Search Results - "Chaudhary, Imran"

Finite element analysis of mechanical properties of woven composites through a micromechanics model by Khan Haris A., Hassan Abid, Saeed M.B., Mazhar Farrukh, Chaudhary Imran A.

“…In a woven fabric composite, arrangement and behavior of the fibers contained in the yarn and the yarns themselves lead to an intricate deformation mechanism…”
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Future of Ethically Effective Leadership by Sarwar, Chaudhary Imran

“…This research focuses on (a) introducing and exploring ethically effective leadership, (b) introducing and testing theory on triad of typical—maximal—ideal…”
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Impact of Human and Social Capital on Economic Development in Pakistan: Empirical Evidence From Primary Data Analysis by Sibt-e- Ali, Muhammad, Chaudhary, Imran Sharif, Farooq, Fatima

“…This study examines the impact of human and social capital on economic development in Pakistan by employing empirical evidence from primary data analysis. The…”
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WALKING IN AND OUT OF THE HOSPITAL WITH A COMPLETE THROMBOTIC LEFT MAIN CORONARY ARTERY OCCLUSION by Wu, Ming Q., Chaudhary, Imran N.

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Pharmacokinetic and safety study of weekly irinotecan and oral capecitabine in patients with advanced solid cancers by Goel, Sanjay, Desai, Kavita, Karri, Sirisha, Gollamudi, Radharani, Chaudhary, Imran, Bulgaru, Anca, Kaubisch, Andreas, Goldberg, Gary, Einstein, Mark, Camacho, Fernando, Baker, Sharyn, Mani, Sridhar

“…Capecitabine and irinotecan have demonstrated in vitro synergistic anti-cancer activity, and both are substrates for carboxyl esterases (CES). We conducted a…”
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Oncolytic Reovirus (pelareorep) Induces Autophagy in KRAS-mutated Colorectal Cancer by Jiffry, Jeeshan, Thavornwatanayong, Thongthai, Rao, Devika, Fogel, Elisha J, Saytoo, Durvanand, Nahata, Rishika, Guzik, Hillary, Chaudhary, Imran, Augustine, Titto, Goel, Sanjay, Maitra, Radhashree

“…To explore the effects of pelareorep on autophagy in multiple models of colorectal cancer, including patient-derived peripheral blood mononuclear cells…”
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Eribulin—A review of preclinical and clinical studies by Swami, Umang, Chaudhary, Imran, Ghalib, Mohammad H, Goel, Sanjay

“…Abstract Eribulin mesylate is a non-taxane, structurally simplified, completely synthetic, halichondrin B derivative with an end poisoning, microtubule…”
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Elucidation of Pelareorep Pharmacodynamics in A Phase I Trial in Patients with KRAS -Mutated Colorectal Cancer by Goel, Sanjay, Ocean, Allyson J, Parakrama, Ruwan Y, Ghalib, Mohammad H, Chaudhary, Imran, Shah, Umang, Viswanathan, Sengottuvel, Kharkwal, Himanshu, Coffey, Matthew, Maitra, Radhashree

“…mutation is a negative predictive biomarker of anti-EGFR agents in patients with metastatic colorectal cancer (mCRC), and remains an elusive target…”
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Clinical benefit for minority patients (pts) with advanced refractory cancer versus non Hispanic whites (NHW) when enrolled on early phase (I) clinical trials by Kam, Audrey E., Ghalib, Mohammad Haroon, Chaudhary, Imran, Mani, Sridhar, Goel, Sanjay

“…Abstract only…”
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Immune response to reovirus (REO) in phase I study with chemotherapy in patients with KRAS mutant metastatic colorectal cancer (mCRC) by Parakrama, Ruwan, Chaudhary, Imran, Coffey, Matthew C., Goel, Sanjay, Maitra, Radhashree

“…Abstract only 217 Background: Viruses are well known immune sensitizing agents. The therapeutic efficacy of oncolytic reovirus in combination with chemotherapy…”
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A phase I safety and efficacy clinical trial of plocabulin and gemcitabine in patients with advanced solid tumors by Ghalib, Mohammad H, Pulla, Mariano Provencio, De Miguel Luken, Maria J, de Juan, Virginia Calvo, Chaudhary, Imran, Hammami, M Bakri, Vikash, Sindhu, Maitra, Radhashree, Martinez, Sara, Kahatt, Carmen, Extremera, Sonia, Fudio, Salvador, Goel, Sanjay

“…Plocabulin (Plo) induces depolymerization of tubulin fibers with disorganization and fragmentation of the microtubule network leading to mitosis. Plo combined…”
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Clinical outcome and prognosis of metastatic colorectal cancer (mCRC) patients (pts) on phase 1 trials: A single institution experience from 1999 to 2016 by Kam, Audrey E., Pendurti, Gopichand, Shah, Umang H., Ghalib, Mohammad Haroon, Chaudhary, Imran, Viswanathan, Sengottuvel, Mantzaris, Ioannis, Goel, Sanjay

