Search Results - "Chau, Nicole G"

Intensive treatment and survival outcomes in NUT midline carcinoma of the head and neck by Chau, Nicole G., Hurwitz, Shelley, Mitchell, Chelsey M., Aserlind, Alexandra, Grunfeld, Noam, Kaplan, Leah, Hsi, Peter, Bauer, Daniel E., Lathan, Christopher S., Rodriguez‐Galindo, Carlos, Tishler, Roy B., Haddad, Robert I., Sallan, Stephen E., Bradner, James E., French, Christopher A.

“…BACKGROUND NUT midline carcinoma is a rare and aggressive genetically characterized subtype of squamous cell carcinoma frequently arising from the head and…”
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Marital status and head and neck cancer outcomes by Inverso, Gino, Mahal, Brandon A., Aizer, Ayal A., Donoff, R. Bruce, Chau, Nicole G., Haddad, Robert I.

“…BACKGROUND The objective of this study was to examine the effects of marital status on stage at presentation, receipt of treatment, and survival in patients…”
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Tipifarnib in recurrent, metastatic HRAS‐mutant salivary gland cancer by Hanna, Glenn J., Guenette, Jeffrey P., Chau, Nicole G., Sayehli, Cyrus M., Wilhelm, Christian, Metcalf, Robert, Wong, Deborah J., Brose, Marcia, Razaq, Mohammad, Pérez‐Ruiz, Elisabeth, Cohen, Ezra E. W., Aggarwal, Rahul, Scholz, Catherine, Gualberto, Antonio, Ho, Alan L.

“…Background To the authors' knowledge, there are no approved therapies for recurrent, metastatic (R/M) salivary gland carcinoma (SGC), but molecularly targeted…”
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Report of the First International Symposium on NUT Carcinoma by French, Christopher A, Cheng, Michael L, Hanna, Glenn J, DuBois, Steven G, Chau, Nicole G, Hann, Christine L, Storck, Simone, Salgia, Ravi, Trucco, Matteo, Tseng, Jennifer, Stathis, Anastasios, Piekarz, Richard, Lauer, Ulrich M, Massard, Christophe, Bennett, Kelly, Coker, Shodeinde, Tontsch-Grunt, Ulrike, Sos, Martin L, Liao, Sida, Wu, Catherine J, Polyak, Kornelia, Piha-Paul, Sarina A, Shapiro, Geoffrey I

“…NUT carcinoma is a rare, aggressive cancer defined by rearrangements of the NUTM1 gene. No routinely effective treatments of NUT carcinoma exist, despite…”
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The Benefits of Adjuvant Trastuzumab for HER‐2‐Positive Salivary Gland Cancers by Hanna, Glenn J., Bae, Ji Eun, Lorch, Jochen H., Haddad, Robert I., Jo, Vickie Y., Schoenfeld, Jonathan D., Margalit, Danielle N., Tishler, Roy B., Goguen, Laura A., Annino, Donald J., Chau, Nicole G.

“…Background Although high‐grade salivary gland cancers (SGCs) often express androgen receptor (AR) and/or HER‐2/neu, therapeutically targeting these receptors…”
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Definitive chemoradiation alters the immunologic landscape and immune checkpoints in head and neck cancer by Sridharan, Vishwajith, Margalit, Danielle N, Lynch, Stephanie A, Severgnini, Mariano, Zhou, Jun, Chau, Nicole G, Rabinowits, Guilherme, Lorch, Jochen H, Hammerman, Peter S, Hodi, F Stephen, Haddad, Robert I, Tishler, Roy B, Schoenfeld, Jonathan D

“…Background: Preclinical and clinical studies suggest potential synergy between high dose per fraction focal radiation and immunotherapy. However,…”
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Long-term outcomes and clinicogenomic correlates in recurrent, metastatic adenoid cystic carcinoma by Hanna, Glenn J., Bae, Ji Eun, Lorch, Jochen H., Schoenfeld, Jonathan D., Margalit, Danielle N., Tishler, Roy B., Haddad, Robert I., Chau, Nicole G.

