Search Results - "Chaudhari, Snehal N."

Increased mitochondrial fusion allows the survival of older animals in diverse C. elegans longevity pathways by Chaudhari, Snehal N., Kipreos, Edward T.

“…Mitochondria are dynamic organelles that undergo fusion and fission events. Mitochondrial dynamics are required for mitochondrial viability and for responses…”
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Expression of HLA class II molecules in humanized NOD.Rag1KO.IL2RgcKO mice is critical for development and function of human T and B cells by Danner, Rebecca, Chaudhari, Snehal N, Rosenberger, John, Surls, Jacqueline, Richie, Thomas L, Brumeanu, Teodor-Doru, Casares, Sofia

“…Humanized mice able to reconstitute a surrogate human immune system (HIS) can be used for studies on human immunology and may provide a predictive preclinical…”
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Bacterial Folates Provide an Exogenous Signal for C. elegans Germline Stem Cell Proliferation by Chaudhari, Snehal N., Mukherjee, Madhumati, Vagasi, Alexandra S., Bi, Gaofeng, Rahman, Mohammad M., Nguyen, Christine Q., Paul, Ligi, Selhub, Jacob, Kipreos, Edward T.

“…Here we describe an in vitro primary culture system for Caenorhabditis elegans germline stem cells. This culture system was used to identify a bacterial folate…”
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Highlights from the 24th workshop on vitamin D in Austin, September 2022 by Meyer, Mark B., Bernal-Mizrachi, Carlos, Bikle, Daniel D., Biyani, Madhu, Campbell, Moray J., Chaudhari, Snehal N., Christakos, Sylvia, Ingles, Sue A., Knuth, Megan M., Lee, Seong Min, Lisse, Thomas S., Liu, Eva S., Piec, Isabelle, Plum, Lori A., Rao, Sudhaker D., Reynolds, Carmen J., Thacher, Tom D., White, John H., Cantorna, Margherita T.

“…The 24th Workshop on Vitamin D was held September 7-9, 2022 in Austin, Texas and covered a wide diversity of research in the vitamin D field from across the…”
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Chains of evidence from correlations to causal molecules in microbiome-linked diseases by Chaudhari, Snehal N., McCurry, Megan D., Devlin, A. Sloan

“…Human-associated microorganisms play a vital role in human health, and microbial imbalance has been linked to a wide range of disease states. In this Review,…”
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Bariatric surgery reveals a gut-restricted TGR5 agonist with anti-diabetic effects by Chaudhari, Snehal N., Harris, David A., Aliakbarian, Hassan, Luo, James N., Henke, Matthew T., Subramaniam, Renuka, Vernon, Ashley H., Tavakkoli, Ali, Sheu, Eric G., Devlin, A. Sloan

“…Bariatric surgery, the most effective treatment for obesity and type 2 diabetes, is associated with increased levels of the incretin hormone glucagon-like…”
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A microbial metabolite remodels the gut-liver axis following bariatric surgery by Chaudhari, Snehal N., Luo, James N., Harris, David A., Aliakbarian, Hassan, Yao, Lina, Paik, Donggi, Subramaniam, Renuka, Adhikari, Arijit A., Vernon, Ashley H., Kiliç, Ayse, Weiss, Scott T., Huh, Jun R., Sheu, Eric G., Devlin, A. Sloan

“…Bariatric surgery is the most effective treatment for type 2 diabetes and is associated with changes in gut metabolites. Previous work uncovered a…”
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The Energy Maintenance Theory of Aging: Maintaining Energy Metabolism to Allow Longevity by Chaudhari, Snehal N., Kipreos, Edward T.

“…Fused, elongated mitochondria are more efficient in generating ATP than fragmented mitochondria. In diverse C. elegans longevity pathways, increased levels of…”
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Host–microbiome orchestration of the sulfated metabolome by D’Agostino, Gabriel D., Chaudhari, Snehal N., Devlin, A. Sloan

“…Recent studies have demonstrated that metabolites produced by commensal bacteria causally influence health and disease. The sulfated metabolome is one class of…”
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Development of a covalent inhibitor of gut bacterial bile salt hydrolases by Adhikari, Arijit A., Seegar, Tom C. M., Ficarro, Scott B., McCurry, Megan D., Ramachandran, Deepti, Yao, Lina, Chaudhari, Snehal N., Ndousse-Fetter, Sula, Banks, Alexander S., Marto, Jarrod A., Blacklow, Stephen C., Devlin, A. Sloan

