Search Results - "Chavarria, Gustavo E."
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Synthesis and biochemical evaluation of benzoylbenzophenone thiosemicarbazone analogues as potent and selective inhibitors of cathepsin L
Published in Bioorganic & medicinal chemistry (01-11-2015)“…[Display omitted] Upregulation of cathepsin L in a variety of tumors and its ability to promote cancer cell invasion and migration through degradation of the…”
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2
Small-molecule inhibitors of cathepsin L incorporating functionalized ring-fused molecular frameworks
Published in Bioorganic & medicinal chemistry letters (01-05-2013)“…Cathepsin L is a cysteine protease that is upregulated in a variety of malignant tumors and plays a significant role in cancer cell invasion and migration. It…”
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Initial evaluation of the antitumour activity of KGP94, a functionalized benzophenone thiosemicarbazone inhibitor of cathepsin L
Published in European journal of medicinal chemistry (01-12-2012)“…Kinetic analysis of the mode of inhibition of cathepsin L by KGP94, a lead compound from a privileged library of functionalized benzophenone thiosemicarbazone…”
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4
Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors
Published in Bioorganic & medicinal chemistry letters (15-02-2010)“…A variety of benzophenone thiosemicarbazone analogs have been designed and prepared by chemical synthesis. A sub-set of these compounds demonstrated potent…”
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Functionalized benzophenone, thiophene, pyridine, and fluorene thiosemicarbazone derivatives as inhibitors of cathepsin L
Published in Bioorganic & medicinal chemistry letters (15-11-2010)“…Brominated-benzophenone thiosemicarbazone inhibitors of cathepsin L. A series of thiosemicarbazone analogs based on the benzophenone, thiophene, pyridine, and…”
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6
Synthesis and Biochemical Evaluation of Thiochromanone Thiosemicarbazone Analogues as Inhibitors of Cathepsin L
Published in ACS medicinal chemistry letters (14-06-2012)“…A series of 36 thiosemicarbazone analogues containing the thiochromanone molecular scaffold functionalized primarily at the C-6 position were prepared by…”
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Kinetic Analysis and Antitumor Activity of Thiosemicarbazone Benzophenone Inhibitors of cathepsin L
Published in The FASEB journal (01-04-2012)“…Abstract only Breast cancer is the most common type of cancer found in female patients. Thus, there is an extensive search of new chemotherapeutic agents that…”
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Abstract 1416: Development and initial evaluation of the antitumor activity of a functionalized benzophenone thiosemicarbazone inhibitor of cathepsin L
Published in Cancer research (Chicago, Ill.) (15-04-2011)“…The discovery of new chemotherapeutic strategies for inhibiting the growth and spread of cancer represents an important goal in the effort to enhance both…”
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Kinetic Characterization of Thiosemicarbazones as Cysteine Protease Inhibitors and Their Potential Use as Therapeutic Agents against Metastatic Cancer and Chagas' Disease
Published 01-01-2012“…Human cathepsins L and K are cysteine proteases that play important roles in physiological and pathological processes, such as cancer metastasis, bone…”
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Dissertation