Search Results - "Chaves, F Javier"
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The association of urine metals and metal mixtures with cardiovascular incidence in an adult population from Spain: the Hortega Follow-Up Study
Published in International journal of epidemiology (01-12-2019)“…Abstract Background The association of low-level exposure to metals and metal mixtures with cardiovascular incidence in the general population has rarely been…”
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Urinary metals and metal mixtures and oxidative stress biomarkers in an adult population from Spain: The Hortega Study
Published in Environment international (01-02-2019)“…Few studies have investigated the role of exposure to metals and metal mixtures on oxidative stress in the general population. We evaluated the cross-sectional…”
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Arsenic exposure, diabetes-related genes and diabetes prevalence in a general population from Spain
Published in Environmental pollution (1987) (01-04-2018)“…Inorganic arsenic exposure may be associated with diabetes, but the evidence at low-moderate levels is not sufficient. Polymorphisms in diabetes-related genes…”
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Urine cadmium levels and albuminuria in a general population from Spain: A gene-environment interaction analysis
Published in Environment international (01-09-2017)“…The interaction of cadmium with genes involved in oxidative stress, cadmium metabolism and transport pathways on albuminuria can provide biological insight on…”
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In silico epigenetics of metal exposure and subclinical atherosclerosis in middle aged men: pilot results from the Aragon Workers Health Study
Published in Philosophical transactions of the Royal Society of London. Series B. Biological sciences (05-06-2018)“…We explored the association of metal levels with subclinical atherosclerosis and epigenetic changes in relevant biological pathways. Whole blood DNA Infinium…”
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Ambient air pollution and thyroid function in Spanish adults. A nationwide population-based study (Di@bet.es study)
Published in Environmental health (17-08-2022)“…Abstract Background Recent reports have suggested that air pollution may impact thyroid function, although the evidence is still scarce and inconclusive. In…”
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Gene-environment interaction analysis of redox-related metals and genetic variants with plasma metabolic patterns in a general population from Spain: The Hortega Study
Published in Redox biology (01-06-2022)“…Limited studies have evaluated the joint influence of redox-related metals and genetic variation on metabolic pathways. We analyzed the association of 11…”
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Reference values for TSH may be inadequate to define hypothyroidism in persons with morbid obesity: Di@bet.es study
Published in Obesity (Silver Spring, Md.) (01-04-2017)“…Objective To analyze the reference range of thyroid‐stimulating hormone (TSH) in different BMI categories and its impact on the classification of…”
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Altered glutathione system is associated with the presence of distal symmetric peripheral polyneuropathy in type 2 diabetic subjects
Published in Journal of diabetes and its complications (01-09-2015)“…Abstract Distal symmetric peripheral polyneuropathy (DSPN) is a highly prevalent complication of diabetes. However, underlying pathophysiological mechanisms…”
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Do genes modify the association of selenium and lipid levels?
Published in Antioxidants & redox signaling (20-05-2015)“…The interaction of selenium, a component of antioxidant selenoproteins, with genetic variation in lipid-related pathways has not been evaluated earlier as a…”
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The nutrigenetic influence of the interaction between dietary vitamin E and TXN and COMT gene polymorphisms on waist circumference: a case control study
Published in Journal of translational medicine (02-09-2015)“…Abdominal obesity (AO) is a common modifiable risk factor for certain non-communicable diseases associated with enhanced oxidative stress (OS). The objective…”
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Plasma homocysteine levels are independently associated with the severity of peripheral polyneuropathy in type 2 diabetic subjects
Published in Journal of the peripheral nervous system (01-06-2012)“…Peripheral polyneuropathy (PN) is a frequent complication of diabetes. However, mechanisms underlying the development of PN are multifactorial and not well…”
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Oxidative stress and antioxidant enzyme values in lymphomonocytes after an oral unsaturated fat load test in familial hypercholesterolemic subjects
Published in Translational research : the journal of laboratory and clinical medicine (2013)“…Oxidative stress (OS) has been observed in conditions affecting the cardiovascular system. Familial hypercholesterolemia (FH) is associated with an increased…”
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Association of C677T Polymorphism in MTHFR Gene, High Homocysteine and Low HDL Cholesterol Plasma Values in Heterozygous Familial Hypercholesterolemia
Published in Journal of Atherosclerosis and Thrombosis (2009)“…Aim: to investigate the association of C677T polymorphism in the methylene tetrahydrofolate reductase (MTHFR) gene, homocysteine plasma values (Hcy), and…”
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Increased oxidative stress levels and normal antioxidant enzyme activity in circulating mononuclear cells from patients of familial hypercholesterolemia
Published in Metabolism, clinical and experimental (01-02-2010)“…Abstract Familial hypercholesterolemia (FH) is a clinical condition with high risk for developing atherosclerosis. Increased oxidative stress (OS) and FH have…”
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Genetic interaction in the association between oxidative stress and diabetes in the Spanish population
Published in Free radical biology & medicine (20-08-2023)“…Oxidative stress (OS) is a relevant intermediate mechanism involved in Type 2 Diabetes Mellitus (T2D) development. To date, the interaction between OS…”
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Metabolomic patterns, redox-related genes and metals, and bone fragility endpoints in the Hortega Study
Published in Free radical biology & medicine (01-01-2023)“…The potential joint influence of metabolites on bone fragility has been rarely evaluated. We assessed the association of plasma metabolic patterns with bone…”
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EOSAL-CNV for Easy and Rapid Detection of CNVs by Fragment Analysis : EOSAL: A Fast and Reliable New Method for CNV Detection
Published in Methods in molecular biology (Clifton, N.J.) (2023)“…Copy number variations (CNVs) are a type of genetic variation involving from 50 base pairs (bps) to millions of bps and, in a general point of view, can…”
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Human and experimental evidence supporting a role for osteopontin in alcoholic hepatitis
Published in Hepatology (Baltimore, Md.) (01-11-2013)“…We identified, in the transcriptome analysis of patients with alcoholic hepatitis (AH), osteopontin (OPN) as one of the most up‐regulated genes. Here, we used…”
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