“…•ACC patients treated within 3 years of recurrent, metastatic diagnosis have poor outcomes.•Disease biology drives prognosis in ACC, despite the use of…”
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Multidisciplinary Canadian consensus on the multimodal management of high-risk and radioactive iodine-refractory thyroid carcinoma by Ezzat, Shereen, Pasternak, Jesse D., Rajaraman, Murali, Abdel-Rahman, Omar, Boucher, Andrée, Chau, Nicole G., Chen, Shirley, Gill, Sabrina, Hyrcza, Martin D., Lamond, Nathan, Massicotte, Marie-Hélène, Winquist, Eric, Mete, Ozgur

“…Most follicular cell-derived differentiated thyroid carcinomas are regarded as low-risk neoplasms prompting conservative therapeutic management. Here, we…”
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Frameshift events predict anti–PD-1/L1 response in head and neck cancer by Hanna, Glenn J., Lizotte, Patrick, Cavanaugh, Megan, Kuo, Frank C., Shivdasani, Priyanka, Frieden, Alexander, Chau, Nicole G., Schoenfeld, Jonathan D., Lorch, Jochen H., Uppaluri, Ravindra, MacConaill, Laura E., Haddad, Robert I.

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Early mortality and overall survival in oncology phase I trial participants: can we improve patient selection? by Chau, Nicole G, Florescu, Ana, Chan, Kelvin K, Wang, Lisa, Chen, Eric X, Bedard, Philippe, Oza, Amit M, Siu, Lillian L

“…Patient selection for phase I trials (PIT) in oncology is challenging. A typical inclusion criterion for PIT is 'life expectancy > 3 months', however the 90…”
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Genomic correlates of response to immune checkpoint blockade in microsatellite-stable solid tumors by Miao, Diana, Margolis, Claire A., Vokes, Natalie I., Liu, David, Taylor-Weiner, Amaro, Wankowicz, Stephanie M., Adeegbe, Dennis, Keliher, Daniel, Schilling, Bastian, Tracy, Adam, Manos, Michael, Chau, Nicole G., Hanna, Glenn J., Polak, Paz, Rodig, Scott J., Signoretti, Sabina, Sholl, Lynette M., Engelman, Jeffrey A., Getz, Gad, Jänne, Pasi A., Haddad, Robert I., Choueiri, Toni K., Barbie, David A., Haq, Rizwan, Awad, Mark M., Schadendorf, Dirk, Hodi, F. Stephen, Bellmunt, Joaquim, Wong, Kwok-Kin, Hammerman, Peter, Van Allen, Eliezer M.

“…Tumor mutational burden correlates with response to immune checkpoint blockade in multiple solid tumors, although in microsatellite-stable tumors this…”
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Microcystic Adnexal Carcinoma of the Face Treated With Definitive Chemoradiation: A Case Report and Review of the Literature by Kim, Daniel W., Lee, Grace, Lam, Miranda B., Harris, Ethan J., Lam, Allen C., Thomas, Tom, Chau, Nicole G., Tishler, Roy B.

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Evaluation of grade in a genotyped cohort of sporadic medullary thyroid carcinomas by Najdawi, Fedaa, Ahmadi, Sara, Capelletti, Marzia, Dong, Fei, Chau, Nicole G, Barletta, Justine A

“…Aims Tumour grade and RET mutation status, especially the presence of high‐risk exon 15 and 16 RET mutations, have been reported to be prognostic in patients…”
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Recurrent IDH2 R172X mutations in sinonasal undifferentiated carcinoma by Jo, Vickie Y, Chau, Nicole G, Hornick, Jason L, Krane, Jeffrey F, Sholl, Lynette M

“…Sinonasal undifferentiated carcinoma is a rare and aggressive malignancy. Sinonasal undifferentiated carcinoma has long been considered a diagnosis of…”
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Vandetanib for the Treatment of Medullary Thyroid Cancer by CHAU, Nicole G, HADDAD, Robert I

“…Vandetanib (ZD6474, Caprelsa, AstraZeneca), an oral small-molecule tyrosine kinase inhibitor (TKI) that targets the rearranged during transfection receptor…”
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Zebrafish blastomere screen identifies retinoic acid suppression of MYB in adenoid cystic carcinoma by Mandelbaum, Joseph, Shestopalov, Ilya A, Henderson, Rachel E, Chau, Nicole G, Knoechel, Birgit, Wick, Michael J, Zon, Leonard I

