Search Results - "Chavkin, W."

Hematopoietic loss of Y chromosome leads to cardiac fibrosis and heart failure mortality by Sano, Soichi, Horitani, Keita, Ogawa, Hayato, Halvardson, Jonatan, Chavkin, Nicholas W, Wang, Ying, Sano, Miho, Mattisson, Jonas, Hata, Atsushi, Danielsson, Marcus, Miura-Yura, Emiri, Zaghlool, Ammar, Evans, Megan A, Fall, Tove, De Hoyos, Henry N, Sundström, Johan, Yura, Yoshimitsu, Kour, Anupreet, Arai, Yohei, Thel, Mark C, Arai, Yuka, Mychaleckyj, Josyf C, Hirschi, Karen K, Forsberg, Lars A, Walsh, Kenneth

“…Hematopoietic mosaic loss of Y chromosome (mLOY) is associated with increased risk of mortality and age-related diseases in men, but the causal and mechanistic…”
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Phosphate uptake-independent signaling functions of the type III sodium-dependent phosphate transporter, PiT-1, in vascular smooth muscle cells by Chavkin, Nicholas W., Chia, Jia Jun, Crouthamel, Matthew H., Giachelli, Cecilia M.

“…Vascular calcification (VC) is prevalent in chronic kidney disease and elevated serum inorganic phosphate (Pi) is a recognized risk factor. The type III…”
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Single Cell Analysis in Vascular Biology by Chavkin, Nicholas W, Hirschi, Karen K

“…The ability to quantify DNA, RNA, and protein variations at the single cell level has revolutionized our understanding of cellular heterogeneity within…”
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Endothelial cell cycle state determines propensity for arterial-venous fate by Chavkin, Nicholas W., Genet, Gael, Poulet, Mathilde, Jeffery, Erin D., Marziano, Corina, Genet, Nafiisha, Vasavada, Hema, Nelson, Elizabeth A., Acharya, Bipul R., Kour, Anupreet, Aragon, Jordon, McDonnell, Stephanie P., Huba, Mahalia, Sheynkman, Gloria M., Walsh, Kenneth, Hirschi, Karen K.

“…During blood vessel development, endothelial cells become specified toward arterial or venous fates to generate a circulatory network that provides nutrients…”
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I066 CONSEQUENCES FOR PATIENTS, PHYSICIANS AND HEALTH SYSTEMS by Chavkin, W.

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SLC20A2 Deficiency in Mice Leads to Elevated Phosphate Levels in Cerbrospinal Fluid and Glymphatic Pathway‐Associated Arteriolar Calcification, and Recapitulates Human Idiopathic Basal Ganglia Calcification by Wallingford, Mary Catherine, Chia, Jia Jun, Leaf, Elizabeth M., Borgeia, Suhaib, Chavkin, Nicholas W., Sawangmake, Chenphop, Marro, Ken, Cox, Timothy C., Speer, Mei Y., Giachelli, Cecilia M.

“…Idiopathic basal ganglia calcification is a brain calcification disorder that has been genetically linked to autosomal dominant mutations in the…”
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Stress produces aversion and potentiates cocaine reward by releasing endogenous dynorphins in the ventral striatum to locally stimulate serotonin reuptake by Schindler, Abigail G, Messinger, Daniel I, Smith, Jeffrey S, Shankar, Haripriya, Gustin, Richard M, Schattauer, Selena S, Lemos, Julia C, Chavkin, Nicholas W, Hagan, Catherine E, Neumaier, John F, Chavkin, Charles

“…Activation of the dynorphin/κ-opioid receptor (KOR) system by repeated stress exposure or agonist treatment produces place aversion, social avoidance, and…”
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Connexin 43-mediated neurovascular interactions regulate neurogenesis in the adult brain subventricular zone by Genet, Nafiisha, Genet, Gael, Chavkin, Nicholas W., Paila, Umadevi, Fang, Jennifer S., Vasavada, Hema H., Goldberg, Joshua S., Acharya, Bipul R., Bhatt, Neha S., Baker, Kasey, McDonnell, Stephanie P., Huba, Mahalia, Sankaranarayanan, Danya, Ma, Gerry Z.M., Eichmann, Anne, Thomas, Jean-Leon, ffrench-Constant, Charles, Hirschi, Karen K.

