Search Results - "Chaves, Rodrigo Dos Santos"
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Heads Up! Interlinked Amyloidogenic and Axonal Transport Pathways in Concussion-Induced Neurodegeneration
Published in Journal of experimental neuroscience (2022)“…Mild traumatic brain injury (mTBI), a condition in which brain function is transiently disrupted by a mechanical force, is a major risk factor for developing…”
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Cholesterol-lowering drugs reduce APP processing to Aβ by inducing APP dimerization
Published in Molecular biology of the cell (01-02-2021)“…Amyloid beta (Aβ) is a major component of amyloid plaques, which are a key pathological hallmark found in the brains of Alzheimer's disease (AD) patients. We…”
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Full-length amyloid precursor protein regulates lipoprotein metabolism and amyloid-β clearance in human astrocytes
Published in The Journal of biological chemistry (20-07-2018)“…Mounting evidence suggests that alterations in cholesterol homeostasis are involved in Alzheimer's disease (AD) pathogenesis. Amyloid precursor protein (APP)…”
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