“…Pluripotent cells have been used to probe developmental pathways that are involved in genetic diseases and oncogenic events. To find new therapies that would…”
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A Randomized Phase 2 Study of Pembrolizumab With or Without Radiation in Patients With Recurrent or Metastatic Adenoid Cystic Carcinoma by Mahmood, Umair, Bang, Andrew, Chen, Yu-Hui, Mak, Raymond H., Lorch, Jochen H., Hanna, Glenn J., Nishino, Mizuki, Manuszak, Claire, Thrash, Emily M., Severgnini, Mariano, Sanborn, Matthew, Sridharan, Vishwajith, Margalit, Danielle N., Tishler, Roy B., Busse, Paul M., Willers, Henning, Mamon, Harvey J., Yoo, Hyung-Jin, Pai, Sara I., Wirth, Lori J., Haddad, Robert I., Chau, Nicole G., Schoenfeld, Jonathan D.

“…We evaluated the safety and efficacy of pembrolizumab (pembro) ± radiation therapy (RT) in a phase 2 study among patients with progressive, metastatic adenoid…”
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Exome and genome sequencing of nasopharynx cancer identifies NF-[kappa]B pathway activating mutations by Li, Yvonne Y, Chung, Grace T Y, Lui, Vivian W Y, To, Ka-fai, Ma, Brigette B Y, Chow, Chit, Woo, John K S, Yip, Kevin Y, Seo, Jeongsun, Hui, Edwin P, Mak, Michael K F, Rusan, Maria, Chau, Nicole G, Or, Yvonne Y Y, Law, Marcus H N, Law, Peggy P Y, Liu, Zoey W Y, Ngan, Hoi-lam, Hau, Pok-man, Verhoeft, Krista R, Poon, Peony H Y, Yoo, Seong-keun, Shin, Jong-yeon, Lee, Sau-dan, Lun, Samantha W M, Jia, Lin, Chan, Anthony W H, Chan, Jason Y K, Lai, Paul B S, Fung, Choi-yi, Hung, Suet-ting, Wang, Lin, Chang, Ann Margaret V, Chiosea, Simion I, Hedberg, Matthew L, Tsao, Sai-wah, Van Hasselt, Andrew C, Chan, Anthony T C, Grandis, Jennifer R, Hammerman, Peter S, Lo, Kwok-wai

“…Nasopharyngeal carcinoma (NPC) is an aggressive head and neck cancer characterized by Epstein-Barr virus (EBV) infection and dense lymphocyte infiltration. The…”
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Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations by Li, Yvonne Y, Chung, Grace T. Y., Lui, Vivian W. Y., To, Ka-Fai, Ma, Brigette B. Y., Chow, Chit, Woo, John K, S., Yip, Kevin Y., Seo, Jeongsun, Hui, Edwin P., Mak, Michael K. F., Rusan, Maria, Chau, Nicole G., Or, Yvonne Y. Y., Law, Marcus H. N., Law, Peggy P. Y., Liu, Zoey W. Y., Ngan, Hoi-Lam, Hau, Pok-Man, Verhoeft, Krista R., Poon, Peony H. Y., Yoo, Seong-Keun, Shin, Jong-Yeon, Lee, Sau-Dan, Lun, Samantha W. M., Jia, Lin, Chan, Anthony W. H., Chan, Jason Y. K., Lai, Paul B. S., Fung, Choi-Yi, Hung, Suet-Ting, Wang, Lin, Chang, Ann Margaret V., Chiosea, Simion I., Hedberg, Matthew L., Tsao, Sai-Wah, van Hasselt, Andrew C., Chan, Anthony T. C., Grandis, Jennifer R., Hammerman, Peter S., Lo, Kwok-Wai

“…Nasopharyngeal carcinoma (NPC) is an aggressive head and neck cancer characterized by Epstein-Barr virus (EBV) infection and dense lymphocyte infiltration. The…”
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An Anatomical Site and Genetic-Based Prognostic Model for Patients With Nuclear Protein in Testis (NUT) Midline Carcinoma: Analysis of 124 Patients by Chau, Nicole G, Ma, Clement, Danga, Kristina, Al-Sayegh, Hasan, Nardi, Valentina, Barrette, Ryan, Lathan, Christopher S, DuBois, Steven G, Haddad, Robert I, Shapiro, Geoffrey I, Sallan, Stephen E, Dhar, Arindam, Nelson, Jeanenne J, French, Christopher A

“…NUT midline carcinoma, renamed NUT carcinoma (NC), is an aggressive squamous cancer defined by rearrangement of the gene. Although a subset of patients can be…”
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