“…Abstract only 828 Background: Pts with mCRC who progress on all standard therapies have a poor prognosis and limited therapy options. Phase 1 trials represent…”
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Excision repair cross-complementing group-1 (ERCC1) gene induction in peripheral blood mononuclear cells as a marker of outcome in patients with colorectal cancer treated with oxaliplatin by Rao, Devika, Basu Mallick, Atrayee, Merla, Amartej, Jiffry, Jeeshan, Chaudhary, Imran, Augustine, Titto A, Rajdev, Lakshmi, Kaubisch, Andreas, Maitra, Radhashree, Goel, Sanjay

“…Abstract only 542 Background: Oxaliplatin is a third generation platinum agent that confers tumoricidal effect by forming platinum-DNA adducts and is an…”
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Does Trade Openness Transfer Pollution across Borders: An Experience of Pakistan by Shareef, Fareed, Chaudhary, Imran Sharif, Azid, Toseef, Zafar, Muhammad Raza

“…The study aims to empirically explore the link between trade openness and emission level in Pakistan by using Johansson co integration technique during the…”
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Excision repair cross-complementing group-1 (ERCC1) induction kinetics and polymorphism are markers of inferior outcome in patients with colorectal cancer treated with oxaliplatin by Rao, Devika, Mallick, Atrayee Basu, Augustine, Titto, Daroqui, Cecilia, Jiffry, Jeeshan, Merla, Amartej, Chaudhary, Imran, Seetharam, Raviraja, Sood, Arjun, Gajavelli, Srikanth, Aparo, Santiago, Rajdev, Lakshmi, Kaubisch, Andreas, Chuy, Jennifer, Negassa, Abdissa, Mariadason, John M, Maitra, Radhashree, Goel, Sanjay

“…ERCC1, a component of nucleotide excision repair pathway, is known to repair DNA breaks induced by platinum drugs. We sought to ascertain if ERCC1 expression…”
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Outcomes Among Racial and Ethnic Minority Patients With Advanced Cancers in Phase 1 Trials: A Meta-Analysis by Goel, Sanjay, Negassa, Abdissa, Ghalib, Mohammad H, Chaudhary, Imran, Desai, Kavita, Shah, Umang, Swami, Umang, Cohen, Bruce, Maitra, Radhashree, Mani, Sridhar

“…Patients from racial and ethnic minority groups (eg, Asian, Hispanic, and non-Hispanic Black patients) have low representation in clinical trials, especially…”
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Abstract 4932: Excision repair cross-complementing group-1 (ERCC1) induction and polymorphism are markers of inferior outcome in patients with colorectal cancer treated with oxaliplatin by Rao, Devika, Mallick, Atrayee Basu, Augustine, Titto, Daroqui, Cecilia, Jiffry, Jeeshan, Merla, Amartej, Chaudhary, Imran, Seetharaman, Raviraja, Sood, Arjun, Gajavelli, Srikanth, Aparo, Santiago, Rajdev, Lakshmi, Kaubisch, Andreas, Chuy, Jennifer, Maitra, Radhashree, Goel, Sanjay

“…Abstract Background: Oxaliplatin confers tumoricidal effect by forming platinum-DNA adducts and is an integral part of the treatment paradigm for patients with…”
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Intravenous administration of Reolysin®, a live replication competent RNA virus is safe in patients with advanced solid tumors by Gollamudi, Radharani, Ghalib, Mohammad H., Desai, Kavita K., Chaudhary, Imran, Wong, Benny, Einstein, Mark, Coffey, Matthew, Gill, George M., Mettinger, Karl, Mariadason, John M., Mani, Sridhar, Goel, Sanjay

“…Summary Background Reolysin® is reovirus serotype 3-Dearing strain, a double-stranded replication-competent RNA non-enveloped icosahedral virus. It induces…”
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Survival outcome and prognostic model of patients with colorectal cancer on phase 1 trials by Kam, Audrey E., Pendurti, Gopichand, Shah, Umang H., Ghalib, Mohammad H., Chaudhary, Imran, Chuy, Jennifer, Rajdev, Lakshmi, Kaubisch, Andreas, Aparo, Santiago, Mantzaris, Ioannis, Goel, Sanjay

“…Summary Background Patients with metastatic colorectal cancer (mCRC) who progress on standard therapies may be eligible for phase I trials. To better delineate…”
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Safety, pharmacokinetics, and activity of EZN‐2208, a novel conjugate of polyethylene glycol and SN38, in patients with advanced malignancies by Kurzrock, Razelle, Goel, Sanjay, Wheler, Jennifer, Hong, David, Fu, Siqing, Rezai, Keyvan, Morgan‐Linnell, Sonia K., Urien, Saik, Mani, Sridhar, Chaudhary, Imran, Ghalib, Mohammed H., Buchbinder, Aby, Lokiec, François, Mulcahy, Mary

“…BACKGROUND: EZN‐2208 is a water‐soluble, polyethylene glycol drug conjugate of SN38, which is the active moiety of irinotecan. In this study, the authors…”
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