Search Results - "Chauvière, G."

Enzymatic reduction studies of nitroheterocycles by Viodé, Cécile, Bettache, Nadir, Cenas, Narimantas, Krauth-Siegel, R.Luise, Chauvière, Gérard, Bakalara, Norbert, Périé, Jacques

“…The nitroimidazole derivative Megazol is a highly active compound used against several strains of Trypanosoma cruzi, the causative agent of Chagas’ disease…”
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Megazol combined with suramin: a chemotherapy regimen which reversed the CNS pathology in a model of human African trypanosomiasis in mice by Enanga, B., Keita, M., Chauvière, G., Dumas, M., Bouteille, B.

“…Chemotherapy for human African trypanosomiasis (HAT), or sleeping sickness, is unreliable because of resistance, refraction and toxic and adverse side‐effects…”
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Expression of receptors for enterotoxigenic Escherichia coli during enterocytic differentiation of human polarized intestinal epithelial cells in culture by KERNEIS, S, CHAUVIERE, G, DARFEUILLLE-MICHAUD, A, AUBEL, D, COCONNIER, M.-H, JOLY, B, SERVIN, A. L

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Simple high-performance liquid chromatographic method to analyse megazol in human and rat plasma by Enanga, B., Labat, C., Boudra, H., Chauvière, G., Keita, M., Bouteille, B., Dumas, M., Houin, G.

“…A simple and sensitive high-performance liquid chromatographic method has been developed to measure megazol in human plasma. The method was optimized and…”
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Topical chemotherapy for experimental African trypanosomiasis with cerebral involvement: the use of melarsoprol combined with the 5‐nitroimidazole, megazol by Jennings, F. W., Chauvière, G., Viode, C., Murray, M.

“…Summary Megazol, one of a number of related 5‐nitroimidazoles, can be dissolved in dimethylsulphoxide and the solution can be converted into a gel by the…”
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Effect of megazol on Trypanosoma brucei brucei acute and subacute infections in Swiss mice by Bouteille, Bernard, Marie-Daragon, Armelle, Chauvière, Gérard, de Albuquerque, Cristina, Enanga, Bertin, Dardé, Marie-Laure, Vallat, Jean-Michel, Périé, Jacques, Dumas, Michel

“…Human African trypanosomiasis (HAT) or sleeping sickness is a major public health problem in 36 sub-Saharan African countries and is caused by Trypanosoma…”
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Cyclic voltammetric studies on nitro radical anion formation from megazol and some related nitroimidazole derivatives by Bollo, S., Núñez-Vergara, L.J., Bontá, M., Chauviere, G., Périé, J., Squella, J.A.

“…Megazol (2-amino-5-(1-methyl-5-nitro-2-imidazolyl)-1,3,4-thiadiazol, CAS 19622-55-0) and related nitroimidazole compounds are being tested as antichagasic…”
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THERAPEUTIC AND NUTRITIONAL EFFECT OF AN ORAL REHYDRATION SOLUTION (ORS) CONTAINING GLUTAMINE. A DOUBLE BLIND RANDOMISED STUDY IN 44 DIARRHEIC INFANTS by Mouterde, O., Mallet, E., Vanhulle, C., Chauvière, G., Hévin, B., Meunier, M., Lenaerts, C., Ginies, J. L., Claeyssens, S., Heckettsweiler, B., Basuyau, J. P.

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Adhesion of human Lactobacillus acidophilus strain LB to human enterocyte-like Caco-2 cells by CHAUVIERE, GILLES, COCONNIER, MARIE-HELENE, KERNEIS, SOPHIE, FOURNIAT, JACKY, SERVIN, ALAIN L

“…Equipe de Pathogènie Microbienne Moléculaire Intestinale, Département de Microbiologie et Immunologie, Université Paris XI, UFR de Sciences Pharmaceutiques,…”
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Voltammetric Study of Nitro Radical Anion Generated from Some Nitrofuran Compounds of Pharmacological Significance by Bollo, S., Núñez-Vergara, L. J., Martinez, C., Chauviere, G., Périé, J., Squella, J. A.

“…The electrochemical behavior of 2‐(5‐amino‐ 1,3,4‐oxadiazolyl)‐5‐nitrofuran (NF359) and its comparison with well‐known drugs such as nifurtimox (NFX) and…”
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Electrochemical Study of 4-Substituted Analogues of Megazol by Bollo, S., Gunckel, S., Núñez-Vergara, L. J., Chauviere, G., Squella, J. A.

