Search Results - "Chavis, Pascale"

Investigating cell-specific effects of FMRP deficiency on spiny projection neurons in a mouse model of Fragile X syndrome by Giua, Gabriele, Lassalle, Olivier, Makrini-Maleville, Leila, Valjent, Emmanuel, Chavis, Pascale, Manzoni, Olivier J J

“…Fragile X syndrome (FXS), resulting from a mutation in the gene, is the most common monogenic cause of autism and inherited intellectual disability. encodes…”
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In utero exposure to cannabidiol disrupts select early-life behaviors in a sex-specific manner by Iezzi, Daniela, Caceres-Rodriguez, Alba, Chavis, Pascale, Manzoni, Olivier J. J.

“…Cannabidiol (CBD), one of the main components of cannabis, is generally considered safe. CBD crosses the placenta and its use during pregnancy is steadily…”
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NMDA Receptor Surface Trafficking and Synaptic Subunit Composition Are Developmentally Regulated by the Extracellular Matrix Protein Reelin by Groc, Laurent, Choquet, Daniel, Stephenson, F. Anne, Verrier, Daniele, Manzoni, Olivier J, Chavis, Pascale

“…During postnatal development, changes in the subunit composition of glutamate receptors of the NMDA subtype (NMDARs) are key to the refinement of excitatory…”
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Sexual differences in neuronal and synaptic properties across subregions of the mouse insular cortex by Iezzi, Daniela, Cáceres-Rodríguez, Alba, Strauss, Benjamin, Chavis, Pascale, Manzoni, Olivier J

“…The insular cortex (IC) plays a pivotal role in processing interoceptive and emotional information, offering insights into sex differences in behavior and…”
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Sex-specific modulation of early life vocalization and cognition by Fmr1 gene dosage in a mouse model of Fragile X Syndrome by Giua, Gabriele, Iezzi, Daniela, Caceres-Rodriguez, Alba, Strauss, Benjamin, Chavis, Pascale, Manzoni, Olivier J

“…Pup-dam ultrasonic vocalizations (USVs) are essential to cognitive and socio-emotional development. In autism and Fragile X Syndrome (FXS), disruptions in…”
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Reelin Supplementation Enhances Cognitive Ability, Synaptic Plasticity, and Dendritic Spine Density by Rogers, Justin T, Rusiana, Ian, Trotter, Justin, Zhao, Lisa, Donaldson, Erika, Pak, Daniel T.S, Babus, Lenard W, Peters, Melinda, Banko, Jessica L, Chavis, Pascale, Rebeck, G. William, Hoe, Hyang-Sook, Weeber, Edwin J

“…Apolipoprotein receptors belong to an evolutionarily conserved surface receptor family that has intimate roles in the modulation of synaptic plasticity and is…”
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Gestational CBD Shapes Insular Cortex in Adulthood by Iezzi, Daniela, Cáceres-Rodríguez, Alba, Pereira-Silva, Jessica, Chavis, Pascale, Manzoni, Olivier Jacques José

“…Many expectant mothers use CBD to alleviate symptoms like nausea, insomnia, anxiety, and pain, despite limited research on its long-term effects. However, CBD…”
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Sex-specific divergent maturational trajectories in the postnatal rat basolateral amygdala by Guily, Pauline, Lassalle, Olivier, Chavis, Pascale, Manzoni, Olivier J.

“…In rodents and humans, the basolateral amygdala (BLA), essential for emotional behaviors, is profoundly reorganized during adolescence. We compared in both…”
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Reelin secreted by GABAergic neurons regulates glutamate receptor homeostasis by Campo, Cecilia Gonzalez, Sinagra, Mélanie, Verrier, Danièle, Manzoni, Olivier J, Chavis, Pascale

“…Reelin is a large secreted protein of the extracellular matrix that has been proposed to participate to the etiology of schizophrenia. During development,…”
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Reelin-Haploinsufficiency Disrupts the Developmental Trajectory of the E/I Balance in the Prefrontal Cortex by Bouamrane, Lamine, Scheyer, Andrew F, Lassalle, Olivier, Iafrati, Jillian, Thomazeau, Aurore, Chavis, Pascale

