Search Results - "Chaudhuri, Rima"

Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates by Hoffman, Nolan J., Parker, Benjamin L., Chaudhuri, Rima, Fisher-Wellman, Kelsey H., Kleinert, Maximilian, Humphrey, Sean J., Yang, Pengyi, Holliday, Mira, Trefely, Sophie, Fazakerley, Daniel J., Stöckli, Jacqueline, Burchfield, James G., Jensen, Thomas E., Jothi, Raja, Kiens, Bente, Wojtaszewski, Jørgen F.P., Richter, Erik A., James, David E.

“…Exercise is essential in regulating energy metabolism and whole-body insulin sensitivity. To explore the exercise signaling network, we undertook a global…”
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Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance by Fazakerley, Daniel J, Chaudhuri, Rima, Yang, Pengyi, Maghzal, Ghassan J, Thomas, Kristen C, Krycer, James R, Humphrey, Sean J, Parker, Benjamin L, Fisher-Wellman, Kelsey H, Meoli, Christopher C, Hoffman, Nolan J, Diskin, Ciana, Burchfield, James G, Cowley, Mark J, Kaplan, Warren, Modrusan, Zora, Kolumam, Ganesh, Yang, Jean Yh, Chen, Daniel L, Samocha-Bonet, Dorit, Greenfield, Jerry R, Hoehn, Kyle L, Stocker, Roland, James, David E

“…Insulin resistance in muscle, adipocytes and liver is a gateway to a number of metabolic diseases. Here, we show a selective deficiency in mitochondrial…”
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noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication by Ratia, Kiira, Pegan, Scott, Takayama, Jun, Sleeman, Katrina, Coughlin, Melissa, Baliji, Surendranath, Chaudhuri, Rima, Fu, Wentao, Prabhakar, Bellur S, Johnson, Michael E, Baker, Susan C, Ghosh, Arun K, Mesecar, Andrew D

“…We report the discovery and optimization of a potent inhibitor against the papain-like protease (PLpro) from the coronavirus that causes severe acute…”
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Targeted phosphoproteomics of insulin signaling using data-independent acquisition mass spectrometry by Parker, Benjamin L, Yang, Guang, Humphrey, Sean J, Chaudhuri, Rima, Ma, Xiuquan, Peterman, Scott, James, David E

“…A major goal in signaling biology is the establishment of high-throughput quantitative methods for measuring changes in protein phosphorylation of entire…”
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Global Phosphoproteomic Mapping of Early Mitotic Exit in Human Cells Identifies Novel Substrate Dephosphorylation Motifs by McCloy, Rachael A., Parker, Benjamin L., Rogers, Samuel, Chaudhuri, Rima, Gayevskiy, Velimir, Hoffman, Nolan J., Ali, Naveid, Watkins, D. Neil, Daly, Roger J., James, David E., Lorca, Thierry, Castro, Anna, Burgess, Andrew

“…Entry into mitosis is driven by the coordinated phosphorylation of thousands of proteins. For the cell to complete mitosis and divide into two identical…”
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Proteomic Analysis of GLUT4 Storage Vesicles Reveals Tumor Suppressor Candidate 5 (TUSC5) as a Novel Regulator of Insulin Action in Adipocytes by Fazakerley, Daniel J., Naghiloo, Sheyda, Chaudhuri, Rima, Koumanov, Françoise, Burchfield, James G., Thomas, Kristen C., Krycer, James R., Prior, Matthew J., Parker, Ben L., Murrow, Beverley A., Stöckli, Jacqueline, Meoli, Christopher C., Holman, Geoffrey D., James, David E.

“…Insulin signaling augments glucose transport by regulating glucose transporter 4 (GLUT4) trafficking from specialized intracellular compartments, termed GLUT4…”
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Kinome Screen Identifies PFKFB3 and Glucose Metabolism as Important Regulators of the Insulin/Insulin-like Growth Factor (IGF)-1 Signaling Pathway by Trefely, Sophie, Khoo, Poh-Sim, Krycer, James R., Chaudhuri, Rima, Fazakerley, Daniel J., Parker, Benjamin L., Sultani, Ghazal, Lee, James, Stephan, Jean-Philippe, Torres, Eric, Jung, Kenneth, Kuijl, Coenraad, James, David E., Junutula, Jagath R., Stöckli, Jacqueline

“…The insulin/insulin-like growth factor (IGF)-1 signaling pathway (ISP) plays a fundamental role in long term health in a range of organisms. Protein kinases…”
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Unraveling Kinase Activation Dynamics Using Kinase-Substrate Relationships from Temporal Large-Scale Phosphoproteomics Studies by Domanova, Westa, Krycer, James, Chaudhuri, Rima, Yang, Pengyi, Vafaee, Fatemeh, Fazakerley, Daniel, Humphrey, Sean, James, David, Kuncic, Zdenka

“…In response to stimuli, biological processes are tightly controlled by dynamic cellular signaling mechanisms. Reversible protein phosphorylation occurs on…”
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Structure-Based Design, Synthesis, and Biological Evaluation of a Series of Novel and Reversible Inhibitors for the Severe Acute Respiratory Syndrome−Coronavirus Papain-Like Protease by Ghosh, Arun K, Takayama, Jun, Aubin, Yoann, Ratia, Kiira, Chaudhuri, Rima, Baez, Yahira, Sleeman, Katrina, Coughlin, Melissa, Nichols, Daniel B, Mulhearn, Debbie C, Prabhakar, Bellur S, Baker, Susan C, Johnson, Michael E, Mesecar, Andrew D

“…We describe here the design, synthesis, molecular modeling, and biological evaluation of a series of small molecule, nonpeptide inhibitors of SARS-CoV PLpro…”
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Hyperactivation of the Insulin Signaling Pathway Improves Intracellular Proteostasis by Coordinately Up-regulating the Proteostatic Machinery in Adipocytes by Minard, Annabel Y., Wong, Martin K.L., Chaudhuri, Rima, Tan, Shi-Xiong, Humphrey, Sean J., Parker, Benjamin L., Yang, Jean Y., Laybutt, D. Ross, Cooney, Gregory J., Coster, Adelle C.F., Stöckli, Jacqueline, James, David E.