“…The electrochemical behavior of three different megazol analogues substituted at position 4 and their comparison with the parent compound megazol in protic and…”
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Nitro radical anions from megazol and related nitroimidazoles in aprotic media. A father–son type reaction triggered by an acidic proton by Bontá, M, Chauviere, G, Périé, J, Núñez-Vergara, L.J, Squella, J.A

“…We have studied the electrochemical reduction of some nitroimidazoles such as megazol(2-amino-5-(1-methyl-5-nitro-2-imidazolyl)-1,3,4-thiadiazol, CAS…”
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Uptake of the nitroimidazole drug megazol by African trypanosomes by Barrett, Michael P, Fairlamb, Alan H, Rousseau, Bernard, Chauvière, Gerard, Perié, Jacques

“…Megazol, CL 64,855 (2-amino-5-[1-methyl-5-nitro-2-imidazolyl]-1,3,4-thiazole) has been shown to be extremely effective in clearing experimental infections of…”
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Polarographic Reduction of Megazol and Derivatives, and Its Polarographic, UV Spectrophotometric, and HPLC Determination by Bollo, S., Núñez-Vergara, L. J., Bontá, M., Chauviere, G., Périé, J., Squella, J. A.

“…Megazol (2‐amino‐5‐(1‐methyl‐5‐nitro‐2‐imidazolyl)‐1,3,4‐thiadiazol, CAS 19622‐55‐0), a highly active compound used against several strains of Trypanosoma…”
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Adhering Heat-killed Human Lactobacillus acidophilus, Strain LB, Inhibits the Process of Pathogenicity of Diarrhoeagenic Bacteria in Cultured Human Intestinal Cells by Coconnier, Marie — Hélène, Bernet, Marie — Françoise, Chauvière, Gilles, Servin, Alain L

“…Heat — killed L. acidophilus, strain LB, was tested for its ability to adhere in vitro onto human enterocyte — like Caco — 2 and muco — secreting HT29 — MTX…”
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Adhesion of enterotoxigenic Escherichia coli to the human colon carcinoma cell line Caco-2 in culture by DARFEUILLE-MICHAUD, A, AUBEL, D, CHAUVIERE, G, RICH, C, BOURGES, M, SERVIN, A, JOLY, B

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Pharmacokinetics, metabolism and excretion of megazol in a trypanosoma brucei gambiense primate model of human African trypanosomiasis : Preliminary study by ENANGA, B, MEZUI ME NDONG, J, HOUIN, G, BOUDRA, H, DEBRAUWER, L, DUBREUIL, G, BOUTEILLE, B, CHAUVIERE, G, LABAT, C, DUMAS, M, PERIE, J

“…The pharmacokinetics of megazol (2-amino-5-(1-methyl-5-nitro-2-imidazolyl)-1,3,4-thiadiazol, CAS 19622-55-0) was investigated after a 100 mg/kg oral…”
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Inhibition of adhesion of enteroinvasive pathogens to human intestinal Caco-2 cells by Lactobacillus acidophilus strain LB decreases bacterial invasion by Coconnier, M H, Bernet, M F, Kernéis, S, Chauvière, G, Fourniat, J, Servin, A L

“…Salmonella typhimurium and enteropathogenic Escherichia coli (EPEC) were found to adhere to the brush border of differentiated human intestinal epithelial…”
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Essais d'efficacité sur Trypanosoma brucei brucei de molécules franchissant la barrière hématoméningée et du mégazol by MARIE-DARAGON, A, ROUILLARD, M. C, BOUTEILLE, B, BISSER, S, DE ALBUQUERQUE, C, CHAUVIERE, G, PERIE, J, DUMAS, M

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Synthesis of 2-amino-5-(1-methyl-5-nitro-[4-3H]-2-imidazolyl)-1,3,4-thiadiazole by Chauviere, G., Rousseau, B., Pillon, F., Perie, J.

“…2‐Amino‐5‐(1‐methyl‐5‐nitro‐4‐iodo‐2‐imidazoyl)‐1,3,4‐thiadiazole (5) was prepared from imidazole via a 4‐steps sequence. Reductive desiodination of 5 using a…”
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