“…The reelin gene is a strong candidate in the etiology of several psychiatric disorders such as schizophrenia, major depression, bipolar disorders, and autism…”
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Complex interactions between mGluRs, intracellular Ca2+ stores and ion channels in neurons by FAGNI, L, CHAVIS, P, ANGO, F, BOCKAERT, J

“…Metabotropic glutamate receptors (mGluRs) can increase intracellular Ca2+ concentration via Ins(1,4,5)P3- and ryanodine-sensitive Ca2+ stores in neurons. Both…”
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Visualization of Cyclic AMP–Regulated Presynaptic Activity at Cerebellar Granule Cells by Chavis, Pascale, Mollard, Patrice, Bockaert, Joël, Manzoni, Olivier

“…Adenylyl cyclase (AC) modulation of vesicular cycling was visualized at cultured cerebellar granule cell synapses using the sequential uptake of antibodies…”
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Adaptive group behavior of Fragile X mice in unfamiliar environments by Giua, Gabriele, Strauss, Benjamin, Lassalle, Olivier, Chavis, Pascale, Manzoni, Olivier J.

“…Fragile X Syndrome (FXS) stands out as a prominent cause of inherited intellectual disability and a prevalent disorder closely linked to autism. FXS is…”
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Cell- and Pathway-Specific Disruptions in the Accumbens of Fragile X Mouse by Giua, Gabriele, Pereira-Silva, Jessica, Caceres-Rodriguez, Alba, Lassalle, Olivier, Chavis, Pascale, Manzoni, Olivier J

“…Fragile X syndrome (FXS) is a genetic cause of intellectual disability and autism spectrum disorder. The mesocorticolimbic system, which includes the…”
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Integrins mediate functional pre- and postsynaptic maturation at a hippocampal synapse by Chavis, Pascale, Westbrook, Gary

“…Coordinated signalling between presynaptic terminals and their postsynaptic targets is essential for the development and function of central synapses. In…”
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Sex-specific divergent maturational trajectories in the postnatal rat basolateral amygdala by Guily, Pauline, Lassalle, Olivier, Chavis, Pascale, Manzoni, Olivier

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Prefrontal deficits in a murine model overexpressing the down syndrome candidate gene dyrk1a by Thomazeau, Aurore, Lassalle, Olivier, Iafrati, Jillian, Souchet, Benoit, Guedj, Fayçal, Janel, Nathalie, Chavis, Pascale, Delabar, Jean, Manzoni, Olivier J

“…The gene Dyrk1a is the mammalian ortholog of Drosophila minibrain. Dyrk1a localizes in the Down syndrome (DS) critical region of chromosome 21q22.2 and is a…”
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Multivariate synaptic and behavioral profiling reveals new developmental endophenotypes in the prefrontal cortex by Iafrati, Jillian, Malvache, Arnaud, Gonzalez Campo, Cecilia, Orejarena, M. Juliana, Lassalle, Olivier, Bouamrane, Lamine, Chavis, Pascale

“…The postnatal maturation of the prefrontal cortex (PFC) represents a period of increased vulnerability to risk factors and emergence of neuropsychiatric…”
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Sexually Dimorphic Adolescent Trajectories of Prefrontal Endocannabinoid Synaptic Plasticity Equalize in Adulthood, Reflected by Endocannabinoid System Gene Expression by Bernabeu, Axel, Bara, Anissa, Murphy Green, Michelle N, Manduca, Antonia, Wager-Miller, Jim, Borsoi, Milene, Lassalle, Olivier, Pelissier-Alicot, Anne-Laure, Chavis, Pascale, Mackie, Ken, Manzoni, Olivier J J

“…How sex influences prefrontal cortexes (PFCs) synaptic development through adolescence remains unclear. In this study we describe sex-specific cellular and…”
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State-dependent, bidirectional modulation of neural network activity by endocannabinoids by Piet, Richard, Garenne, André, Farrugia, Fanny, Le Masson, Gwendal, Marsicano, Giovanni, Chavis, Pascale, Manzoni, Olivier J

“…The endocannabinoid (eCB) system and the cannabinoid CB1 receptor (CB1R) play key roles in the modulation of brain functions. Although actions of eCBs and…”
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