Search Results - "Chavarria, Gustavo E."

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    Synthesis and Biochemical Evaluation of Thiochromanone Thiosemicarbazone Analogues as Inhibitors of Cathepsin L by Song, Jiangli, Jones, Lindsay M, Kumar, G. D. Kishore, Conner, Elizabeth S, Bayeh, Liela, Chavarria, Gustavo E, Charlton-Sevcik, Amanda K, Chen, Shen-En, Chaplin, David J, Trawick, Mary Lynn, Pinney, Kevin G

    Published in ACS medicinal chemistry letters (14-06-2012)
    “…A series of 36 thiosemicarbazone analogues containing the thiochromanone molecular scaffold functionalized primarily at the C-6 position were prepared by…”
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    Journal Article
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    Kinetic Analysis and Antitumor Activity of Thiosemicarbazone Benzophenone Inhibitors of cathepsin L by Chavarria, Gustavo E, Strecker, Tracy E, Kumar, G. D Kishore, Jones, Lindsay, Chaplin, David J., Pinney, Kevin G, Trawick, Mary Lynn

    Published in The FASEB journal (01-04-2012)
    “…Abstract only Breast cancer is the most common type of cancer found in female patients. Thus, there is an extensive search of new chemotherapeutic agents that…”
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    Journal Article
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    Abstract 1416: Development and initial evaluation of the antitumor activity of a functionalized benzophenone thiosemicarbazone inhibitor of cathepsin L by Trawick, Mary Lynn, Pinney, Kevin G., Chaplin, David J., Horsman, Michael R., Chavarria, Gustavo E., Arispe, Wara M., Kishore Kumar, G. D.

    Published in Cancer research (Chicago, Ill.) (15-04-2011)
    “…The discovery of new chemotherapeutic strategies for inhibiting the growth and spread of cancer represents an important goal in the effort to enhance both…”
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    Journal Article
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    Kinetic Characterization of Thiosemicarbazones as Cysteine Protease Inhibitors and Their Potential Use as Therapeutic Agents against Metastatic Cancer and Chagas' Disease by Chavarria, Gustavo E

    Published 01-01-2012
    “…Human cathepsins L and K are cysteine proteases that play important roles in physiological and pathological processes, such as cancer metastasis, bone…”
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    Dissertation