ailments including cutaneous diseases and as antispasmodics. Scientific evidence…”
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Distinguishing anxiolysis and hyperactivity in an open space behavioral test by Ennaceur, A., Michalikova, S., van Rensburg, R., Chazot, P.L.

“…This report describes the emotional responses of mice exposed to an unfamiliar elevated platform that is extended on two opposite sides by downward lowered…”
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Tolerance, sensitization and dependence to diazepam in Balb/c mice exposed to a novel open space anxiety test by Ennaceur, A., Michalikova, S., van Rensburg, R., Chazot, P.L.

“…Balb/c mice were exposed to an elevated platform that is extended on two opposite sides with lowered steep slopes. They were tested for 12 min per session in 6…”
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Are benzodiazepines really anxiolytic? Evidence from a 3D maze spatial navigation task by ENNACEUR, A, MICHALIKOVA, S, VAN RENSBURG, R, CHAZOT, P. L

“…The effects of diazepam and chlordiazepoxide were assessed in a 3D maze which is a modification of an 8-arm radial maze. Each arm of the maze is attached to a…”
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Models of anxiety: Responses of mice to novelty and open spaces in a 3D maze by Ennaceur, A., Michalikova, S., van Rensburg, R., Chazot, P.L.

“…The present report describes the emotional responses of different strains of mice to exposure to a novel open space model of anxiety using a 3D spatial…”
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Detailed analysis of the behavior and memory performance of middle-aged male and female CD-1 mice in a 3D maze by Ennaceur, A., Michalikova, S., van Rensburg, R., Chazot, P.L.

“…Fifty percent of CD-1 mice from both sex die by the end of 2 years. The survival rate is higher in females than in males. This high mortality rate is…”
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The NMDA receptor NR2B subunit: a valid therapeutic target for multiple CNS pathologies by Chazot, Paul L

“…The NMDAR2B subunit is the focus of increasing interest as a therapeutic target in a wide range of CNS pathologies, including acute and chronic pain, stroke…”
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Non-invasive infra-red therapy (1072nm) reduces β-amyloid protein levels in the brain of an Alzheimer’s disease mouse model, TASTPM by Grillo, S.L., Duggett, N.A., Ennaceur, A., Chazot, P.L.

“…► Behavioural deficits coincide with higher aB-crystallin, Aβ and tau-P levels. ► IR1072 exposure elicited differential changes in HSPs with neuroprotective…”
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Immunohistochemical localization of N-methyl- d-aspartate receptor NR1, NR2A, NR2B and NR2C/D subunits in the adult mammalian cerebellum by Thompson, C.L, Drewery, D.L, Atkins, H.D, Stephenson, F.A, Chazot, P.L

“…The distributions of the N-methyl- d-aspartate (NMDA) receptor NR1, NR2A, NR2B and NR2C/D subunits were mapped in adult mouse cerebellum using subunit-specific…”
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Altered GABAA α5 subunit expression in the hypothalamic paraventricular nucleus of hypertensive and pregnant rats by Cork, S.C., Chazot, P.L., Pyner, S.

“…•Common to hypertension and pregnancy is exaggerated sympathetic activity.•Characterisation of the GABAA receptor expression in the PVN.•Significant decrease…”
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Optimal expression of cloned NMDAR1/NMDAR2A heteromeric glutamate receptors : a biochemical characterization by CIK, M, CHAZOT, P. L, STEPHENSON, F. A

“…The N-methyl-D-aspartate R1 (NMDAR1) and NMDAR2A subunits were expressed transiently either alone or in combination in human embryonic kidney (HEK) 293 cells…”
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Molecular Dissection of Native Mammalian Forebrain NMDA Receptors Containing the NR1 C2 Exon: Direct Demonstration of NMDA Receptors Comprising NR1, NR2A, and NR2B Subunits Within the Same Complex by Chazot, Paul L., Stephenson, F. Anne

“…: The subunit compositions of the NR1 C2 exon‐containing N‐methyl‐d‐aspartate (NMDA) receptors of adult mammalian forebrain were determined by using a…”
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Spreading depression‐induced preconditioning in the mouse cortex: differential changes in the protein expression of ionotropic nicotinic acetylcholine and glutamate receptors by Chazot, P. L., Godukhin, O. V., McDonald, A., Obrenovitch, T. P.

“…Preconditioning of the cerebral cortex was induced in mice by repeated cortical spreading depression (CSD), and the major ionotropic glutamate (GluRs) and…”
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Slope climbing challenges, fear of heights, anxiety and time of the day by Ennaceur, A., Hussain, M.D., Abuhamdah, R.M., Mostafa, R.M., Chazot, P.L.

“…•An elevated platform with steep slopes on two opposite sides is proposed to test anxiety in mice.•The test apparatus offers a 3-dimensional open-field that…”
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Pre-training in a radial arm maze abolished anxiety and impaired habituation in C57BL6/J mice treated with dizocilpine by Abuhamdah, R.M, Hussain, M.D, Chazot, P.L, Ennaceur, A

“…Abstract Familiarity can imply a reduction of fear and anxiety, which may render learning and memory performance insensitive to NMDA receptor antagonism. Our…”
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