Search Results - "Chau, Chalmers C"

Macromolecular Crowding Enhances the Detection of DNA and Proteins by a Solid-State Nanopore by Chau, Chalmers C, Radford, Sheena E, Hewitt, Eric W, Actis, Paolo

“…Nanopore analysis of nucleic acid is now routine, but detection of proteins remains challenging. Here, we report the systematic characterization of the effect…”
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Single molecule delivery into living cells by Chau, Chalmers C., Maffeo, Christopher M., Aksimentiev, Aleksei, Radford, Sheena E., Hewitt, Eric W., Actis, Paolo

“…Controlled manipulation of cultured cells by delivery of exogenous macromolecules is a cornerstone of experimental biology. Here we describe a platform that…”
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Mechanistic Study of the Conductance and Enhanced Single-Molecule Detection in a Polymer–Electrolyte Nanopore by Marcuccio, Fabio, Soulias, Dimitrios, Chau, Chalmers C. C., Radford, Sheena E., Hewitt, Eric, Actis, Paolo, Edwards, Martin Andrew

“…Solid-state nanopores have been widely employed in the detection of biomolecules, but low signal-to-noise ratios still represent a major obstacle in the…”
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Single-cell nanobiopsy enables multigenerational longitudinal transcriptomics of cancer cells by Marcuccio, Fabio, Chau, Chalmers C, Tanner, Georgette, Elpidorou, Marilena, Finetti, Martina A, Ajaib, Shoaib, Taylor, Morag, Lascelles, Carolina, Carr, Ian, Macaulay, Iain, Stead, Lucy F, Actis, Paolo

“…Single-cell RNA sequencing has revolutionized our understanding of cellular heterogeneity, but routine methods require cell lysis and fail to probe the dynamic…”
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The role of macromolecular crowding in single-entity electrochemistry: Friend or foe? by Chau, Chalmers C., Hewitt, Eric W., Actis, Paolo

“…The recent development of nanoscale probes has enabled the study of single molecules and single cells with unprecedented resolution and the expansion of the…”
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