Search Results - "Chavez, Shawn L."

Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells by Grow, Edward J., Flynn, Ryan A., Chavez, Shawn L., Bayless, Nicholas L., Wossidlo, Mark, Wesche, Daniel J., Martin, Lance, Ware, Carol B., Blish, Catherine A., Chang, Howard Y., Reijo Pera, Renee A., Wysocka, Joanna

“…The human endogenous retrovirus HERVK is normally silenced, but here the surprising discovery is made that in early human embryo development it is expressed,…”
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Chromosomal instability in mammalian pre-implantation embryos: potential causes, detection methods, and clinical consequences by Daughtry, Brittany L, Chavez, Shawn L

“…Formation of a totipotent blastocyst capable of implantation is one of the first major milestones in early mammalian embryogenesis, but less than half of in…”
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Prediction model for aneuploidy in early human embryo development revealed by single-cell analysis by Vera-Rodriguez, Maria, Chavez, Shawn L., Rubio, Carmen, Pera, Renee A. Reijo, Simon, Carlos

“…Aneuploidies are prevalent in the human embryo and impair proper development, leading to cell cycle arrest. Recent advances in imaging and molecular and…”
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Single-cell sequencing of primate preimplantation embryos reveals chromosome elimination via cellular fragmentation and blastomere exclusion by Daughtry, Brittany L, Rosenkrantz, Jimi L, Lazar, Nathan H, Fei, Suzanne S, Redmayne, Nash, Torkenczy, Kristof A, Adey, Andrew, Yan, Melissa, Gao, Lina, Park, Byung, Nevonen, Kimberly A, Carbone, Lucia, Chavez, Shawn L

“…Aneuploidy that arises during meiosis and/or mitosis is a major contributor to early embryo loss. We previously showed that human preimplantation embryos…”
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Molecular contribution to embryonic aneuploidy and karyotypic complexity in initial cleavage divisions of mammalian development by Brooks, Kelsey E, Daughtry, Brittany L, Davis, Brett, Yan, Melissa Y, Fei, Suzanne S, Shepherd, Selma, Carbone, Lucia, Chavez, Shawn L

“…Embryonic aneuploidy is highly complex, often leading to developmental arrest, implantation failure or spontaneous miscarriage in both natural and assisted…”
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Insights into embryonic chromosomal instability: mechanisms of DNA elimination during mammalian preimplantation development by Budrewicz, Jacqueline, Chavez, Shawn L

“…Mammalian preimplantation embryos often contend with aneuploidy that arose either by the inheritance of meiotic errors from the gametes, or from mitotic…”
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Metabolomics analysis of follicular fluid coupled with oocyte aspiration reveals importance of glucocorticoids in primate periovulatory follicle competency by Ravisankar, Sweta, Hanna, Carol B., Brooks, Kelsey E., Murphy, Melinda J., Redmayne, Nash, Ryu, Junghyun, Kinchen, Jason M., Chavez, Shawn L., Hennebold, Jon D.

“…Gonadotropin administration during infertility treatment stimulates the growth and development of multiple ovarian follicles, yielding heterogeneous oocytes…”
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Transcriptomic analysis of primate placentas and novel rhesus trophoblast cell lines informs investigations of human placentation by Rosenkrantz, Jimi L, Gaffney, Jessica E, Roberts, Victoria H J, Carbone, Lucia, Chavez, Shawn L

“…Proper placentation, including trophoblast differentiation and function, is essential for the health and well-being of both the mother and baby throughout…”
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Author Correction: Metabolomics analysis of follicular fluid coupled with oocyte aspiration reveals importance of glucocorticoids in primate periovulatory follicle competency by Ravisankar, Sweta, Hanna, Carol B., Brooks, Kelsey E., Murphy, Melinda J., Redmayne, Nash, Ryu, Junghyun, Kinchen, Jason M., Chavez, Shawn L., Hennebold, Jon D.

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Single‐Cell XIST Expression in Human Preimplantation Embryos and Newly Reprogrammed Female Induced Pluripotent Stem Cells by Briggs, Sharon F., Dominguez, Antonia A., Chavez, Shawn L., Reijo Pera, Renee A.