“…The subventricular zone (SVZ) is the largest neural stem cell (NSC) niche in the adult brain; herein, the blood-brain barrier is leaky, allowing direct…”
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Obesity accelerates endothelial-to-mesenchymal transition in adipose tissues of mice and humans by Chavkin, Nicholas W, Vippa, Tanvi, Jung, Changhee, McDonnell, Stephanie, Hirschi, Karen K, Gokce, Noyan, Walsh, Kenneth

“…Vascular dysfunction and chronic inflammation are characteristics of obesity-induced adipose tissue dysfunction. Proinflammatory cytokines can drive an…”
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Placental Vascular Calcification and Cardiovascular Health: It Is Time to Determine How Much of Maternal and Offspring Health Is Written in Stone by Wallingford, Mary C, Benson, Ciara, Chavkin, Nicholas W, Chin, Michael T, Frasch, Martin G

“…Vascular calcification is the deposition of calcium phosphate minerals in vascular tissue. Vascular calcification occurs by both active and passive processes…”
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The Cell Surface Receptors Ror1/2 Control Cardiac Myofibroblast Differentiation by Chavkin, Nicholas W, Sano, Soichi, Wang, Ying, Oshima, Kosei, Ogawa, Hayato, Horitani, Keita, Sano, Miho, MacLauchlan, Susan, Nelson, Anders, Setia, Karishma, Vippa, Tanvi, Watanabe, Yosuke, Saucerman, Jeffrey J, Hirschi, Karen K, Gokce, Noyan, Walsh, Kenneth

“…Background A hallmark of heart failure is cardiac fibrosis, which results from the injury-induced differentiation response of resident fibroblasts to…”
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A multinational review of efforts to regulate conscience-based objection to abortion by Aksel, S, Kumar, B, Chavkin, W

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I255 RELIGIOUSLY BASED “CONSCIENTIOUS” REFUSAL OF REPRODUCTIVE HEALTH CARE by Monni, G., Chavkin, W., de Zordo, S., Velez, A.C. Gonzalez

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Importance of clonal hematopoiesis in heart failure by Chavkin, Nicholas W., Min, Kyung-Duk, Walsh, Kenneth

“…Heart failure is prevalent in the elderly population. Inflammatory processes can contribute to the progression of heart failure by altering the balance of…”
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Cocaine and Pregnancy—Time to Look at the Evidence by Chavkin, Wendy

“…Drawing from the evidence in a recent study of the developmental effects of children exposed to cocaine before birth, Chavkin considers the reasons for all of…”
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Isolation of Highly Purified and Viable Retinal Endothelial Cells by Chavkin, Nicholas W, Walsh, Kenneth, Hirschi, Karen K

“…The neonatal mouse retinal vascularization model has been widely used in the vascular biology field to investigate mechanisms of angiogenesis and…”
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Fibroblast growth factor 23 is not associated with and does not induce arterial calcification by Scialla, Julia J, Lau, Wei Ling, Reilly, Muredach P, Isakova, Tamara, Yang, Hsueh-Ying, Crouthamel, Matthew H, Chavkin, Nicholas W, Rahman, Mahboob, Wahl, Patricia, Amaral, Ansel P, Hamano, Takayuki, Master, Stephen R, Nessel, Lisa, Chai, Boyang, Xie, Dawei, Kallem, Radhakrishna R, Chen, Jing, Lash, James P, Kusek, John W, Budoff, Matthew J, Giachelli, Cecilia M, Wolf, Myles

“…Elevated fibroblast growth factor 23 (FGF23) is associated with cardiovascular disease in patients with chronic kidney disease. As a potential mediating…”
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SLC20a1/PiT-1 is required for chorioallantoic placental morphogenesis by Correia-Branco, Ana, Mei, Ariel, Pillai, Sreehari, Jayaraman, Nirmala, Sharma, Radhika, Paquette, Alison G, Neradugomma, Naveen K, Benson, Ciara, Chavkin, Nicholas W, Mao, Qingcheng, Wallingford, Mary C

“…The placenta mediates the transport of nutrients, such as inorganic phosphate (Pi), between the maternal and fetal circulatory systems. The placenta itself…”
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Clonal Hematopoiesis in Clinical and Experimental Heart Failure With Preserved Ejection Fraction by Cochran, Jesse D, Yura, Yoshimitsu, Thel, Mark C, Doviak, Heather, Polizio, Ariel H, Arai, Yuka, Arai, Yohei, Horitani, Keita, Park, Eunbee, Chavkin, Nicholas W, Kour, Anupreet, Sano, Soichi, Mahajan, Nitin, Evans, Megan, Huba, Mahalia, Naya, Nadia Martinez, Sun, Hanna, Ban, Young Ho, Hirschi, Karen K, Toldo, Stefano, Abbate, Antonio, Druley, Todd E, Ruberg, Frederick L, Maurer, Mathew S, Ezekowitz, Justin A, Dyck, Jason R B, Walsh, Kenneth

“…Clonal hematopoiesis (CH), which results from an array of nonmalignant driver gene mutations, can lead to altered immune cell function and chronic disease, and…”
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Sodium-Dependent Phosphate Cotransporters and Phosphate-Induced Calcification of Vascular Smooth Muscle Cells: Redundant Roles for PiT-1 and PiT-2 by Crouthamel, Matthew H, Lau, Wei Ling, Leaf, Elizabeth M, Chavkin, Nicholas W, Wallingford, Mary C, Peterson, Danielle F, Li, Xianwu, Liu, Yonggang, Chin, Michael T, Levi, Moshe, Giachelli, Cecilia M

“…OBJECTIVE—Elevated serum phosphate has emerged as a major risk factor for vascular calcification. The sodium-dependent phosphate cotransporter, PiT-1, was…”
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