“…Hyperinsulinemia, which is associated with aging and metabolic disease, may lead to defective protein homeostasis (proteostasis) due to hyperactivation of…”
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Correction: Unraveling Kinase Activation Dynamics Using Kinase-Substrate Relationships from Temporal Large-Scale Phosphoproteomics Studies by Domanova, Westa, Krycer, James R, Chaudhuri, Rima, Yang, Pengyi, Vafaee, Fatemeh, Fazakerley, Daniel J, Humphrey, Sean J, James, David E, Kuncic, Zdenka

“…[This corrects the article DOI: 10.1371/journal.pone.0157763.]…”
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mTORC2 and AMPK differentially regulate muscle triglyceride content via Perilipin 3 by Kleinert, Maximilian, Parker, Benjamin L, Chaudhuri, Rima, Fazakerley, Daniel J, Serup, Annette, Thomas, Kristen C, Krycer, James R, Sylow, Lykke, Fritzen, Andreas M, Hoffman, Nolan J, Jeppesen, Jacob, Schjerling, Peter, Ruegg, Markus A, Kiens, Bente, James, David E, Richter, Erik A

“…Abstract Objective We have recently shown that acute inhibition of both mTOR complexes (mTORC1 and mTORC2) increases whole-body lipid utilization, while mTORC1…”
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DOC2 isoforms play dual roles in insulin secretion and insulin-stimulated glucose uptake by Li, Jia, Cantley, James, Burchfield, James G., Meoli, Christopher C., Stöckli, Jacqueline, Whitworth, P. Tess, Pant, Himani, Chaudhuri, Rima, Groffen, Alexander J. A., Verhage, Matthijs, James, David E.

“…Aims/hypothesis Glucose-stimulated insulin secretion (GSIS) and insulin-stimulated glucose uptake are processes that rely on regulated intracellular vesicle…”
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Integrated expression analysis of muscle hypertrophy identifies Asb2 as a negative regulator of muscle mass by Davey, Jonathan R, Watt, Kevin I, Parker, Benjamin L, Chaudhuri, Rima, Ryall, James G, Cunningham, Louise, Qian, Hongwei, Sartorelli, Vittorio, Sandri, Marco, Chamberlain, Jeffrey, James, David E, Gregorevic, Paul

“…The transforming growth factor-β (TGF-β) signaling network is a critical regulator of skeletal muscle mass and function and, thus, is an attractive therapeutic…”
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Dataset from the global phosphoproteomic mapping of early mitotic exit in human cells by Rogers, Samuel, McCloy, Rachael A., Parker, Benjamin L., Chaudhuri, Rima, Gayevskiy, Velimir, Hoffman, Nolan J., Watkins, D. Neil, Daly, Roger J., James, David E., Burgess, Andrew

“…The presence or absence of a phosphorylation on a substrate at any particular point in time is a functional readout of the balance in activity between the…”
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Skeletal muscle and plasma lipidomic signatures of insulin resistance and overweight/obesity in humans by Tonks, Katherine T., Coster, Adelle CF, Christopher, Michael J., Chaudhuri, Rima, Xu, Aimin, Gagnon‐Bartsch, Johann, Chisholm, Donald J., James, David E., Meikle, Peter J., Greenfield, Jerry R., Samocha‐Bonet, Dorit

“…Objective Alterations in lipids in muscle and plasma have been documented in insulin‐resistant people with obesity. Whether these lipid alterations are a…”
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Phosphoproteomics reveals conserved exercise‐stimulated signaling and AMPK regulation of store‐operated calcium entry by Nelson, Marin E, Parker, Benjamin L, Burchfield, James G, Hoffman, Nolan J, Needham, Elise J, Cooke, Kristen C, Naim, Timur, Sylow, Lykke, Ling, Naomi XY, Francis, Deanne, Norris, Dougall M, Chaudhuri, Rima, Oakhill, Jonathan S, Richter, Erik A, Lynch, Gordon S, Stöckli, Jacqueline, James, David E

“…Exercise stimulates cellular and physiological adaptations that are associated with widespread health benefits. To uncover conserved protein phosphorylation…”
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Cross-Species PTM Mapping from Phosphoproteomic Data by Chaudhuri, Rima, Yang, Jean Yee Hwa

“…Protein post-translational modifications (PTMs) are crucial for signal transduction in cells. In order to understand key cell signaling events, identification…”
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Skeletal muscle extracellular matrix remodelling after short-term overfeeding in healthy humans by Tam, Charmaine S, Chaudhuri, Rima, Hutchison, Amy T, Samocha-Bonet, Dorit, Heilbronn, Leonie K

“…Abstract Background Skeletal muscle extracellular matrix (ECM) remodeling has been proposed as a feature of the pathogenic milieu associated with obesity and…”
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Reducing agents affect inhibitory activities of compounds: Results from multiple drug targets by Lee, Hyun, Torres, Jaime, Truong, Lena, Chaudhuri, Rima, Mittal, Anuradha, Johnson, Michael E.

“…High-throughput screening (HTS) of large compound libraries has become a commonly used method for the identification of drug leads, and nonphysiological…”
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