“…The process of X chromosome inactivation (XCI) during reprogramming to produce human induced pluripotent stem cells (iPSCs), as well as during the extensive…”
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The Role of Apoptosis in the Regulation of Trophoblast Survival and Differentiation during Pregnancy by Straszewski-Chavez, Shawn L, Abrahams, Vikki M, Mor, Gil

“…Apoptosis is important for normal placental development, but it may also be involved in the pathophysiology of pregnancy-related diseases. Normal placental…”
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Generation of human induced pluripotent stem cells using epigenetic regulators reveals a germ cell-like identity in partially reprogrammed colonies by Goyal, Akshi, Chavez, Shawn L, Reijo Pera, Renee A

“…Previous studies have shown that induced pluripotent stem cells (iPSCs) can be derived from fibroblasts by ectopic expression of four transcription factors,…”
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Divergent Trophoblast Responses to Bacterial Products Mediated by TLRs by Abrahams, Vikki M, Bole-Aldo, Paulomi, Kim, Yeon Mee, Straszewski-Chavez, Shawn L, Chaiworapongsa, Tinnakorn, Romero, Roberto, Mor, Gil

“…Intrauterine infections have been associated with pregnancy complications that are also linked with increased trophoblast apoptosis. TLRs are key components of…”
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Short-term Western-style diet negatively impacts reproductive outcomes in primates by Ravisankar, Sweta, Ting, Alison Y, Murphy, Melinda J, Redmayne, Nash, Wang, Dorothy, McArthur, Carrie A, Takahashi, Diana L, Kievit, Paul, Chavez, Shawn L, Hennebold, Jon D

“…A maternal Western-style diet (WSD) is associated with poor reproductive outcomes, but whether this is from the diet itself or underlying metabolic dysfunction…”
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Parthenogenic blastocysts derived from cumulus-free in vitro matured human oocytes by McElroy, Sohyun L, Byrne, James A, Chavez, Shawn L, Behr, Barry, Hsueh, Aaron J, Westphal, Lynn M, Pera, Renee A Reijo

“…Approximately 20% of oocytes are classified as immature and discarded following intracytoplasmic sperm injection (ICSI) procedures. These oocytes are obtained…”
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Instructing an Embryonic Stem Cell-Derived Oocyte Fate: Lessons from Endogenous Oogenesis by Nicholas, Cory R, Chavez, Shawn L, Baker, Valerie L, Reijo Pera, Renee A

“…Female reproductive potential is limited in the majority of species due to oocyte depletion. Because functional human oocytes are restricted in number and…”
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Microfluidics in reproductive biology: applying lab-on-a-chip technologies to assisted reproduction by Chavez, Shawn L

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Dynamic blastomere behaviour reflects human embryo ploidy by the four-cell stage by Chavez, Shawn L., Loewke, Kevin E., Han, Jinnuo, Moussavi, Farshid, Colls, Pere, Munne, Santiago, Behr, Barry, Reijo Pera, Renee A.

“…Previous studies have demonstrated that aneuploidy in human embryos is surprisingly frequent with 50–80% of cleavage-stage human embryos carrying an abnormal…”
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GATA2/3-TFAP2A/C transcription factor network couples human pluripotent stem cell differentiation to trophectoderm with repression of pluripotency by Krendl, Christian, Shaposhnikov, Dmitry, Rishko, Valentyna, Ori, Chaido, Ziegenhain, Christoph, Sass, Steffen, Simon, Lukas, Müller, Nikola S., Straub, Tobias, Brooks, Kelsey E., Chavez, Shawn L., Enard, Wolfgang, Theis, Fabian J., Drukker, Micha

“…To elucidate the molecular basis of BMP4-induced differentiation of human pluripotent stem cells (PSCs) toward progeny with trophectoderm characteristics, we…”
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An antibody against SSEA-5 glycan on human pluripotent stem cells enables removal of teratoma-forming cells by Weissman, Irving L, Drukker, Micha, Tang, Chad, Lee, Andrew S, Volkmer, Jens-Peter, Sahoo, Debashis, Nag, Divya, Mosley, Adriane R, Inlay, Matthew A, Ardehali, Reza, Chavez, Shawn L, Pera, Renee Reijo, Behr, Barry, Wu, Joseph C

“…An important risk in the clinical application of human pluripotent stem cells (hPSCs), including human embryonic and induced pluripotent stem cells (hESCs and…”
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