“…Bile salt hydrolase (BSH) enzymes are widely expressed by human gut bacteria and catalyze the gateway reaction leading to secondary bile acid formation. Bile…”
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A Gut-Restricted Lithocholic Acid Analog as an Inhibitor of Gut Bacterial Bile Salt Hydrolases by Adhikari, Arijit A, Ramachandran, Deepti, Chaudhari, Snehal N, Powell, Chelsea E, Li, Wei, McCurry, Megan D, Banks, Alexander S, Devlin, A. Sloan

“…Bile acids play crucial roles in host physiology by acting both as detergents that aid in digestion and as signaling molecules that bind to host receptors. Gut…”
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A small intestinal bile acid modulates the gut microbiome to improve host metabolic phenotypes following bariatric surgery by Chen, Yingjia, Chaudhari, Snehal N, Harris, David A, Roberts, Cullen F, Moscalu, Andrei, Mathur, Vasundhara, Zhao, Lei, Tavakkoli, Ali, Devlin, A Sloan, Sheu, Eric G

“…Bariatric surgical procedures such as sleeve gastrectomy (SG) provide effective type 2 diabetes (T2D) remission in human patients. Previous work demonstrated…”
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Enhanced resolution through thick tissue with structured illumination and adaptive optics by Thomas, Benjamin, Wolstenholme, Adrian, Chaudhari, Snehal N, Kipreos, Edward T, Kner, Peter

“…Structured illumination microscopy provides twice the linear resolution of conventional fluorescence microscopy, but in thick samples, aberrations degrade the…”
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Dafachronic acid inhibits C. elegans germ cell proliferation in a DAF-12-dependent manner by Mukherjee, Madhumati, Chaudhari, Snehal N., Balachandran, Riju S., Vagasi, Alexandra S., Kipreos, Edward T.

“…Dafachronic acid (DA) is a bile acid-like steroid hormone that regulates dauer formation, heterochrony, and lifespan in C. elegans. Here, we describe that DA…”
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Inhibition of microbial deconjugation of micellar bile acids protects against intestinal permeability and liver injury by Li, Darrick K, Chaudhari, Snehal N, Lee, Yoojin, Sojoodi, Mozhdeh, Adhikari, Arijit A, Zukerberg, Lawrence, Shroff, Stuti, Barrett, Stephen Cole, Tanabe, Kenneth, Chung, Raymond T, Devlin, A Sloan

“…Altered host-microbe interactions and increased intestinal permeability have been implicated in disease pathogenesis. However, the mechanisms by which…”
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Intestinal Co-culture System to Study TGR5 Agonism and Gut Restriction by Chaudhari, Snehal N, Devlin, A Sloan

“…The activation of the Takeda G-protein receptor 5 (TGR5, also known as the G protein-coupled bile acid receptor 1, GPBAR1) in enteroendocrine L-cells results…”
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Primary Culture System for Germ Cells from Caenorhabditis elegans Tumorous Germline Mutants by Vagasi, Alexandra S, Rahman, Mohammad M, Chaudhari, Snehal N, Kipreos, Edward T

“…The germ line is an important model system for the study of germ stem cells. Wild-type germ cells are syncytial and therefore cannot be isolated in cultures…”
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42-OR: A Small Intestinal Bile Acid Modulates the Gut Microbiome to Improve Glucose Regulation following Bariatric Surgery by Chen, Yingjia, Chaudhari, Snehal N, Harris, David A, Tavakkoli, Ali, Devlin, Sloan, Sheu, Eric

“…Bariatric surgical procedures such as sleeve gastrectomy (SG) provide the most effective and durable therapy for type 2 diabetes (T2D). This work is aimed at…”
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A Bariatric Surgery-Derived Gut Metabolite Is a Potent Single and Combination Oral Therapy for Type 2 Diabetes by Moscalu, Andrei, Chen, Yingjia, Chaudhari, Snehal N, Haridas, Renuka S, Luo, James, Roberts, Cullen F, Karvar, Mehran, Tavakkoli, Ali, Devlin, A Sloan, Sheu, Eric G

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