Search Results - "Chau, Gilda P"

Context matters – Daxx and Atrx are not robust tumor suppressors in the murine endocrine pancreas by Sun, Chang, Estrella, Jeannelyn S., Whitley, Elizabeth M., Chau, Gilda P., Lozano, Guillermina, Wasylishen, Amanda R.

“…ABSTRACT Genome sequencing has revealed the importance of epigenetic regulators in tumorigenesis. The genes encoding the chromatin remodeling complex DAXX:ATRX…”
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Daxx maintains endogenous retroviral silencing and restricts cellular plasticity in vivo by Wasylishen, Amanda R, Sun, Chang, Moyer, Sydney M, Qi, Yuan, Chau, Gilda P, Aryal, Neeraj K, McAllister, Florencia, Kim, Michael P, Barton, Michelle C, Estrella, Jeannelyn S, Su, Xiaoping, Lozano, Guillermina

“…Tumor sequencing studies have emphasized the role of epigenetics and altered chromatin homeostasis in cancer. Mutations in , which encodes a chaperone for the…”
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High levels of the p53 inhibitor MDM4 in head and neck squamous carcinomas by Valentin-Vega, Yasmine A., BS, Barboza, Juan A., PhD, Chau, Gilda P., MS, El-Naggar, Adel K., MD, PhD, Lozano, Guillermina, PhD

“…Summary The p53 tumor suppressor is mutated in most human tumors. MDM2, a well-known inhibitor of p53, is overexpressed in a large number of tumors, suggesting…”
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Alterations of the Mdm2 C-Terminus Differentially Impact Its Function In Vivo by Pant, Vinod, Aryal, Neeraj K, Xiong, Shunbin, Chau, Gilda P, Fowlkes, Natalie W, Lozano, Guillermina

“…Murine double minute 2 (Mdm2) is the principal E3-ubiquitin ligase for p53 and contains a C2H2C4 type RING domain wherein the last cysteine residue is followed…”
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Omics analyses of a somatic Trp53 R245W/+ breast cancer model identify cooperating driver events activating PI3K/AKT/mTOR signaling by Yu, Xiaojie, Zhang, Yun, Xiong, Shunbin, McDaniel, Joy M, Sun, Chang, Chau, Gilda P, Gencel-Augusto, Jovanka, Chachad, Dhruv, Morrissey, Rhiannon L, Rao, Xiayu, Wang, Jing, Lozano, Guillermina

“…Alterations of the tumor suppressor , one of the most common events in cancer, alone are insufficient for tumor development but serve as drivers of…”
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Omics analyses of a somatic Trp53R245W/+ breast cancer model identify cooperating driver events activating PI3K/AKT/mTOR signaling by Yu, Xiaojie, Zhang, Yun, Xiong, Shunbin, McDaniel, Joy M, Sun, Chang, Chau, Gilda P, Gencel-Augusto, Jovanka, Chachad, Dhruv, Morrissey, Rhiannon L, Rao, Xiayu, Wang, Jing, Lozano, Guillermina

“…Alterations of the tumor suppressor TP53, one of the most common events in cancer, alone are insufficient for tumor development but serve as drivers of…”
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Men1 maintains exocrine pancreas homeostasis in response to inflammation and oncogenic stress by Wasylishen, Amanda R., Sun, Chang, Chau, Gilda P., Qi, Yuan, Su, Xiaoping, Kim, Michael P., Estrella, Jeannelyn S., Lozano, Guillermina

“…A more comprehensive understanding of the molecular mechanisms underlying pancreatic diseases, including pancreatitis and cancer, is essential to improve…”
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Daxx Functions Are p53-Independent In Vivo by Wasylishen, Amanda R, Estrella, Jeannelyn S, Pant, Vinod, Chau, Gilda P, Lozano, Guillermina

“…Mutations in the death domain-associated protein (DAXX) have been recently identified in a substantial proportion of human pancreatic neuroendocrine tumors…”
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p53R245W Mutation Fuels Cancer Initiation and Metastases in NASH-driven Liver Tumorigenesis by Dibra, Denada, Gagea, Mihai, Qi, Yuan, Chau, Gilda P, Su, Xiaoping, Lozano, Guillermina

“…Obesity is a significant global health concern. Non-alcoholic fatty liver disease and non-alcoholic steatohepatitis (NASH) are common risk factors for…”
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p53R172H and p53R245W Hotspot Mutations Drive Distinct Transcriptomes in Mouse Mammary Tumors Through a Convergent Transcriptional Mediator by McDaniel, Joy M, Morrissey, Rhiannon L, Dibra, Denada, Patel, Lalit R, Xiong, Shunbin, Zhang, Yun, Chau, Gilda P, Su, Xiaoping, Qi, Yuan, El-Naggar, Adel K, Lozano, Guillermina

“…Aggressive breast cancers harbor TP53 missense mutations. Tumor cells with TP53 missense mutations exhibit enhanced growth and survival through transcriptional…”
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Overexpression of the p53 inhibitor MDM4 in Head and Neck Squamous Carcinomas by Valentin-Vega, Yasmine A., Barboza, Juan A., Chau, Gilda P., El-Naggar, Adel K., Lozano, Guillermina

“…The p53 tumor suppressor is mutated in the majority of human tumors. MDM2, a well-known inhibitor of p53, is overexpressed in a large number of tumors…”
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