Search Results - "Chaudhry, Afzal"

Generating an iPSC Bank for HLA-Matched Tissue Transplantation Based on Known Donor and Recipient HLA Types by Taylor, Craig J., Peacock, Sarah, Chaudhry, Afzal N., Bradley, J. Andrew, Bolton, Eleanor M.

“…The likelihood for immunological rejection of Human Leukocyte Antigens (HLA)-mismatched induced pluripotent stem cells (iPSCs) limits their therapeutic…”
Get full text

Clinical features and radiological findings in large vessel vasculitis: are Takayasu arteritis and giant cell arteritis 2 different diseases or a single entity? by Furuta, Shunsuke, Cousins, Claire, Chaudhry, Afzal, Jayne, David

“…Takayasu arteritis (TAK) and giant cell arteritis (GCA) are 2 major variants of large vessel vasculitis (LVV). The frequent involvement of large vessels in GCA…”
Get full text

The effect of rituximab therapy on immunoglobulin levels in patients with multisystem autoimmune disease by Marco, Helena, Smith, Rona M, Jones, Rachel B, Guerry, Mary-Jane, Catapano, Fausta, Burns, Stella, Chaudhry, Afzal N, Smith, Kenneth G C, Jayne, David R W

“…Rituximab is a B cell depleting anti-CD20 monoclonal antibody. CD20 is not expressed on mature plasma cells and accordingly rituximab does not have immediate…”
Get full text

Comparison of the Phenotype and Outcome of Granulomatosis with Polyangiitis Between UK and Japanese Cohorts by Furuta, Shunsuke, Chaudhry, Afzal N, Arimura, Yoshihiro, Dobashi, Hiroaki, Fujimoto, Shouichi, Homma, Sakae, Rasmussen, Niels, Jayne, David R

“…There are differences in the frequencies of antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis subgroups between different geographic regions,…”
Get full text

ACE inhibitor and angiotensin receptor-II antagonist prescribing and hospital admissions with acute kidney injury: a longitudinal ecological study by Tomlinson, Laurie A, Abel, Gary A, Chaudhry, Afzal N, Tomson, Charles R, Wilkinson, Ian B, Roland, Martin O, Payne, Rupert A

“…ACE Inhibitors (ACE-I) and Angiotensin-Receptor Antagonists (ARAs) are commonly prescribed but can cause acute kidney injury (AKI) during intercurrent illness…”
Get full text

Alemtuzumab for refractory primary systemic vasculitis-a randomised controlled dose ranging clinical trial of efficacy and safety (ALEVIATE) by Gopaluni, Seerapani, Smith, Rona, Goymer, Donna, Cahill, Hugh, Broadhurst, Elizabeth, Wallin, Elizabeth, McClure, Mark, Chaudhry, Afzal, Jayne, David

“…Primary systemic vasculitis (PSV) is a heterogeneous group of autoimmune conditions. There is an unmet need for alternative therapies that lead to sustained…”
Get full text

Rituximab for remission maintenance in relapsing antineutrophil cytoplasmic antibody-associated vasculitis by Smith, Rona M., Jones, Rachel B., Guerry, Mary-Jane, Laurino, Simona, Catapano, Fausta, Chaudhry, Afzal, Smith, Kenneth G. C., Jayne, David R. W.

“…Objective Rituximab is effective induction therapy in refractory or relapsing antineutrophil cytoplasmic antibody–associated vasculitis (AAV). However, further…”
Get full text

B-Cell–Depleting Induction Therapy and Acute Cellular Rejection by Clatworthy, Menna R, Watson, Christopher J.E, Plotnek, Gemma, Bardsley, Vicky, Chaudhry, Afzal N, Bradley, J. Andrew, Smith, Kenneth G.C

“…To the Editor: B-cell depletion is an effective treatment for a number of autoimmune diseases in which B cells were not previously considered to be important,…”
Get full text

A CD8 + T cell transcription signature predicts prognosis in autoimmune disease by Lyons, Paul A, Smith, Kenneth G C, McKinney, Eoin F, Carr, Edward J, Hollis, Jane L, Jayne, David R W, Willcocks, Lisa C, Koukoulaki, Maria, Brazma, Alvis, Jovanovic, Vojislav, Kemeny, D Michael, Pollard, Andrew J, MacAry, Paul A, Chaudhry, Afzal N

“…Autoimmune diseases are common and debilitating, but their severe manifestations could be reduced if biomarkers were available to allow individual tailoring of…”
Get full text

Long-term follow-up of patients who received repeat-dose rituximab as maintenance therapy for ANCA-associated vasculitis by Alberici, Federico, Smith, Rona M, Jones, Rachel B, Roberts, Darren M, Willcocks, Lisa C, Chaudhry, Afzal, Smith, Kenneth G C, Jayne, David R W

“…ANCA-associated vasculitis (AAV) is characterized by a chronic relapsing course. Rituximab (RTX) is an effective maintenance treatment; however, the long-term…”
Get full text

Comparison of Phenotype and Outcome in Microscopic Polyangiitis Between Europe and Japan by FURUTA, Shunsuke, CHAUDHRY, Afzal N, ITO, Chiharu, KUSANO, Eiji, YAMAGATA, Mieko, IKEDA, Kei, KASHIWAKUMA, Daisuke, IWAMOTO, Itsuo, WESTMAN, Kerstin, JAYNE, David, HAMANO, Yoshitomo, FUJIMOTO, Shouichi, NAGAFUCHI, Hiroko, MAKINO, Hirofumi, MATSUO, Seiichi, OZAKI, Shoichi, ENDO, Tomomi, MUSO, Eri

