Reinforced electrospun nanofiber composites for drug delivery applications

Reinforced electrospun nanofiber composites for drug delivery applications

Electrospun technology becomes a valuable means of fabricating functional polymeric nanofibers with distinctive morphological properties for drug delivery applications. Nanofibers are prepared from the polymer solution, which allows the direct incorporation of therapeutics such as small drug molecul...

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Bibliographic Details
Published in:Journal of biomedical materials research. Part A Vol. 109; no. 10; pp. 2036 - 2064
Main Authors: Anup, Neelima, Chavan, Tejas, Chavan, Shruti, Polaka, Suryanarayana, Kalyane, Dnyaneshwar, Abed, Sara Nidal, Venugopala, Katharigatta N., Kalia, Kiran, Tekade, Rakesh K.
Format: Journal Article
Language:English
Published: Hoboken, USA John Wiley & Sons, Inc 01-10-2021
Wiley Subscription Services, Inc
Subjects:
Animals
Biocompatibility
Biomedical materials
Biomedical Technology
Drug Administration Routes
Drug delivery
Drug Delivery Systems
Electrospinning
Genes
Humans
nanofiber composite
Nanofibers
Nanofibers - chemistry
Nanotubes, Carbon - chemistry
Polymers
Proteins
Sterility
therapeutics
Tissue Engineering
therapeutics
drug delivery
nanofiber composite
electrospinning
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Summary:Electrospun technology becomes a valuable means of fabricating functional polymeric nanofibers with distinctive morphological properties for drug delivery applications. Nanofibers are prepared from the polymer solution, which allows the direct incorporation of therapeutics such as small drug molecules, genes, and proteins by merely mixing them into the polymeric solution. Due to their biocompatibility, adhesiveness, sterility, and efficiency in delivering diverse cargoes, electrospun nanofibers have gained much attention. This review discusses the capabilities of the electrospun nanofibers in delivering different therapeutics like small molecules, genes, and proteins to their desired target site for treating various ailments. The potential of nanofibers in administering through multiple administration routes and the associated challenges has also been expounded along with a cross‐talk about the commercial products of nanofibers for biomedical applications.
Bibliography:Funding information
Dr. Tekade's Laboaratory, Grant/Award Number: PDF/2016/003329; Department of Science and Technology, Government of India, Grant/Award Number: ECR/2016/001964; Science and Engineering Research Board, Grant/Award Number: SERB Act 2008; Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Government of India
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1549-3296
1552-4965
DOI:10.1002/jbm.a.37187