“…There are differences between Europe and Japan in the incidence and antineutrophil cytoplasmic antibody (ANCA) serotype of patients with microscopic…”
Get full text

Alemtuzumab as Remission Induction Therapy in Behçet Disease: A 20-year Experience by Mohammad, Aladdin J, Smith, Rona M, Chow, Yok W, Chaudhry, Afzal N, Jayne, David R W

“…To study the efficacy and safety of anti-CD52 antibody (alemtuzumab) in the treatment of refractory and relapsing Behçet disease (BD). Thirty-two patients (22…”
Get full text

Proof-of-concept solution to create an interoperable timeline of healthcare data by Trivedi, Sapna, Hall, Stephen, Inglis, Fiona, Chaudhry, Afzal

“…ObjectivesTo overcome the barriers of interoperability by sharing simulated patient data from different electronic health records systems and presenting them…”
Get full text

A Comprehensive Study of Clinical, Biochemical, Radiological, Vascular, Cardiac, and Sleep Parameters in an Unselected Cohort of Patients With Acromegaly Undergoing Presurgical Somatostatin Receptor Ligand Therapy by Annamalai, Anand K, Webb, Alison, Kandasamy, Narayanan, Elkhawad, Maysoon, Moir, Samantha, Khan, Fakhar, Maki-Petaja, Kaisa, Gayton, Emma L, Strey, Christopher H, O'Toole, Samuel, Ariyaratnam, Shaumya, Halsall, David J, Chaudhry, Afzal N, Berman, Laurence, Scoffings, Daniel J, Antoun, Nagui M, Dutka, David P, Wilkinson, Ian B, Shneerson, John M, Pickard, John D, Simpson, Helen L, Gurnell, Mark

“…Context: Attainment of safe GH and IGF-1 levels is a central goal of acromegaly management. Objective: The aim of this study was to determine the extent to…”
Get full text

Impact of donor mismatches at individual HLA-A, -B, -C, -DR, and -DQ loci on the development of HLA-specific antibodies in patients listed for repeat renal transplantation by Kosmoliaptsis, Vasilios, Gjorgjimajkoska, Olivera, Sharples, Linda D, Chaudhry, Afzal N, Chatzizacharias, Nikolaos, Peacock, Sarah, Torpey, Nicholas, Bolton, Eleanor M, Taylor, Craig J, Bradley, J Andrew

“…We have analyzed the relationship between donor mismatches at each HLA locus and development of HLA locus-specific antibodies in patients listed for repeat…”
Get more information

Predicting HLA Class II Alloantigen Immunogenicity From the Number and Physiochemical Properties of Amino Acid Polymorphisms by KOSMOLIAPTSIS, Vasilis, SHARPLES, Linda D, CHAUDHRY, Afzal N, HALSALL, David J, BRADLEY, J. Andrew, TAYLOR, Craig J

“…We have shown previously that human leukocyte antigen (HLA) class I immunogenicity can be predicted by the number, position, and physiochemical differences of…”
Get full text

Microarray analysis of human leucocyte subsets: the advantages of positive selection and rapid purification by Lyons, Paul A, Koukoulaki, Maria, Hatton, Alexander, Doggett, Karen, Woffendin, Hayley B, Chaudhry, Afzal N, Smith, Kenneth G C

“…For expression profiling to have a practical impact in the management of immune-related disease it is essential that it can be applied to peripheral blood…”
Get full text

Novel expression signatures identified by transcriptional analysis of separated leucocyte subsets in systemic lupus erythematosus and vasculitis by Lyons, Paul A, McKinney, Eoin F, Rayner, Tim F, Hatton, Alexander, Woffendin, Hayley B, Koukoulaki, Maria, Freeman, Thomas C, Jayne, David R W, Chaudhry, Afzal N, Smith, Kenneth G C

“…To optimise a strategy for identifying gene expression signatures differentiating systemic lupus erythematosus (SLE) and antineutrophil cytoplasmic…”
Get more information

Detection of Immunoglobulin G Human Leukocyte Antigen-Specific Alloantibodies in Renal Transplant Patients Using Single-Antigen-Beads is Compromised by the Presence of Immunoglobulin M Human Leukocyte Antigen-Specific Alloantibodies by KOSMOLIAPTSIS, Vasilis, BRADLEY, J. Andrew, PEACOCK, Sarah, CHAUDHRY, Afzal N, TAYLOR, Craig J

“…Luminex-based single-antigen human leukocyte antigen (HLA) antibody detection beads (SAB) are a major advance for the characterization of HLA-specific…”
Get full text

Using machine learning to model older adult inpatient trajectories from electronic health records data by Herrero-Zazo, Maria, Fitzgerald, Tomas, Taylor, Vince, Street, Helen, Chaudhry, Afzal N., Bradley, John R., Birney, Ewan, Keevil, Victoria L.

“…Electronic Health Records (EHR) data can provide novel insights into inpatient trajectories. Blood tests and vital signs from de-identified patients’ hospital…”
Get full text